AP9901637A0 - Crystalline hydrated sodium salt of (E)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidin-3-ylidene methyl)-1H-indole-2-carboxylic acid. - Google Patents

Crystalline hydrated sodium salt of (E)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidin-3-ylidene methyl)-1H-indole-2-carboxylic acid.

Info

Publication number: AP9901637A0
Authority: AP; ARIPO
Prior art keywords: sodium salt; phenylpyrrolidin; indole; dichloro; oxo
Prior art date: 1997-03-05

Application number

APAP/P/1999/001637A

Other languages

English (en)

Inventor

Zadeo Cimarosti

Paolo Maragni

Original Assignee

Glaxo Wellcome Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-05

Filing date

1998-03-03

Publication date

1999-09-30

1998-03-03 Application filed by Glaxo Wellcome Spa filed Critical Glaxo Wellcome Spa

1999-09-30 Publication of AP9901637A0 publication Critical patent/AP9901637A0/en

Links

159000000000 sodium salts Chemical class 0.000 title abstract 2
VDIRQCDDCGAGET-DHZHZOJOSA-N 4,6-dichloro-3-[(e)-(2-oxo-1-phenylpyrrolidin-3-ylidene)methyl]-1h-indole-2-carboxylic acid Chemical compound OC(=O)C=1NC2=CC(Cl)=CC(Cl)=C2C=1\C=C(C1=O)/CCN1C1=CC=CC=C1 VDIRQCDDCGAGET-DHZHZOJOSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Medicinal Chemistry (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

APAP/P/1999/001637A 1997-03-05 1998-03-03 Crystalline hydrated sodium salt of (E)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidin-3-ylidene methyl)-1H-indole-2-carboxylic acid. AP9901637A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9704498.6A GB9704498D0 (en)	1997-03-05	1997-03-05	Chemical compound
PCT/EP1998/001146 WO1998039327A1 (fr)	1997-03-05	1998-03-03	Sel hydrate cristallin de sodium de l'acide (e)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidine-3-ylidene methyle)-1h-indole-2-carboxylique

Publications (1)

Publication Number	Publication Date
AP9901637A0 true AP9901637A0 (en)	1999-09-30

Family

ID=10808697

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/1999/001637A AP9901637A0 (en)	1997-03-05	1998-03-03	Crystalline hydrated sodium salt of (E)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidin-3-ylidene methyl)-1H-indole-2-carboxylic acid.

Country Status (29)

Country	Link
EP (1)	EP0966463A1 (fr)
JP (1)	JP2001513796A (fr)
KR (1)	KR20000075907A (fr)
CN (1)	CN1249750A (fr)
AP (1)	AP9901637A0 (fr)
AR (1)	AR011178A1 (fr)
AU (1)	AU6825198A (fr)
BG (1)	BG103779A (fr)
BR (1)	BR9808305A (fr)
CA (1)	CA2282851A1 (fr)
CO (1)	CO4940415A1 (fr)
EA (1)	EA199900710A1 (fr)
EE (1)	EE9900387A (fr)
GB (1)	GB9704498D0 (fr)
HR (1)	HRP980114A2 (fr)
HU (1)	HUP0002109A2 (fr)
ID (1)	ID24207A (fr)
IL (1)	IL131489A0 (fr)
IS (1)	IS5166A (fr)
NO (1)	NO994303L (fr)
NZ (1)	NZ337315A (fr)
OA (1)	OA11154A (fr)
PE (1)	PE51399A1 (fr)
PL (1)	PL335652A1 (fr)
SK (1)	SK119699A3 (fr)
TR (1)	TR199902117T2 (fr)
WO (1)	WO1998039327A1 (fr)
YU (1)	YU43499A (fr)
ZA (1)	ZA981791B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9704499D0 (en) *	1997-03-05	1997-04-23	Glaxo Wellcome Spa	Method of manufacture
GB9825988D0 (en) *	1998-11-27	1999-01-20	Pfizer Ltd	Indole derivatives
GB9915231D0 (en)	1999-06-29	1999-09-01	Pfizer Ltd	Pharmaceutical complex
US9737531B2 (en)	2012-07-12	2017-08-22	Glytech, Llc	Composition and method for treatment of depression and psychosis in humans
CA3067162A1 (fr)	2017-06-12	2018-12-20	Glytech Llc.	Traitement de la depression avec des antagonistes du nmda et de la d2/5ht2a ou des antagonistes de la 5ht2a selectifs

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9321221D0 (en) *	1993-10-14	1993-12-01	Glaxo Spa	Heterocyclic compounds

1997
- 1997-03-05 GB GBGB9704498.6A patent/GB9704498D0/en active Pending
1998
- 1998-03-03 EE EEP199900387A patent/EE9900387A/xx unknown
- 1998-03-03 IL IL13148998A patent/IL131489A0/xx unknown
- 1998-03-03 ZA ZA9801791A patent/ZA981791B/xx unknown
- 1998-03-03 PL PL98335652A patent/PL335652A1/xx unknown
- 1998-03-03 HU HU0002109A patent/HUP0002109A2/hu unknown
- 1998-03-03 AR ARP980100948A patent/AR011178A1/es unknown
- 1998-03-03 CA CA002282851A patent/CA2282851A1/fr not_active Abandoned
- 1998-03-03 CO CO98011404A patent/CO4940415A1/es unknown
- 1998-03-03 ID IDW990976A patent/ID24207A/id unknown
- 1998-03-03 PE PE1998000149A patent/PE51399A1/es not_active Application Discontinuation
- 1998-03-03 WO PCT/EP1998/001146 patent/WO1998039327A1/fr not_active Ceased
- 1998-03-03 EA EA199900710A patent/EA199900710A1/ru unknown
- 1998-03-03 NZ NZ337315A patent/NZ337315A/en unknown
- 1998-03-03 SK SK1196-99A patent/SK119699A3/sk unknown
- 1998-03-03 JP JP53813598A patent/JP2001513796A/ja active Pending
- 1998-03-03 TR TR1999/02117T patent/TR199902117T2/xx unknown
- 1998-03-03 YU YU43499A patent/YU43499A/sh unknown
- 1998-03-03 EP EP98913613A patent/EP0966463A1/fr not_active Withdrawn
- 1998-03-03 CN CN98803053A patent/CN1249750A/zh active Pending
- 1998-03-03 BR BR9808305-8A patent/BR9808305A/pt not_active Application Discontinuation
- 1998-03-03 AU AU68251/98A patent/AU6825198A/en not_active Abandoned
- 1998-03-03 AP APAP/P/1999/001637A patent/AP9901637A0/en unknown
- 1998-03-03 KR KR1019997007987A patent/KR20000075907A/ko not_active Withdrawn
- 1998-03-04 HR HR9704498.6A patent/HRP980114A2/hr not_active Application Discontinuation
1999
- 1999-08-27 IS IS5166A patent/IS5166A/is unknown
- 1999-09-02 OA OA9900201A patent/OA11154A/fr unknown
- 1999-09-03 NO NO994303A patent/NO994303L/no not_active Application Discontinuation
- 1999-10-04 BG BG103779A patent/BG103779A/xx unknown

Also Published As

Publication number	Publication date
NO994303L (no)	1999-11-03
SK119699A3 (en)	2000-05-16
JP2001513796A (ja)	2001-09-04
KR20000075907A (ko)	2000-12-26
BR9808305A (pt)	2000-05-16
AU6825198A (en)	1998-09-22
WO1998039327A1 (fr)	1998-09-11
PL335652A1 (en)	2000-05-08
YU43499A (sh)	2000-12-28
CN1249750A (zh)	2000-04-05
EP0966463A1 (fr)	1999-12-29
ID24207A (id)	2000-07-13
EA199900710A1 (ru)	2000-04-24
IS5166A (is)	1999-08-27
CO4940415A1 (es)	2000-07-24
NZ337315A (en)	2001-02-23
PE51399A1 (es)	1999-06-07
AR011178A1 (es)	2000-08-02
EE9900387A (et)	2000-04-17
HRP980114A2 (en)	1998-12-31
TR199902117T2 (xx)	2000-03-21
HUP0002109A2 (hu)	2001-04-28
OA11154A (en)	2003-04-16
ZA981791B (en)	1999-09-03
NO994303D0 (no)	1999-09-03
GB9704498D0 (en)	1997-04-23
IL131489A0 (en)	2001-01-28
BG103779A (en)	2000-06-30
CA2282851A1 (fr)	1998-09-11

Publication	Publication Date	Title
CA2260337A1 (fr)	1999-07-27	Agents therapeutiques
TW200407287A (en)	2004-05-16	A sulfonated amine acid derivative and the metalloproteinase inhibitor containing it (I)
AU6613896A (en)	1996-10-30	Chemical compounds
TR200200579T2 (tr)	2002-12-23	Amino-tirazolpiridin türevleri.
EP1193270A3 (fr)	2002-04-17	Pyrrolobenzodiazépines
MXPA02003977A (es)	2003-09-25	Inhibidores de adhesion de celula mediada por al°2.
HUP0204034A3 (en)	2004-12-28	Stable salts of novel derivatives of 3,3-diphenylpropylamines
GB9514518D0 (en)	1995-09-13	Guanidine salt inhibitors of NO synthase and cyclooxygenase
AU2001266575A1 (en)	2002-01-08	Chemical compounds
AP2000001900A0 (en)	2000-09-30	Halogeneted amidino amino acid derivatives useful as nitric oxide synthase inhibitors.
MXPA00012647A (es)	2003-07-14	Derivados n-sustituidos de acido 5-oxiiminobarbiturico.
AU5727899A (en)	2000-04-26	Diaminocyclobutene-3,4-dione derivatives, their preparation and use
TR200001909T2 (tr)	2000-12-21	Matris metaloprotez inhibitörleri.
AU2001261707A1 (en)	2002-01-08	Pirazino '1$m(1)2$m(1) :1, 6! pyrido '3,4-b! indole derivatives
AU2002211493A1 (en)	2002-05-15	Indole derivatives as pde5-inhibitors
AU8631698A (en)	1999-02-16	A process for the preparation of tetraazamacrocycles
TR200001121T2 (tr)	2000-09-21	Antiromatizmal madde.
PL348721A1 (en)	2002-06-03	Use of phosphonoformic acid derivatives for treating infections
NO994303L (no)	1999-11-03	Krystallinsk hydrert natriumsalt av (E)-4,6-diklor-3-(2-okso-1-fenylpyrrolidin-3-ylidenmetyl)-1H-indol-2-karboksylsyre
AU4944899A (en)	2000-02-01	New pharmaceutically active compounds
IL142775A0 (en)	2002-03-10	Use of phosphonoformic acid derivatives for treating infections
HK1022899A (en)	2000-08-25	Crystalline hydrated sodium salt of (e)-4, 6-dichloro-3-(2-oxo-1-phenylpyrrolidin-3-ylidene methyl)-1h-indole-2-carboxylic acid
TW358809B (en)	1999-05-21	Phenylamidinothiophene compound and anti-inflammatory agent containing the same
IL132344A0 (en)	2001-03-19	Alkaloid halide salts of swainsonine compositions containing the same and the use thereof
MX9605794A (es)	1997-12-31	Intermediario para preparar un compuesto farmaceuticamente activo.