MA24632A1 - Derives de 2-(4-aryl-ou heteroaryl-piperazine-1-ylmethyle)-1h- indole - Google Patents

Derives de 2-(4-aryl-ou heteroaryl-piperazine-1-ylmethyle)-1h- indole

Info

Publication number: MA24632A1
Authority: MA; Morocco
Prior art keywords: ylmethyle; indole; piperazine; heteroaryl; aryl
Prior art date: 1997-08-15

Application number

MA25210A

Other languages

English (en)

Inventor

Anton Franz Josef Fliri

Stevin Howard Zorn

Mark Jerome Majchrzak

Patricia Ann Seymour

Hans Rollema

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-15

Filing date

1998-08-12

Publication date

1999-04-01

1998-08-12 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

1999-04-01 Publication of MA24632A1 publication Critical patent/MA24632A1/fr

Links

SIKJAQJRHWYJAI-UHFFFAOYSA-N benzopyrrole Natural products C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 title 1
RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Ophthalmology & Optometry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Anesthesiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

MA25210A 1997-08-15 1998-08-12 Derives de 2-(4-aryl-ou heteroaryl-piperazine-1-ylmethyle)-1h- indole MA24632A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US5576497P	1997-08-15	1997-08-15

Publications (1)

Publication Number	Publication Date
MA24632A1 true MA24632A1 (fr)	1999-04-01

Family

ID=22000003

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA25210A MA24632A1 (fr)	1997-08-15	1998-08-12	Derives de 2-(4-aryl-ou heteroaryl-piperazine-1-ylmethyle)-1h- indole

Country Status (30)

Country	Link
EP (1)	EP1003739A2 (fr)
JP (1)	JP2002536291A (fr)
KR (1)	KR20010022507A (fr)
CN (1)	CN1265660A (fr)
AP (1)	AP9801321A0 (fr)
AR (1)	AR017019A1 (fr)
AU (1)	AU8457298A (fr)
BG (1)	BG104069A (fr)
BR (1)	BR9811557A (fr)
CA (1)	CA2297486C (fr)
CO (1)	CO4960656A1 (fr)
DZ (1)	DZ2583A1 (fr)
EA (1)	EA200000023A1 (fr)
HR (1)	HRP980441A2 (fr)
HU (1)	HUP0003425A3 (fr)
ID (1)	ID23803A (fr)
IL (1)	IL133960A0 (fr)
IS (1)	IS5336A (fr)
MA (1)	MA24632A1 (fr)
NO (1)	NO20000722L (fr)
OA (1)	OA11286A (fr)
PA (1)	PA8457001A1 (fr)
PE (1)	PE106299A1 (fr)
PL (1)	PL338947A1 (fr)
SK (1)	SK1352000A3 (fr)
TN (1)	TNSN98151A1 (fr)
TR (1)	TR200000414T2 (fr)
UY (1)	UY25144A1 (fr)
WO (1)	WO1999009025A2 (fr)
ZA (1)	ZA987304B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EE04588B1 (et) *	1997-10-27	2006-02-15	Neurosearch A/S	Heteroarüüldiasatsükloalkaanid kui atsetüülkoliini nikotiinretseptorite kolinergilised ligandid, nende kasutamine ravimitena ning neid sisaldav farmatseutiline kompositsioon
EP0953567A3 (fr)	1998-04-29	2003-04-02	Pfizer Products Inc.	Dérivés de piperazin-, piperidine- et tetrahydropyridine bicyclique substitués, leur préparation et leur utilisation comme agents a activité dopaminergique (recepteur D4 de la dopamine) centrale
EP1464641B1 (fr) *	1999-12-30	2008-05-14	H. Lundbeck A/S	Dérivés de 4-phenylpiperazinyle, -piperidinyle et -tetrahydropyridyle à titre de antagonistes de dopamine D4
GB0017952D0 (en) *	2000-07-22	2000-09-13	Univ Manchester	Treatment of dyskinesia
EP1177792A3 (fr)	2000-07-27	2002-10-23	Pfizer Products Inc.	Ligands dopamine d4 destines au traitement des troubles associees a la cherche de la nouveaute
EP1373204B1 (fr)	2001-03-09	2016-10-26	Janssen Pharmaceuticals, Inc.	Composes heterocycliques
WO2004022060A2 (fr)	2002-09-06	2004-03-18	Janssen Pharmaceutica, N.V.	Composes heterocycliques
WO2004108671A1 (fr) *	2003-06-06	2004-12-16	Suven Life Sciences Limited	Indoles substitues dotes d'une affinite pour le recepteur de la serotonine, leur procede de fabrication et compositions pharmaceutiques les contenant
US7517910B2 (en)	2004-03-30	2009-04-14	Takeda Pharmaceutical Company Limited	Alkoxyphenylpropanoic acid derivatives
US7572805B2 (en)	2004-07-14	2009-08-11	Bristol-Myers Squibb Company	Pyrrolo(oxo)isoquinolines as 5HT ligands
US7618980B2 (en)	2004-07-14	2009-11-17	Bristol-Myers Squibb Company	Pyrrolo(oxo)quinolines as 5HT ligands
JO2769B1 (en) *	2005-10-26	2014-03-15	جانسين فارماسوتيكا ان. في	Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
JO2642B1 (en)	2006-12-08	2012-06-17	جانسين فارماسوتيكا ان. في	Dopamine 2 receptor antagonists are rapidly hydrolyzed
JO2849B1 (en) *	2007-02-13	2015-03-15	جانسين فارماسوتيكا ان. في	Dopamine 2 receptor antagonists are rapidly hydrolyzed
MX2009011416A (es)	2007-04-23	2009-11-05	Janssen Pharmaceutica Nv	Tia(di)azoles como antagonistas del receptor de dopamina 2 de disociacion rapida.
RS52518B (sr)	2007-04-23	2013-04-30	Janssen Pharmaceutica N.V.	Derivati 4-alkoksipiridazina kao brzo disocirajući dopamin 2 receptorski antagonisti
CA2729313C (fr)	2008-07-03	2016-08-30	Janssen Pharmaceutica Nv	6-(1-piperazinyl)-pyridazines substituees comme antagonistes du recepteur 5-ht<sb>6</sb>
ES2622161T3 (es)	2008-07-31	2017-07-05	Janssen Pharmaceutica, N.V.	Piridinas sustituidas con piperazin-1-il-trifluorometilo como antagonistas del receptor de la dopamina 2 de disociación rápida
US11266640B2 (en) *	2017-09-20	2022-03-08	Hangzhou Innogate Pharma Co., Ltd.	Polycyclic compound acting as IDO inhibitor and/or IDO-HDAC dual inhibitor
IL296423A (en) *	2020-04-22	2022-11-01	Anima Biotech Inc	Collagen 1 translation inhibitors and methods of use thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB944443A (fr) *	1959-09-25	1900-01-01
EP0594702B1 (fr) *	1991-07-03	1997-01-29	PHARMACIA & UPJOHN COMPANY	Indoles substitues utilises comme produits pharmaceutiques dans le traitement du sida
JPH05255089A (ja) *	1991-12-18	1993-10-05	Sanwa Kagaku Kenkyusho Co Ltd	抗ウイルス剤
EP0665840A1 (fr) *	1992-10-23	1995-08-09	MERCK SHARP & DOHME LTD.	Ligands pour les sous-types de recepteurs de dopamine
US5576336A (en) *	1993-03-18	1996-11-19	Merck Sharp & Dohme Limited	Indole derivatives as dopamine D4 antagonists
GB9305644D0 (en) *	1993-03-18	1993-05-05	Merck Sharp & Dohme	Therapeutic agents
AU6435594A (en) *	1993-04-15	1994-11-08	Merck Sharp & Dohme Limited	Indole derivatives as dopamine d4 antagonists
DE4414113A1 (de) *	1994-04-22	1995-10-26	Merck Patent Gmbh	3-Indolylpiperidine
TW406075B (en) *	1994-12-13	2000-09-21	Upjohn Co	Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds
ZA968661B (en) *	1995-11-17	1998-04-14	Upjohn Co	Oxazolidinone antibacterial agent with tricyclic substituents.
TW504510B (en) *	1996-05-10	2002-10-01	Janssen Pharmaceutica Nv	2,4-diaminopyrimidine derivatives

1998
- 1998-08-05 IL IL13396098A patent/IL133960A0/xx unknown
- 1998-08-05 CN CN98807831A patent/CN1265660A/zh active Pending
- 1998-08-05 SK SK135-2000A patent/SK1352000A3/sk unknown
- 1998-08-05 AP APAP/P/1998/001321A patent/AP9801321A0/en unknown
- 1998-08-05 TR TR2000/00414T patent/TR200000414T2/xx unknown
- 1998-08-05 CA CA002297486A patent/CA2297486C/fr not_active Expired - Fee Related
- 1998-08-05 AU AU84572/98A patent/AU8457298A/en not_active Abandoned
- 1998-08-05 ID IDW20000197A patent/ID23803A/id unknown
- 1998-08-05 JP JP2000509706A patent/JP2002536291A/ja active Pending
- 1998-08-05 BR BR9811557-0A patent/BR9811557A/pt not_active IP Right Cessation
- 1998-08-05 WO PCT/IB1998/001198 patent/WO1999009025A2/fr not_active Ceased
- 1998-08-05 KR KR1020007001093A patent/KR20010022507A/ko not_active Ceased
- 1998-08-05 PL PL98338947A patent/PL338947A1/xx unknown
- 1998-08-05 EP EP98935229A patent/EP1003739A2/fr not_active Withdrawn
- 1998-08-05 HU HU0003425A patent/HUP0003425A3/hu unknown
- 1998-08-05 EA EA200000023A patent/EA200000023A1/ru unknown
- 1998-08-10 PA PA19988457001A patent/PA8457001A1/es unknown
- 1998-08-10 PE PE1998000717A patent/PE106299A1/es not_active Application Discontinuation
- 1998-08-12 MA MA25210A patent/MA24632A1/fr unknown
- 1998-08-12 DZ DZ980193A patent/DZ2583A1/fr active
- 1998-08-12 TN TNTNSN98151A patent/TNSN98151A1/fr unknown
- 1998-08-13 AR ARP980104021A patent/AR017019A1/es unknown
- 1998-08-14 HR HR60/055,764A patent/HRP980441A2/hr not_active Application Discontinuation
- 1998-08-14 ZA ZA9807304A patent/ZA987304B/xx unknown
- 1998-08-14 CO CO98046788A patent/CO4960656A1/es unknown
- 1998-08-17 UY UY25144A patent/UY25144A1/es not_active Application Discontinuation
2000
- 2000-01-10 BG BG104069A patent/BG104069A/xx unknown
- 2000-01-11 IS IS5336A patent/IS5336A/is unknown
- 2000-02-08 OA OA1200000030A patent/OA11286A/en unknown
- 2000-02-14 NO NO20000722A patent/NO20000722L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
KR20010022507A (ko)	2001-03-15
ZA987304B (en)	2000-02-14
DZ2583A1 (fr)	2003-02-22
NO20000722D0 (no)	2000-02-14
TNSN98151A1 (fr)	2005-03-15
PL338947A1 (en)	2000-12-04
IL133960A0 (en)	2001-04-30
EA200000023A1 (ru)	2000-08-28
AR017019A1 (es)	2001-08-22
PE106299A1 (es)	1999-11-02
UY25144A1 (es)	2000-12-29
ID23803A (id)	2000-05-11
BG104069A (en)	2001-05-31
JP2002536291A (ja)	2002-10-29
TR200000414T2 (tr)	2000-08-21
HRP980441A2 (en)	1999-04-30
EP1003739A2 (fr)	2000-05-31
NO20000722L (no)	2000-02-14
IS5336A (is)	2000-01-11
HUP0003425A3 (en)	2002-02-28
AP9801321A0 (en)	2000-02-14
OA11286A (en)	2003-10-22
WO1999009025A2 (fr)	1999-02-25
PA8457001A1 (es)	2000-09-29
CN1265660A (zh)	2000-09-06
SK1352000A3 (en)	2000-08-14
HUP0003425A2 (hu)	2001-10-28
CA2297486A1 (fr)	1999-02-25
AU8457298A (en)	1999-03-08
CA2297486C (fr)	2005-05-03
CO4960656A1 (es)	2000-09-25
BR9811557A (pt)	2000-08-22
WO1999009025A3 (fr)	1999-04-15

Publication	Publication Date	Title
PT994890E (pt)	2003-11-28	Derivados de benzimidazole
MA24632A1 (fr)	1999-04-01	Derives de 2-(4-aryl-ou heteroaryl-piperazine-1-ylmethyle)-1h- indole
PT1005446E (pt)	2004-06-30	Derivados de n-aroilfenilalanina
ATE426598T1 (de)	2009-04-15	Epothilonderivate
ATE235220T1 (de)	2003-04-15	Resorcinderivate
ID22781A (id)	1999-12-09	Turunan-turunan nikotinamida
DE69817186D1 (de)	2003-09-18	Diaminorhodamin-derivate
PT915088E (pt)	2003-01-31	Derivados de d-prolina
PT1000048E (pt)	2003-03-31	Derivados substituidos do 1,2,3,4-tetrahidronaftaleno
DK0842143T5 (da)	2009-06-02	2-(4-substituerede)-benzylamino-2-methyl-propanamid derivater
ATE255098T1 (de)	2003-12-15	Substituierte chromanderivate
PT921125E (pt)	2002-06-28	Derivados de 1,38-triaza-espiro 4,5 decan-4-ona
PT1003719E (pt)	2002-10-31	Derivados microbicidas de n-sulfonil-glicinalquiniloxifenemetilamida
PT869121E (pt)	2004-10-29	Derivados de propanolamina hipolipidemicos
PT1027362E (pt)	2005-08-31	Derivados de cetolidos 2-halogeno-6-o-substituidos
ATE440854T1 (de)	2009-09-15	5-deoxy-cytidin-derivate
ATE255099T1 (de)	2003-12-15	Substituierte chromanderivate
BR9508380A (pt)	1997-12-23	Derivados de azalonas heterocíclicos anti-helicobacter
PT966437E (pt)	2002-11-29	Derivados de 5-aroilnaftaleno
DE69829682D1 (de)	2005-05-12	Cis-disubstituierte aminocycloalkyl-pyrrolidin-derivate
MA26480A1 (fr)	2004-12-20	Derives de phenoxymethylpiperidine
DE69828780D1 (de)	2005-03-03	Amidinocamptpthecin-derivate
PT1178984E (pt)	2003-06-30	Derivados de 1-trifluorometil-4-hidroxi-7-piperidinilamimometilcromano
ATE372989T1 (de)	2007-09-15	Azolinderivate
MA26756A1 (fr)	2004-12-20	Derives de thiazole