AR005672A1 - Derivados de la distamicina, proceso para prepararlos, y su utilizacion como agentes antitumorales y antivirales. - Google Patents
Derivados de la distamicina, proceso para prepararlos, y su utilizacion como agentes antitumorales y antivirales.Info
- Publication number
- AR005672A1 AR005672A1 ARP970100402A ARP970100402A AR005672A1 AR 005672 A1 AR005672 A1 AR 005672A1 AR P970100402 A ARP970100402 A AR P970100402A AR P970100402 A ARP970100402 A AR P970100402A AR 005672 A1 AR005672 A1 AR 005672A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivatives
- antiviral agents
- distamicine
- tumor
- prepare
- Prior art date
Links
- 239000003443 antiviral agent Substances 0.000 title abstract 2
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- UPBAOYRENQEPJO-UHFFFAOYSA-N n-[5-[[5-[(3-amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-formamido-1-methylpyrrole-2-carboxamide Chemical class CN1C=C(NC=O)C=C1C(=O)NC1=CN(C)C(C(=O)NC2=CN(C)C(C(=O)NCCC(N)=N)=C2)=C1 UPBAOYRENQEPJO-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Derivados de la distamicina de fórmula (I), donde: n es 2, 3 o 4; R0 es C1-C4 alquilo o CH2CH2-X2, donde X2 es un átomo halógeno; R1 y R2 sonseleccionados, cada uno por separado, de: hidrógeno, C1-C4 alquilo es opcionalmente sustituidopor uno o más átomos de fluor, C1-C4 alcoxi, yhalógenos, X1 es un halógeno; B es seleccionado de fórmulas (II), donde R3--- R9 son, cada uno en forma independiente, hidrógeno o C1-C1alquilo, y m es 0, 1,o 2, con la condición que, cuando R0 es -CH2CH2- X2, B es diferente de -(CH2)m -NR6R7, y por lo menos uno de R3, R4, R5 es C1-C5 alquilo o una de de la mismafarmacéuticamente aceptable. Dichos compuestos son útiles como agentes antincoplásicos y antivirales.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9602163.9A GB9602163D0 (en) | 1996-02-02 | 1996-02-02 | Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents |
| GBGB9613987.8A GB9613987D0 (en) | 1996-07-03 | 1996-07-03 | Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR005672A1 true AR005672A1 (es) | 1999-07-14 |
Family
ID=26308589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970100402A AR005672A1 (es) | 1996-02-02 | 1997-01-31 | Derivados de la distamicina, proceso para prepararlos, y su utilizacion como agentes antitumorales y antivirales. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6165980A (es) |
| EP (1) | EP0880499A1 (es) |
| JP (1) | JP2000503999A (es) |
| AR (1) | AR005672A1 (es) |
| AU (1) | AU1596097A (es) |
| CA (1) | CA2244139C (es) |
| WO (1) | WO1997028123A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9806692D0 (en) * | 1998-03-27 | 1998-05-27 | Pharmacia & Upjohn Spa | Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents |
| GB9816652D0 (en) * | 1998-07-30 | 1998-09-30 | Pharmacia & Upjohn Spa | Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents |
| GB9816653D0 (en) * | 1998-07-30 | 1998-09-30 | Pharmacia & Upjohn Spa | Oxidised sulfurated distamycin derivatives process for preparing them and their use as antitumor agents |
| US6559125B1 (en) | 2000-01-28 | 2003-05-06 | California Institute Of Technology | Polyamide-alkylator conjugates and related products and method |
| GB0011059D0 (en) | 2000-05-08 | 2000-06-28 | Pharmacia & Upjohn Spa | Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione |
| GB0015447D0 (en) | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents |
| GB0015446D0 (en) | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites |
| GB0016447D0 (en) | 2000-07-04 | 2000-08-23 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
| GB0017852D0 (en) * | 2000-07-20 | 2000-09-06 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
| AU2002312370A1 (en) | 2001-06-13 | 2002-12-23 | Roland W. Burli | Antipathogenic benzamide compounds |
| US6562656B1 (en) * | 2001-06-25 | 2003-05-13 | Thin Film Module, Inc. | Cavity down flip chip BGA |
| US6969592B2 (en) | 2001-09-26 | 2005-11-29 | Pharmacia Italia S.P.A. | Method for predicting the sensitivity to chemotherapy |
| GB0130868D0 (en) * | 2001-12-24 | 2002-02-06 | Univ Strathclyde | New compounds |
| GB2389581A (en) * | 2002-06-12 | 2003-12-17 | Viaxxel Biotech Gmbh | Hydrogenated pyrimidines and their use as inhibitors of deoxyhypusine-synthase or hypusination of eIF-5A |
| CA2494139A1 (en) | 2002-08-02 | 2004-02-12 | Genesoft Pharmaceuticals, Inc. | Biaryl compounds having anti-infective activity |
| AU2003285958A1 (en) | 2002-10-25 | 2004-05-25 | Genesoft Pharmaceuticals, Inc. | Anti-infective biaryl compounds |
| US7129214B2 (en) | 2002-12-10 | 2006-10-31 | Oscient Pharmaceuticals Corporation | Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif |
| GB0619325D0 (en) | 2006-09-30 | 2006-11-08 | Univ Strathclyde | New compounds |
| CN104845967B (zh) | 2015-04-15 | 2020-12-11 | 苏州新海生物科技股份有限公司 | 寡聚核苷酸片段及使用其的选择性扩增目标核酸序列变异体的方法及应用 |
| WO2018047148A1 (en) | 2016-09-12 | 2018-03-15 | Novartis Ag | Compounds for the inhibition of mirna |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8517922D0 (en) * | 1985-07-16 | 1985-08-21 | Erba Farmitalia | Carboxamido derivatives |
| SE468642B (sv) * | 1985-07-16 | 1993-02-22 | Erba Farmitalia | Poly-4-aminopyrrol-2-karboxamidoderivat och foerfarande foer deras framstaellning och en farmaceutisk komposition |
| GB8612218D0 (en) * | 1986-05-20 | 1986-06-25 | Erba Farmitalia | Site specific alkylating agents |
-
1997
- 1997-01-22 JP JP9527287A patent/JP2000503999A/ja not_active Withdrawn
- 1997-01-22 US US09/101,758 patent/US6165980A/en not_active Expired - Fee Related
- 1997-01-22 WO PCT/EP1997/000369 patent/WO1997028123A1/en not_active Ceased
- 1997-01-22 EP EP97902243A patent/EP0880499A1/en not_active Withdrawn
- 1997-01-22 AU AU15960/97A patent/AU1596097A/en not_active Abandoned
- 1997-01-22 CA CA002244139A patent/CA2244139C/en not_active Expired - Fee Related
- 1997-01-31 AR ARP970100402A patent/AR005672A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2244139C (en) | 2005-06-07 |
| CA2244139A1 (en) | 1997-08-07 |
| JP2000503999A (ja) | 2000-04-04 |
| EP0880499A1 (en) | 1998-12-02 |
| US6165980A (en) | 2000-12-26 |
| WO1997028123A1 (en) | 1997-08-07 |
| AU1596097A (en) | 1997-08-22 |
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