AP9801321A0 - 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-h-indole derivatives. - Google Patents

2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-h-indole derivatives.

Info

Publication number: AP9801321A0
Authority: AP; ARIPO
Prior art keywords: piperazin; ylmethyl; heteroaryl; aryl; indole derivatives
Prior art date: 1997-08-15

Application number

APAP/P/1998/001321A

Other languages

English (en)

Inventor

Anton Franz Joseph Fliri

Mark Jerom Majchrzak

Patricia Ann Seymour

Stevin Howard Zorn

Hans Rollema

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-15

Filing date

1998-08-05

Publication date

2000-02-14

1998-08-05 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2000-02-14 Publication of AP9801321A0 publication Critical patent/AP9801321A0/en

Links

229940054051 antipsychotic indole derivative Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Ophthalmology & Optometry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Anesthesiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

APAP/P/1998/001321A 1997-08-15 1998-08-05 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-h-indole derivatives. AP9801321A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5576497P	1997-08-15	1997-08-15
PCT/IB1998/001198 WO1999009025A2 (en)	1997-08-15	1998-08-05	2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1h-indole derivatives interacting with the dopamine d4 receptor

Publications (1)

Publication Number	Publication Date
AP9801321A0 true AP9801321A0 (en)	2000-02-14

Family

ID=22000003

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/1998/001321A AP9801321A0 (en)	1997-08-15	1998-08-05	2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-h-indole derivatives.

Country Status (30)

Country	Link
EP (1)	EP1003739A2 (is)
JP (1)	JP2002536291A (is)
KR (1)	KR20010022507A (is)
CN (1)	CN1265660A (is)
AP (1)	AP9801321A0 (is)
AR (1)	AR017019A1 (is)
AU (1)	AU8457298A (is)
BG (1)	BG104069A (is)
BR (1)	BR9811557A (is)
CA (1)	CA2297486C (is)
CO (1)	CO4960656A1 (is)
DZ (1)	DZ2583A1 (is)
EA (1)	EA200000023A1 (is)
HR (1)	HRP980441A2 (is)
HU (1)	HUP0003425A3 (is)
ID (1)	ID23803A (is)
IL (1)	IL133960A0 (is)
IS (1)	IS5336A (is)
MA (1)	MA24632A1 (is)
NO (1)	NO20000722L (is)
OA (1)	OA11286A (is)
PA (1)	PA8457001A1 (is)
PE (1)	PE106299A1 (is)
PL (1)	PL338947A1 (is)
SK (1)	SK1352000A3 (is)
TN (1)	TNSN98151A1 (is)
TR (1)	TR200000414T2 (is)
UY (1)	UY25144A1 (is)
WO (1)	WO1999009025A2 (is)
ZA (1)	ZA987304B (is)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EE04588B1 (et) *	1997-10-27	2006-02-15	Neurosearch A/S	Heteroarüüldiasatsükloalkaanid kui atsetüülkoliini nikotiinretseptorite kolinergilised ligandid, nende kasutamine ravimitena ning neid sisaldav farmatseutiline kompositsioon
EP0953567A3 (en)	1998-04-29	2003-04-02	Pfizer Products Inc.	Bicyclic substituted piperazine-, piperidine- and tetrahydropyridine derivatives, their preparation and their use as agents with central dopaminergic (dopamine D4 receptor) activity
EP1464641B1 (en) *	1999-12-30	2008-05-14	H. Lundbeck A/S	4-Phenyl-piperazinyl, -piperidinyl and tetrahydropyridyl derivatives as dopamine D4 antagonists
GB0017952D0 (en) *	2000-07-22	2000-09-13	Univ Manchester	Treatment of dyskinesia
EP1177792A3 (en)	2000-07-27	2002-10-23	Pfizer Products Inc.	Dopamine D4 Ligands for the treatment of novelty-seeking disorders
EP1373204B1 (en)	2001-03-09	2016-10-26	Janssen Pharmaceuticals, Inc.	Heterocyclic compounds
WO2004022060A2 (en)	2002-09-06	2004-03-18	Janssen Pharmaceutica, N.V.	(1h-benzoimidazol-2-yl)-(piperazinyl)-methanone derivatives and related compounds as histamine h4-receptor antagonists for the treatment of inflammatory and allergic disorders
WO2004108671A1 (en) *	2003-06-06	2004-12-16	Suven Life Sciences Limited	Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them
US7517910B2 (en)	2004-03-30	2009-04-14	Takeda Pharmaceutical Company Limited	Alkoxyphenylpropanoic acid derivatives
US7572805B2 (en)	2004-07-14	2009-08-11	Bristol-Myers Squibb Company	Pyrrolo(oxo)isoquinolines as 5HT ligands
US7618980B2 (en)	2004-07-14	2009-11-17	Bristol-Myers Squibb Company	Pyrrolo(oxo)quinolines as 5HT ligands
JO2769B1 (en) *	2005-10-26	2014-03-15	جانسين فارماسوتيكا ان. في	Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
JO2642B1 (en)	2006-12-08	2012-06-17	جانسين فارماسوتيكا ان. في	Dopamine 2 receptor antagonists are rapidly hydrolyzed
JO2849B1 (en) *	2007-02-13	2015-03-15	جانسين فارماسوتيكا ان. في	Dopamine 2 receptor antagonists are rapidly hydrolyzed
MX2009011416A (es)	2007-04-23	2009-11-05	Janssen Pharmaceutica Nv	Tia(di)azoles como antagonistas del receptor de dopamina 2 de disociacion rapida.
RS52518B (sr)	2007-04-23	2013-04-30	Janssen Pharmaceutica N.V.	Derivati 4-alkoksipiridazina kao brzo disocirajući dopamin 2 receptorski antagonisti
CA2729313C (en)	2008-07-03	2016-08-30	Janssen Pharmaceutica Nv	Substituted 6-(1-piperazinyl)-pyridazines as 5-ht6 receptor antagonists
ES2622161T3 (es)	2008-07-31	2017-07-05	Janssen Pharmaceutica, N.V.	Piridinas sustituidas con piperazin-1-il-trifluorometilo como antagonistas del receptor de la dopamina 2 de disociación rápida
US11266640B2 (en) *	2017-09-20	2022-03-08	Hangzhou Innogate Pharma Co., Ltd.	Polycyclic compound acting as IDO inhibitor and/or IDO-HDAC dual inhibitor
IL296423A (en) *	2020-04-22	2022-11-01	Anima Biotech Inc	Collagen 1 translation inhibitors and methods of use thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB944443A (is) *	1959-09-25	1900-01-01
EP0594702B1 (en) *	1991-07-03	1997-01-29	PHARMACIA & UPJOHN COMPANY	Substituted indoles as anti-aids pharmaceuticals
JPH05255089A (ja) *	1991-12-18	1993-10-05	Sanwa Kagaku Kenkyusho Co Ltd	抗ウイルス剤
EP0665840A1 (en) *	1992-10-23	1995-08-09	MERCK SHARP & DOHME LTD.	Dopamine receptor subtype ligands
US5576336A (en) *	1993-03-18	1996-11-19	Merck Sharp & Dohme Limited	Indole derivatives as dopamine D4 antagonists
GB9305644D0 (en) *	1993-03-18	1993-05-05	Merck Sharp & Dohme	Therapeutic agents
AU6435594A (en) *	1993-04-15	1994-11-08	Merck Sharp & Dohme Limited	Indole derivatives as dopamine d4 antagonists
DE4414113A1 (de) *	1994-04-22	1995-10-26	Merck Patent Gmbh	3-Indolylpiperidine
TW406075B (en) *	1994-12-13	2000-09-21	Upjohn Co	Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds
ZA968661B (en) *	1995-11-17	1998-04-14	Upjohn Co	Oxazolidinone antibacterial agent with tricyclic substituents.
TW504510B (en) *	1996-05-10	2002-10-01	Janssen Pharmaceutica Nv	2,4-diaminopyrimidine derivatives

1998
- 1998-08-05 IL IL13396098A patent/IL133960A0/xx unknown
- 1998-08-05 CN CN98807831A patent/CN1265660A/zh active Pending
- 1998-08-05 SK SK135-2000A patent/SK1352000A3/sk unknown
- 1998-08-05 AP APAP/P/1998/001321A patent/AP9801321A0/en unknown
- 1998-08-05 TR TR2000/00414T patent/TR200000414T2/xx unknown
- 1998-08-05 CA CA002297486A patent/CA2297486C/en not_active Expired - Fee Related
- 1998-08-05 AU AU84572/98A patent/AU8457298A/en not_active Abandoned
- 1998-08-05 ID IDW20000197A patent/ID23803A/id unknown
- 1998-08-05 JP JP2000509706A patent/JP2002536291A/ja active Pending
- 1998-08-05 BR BR9811557-0A patent/BR9811557A/pt not_active IP Right Cessation
- 1998-08-05 WO PCT/IB1998/001198 patent/WO1999009025A2/en not_active Ceased
- 1998-08-05 KR KR1020007001093A patent/KR20010022507A/ko not_active Ceased
- 1998-08-05 PL PL98338947A patent/PL338947A1/xx unknown
- 1998-08-05 EP EP98935229A patent/EP1003739A2/en not_active Withdrawn
- 1998-08-05 HU HU0003425A patent/HUP0003425A3/hu unknown
- 1998-08-05 EA EA200000023A patent/EA200000023A1/ru unknown
- 1998-08-10 PA PA19988457001A patent/PA8457001A1/es unknown
- 1998-08-10 PE PE1998000717A patent/PE106299A1/es not_active Application Discontinuation
- 1998-08-12 MA MA25210A patent/MA24632A1/fr unknown
- 1998-08-12 DZ DZ980193A patent/DZ2583A1/xx active
- 1998-08-12 TN TNTNSN98151A patent/TNSN98151A1/fr unknown
- 1998-08-13 AR ARP980104021A patent/AR017019A1/es unknown
- 1998-08-14 HR HR60/055,764A patent/HRP980441A2/hr not_active Application Discontinuation
- 1998-08-14 ZA ZA9807304A patent/ZA987304B/xx unknown
- 1998-08-14 CO CO98046788A patent/CO4960656A1/es unknown
- 1998-08-17 UY UY25144A patent/UY25144A1/es not_active Application Discontinuation
2000
- 2000-01-10 BG BG104069A patent/BG104069A/xx unknown
- 2000-01-11 IS IS5336A patent/IS5336A/is unknown
- 2000-02-08 OA OA1200000030A patent/OA11286A/en unknown
- 2000-02-14 NO NO20000722A patent/NO20000722L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
KR20010022507A (ko)	2001-03-15
ZA987304B (en)	2000-02-14
DZ2583A1 (fr)	2003-02-22
NO20000722D0 (no)	2000-02-14
TNSN98151A1 (fr)	2005-03-15
PL338947A1 (en)	2000-12-04
IL133960A0 (en)	2001-04-30
EA200000023A1 (ru)	2000-08-28
AR017019A1 (es)	2001-08-22
PE106299A1 (es)	1999-11-02
UY25144A1 (es)	2000-12-29
ID23803A (id)	2000-05-11
BG104069A (en)	2001-05-31
JP2002536291A (ja)	2002-10-29
TR200000414T2 (tr)	2000-08-21
HRP980441A2 (en)	1999-04-30
EP1003739A2 (en)	2000-05-31
NO20000722L (no)	2000-02-14
IS5336A (is)	2000-01-11
HUP0003425A3 (en)	2002-02-28
OA11286A (en)	2003-10-22
WO1999009025A2 (en)	1999-02-25
PA8457001A1 (es)	2000-09-29
CN1265660A (zh)	2000-09-06
SK1352000A3 (en)	2000-08-14
HUP0003425A2 (hu)	2001-10-28
CA2297486A1 (en)	1999-02-25
AU8457298A (en)	1999-03-08
MA24632A1 (fr)	1999-04-01
CA2297486C (en)	2005-05-03
CO4960656A1 (es)	2000-09-25
BR9811557A (pt)	2000-08-22
WO1999009025A3 (en)	1999-04-15

Publication	Publication Date	Title
AP9801321A0 (en)	2000-02-14	2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-h-indole derivatives.
IL124537A0 (en)	1998-12-06	Naphthyl-substituted benzimidazole derivatives and pharmaceutical compositions containing the same
AU4264396A (en)	1996-06-19	Cosmetic or pharmaceutical compositions containing mangiferin or derivatives thereof
EP0984947B8 (en)	2005-06-15	Oxazolidinone antibacterial agents having a thiocarbonyl functionality
GR3034542T3 (en)	2001-01-31	4,5-diaryloxazole derivatives
MY132671A (en)	2007-10-31	Substituted 6,6-hetero-bicyclic derivatives
HU9500240D0 (en)	1995-03-28	New prolin-amide derivatives and pharmaceutical compositions containing them as active component
MY119150A (en)	2005-04-30	Azetidine derivatives, their preparation and medicaments containing them
AP9801378A0 (en)	2000-04-29	9-amino-3- keto erythromycin derivatives.
DK0928788T3 (da)	2003-03-24	Imidazolidin-4-on-derivater, der er nyttige som anticancer-midler
YU11997A (sh)	1999-09-27	Laktamski derivati i njihove farmaceutske kompozicije
SG52667A1 (en)	1998-09-28	Cyclic amide derivatives
PL334915A1 (en)	2000-03-27	Pyrrolidine derivatives exhibiting phospholipase a2 inhibiting activity
CA2373117A1 (en)	2000-11-30	13-methyl-erythromycin derivatives
NO996108L (no)	2000-02-10	9-oksinerytromycinderivater
HU229443B1 (en)	2013-12-30	Betha-carboline particulate form, pharmaceutical compositions containing it, their preparations and their use
GB9718903D0 (en)	1997-11-12	Method,compositions and kits for increasing the oral bioavailability of pharmaceutical agents
MY117092A (en)	2004-05-31	Chemotherapeutic pyrrolocarbazole derivatives
BG104447A (en)	2001-01-31	Biphenylamidine derivatives
MX9805023A (es)	1998-11-30	Derivados de 1-metilcarbapenem.
TW334425B (en)	1998-06-21	Annelated dihydropyridines for preparing pharmaceutical preparations
DE69330601D1 (de)	2001-09-20	Serotoninergische ergolin derivate
GEP20063759B (en)	2006-02-27	Novel Benzothiazine and Benzothiadiazine Derivatives, Method for Preparing Same and Pharmaceutical Compositions Containing Same
AUPP109097A0 (en)	1998-01-22	Napthalene derivatives
CA2245484A1 (en)	1999-02-27	Novel urea derivatives