AP9300542A0 - 17a and 17b-alkylketone-3-carboxyaromatic a ring steroidal compounds and pharmaceutical compositions containing these compounds - Google Patents

17a and 17b-alkylketone-3-carboxyaromatic a ring steroidal compounds and pharmaceutical compositions containing these compounds

Info

Publication number: AP9300542A0
Authority: AP; ARIPO
Prior art keywords: compounds; carboxyaromatic; alkylketone; pharmaceutical compositions; compositions containing
Prior art date: 1992-06-30

Application number

AP93/00542A

Other versions

AP412A (en

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-30

Filing date

1993-06-30

Publication date

1993-07-31

1993-06-30 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1993-07-31 Publication of AP9300542A0 publication Critical patent/AP9300542A0/en

1995-09-29 Application granted granted Critical

1995-09-29 Publication of AP412A publication Critical patent/AP412A/en

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
- C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Toxicology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

APAP/P/1993/000542A 1992-06-30 1993-06-30 17a and 17B-Alkylketone-3-carboxyaromatic a ring steroidal compounds and pharmaceutical compositions containing these compounds. AP412A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB929213835A GB9213835D0 (en)	1992-06-30	1992-06-30	Compounds

Publications (2)

Publication Number	Publication Date
AP9300542A0 true AP9300542A0 (en)	1993-07-31
AP412A AP412A (en)	1995-09-29

Family

ID=10717920

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/1993/000542A AP412A (en)	1992-06-30	1993-06-30	17a and 17B-Alkylketone-3-carboxyaromatic a ring steroidal compounds and pharmaceutical compositions containing these compounds.

Country Status (23)

Country	Link
EP (1)	EP0651643A4 (en)
JP (1)	JPH08500821A (en)
KR (1)	KR950702118A (en)
CN (1)	CN1095382A (en)
AP (1)	AP412A (en)
AU (1)	AU4545993A (en)
BG (1)	BG99313A (en)
BR (1)	BR9306748A (en)
CA (1)	CA2138956A1 (en)
CZ (1)	CZ334694A3 (en)
FI (1)	FI946189A7 (en)
GB (1)	GB9213835D0 (en)
HU (1)	HUT69409A (en)
IL (1)	IL106158A0 (en)
MA (1)	MA22927A1 (en)
MX (1)	MX9303970A (en)
NO (1)	NO945074L (en)
OA (1)	OA10122A (en)
RU (1)	RU94046378A (en)
SI (1)	SI9300350A (en)
SK (1)	SK159994A3 (en)
WO (1)	WO1994000125A1 (en)
ZA (1)	ZA934645B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5925774A (en)	1991-01-07	1999-07-20	Pherin Corporation	Estrenes for inducing hypothalamic effects
US5510351A (en) *	1992-05-20	1996-04-23	Merck & Co., Inc.	Delta-17 and delta-20 olefinic and saturated 17 beta-substituted 4-aza-5 alpha-androstan-ones as 5 alpha reductase inhibitors useful in the prevention and treatment of hyperandrogenic disorders
US5543417A (en) *	1994-10-21	1996-08-06	Merck & Co., Inc.	Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
GB201102913D0 (en)	2011-02-18	2011-04-06	Univ Birmingham	Novel therapeutic
JP2015129095A (en)	2013-12-19	2015-07-16	ロレアル	Composition
KR102917075B1 (en) *	2018-02-11	2026-01-26	장쑤 한서 파마슈티칼 그룹 캄파니 리미티드	Steroid derivative modulator, method for preparing the same and use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4954446A (en) *	1988-05-25	1990-09-04	Smithkline Beecham Corporation	Aromatic steroid 5-α-reductase inhibitors

1992
- 1992-06-30 GB GB929213835A patent/GB9213835D0/en active Pending
1993
- 1993-06-26 ZA ZA934645A patent/ZA934645B/en unknown
- 1993-06-28 MA MA23217A patent/MA22927A1/en unknown
- 1993-06-28 IL IL106158A patent/IL106158A0/en unknown
- 1993-06-30 MX MX9303970A patent/MX9303970A/en unknown
- 1993-06-30 CZ CZ943346A patent/CZ334694A3/en unknown
- 1993-06-30 RU RU94046378/04A patent/RU94046378A/en unknown
- 1993-06-30 CN CN93109540A patent/CN1095382A/en active Pending
- 1993-06-30 CA CA002138956A patent/CA2138956A1/en not_active Abandoned
- 1993-06-30 JP JP6502660A patent/JPH08500821A/en active Pending
- 1993-06-30 HU HU9403833A patent/HUT69409A/en unknown
- 1993-06-30 AP APAP/P/1993/000542A patent/AP412A/en active
- 1993-06-30 EP EP93915499A patent/EP0651643A4/en not_active Withdrawn
- 1993-06-30 SI SI9300350A patent/SI9300350A/en unknown
- 1993-06-30 WO PCT/US1993/006238 patent/WO1994000125A1/en not_active Ceased
- 1993-06-30 AU AU45459/93A patent/AU4545993A/en not_active Abandoned
- 1993-06-30 SK SK1599-94A patent/SK159994A3/en unknown
- 1993-06-30 BR BR9306748A patent/BR9306748A/en not_active Application Discontinuation
- 1993-06-30 FI FI946189A patent/FI946189A7/en not_active Application Discontinuation
1994
- 1994-12-29 BG BG99313A patent/BG99313A/en unknown
- 1994-12-29 OA OA60599A patent/OA10122A/en unknown
- 1994-12-29 NO NO945074A patent/NO945074L/en unknown
- 1994-12-29 KR KR1019940704802A patent/KR950702118A/en not_active Withdrawn

Also Published As

Publication number	Publication date
RU94046378A (en)	1996-10-10
BR9306748A (en)	1998-12-08
NO945074D0 (en)	1994-12-29
HUT69409A (en)	1995-09-28
MX9303970A (en)	1994-04-29
AP412A (en)	1995-09-29
JPH08500821A (en)	1996-01-30
EP0651643A4 (en)	1995-10-04
OA10122A (en)	1996-12-18
GB9213835D0 (en)	1992-08-12
SI9300350A (en)	1993-12-31
IL106158A0 (en)	1993-10-20
NO945074L (en)	1995-02-16
EP0651643A1 (en)	1995-05-10
SK159994A3 (en)	1996-01-10
KR950702118A (en)	1995-06-19
MA22927A1 (en)	1994-04-01
BG99313A (en)	1995-09-29
CA2138956A1 (en)	1994-01-06
CZ334694A3 (en)	1995-10-18
FI946189L (en)	1994-12-30
ZA934645B (en)	1994-01-25
FI946189A0 (en)	1994-12-30
AU4545993A (en)	1994-01-24
CN1095382A (en)	1994-11-23
WO1994000125A1 (en)	1994-01-06
FI946189A7 (en)	1994-12-30

Publication	Publication Date	Title
IL105220A0 (en)	1994-08-26	Cyclohexanylidene compounds and pharmaceutical compositions containing them
IL104628A0 (en)	1993-06-10	Pharmaceutical compositions containing a certain steroid derivative of the pregnane series
IL105223A0 (en)	1994-08-26	Cyclohexane-ylidenes and pharmaceutical compositions containing them
IL110503A (en)	2000-06-29	Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation and pharmaceutical compositions containing them
NZ244766A (en)	1995-01-27	Bi-aromatic compounds and pharmaceutical compositions
ZA938825B (en)	1995-05-25	Pharmaceutical compositions
GB9209078D0 (en)	1992-06-10	Pharmaceutical compositions
HUT66864A (en)	1995-01-30	Pharmaceutical compositions
IL106098A0 (en)	1993-10-20	Heteroarylnaphthalenes and pharmaceutical compositions containing them
AU5100393A (en)	1994-04-26	Diindolo compounds and pharmaceutical compositions containing them
SG43083A1 (en)	1997-10-17	Benzinidaziles pharmaceutical compositions containing these compounds and processes for preparing them
GB2272375B (en)	1996-02-14	Pharmaceutical composition
EP0587047A3 (en)	1997-01-15	Gestagenes containing pharmaceutical composition
IL107611A0 (en)	1994-02-27	Steroid compounds and pharmaceutical compositions containing them
IL104417A0 (en)	1993-05-13	Substituted dihydroindene and-acenaphthene derivatives and pharmaceutical compositions containing them
GB9209874D0 (en)	1992-06-24	Pharmaceutical compositions
ZA933638B (en)	1994-03-22	Heterocyclic compounds a process for the preparation thereof and pharmaceutical compositions containing them
GB9226377D0 (en)	1993-02-10	Pharmaceutical compositions
IL103132A0 (en)	1993-02-21	Digitalis-like compounds and pharmaceutical compositions containing them
IL106352A0 (en)	1993-11-15	Pyridoindolo-benzodiazepines and pharmaceutical compositions containing them
IL115853A (en)	1999-08-17	Aryloxycycloalkenyl and aryloxyiminocyclo-alkenylhydroxyureas and pharmaceutical compositions containing these compounds
GB9211276D0 (en)	1992-07-15	Pharmaceutical compositions
IL105740A0 (en)	1993-09-22	Tetrahydro-and perhydroisoquinoline derivatives and pharmaceutical compositions containing them
ZA935931B (en)	1994-03-07	Pharmaceutical composition
GB9205556D0 (en)	1992-04-29	Novel use of a pharmaceutical composition