AP911A - Combinatin of aldose reductase inhibitor and a glycogen phosphorylase inhibitor. - Google Patents

Combinatin of aldose reductase inhibitor and a glycogen phosphorylase inhibitor. Download PDF

Info

Publication number: AP911A
Authority: AP; ARIPO
Prior art keywords: alkyl; mono; inhibitor; aldose reductase; glycogen phosphorylase
Prior art date: 1997-11-21

Application number

APAP/P/1998/001401A

Other languages

English (en)

Other versions

AP9801401A0 (en

Inventor

Banavara L Mylari

Denis Jay Hoover

Bernard Hulin

Judith Lee Treadway

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-21

Filing date

1998-11-19

Publication date

2000-12-07

1998-11-19 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

1998-12-31 Publication of AP9801401A0 publication Critical patent/AP9801401A0/xx

2000-12-07 Application granted granted Critical

2000-12-07 Publication of AP911A publication Critical patent/AP911A/en

Links

239000003288 aldose reductase inhibitor Substances 0.000 title abstract description 13
229940118148 Aldose reductase inhibitor Drugs 0.000 title description 7
ROJNYKZWTOHRNU-UHFFFAOYSA-N 2-chloro-4,5-difluoro-n-[[2-methoxy-5-(methylcarbamoylamino)phenyl]carbamoyl]benzamide Chemical compound CNC(=O)NC1=CC=C(OC)C(NC(=O)NC(=O)C=2C(=CC(F)=C(F)C=2)Cl)=C1 ROJNYKZWTOHRNU-UHFFFAOYSA-N 0.000 title description 5
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract description 22
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Classifications

- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

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Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
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Urology & Nephrology (AREA)
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Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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APAP/P/1998/001401A 1997-11-21 1998-11-19 Combinatin of aldose reductase inhibitor and a glycogen phosphorylase inhibitor. AP911A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US6636597P	1997-11-21	1997-11-21

Publications (2)

Publication Number	Publication Date
AP9801401A0 AP9801401A0 (en)	1998-12-31
AP911A true AP911A (en)	2000-12-07

Family

ID=22069038

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/1998/001401A AP911A (en)	1997-11-21	1998-11-19	Combinatin of aldose reductase inhibitor and a glycogen phosphorylase inhibitor.

Country Status (38)

Country	Link
EP (1)	EP1032424B9 (de)
JP (1)	JP2002504478A (de)
KR (2)	KR20010032304A (de)
CN (1)	CN1279617A (de)
AP (1)	AP911A (de)
AR (1)	AR016423A1 (de)
AT (1)	ATE205403T1 (de)
AU (1)	AU733304B2 (de)
BG (1)	BG104435A (de)
BR (1)	BR9814698A (de)
CA (1)	CA2310069A1 (de)
DE (1)	DE69801680T2 (de)
DK (1)	DK1032424T3 (de)
DZ (1)	DZ2656A1 (de)
EA (1)	EA002365B1 (de)
ES (1)	ES2161548T3 (de)
GR (1)	GR3037071T3 (de)
GT (1)	GT199800166A (de)
HR (1)	HRP20000327A2 (de)
HU (1)	HUP0100272A3 (de)
ID (1)	ID24524A (de)
IL (1)	IL135713A0 (de)
IS (1)	IS5453A (de)
MA (1)	MA26568A1 (de)
NO (1)	NO20002164L (de)
OA (1)	OA11379A (de)
PA (1)	PA8462301A1 (de)
PE (1)	PE135399A1 (de)
PL (1)	PL340643A1 (de)
PT (1)	PT1032424E (de)
SK (1)	SK7222000A3 (de)
TN (1)	TNSN98211A1 (de)
TR (1)	TR200001451T2 (de)
UA (1)	UA57811C2 (de)
UY (1)	UY25258A1 (de)
WO (1)	WO1999026659A1 (de)
YU (1)	YU30700A (de)
ZA (1)	ZA9810636B (de)

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US7825139B2 (en)	2005-05-25	2010-11-02	Forest Laboratories Holdings Limited (BM)	Compounds and methods for selective inhibition of dipeptidyl peptidase-IV
PT1931350E (pt)	2005-09-14	2014-02-12	Takeda Pharmaceutical	Administração de inibidores de dipeptidil peptidase
EP2046753A2 (de)	2006-07-06	2009-04-15	Brystol-Myers Squibb Company	Pyridon/hydroxypyridin-11-beta-hydroxysteroid-dehydrogenase-hemmer vom typ i
US7727978B2 (en)	2006-08-24	2010-06-01	Bristol-Myers Squibb Company	Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors
EP2142551B1 (de)	2007-04-17	2015-10-14	Bristol-Myers Squibb Company	KONDENSIERTE HETEROCYCLISCHE Verbindungen als Hemmer der BETA-HYDROXYSTEROID-DEHYDROGENASE -TYP I
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PL2531501T3 (pl)	2010-02-03	2014-05-30	Takeda Pharmaceuticals Co	Inhibitory kinazy 1 regulującej sygnał apoptotyczny
SG184168A1 (en)	2010-04-08	2012-10-30	Bristol Myers Squibb Co	Pyrimidinylpiperidinyloxypyridinone analogues as gpr119 modulators
CN102971313A (zh)	2010-04-14	2013-03-13	百时美施贵宝公司	新颖的葡糖激酶激活剂及其使用方法
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1998
- 1998-02-11 UA UA2000052869A patent/UA57811C2/uk unknown
- 1998-10-27 GT GT199800166A patent/GT199800166A/es unknown
- 1998-10-28 PA PA19988462301A patent/PA8462301A1/es unknown
- 1998-11-02 TR TR2000/01451T patent/TR200001451T2/xx unknown
- 1998-11-02 AT AT98949193T patent/ATE205403T1/de not_active IP Right Cessation
- 1998-11-02 KR KR1020007005514A patent/KR20010032304A/ko not_active Ceased
- 1998-11-02 DK DK98949193T patent/DK1032424T3/da active
- 1998-11-02 ID IDW20000958A patent/ID24524A/id unknown
- 1998-11-02 CA CA002310069A patent/CA2310069A1/en not_active Abandoned
- 1998-11-02 EP EP98949193A patent/EP1032424B9/de not_active Expired - Lifetime
- 1998-11-02 PL PL98340643A patent/PL340643A1/xx unknown
- 1998-11-02 IL IL13571398A patent/IL135713A0/xx unknown
- 1998-11-02 EA EA200000433A patent/EA002365B1/ru not_active IP Right Cessation
- 1998-11-02 JP JP2000521860A patent/JP2002504478A/ja active Pending
- 1998-11-02 CN CN98811329A patent/CN1279617A/zh active Pending
- 1998-11-02 ES ES98949193T patent/ES2161548T3/es not_active Expired - Lifetime
- 1998-11-02 YU YU30700A patent/YU30700A/sh unknown
- 1998-11-02 HR HR20000327A patent/HRP20000327A2/hr not_active Application Discontinuation
- 1998-11-02 HU HU0100272A patent/HUP0100272A3/hu unknown
- 1998-11-02 DE DE69801680T patent/DE69801680T2/de not_active Expired - Fee Related
- 1998-11-02 PT PT81300054T patent/PT1032424E/pt unknown
- 1998-11-02 AU AU95558/98A patent/AU733304B2/en not_active Ceased
- 1998-11-02 SK SK722-2000A patent/SK7222000A3/sk unknown
- 1998-11-02 WO PCT/IB1998/001752 patent/WO1999026659A1/en not_active Ceased
- 1998-11-02 BR BR9814698-0A patent/BR9814698A/pt not_active IP Right Cessation
- 1998-11-16 PE PE1998001113A patent/PE135399A1/es not_active Application Discontinuation
- 1998-11-18 DZ DZ980266A patent/DZ2656A1/xx active
- 1998-11-18 TN TNTNSN98211A patent/TNSN98211A1/fr unknown
- 1998-11-19 UY UY25258A patent/UY25258A1/es not_active Application Discontinuation
- 1998-11-19 AP APAP/P/1998/001401A patent/AP911A/en active
- 1998-11-19 MA MA25356A patent/MA26568A1/fr unknown
- 1998-11-19 AR ARP980105883A patent/AR016423A1/es not_active Application Discontinuation
- 1998-11-20 ZA ZA9810636A patent/ZA9810636B/xx unknown
1999
- 1999-05-07 KR KR1020007013394A patent/KR100661214B1/ko not_active Expired - Fee Related
2000
- 2000-04-14 IS IS5453A patent/IS5453A/is unknown
- 2000-04-27 NO NO20002164A patent/NO20002164L/no not_active Application Discontinuation
- 2000-05-12 OA OA1200000137A patent/OA11379A/en unknown
- 2000-05-15 BG BG104435A patent/BG104435A/bg unknown
2001
- 2001-10-30 GR GR20010401943T patent/GR3037071T3/el not_active IP Right Cessation

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WO1996039385A1 (en) *	1995-06-06	1996-12-12	Pfizer Inc.	Substituted n-(indole-2-carbonyl-) amides and derivatives as glycogen phosphorylase inhibitors
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Also Published As

Publication number	Publication date
WO1999026659A1 (en)	1999-06-03
ATE205403T1 (de)	2001-09-15
YU30700A (sh)	2002-12-10
PT1032424E (pt)	2001-12-28
ID24524A (id)	2000-07-20
MA26568A1 (fr)	2004-12-20
BG104435A (bg)	2001-01-31
EP1032424B9 (de)	2004-10-06
HUP0100272A2 (hu)	2001-06-28
EP1032424A1 (de)	2000-09-06
PL340643A1 (en)	2001-02-12
EP1032424B1 (de)	2001-09-12
OA11379A (en)	2004-01-28
NO20002164L (no)	2000-07-19
NO20002164D0 (no)	2000-04-27
AU9555898A (en)	1999-06-15
TNSN98211A1 (fr)	2005-03-15
GR3037071T3 (en)	2002-01-31
PE135399A1 (es)	2000-01-15
IL135713A0 (en)	2001-05-20
KR20010032304A (ko)	2001-04-16
CA2310069A1 (en)	1999-06-03
CN1279617A (zh)	2001-01-10
AU733304B2 (en)	2001-05-10
AP9801401A0 (en)	1998-12-31
HUP0100272A3 (en)	2002-11-28
DE69801680T2 (de)	2002-02-07
KR20010032300A (ko)	2001-04-16
PA8462301A1 (es)	2000-05-24
DZ2656A1 (fr)	2003-03-22
DE69801680D1 (de)	2001-10-18
SK7222000A3 (en)	2001-09-11
IS5453A (is)	2000-04-14
AR016423A1 (es)	2001-07-04
ES2161548T3 (es)	2001-12-01
DK1032424T3 (da)	2001-11-19
EA002365B1 (ru)	2002-04-25
KR100661214B1 (ko)	2006-12-26
TR200001451T2 (tr)	2002-06-21
JP2002504478A (ja)	2002-02-12
EA200000433A1 (ru)	2000-12-25
GT199800166A (es)	2000-04-19
HRP20000327A2 (en)	2001-02-28
UY25258A1 (es)	2000-12-29
UA57811C2 (uk)	2003-07-15
ZA9810636B (en)	2000-05-22
BR9814698A (pt)	2000-10-03

Publication	Publication Date	Title
AP911A (en)	2000-12-07	Combinatin of aldose reductase inhibitor and a glycogen phosphorylase inhibitor.
US5798375A (en)	1998-08-25	Treatment of arteriosclerosis and xanthoma
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US20030027820A1 (en)	2003-02-06	Method for treating fibrotic diseases or other indications V
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EA015169B1 (ru)	2011-06-30	Применение ингибиторов дипептидилпептидазы
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CA2448294A1 (en)	2002-12-05	Method for treating fibrotic diseases or other indications vi
US20070043016A1 (en)	2007-02-22	Method of treating fibrotic diseases or other indications with imidazolium agents
AU2002241670B2 (en)	2006-08-17	Method for treating glaucoma IB
CA2448449A1 (en)	2002-11-28	Treatment of renal fibrosis
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EP1370266A1 (de)	2003-12-17	Behandlungsverfahren
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MXPA96002577A (en)	1998-01-01	Treatment of arterioesclerosis and xant