BRPI0822462A2 - derivados de 6-1h-imidazo-quinazolina e de quinolinas, novos inibidores de mao e ligantes a receptor de imidazolina. - Google Patents
derivados de 6-1h-imidazo-quinazolina e de quinolinas, novos inibidores de mao e ligantes a receptor de imidazolina.Info
- Publication number
- BRPI0822462A2 BRPI0822462A2 BRPI0822462A BRPI0822462A BRPI0822462A2 BR PI0822462 A2 BRPI0822462 A2 BR PI0822462A2 BR PI0822462 A BRPI0822462 A BR PI0822462A BR PI0822462 A BRPI0822462 A BR PI0822462A BR PI0822462 A2 BRPI0822462 A2 BR PI0822462A2
- Authority
- BR
- Brazil
- Prior art keywords
- quinazoline
- imidazo
- inhibitors
- quinoline derivatives
- novel hand
- Prior art date
Links
- 102000009032 Imidazoline Receptors Human genes 0.000 title 1
- 108010049134 Imidazoline Receptors Proteins 0.000 title 1
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 239000011230 binding agent Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2008/057908 WO2009152868A1 (en) | 2008-06-20 | 2008-06-20 | 6-1h-imidazo-quinazoline and quinolines derivatives, new mao inhibitors and imidazoline receptor ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0822462A2 true BRPI0822462A2 (pt) | 2015-10-13 |
Family
ID=40220723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0822462A BRPI0822462A2 (pt) | 2008-06-20 | 2008-06-20 | derivados de 6-1h-imidazo-quinazolina e de quinolinas, novos inibidores de mao e ligantes a receptor de imidazolina. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8633208B2 (pt) |
| EP (1) | EP2315588B1 (pt) |
| JP (1) | JP2011524383A (pt) |
| KR (1) | KR20110036583A (pt) |
| CN (1) | CN102159208B (pt) |
| AU (1) | AU2008357946B2 (pt) |
| BR (1) | BRPI0822462A2 (pt) |
| CA (1) | CA2728376C (pt) |
| ES (1) | ES2401679T3 (pt) |
| MX (1) | MX2010014394A (pt) |
| PT (1) | PT2315588E (pt) |
| RU (1) | RU2472508C2 (pt) |
| WO (1) | WO2009152868A1 (pt) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1395963B1 (it) * | 2009-06-04 | 2012-11-02 | Rottapharm Spa | Forme cristalline di 6-(1h-imidazol-1-il)-2-fenil chinazolina e dei suoi sali |
| TW201210597A (en) * | 2010-06-09 | 2012-03-16 | Gilead Sciences Inc | Inhibitors of hepatitis C virus |
| UA113280C2 (xx) | 2010-11-11 | 2017-01-10 | АМІНОСПИРТЗАМІЩЕНІ ПОХІДНІ 2,3-ДИГІДРОІМІДАЗО$1,2-c]ХІНАЗОЛІНУ, ПРИДАТНІ ДЛЯ ЛІКУВАННЯ ГІПЕРПРОЛІФЕРАТИВНИХ ПОРУШЕНЬ І ЗАХВОРЮВАНЬ, ПОВ'ЯЗАНИХ З АНГІОГЕНЕЗОМ | |
| IN2014CN02646A (pt) | 2011-09-14 | 2015-08-07 | Samumed Llc | |
| WO2014158916A1 (en) * | 2013-03-14 | 2014-10-02 | Dart Neuroscience, Llc | Substituted naphthyridine and quinoline compounds as mao inhibitors |
| WO2015157005A1 (en) | 2014-04-10 | 2015-10-15 | E I Du Pont De Nemours And Company | Substituted tolyl fungicide mixtures |
| EP3226868A4 (en) | 2014-12-05 | 2018-08-15 | Subramaniam Ananthan | Novel quinazolines as biogenic amine transport modulators |
| CA2969839A1 (en) * | 2014-12-05 | 2016-06-09 | Subramaniam Ananthan | Heterocyclic compounds as biogenic amine transport modulators |
| JP6501251B2 (ja) * | 2015-03-12 | 2019-04-17 | 国立大学法人 長崎大学 | 慢性疼痛の治療薬 |
| MX380092B (es) | 2015-11-06 | 2025-03-11 | Samumed Llc | Tratamiento de la osteoartritis. |
| IL294124B2 (en) | 2015-12-10 | 2024-02-01 | Ptc Therapeutics Inc | Methods for treating huntington's disease |
| CN105461626B (zh) * | 2015-12-17 | 2018-05-08 | 浙江工业大学 | 芳环或稠杂环联3,4-二氢异喹啉类共轭结构化合物及其应用 |
| MX390577B (es) | 2016-06-01 | 2025-03-20 | Samumed Llc | Proceso de preparación de n-(5-(3-(7-(3-fluorofenil)-3h-imidazo[4,5-c]piridin-2-il)-1h-indazol-5-il)piridin-3-il)-3-metilbutanamida. |
| JP2019535672A (ja) | 2016-10-21 | 2019-12-12 | サミュメッド リミテッド ライアビリティ カンパニー | インダゾール−３−カルボキサミドの使用方法およびｗｎｔ／β−カテニンシグナル伝達経路阻害剤としてのそれらの使用 |
| MA46696A (fr) | 2016-11-07 | 2019-09-11 | Samumed Llc | Formulations injectables à dose unique prêtes à l'emploi |
| US11407753B2 (en) * | 2017-06-05 | 2022-08-09 | Ptc Therapeutics, Inc. | Compounds for treating Huntington's disease |
| WO2019005993A1 (en) | 2017-06-28 | 2019-01-03 | Ptc Therapeutics, Inc. | METHODS OF TREATING HUNTINGTON'S DISEASE |
| US11382918B2 (en) | 2017-06-28 | 2022-07-12 | Ptc Therapeutics, Inc. | Methods for treating Huntington's Disease |
| MX2020009957A (es) | 2018-03-27 | 2021-01-15 | Ptc Therapeutics Inc | Compuestos para el tratamiento de enfermedad de hungtinton. |
| EP3814345B8 (en) | 2018-06-27 | 2024-10-30 | PTC Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| PL3814357T3 (pl) | 2018-06-27 | 2024-09-16 | Ptc Therapeutics, Inc. | Związki heterocykliczne i heteroarylowe do leczenia choroby huntingtona |
| EP3814360B8 (en) | 2018-06-27 | 2024-11-06 | PTC Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| TWI846654B (zh) * | 2018-11-06 | 2024-06-21 | 美商富曼西公司 | 經取代之甲苯基殺真菌劑 |
| EP3735974A1 (en) | 2019-05-10 | 2020-11-11 | Rottapharm Biotech S.r.l. | Use of 2-phenyl-6-(1h-imidazol-1-yl)quinazoline for treating neurodegenerative diseases, preferably alzheimer's disease |
| WO2020231977A1 (en) | 2019-05-13 | 2020-11-19 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
| WO2021104639A1 (en) | 2019-11-29 | 2021-06-03 | Rottapharm Biotech S.R.L. | Use of 2-phenyl-6-(1h-imidazol-1-yl) quinazoline for the prevention of abuse and of side effects of at least one opioid |
| PY2133975A (es) | 2020-05-06 | 2022-01-19 | Fmc Corp | Fungicidas de tolilo sustituido y sus mezclas |
| WO2022137085A1 (en) | 2020-12-22 | 2022-06-30 | Novartis Ag | Indole derivatives useful in treating conditions associated with cgas |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5455252A (en) | 1993-03-31 | 1995-10-03 | Syntex (U.S.A.) Inc. | Optionally substituted 6,8-quinolines |
| US6627647B1 (en) | 2000-03-23 | 2003-09-30 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 1-(4-aminophenyl)imidazoles and their use as anti-inflammatory agents |
| JP4533391B2 (ja) * | 2004-01-16 | 2010-09-01 | エフ．ホフマン−ラ ロシュ アーゲー | 中枢神経系疾患の処置のための５−ヒドロキシトリプタミンレセプター（５−ｈｔ）のモジュレーターとしての、１−ベンジル−５−ピペラジン−１−イル−３，４−ジヒドロ−１ｈ−キナゾリン−２−オン誘導体、ならびにそれぞれの１ｈ−ベンゾ（１，２，６）チアジアジン−２，２−ジオキシドおよび１，４−ジヒドロベンゾ（ｄ）（１，３）オキサジン−２−オン誘導体 |
| ITTO20040125A1 (it) | 2004-03-01 | 2004-06-01 | Rotta Research Lab | Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica |
| RU2304029C1 (ru) * | 2005-11-07 | 2007-08-10 | Открытое акционерное общество "Электростальский завод тяжелого машиностроения" | Устройство для перемещения труб конечной длины |
| EP2066653B1 (en) * | 2006-08-03 | 2012-09-12 | Rottapharm S.p.A. | 6-1h-imidazo-quinazoline and quinolines derivatives, new potent analgesics and anti-inflammatory agents |
-
2008
- 2008-06-20 MX MX2010014394A patent/MX2010014394A/es active IP Right Grant
- 2008-06-20 US US12/999,862 patent/US8633208B2/en not_active Expired - Fee Related
- 2008-06-20 RU RU2011101952/15A patent/RU2472508C2/ru active
- 2008-06-20 ES ES08774197T patent/ES2401679T3/es active Active
- 2008-06-20 BR BRPI0822462A patent/BRPI0822462A2/pt not_active IP Right Cessation
- 2008-06-20 PT PT87741971T patent/PT2315588E/pt unknown
- 2008-06-20 KR KR1020117001213A patent/KR20110036583A/ko not_active Withdrawn
- 2008-06-20 WO PCT/EP2008/057908 patent/WO2009152868A1/en not_active Ceased
- 2008-06-20 CN CN200880130846.XA patent/CN102159208B/zh active Active
- 2008-06-20 EP EP08774197A patent/EP2315588B1/en active Active
- 2008-06-20 JP JP2011513886A patent/JP2011524383A/ja active Pending
- 2008-06-20 AU AU2008357946A patent/AU2008357946B2/en not_active Ceased
- 2008-06-20 CA CA2728376A patent/CA2728376C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008357946A1 (en) | 2009-12-23 |
| RU2011101952A (ru) | 2012-07-27 |
| MX2010014394A (es) | 2011-05-19 |
| CN102159208A (zh) | 2011-08-17 |
| KR20110036583A (ko) | 2011-04-07 |
| US8633208B2 (en) | 2014-01-21 |
| EP2315588A1 (en) | 2011-05-04 |
| CN102159208B (zh) | 2014-05-28 |
| US20110118289A1 (en) | 2011-05-19 |
| CA2728376C (en) | 2015-05-12 |
| PT2315588E (pt) | 2013-03-25 |
| JP2011524383A (ja) | 2011-09-01 |
| RU2472508C2 (ru) | 2013-01-20 |
| AU2008357946B2 (en) | 2013-06-20 |
| ES2401679T3 (es) | 2013-04-23 |
| EP2315588B1 (en) | 2012-12-19 |
| CA2728376A1 (en) | 2009-12-23 |
| WO2009152868A1 (en) | 2009-12-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0822462A2 (pt) | derivados de 6-1h-imidazo-quinazolina e de quinolinas, novos inibidores de mao e ligantes a receptor de imidazolina. | |
| LT3216803T (lt) | Stabilūs ir tirpūs antikūnai, slopinantys vegf | |
| NO2021006I1 (no) | Quofenix, delafloksacin | |
| AP2377A (en) | Benzimidazole derivatives. | |
| ATE513831T1 (de) | Pyridinä3,4-büpyrazinone | |
| HRP20151058T1 (xx) | Ariloazol-2-il-cijanoetilamino-spojevi, postupak njihove proizvodnje i postupak njihove uporabe | |
| BRPI0919841A2 (pt) | Anticorpo de cadeia unica biespecifico de psmaxcd3, especifico de especies cruzadas | |
| ATE555107T1 (de) | 2-aza-bicyclo-ä2,2,1-üheptan-derivate | |
| NL2000537A1 (nl) | Aminederivaten. | |
| HUE055338T2 (hu) | Indolamin-2,3-dioxigenáz-alapú immunterápia | |
| BRPI0907563A2 (pt) | Derivados de 4,5-di-hidro-xazol-2-il amina | |
| BRPI0910307A2 (pt) | inibidores de hiv integrase | |
| BRPI1008060A2 (pt) | Agonistas e antagonistas do receptor s1p5, e métodos de uso do mesmo. | |
| BRPI0907364A2 (pt) | Antagonistas aminoalquilbifenil n,n-disubstituídos de receptores d2 de prostaglandina | |
| EP2344471A4 (en) | 7-PIPERIDINALKYL-3,4-dihydroquinolone DERIVATIVE | |
| ATE545417T1 (de) | Pyrazoloä3,4-büpyridin-derivate als phosphodiesterasehemmer | |
| BRPI0820805A2 (pt) | Antagonista do receptor de mineralocorticóides derivados da 6h-di-benzo[b,e]oxepina | |
| BRPI0913188A2 (pt) | moduladores de receptores 5-ht3, métodos de fabricação, e uso dos mesmos | |
| ATE527260T1 (de) | (dihydro)pyrroloä2,1-aüisoquinoline | |
| DE502007005744D1 (de) | Schallgedämpftes, gasführendes Bauteil | |
| BRPI0917446A2 (pt) | derivados de acilaminobenzamida. | |
| EP2023715A4 (en) | Indoleamine-2,3-dioxygenase 2 | |
| EP2459573A4 (en) | SUBSTITUTED 1,2-AZABORIN HETEROCYCLES | |
| BRPI0906714A2 (pt) | Derivados de oxazepinopirimidona heteroarilamida substituídos. | |
| DK2148873T3 (da) | 4-alkoxypyridazinderivater som hurtigt dissocierende dopamin 2- receptorantagonister |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B25A | Requested transfer of rights approved |
Owner name: ROTTAPHARM BIOTECH S.R.L. (IT) |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |