BG99313A - 117-alkylketonesteroids as 5- -reductase inhibitors - Google Patents

117-alkylketonesteroids as 5- -reductase inhibitors

Info

Publication number
BG99313A
BG99313A BG99313A BG9931394A BG99313A BG 99313 A BG99313 A BG 99313A BG 99313 A BG99313 A BG 99313A BG 9931394 A BG9931394 A BG 9931394A BG 99313 A BG99313 A BG 99313A
Authority
BG
Bulgaria
Prior art keywords
alkylketonesteroids
reductase inhibitors
steroid
methods
relates
Prior art date
Application number
BG99313A
Other languages
Bulgarian (bg)
Inventor
Dennis Holt
Mark Levy
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of BG99313A publication Critical patent/BG99313A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
    • C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретението се отнася до 17 и 17 -алкилкетон-3-карбоксиароматни А пръстенни аналози на стероидни синтетични съединения, до фармацевтични състави,които ги съдържат, и до методи за използването имза инхибиране на стероиден 5- -редуктазен изозим 1 и стероиден 5- -редуктазен изозим 2. Изобретението се отнася също до междинни съединения и методиза тяхното получаване.The invention relates to 17- and 17-alkylketone-3-carboxaromatic A ring analogs of steroid synthetic compounds, to pharmaceutical compositions containing them and to methods for their use for inhibiting steroid 5-reductase isozyme 1 and steroid 5-reductase isozyme 2. The invention also relates to intermediates and methods for their preparation.

BG99313A 1992-06-30 1994-12-29 117-alkylketonesteroids as 5- -reductase inhibitors BG99313A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929213835A GB9213835D0 (en) 1992-06-30 1992-06-30 Compounds
PCT/US1993/006238 WO1994000125A1 (en) 1992-06-30 1993-06-30 17-ALKYLKETONE STEROIDS USEFUL AS 5-α-REDUCTASE INHIBITORS

Publications (1)

Publication Number Publication Date
BG99313A true BG99313A (en) 1995-09-29

Family

ID=10717920

Family Applications (1)

Application Number Title Priority Date Filing Date
BG99313A BG99313A (en) 1992-06-30 1994-12-29 117-alkylketonesteroids as 5- -reductase inhibitors

Country Status (23)

Country Link
EP (1) EP0651643A4 (en)
JP (1) JPH08500821A (en)
KR (1) KR950702118A (en)
CN (1) CN1095382A (en)
AP (1) AP412A (en)
AU (1) AU4545993A (en)
BG (1) BG99313A (en)
BR (1) BR9306748A (en)
CA (1) CA2138956A1 (en)
CZ (1) CZ334694A3 (en)
FI (1) FI946189A0 (en)
GB (1) GB9213835D0 (en)
HU (1) HUT69409A (en)
IL (1) IL106158A0 (en)
MA (1) MA22927A1 (en)
MX (1) MX9303970A (en)
NO (1) NO945074L (en)
OA (1) OA10122A (en)
RU (1) RU94046378A (en)
SI (1) SI9300350A (en)
SK (1) SK159994A3 (en)
WO (1) WO1994000125A1 (en)
ZA (1) ZA934645B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925774A (en) * 1991-01-07 1999-07-20 Pherin Corporation Estrenes for inducing hypothalamic effects
DE69313114T2 (en) * 1992-05-20 1998-03-19 Merck & Co Inc NEW DELTA-17 AND DELTA-20 UNSATURATED AND SATURATED 17 - g (b) -SUBSTITUTED-4-AZA-5-g (a) -ANDROSTAN-3-ON COMPOUNDS AS INHIBITORS OF 5-ALPHA REDUCTASE
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
GB201102913D0 (en) 2011-02-18 2011-04-06 Univ Birmingham Novel therapeutic
JP2015129095A (en) 2013-12-19 2015-07-16 ロレアル Composition
WO2019154257A1 (en) * 2018-02-11 2019-08-15 江苏豪森药业集团有限公司 Steroid derivative regulators, method for preparing the same, and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954446A (en) * 1988-05-25 1990-09-04 Smithkline Beecham Corporation Aromatic steroid 5-α-reductase inhibitors

Also Published As

Publication number Publication date
ZA934645B (en) 1994-01-25
EP0651643A1 (en) 1995-05-10
GB9213835D0 (en) 1992-08-12
NO945074D0 (en) 1994-12-29
AP412A (en) 1995-09-29
NO945074L (en) 1995-02-16
AU4545993A (en) 1994-01-24
FI946189A7 (en) 1994-12-30
OA10122A (en) 1996-12-18
FI946189L (en) 1994-12-30
CA2138956A1 (en) 1994-01-06
MA22927A1 (en) 1994-04-01
CZ334694A3 (en) 1995-10-18
BR9306748A (en) 1998-12-08
CN1095382A (en) 1994-11-23
SK159994A3 (en) 1996-01-10
KR950702118A (en) 1995-06-19
MX9303970A (en) 1994-04-29
FI946189A0 (en) 1994-12-30
WO1994000125A1 (en) 1994-01-06
HUT69409A (en) 1995-09-28
IL106158A0 (en) 1993-10-20
JPH08500821A (en) 1996-01-30
SI9300350A (en) 1993-12-31
EP0651643A4 (en) 1995-10-04
RU94046378A (en) 1996-10-10
AP9300542A0 (en) 1993-07-31

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