CA2282851A1 - Sel hydrate cristallin de sodium de l'acide (e)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidine-3-ylidene methyle)-1h-indole-2-carboxylique - Google Patents
Sel hydrate cristallin de sodium de l'acide (e)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidine-3-ylidene methyle)-1h-indole-2-carboxylique Download PDFInfo
- Publication number
- CA2282851A1 CA2282851A1 CA002282851A CA2282851A CA2282851A1 CA 2282851 A1 CA2282851 A1 CA 2282851A1 CA 002282851 A CA002282851 A CA 002282851A CA 2282851 A CA2282851 A CA 2282851A CA 2282851 A1 CA2282851 A1 CA 2282851A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- crystalline hydrated
- sodium salt
- hydrated form
- theta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 239000002687 nonaqueous vehicle Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 229940127240 opiate Drugs 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 208000033300 perinatal asphyxia Diseases 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- PMOIAJVKYNVHQE-UHFFFAOYSA-N phosphanium;bromide Chemical compound [PH4+].[Br-] PMOIAJVKYNVHQE-UHFFFAOYSA-N 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229940068965 polysorbates Drugs 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical class CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000020374 simple syrup Nutrition 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229940080313 sodium starch Drugs 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- NOJNFULGOQGBKB-UHFFFAOYSA-M sodium;3-[3-tert-butylsulfanyl-1-[[4-(6-ethoxypyridin-3-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoate Chemical compound [Na+].C1=NC(OCC)=CC=C1C(C=C1)=CC=C1CN1C2=CC=C(OCC=3N=CC(C)=CC=3)C=C2C(SC(C)(C)C)=C1CC(C)(C)C([O-])=O NOJNFULGOQGBKB-UHFFFAOYSA-M 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 208000020431 spinal cord injury Diseases 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000003019 stabilising effect Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229960005453 strychnine Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000002511 suppository base Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- TUQOTMZNTHZOKS-UHFFFAOYSA-N tributylphosphine Chemical compound CCCCP(CCCC)CCCC TUQOTMZNTHZOKS-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- FTVLMFQEYACZNP-UHFFFAOYSA-N trimethylsilyl trifluoromethanesulfonate Chemical compound C[Si](C)(C)OS(=O)(=O)C(F)(F)F FTVLMFQEYACZNP-UHFFFAOYSA-N 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
L'invention a pour objet une forme hydratée cristalline du sel de sodium du composé présentant la formule (I). L'invention traite aussi de la préparation de ce sel et de son utilisation comme produit thérapeutique.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9704498.6A GB9704498D0 (en) | 1997-03-05 | 1997-03-05 | Chemical compound |
| GB9704498.6 | 1997-03-05 | ||
| PCT/EP1998/001146 WO1998039327A1 (fr) | 1997-03-05 | 1998-03-03 | Sel hydrate cristallin de sodium de l'acide (e)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidine-3-ylidene methyle)-1h-indole-2-carboxylique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2282851A1 true CA2282851A1 (fr) | 1998-09-11 |
Family
ID=10808697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002282851A Abandoned CA2282851A1 (fr) | 1997-03-05 | 1998-03-03 | Sel hydrate cristallin de sodium de l'acide (e)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidine-3-ylidene methyle)-1h-indole-2-carboxylique |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP0966463A1 (fr) |
| JP (1) | JP2001513796A (fr) |
| KR (1) | KR20000075907A (fr) |
| CN (1) | CN1249750A (fr) |
| AP (1) | AP9901637A0 (fr) |
| AR (1) | AR011178A1 (fr) |
| AU (1) | AU6825198A (fr) |
| BG (1) | BG103779A (fr) |
| BR (1) | BR9808305A (fr) |
| CA (1) | CA2282851A1 (fr) |
| CO (1) | CO4940415A1 (fr) |
| EA (1) | EA199900710A1 (fr) |
| EE (1) | EE9900387A (fr) |
| GB (1) | GB9704498D0 (fr) |
| HR (1) | HRP980114A2 (fr) |
| HU (1) | HUP0002109A2 (fr) |
| ID (1) | ID24207A (fr) |
| IL (1) | IL131489A0 (fr) |
| IS (1) | IS5166A (fr) |
| NO (1) | NO994303L (fr) |
| NZ (1) | NZ337315A (fr) |
| OA (1) | OA11154A (fr) |
| PE (1) | PE51399A1 (fr) |
| PL (1) | PL335652A1 (fr) |
| SK (1) | SK119699A3 (fr) |
| TR (1) | TR199902117T2 (fr) |
| WO (1) | WO1998039327A1 (fr) |
| YU (1) | YU43499A (fr) |
| ZA (1) | ZA981791B (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9704499D0 (en) * | 1997-03-05 | 1997-04-23 | Glaxo Wellcome Spa | Method of manufacture |
| GB9825988D0 (en) * | 1998-11-27 | 1999-01-20 | Pfizer Ltd | Indole derivatives |
| GB9915231D0 (en) | 1999-06-29 | 1999-09-01 | Pfizer Ltd | Pharmaceutical complex |
| US9737531B2 (en) | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| CN110996948A (zh) | 2017-06-12 | 2020-04-10 | 格莱泰施有限责任公司 | 用nmda拮抗剂和d2/5ht2a或选择性5ht2a拮抗剂治疗抑郁症 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9321221D0 (en) * | 1993-10-14 | 1993-12-01 | Glaxo Spa | Heterocyclic compounds |
-
1997
- 1997-03-05 GB GBGB9704498.6A patent/GB9704498D0/en active Pending
-
1998
- 1998-03-03 KR KR1019997007987A patent/KR20000075907A/ko not_active Withdrawn
- 1998-03-03 WO PCT/EP1998/001146 patent/WO1998039327A1/fr not_active Ceased
- 1998-03-03 EE EEP199900387A patent/EE9900387A/xx unknown
- 1998-03-03 EP EP98913613A patent/EP0966463A1/fr not_active Withdrawn
- 1998-03-03 AU AU68251/98A patent/AU6825198A/en not_active Abandoned
- 1998-03-03 NZ NZ337315A patent/NZ337315A/en unknown
- 1998-03-03 SK SK1196-99A patent/SK119699A3/sk unknown
- 1998-03-03 TR TR1999/02117T patent/TR199902117T2/xx unknown
- 1998-03-03 JP JP53813598A patent/JP2001513796A/ja active Pending
- 1998-03-03 PE PE1998000149A patent/PE51399A1/es not_active Application Discontinuation
- 1998-03-03 CA CA002282851A patent/CA2282851A1/fr not_active Abandoned
- 1998-03-03 HU HU0002109A patent/HUP0002109A2/hu unknown
- 1998-03-03 CN CN98803053A patent/CN1249750A/zh active Pending
- 1998-03-03 ZA ZA9801791A patent/ZA981791B/xx unknown
- 1998-03-03 PL PL98335652A patent/PL335652A1/xx unknown
- 1998-03-03 IL IL13148998A patent/IL131489A0/xx unknown
- 1998-03-03 AP APAP/P/1999/001637A patent/AP9901637A0/en unknown
- 1998-03-03 EA EA199900710A patent/EA199900710A1/ru unknown
- 1998-03-03 YU YU43499A patent/YU43499A/sh unknown
- 1998-03-03 AR ARP980100948A patent/AR011178A1/es unknown
- 1998-03-03 BR BR9808305-8A patent/BR9808305A/pt not_active Application Discontinuation
- 1998-03-03 CO CO98011404A patent/CO4940415A1/es unknown
- 1998-03-03 ID IDW990976A patent/ID24207A/id unknown
- 1998-03-04 HR HR9704498.6A patent/HRP980114A2/hr not_active Application Discontinuation
-
1999
- 1999-08-27 IS IS5166A patent/IS5166A/is unknown
- 1999-09-02 OA OA9900201A patent/OA11154A/fr unknown
- 1999-09-03 NO NO994303A patent/NO994303L/no not_active Application Discontinuation
- 1999-10-04 BG BG103779A patent/BG103779A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB9704498D0 (en) | 1997-04-23 |
| WO1998039327A1 (fr) | 1998-09-11 |
| BR9808305A (pt) | 2000-05-16 |
| EP0966463A1 (fr) | 1999-12-29 |
| ID24207A (id) | 2000-07-13 |
| EE9900387A (et) | 2000-04-17 |
| CO4940415A1 (es) | 2000-07-24 |
| PE51399A1 (es) | 1999-06-07 |
| IS5166A (is) | 1999-08-27 |
| IL131489A0 (en) | 2001-01-28 |
| AU6825198A (en) | 1998-09-22 |
| SK119699A3 (en) | 2000-05-16 |
| KR20000075907A (ko) | 2000-12-26 |
| ZA981791B (en) | 1999-09-03 |
| TR199902117T2 (xx) | 2000-03-21 |
| HRP980114A2 (en) | 1998-12-31 |
| NO994303L (no) | 1999-11-03 |
| PL335652A1 (en) | 2000-05-08 |
| JP2001513796A (ja) | 2001-09-04 |
| OA11154A (en) | 2003-04-16 |
| CN1249750A (zh) | 2000-04-05 |
| NO994303D0 (no) | 1999-09-03 |
| AP9901637A0 (en) | 1999-09-30 |
| YU43499A (sh) | 2000-12-28 |
| NZ337315A (en) | 2001-02-23 |
| EA199900710A1 (ru) | 2000-04-24 |
| AR011178A1 (es) | 2000-08-02 |
| BG103779A (en) | 2000-06-30 |
| HUP0002109A2 (hu) | 2001-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |