ATE135348T1 - Pyrimidin-4-carboxamidderivate, ihre herstellung und ihre verwendung in der therapie - Google Patents

Pyrimidin-4-carboxamidderivate, ihre herstellung und ihre verwendung in der therapie

Info

Publication number
ATE135348T1
ATE135348T1 AT92401772T AT92401772T ATE135348T1 AT E135348 T1 ATE135348 T1 AT E135348T1 AT 92401772 T AT92401772 T AT 92401772T AT 92401772 T AT92401772 T AT 92401772T AT E135348 T1 ATE135348 T1 AT E135348T1
Authority
AT
Austria
Prior art keywords
pyrimidine
therapy
preparation
carboxamide derivatives
hydrogen atom
Prior art date
Application number
AT92401772T
Other languages
English (en)
Inventor
Pascal George
Jacques Froissant
Arlette Tixidre
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Application granted granted Critical
Publication of ATE135348T1 publication Critical patent/ATE135348T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT92401772T 1991-06-27 1992-06-24 Pyrimidin-4-carboxamidderivate, ihre herstellung und ihre verwendung in der therapie ATE135348T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9107937A FR2678271B1 (fr) 1991-06-27 1991-06-27 Derives de pyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.

Publications (1)

Publication Number Publication Date
ATE135348T1 true ATE135348T1 (de) 1996-03-15

Family

ID=9414357

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92401772T ATE135348T1 (de) 1991-06-27 1992-06-24 Pyrimidin-4-carboxamidderivate, ihre herstellung und ihre verwendung in der therapie

Country Status (21)

Country Link
US (1) US5244901A (de)
EP (1) EP0522915B1 (de)
JP (1) JP3160371B2 (de)
KR (1) KR930000509A (de)
CN (1) CN1067884A (de)
AT (1) ATE135348T1 (de)
AU (1) AU645698B2 (de)
CA (1) CA2072528A1 (de)
CZ (1) CZ9202002A3 (de)
DE (1) DE69208955T2 (de)
DK (1) DK0522915T3 (de)
ES (1) ES2087477T3 (de)
FI (1) FI922983A7 (de)
FR (1) FR2678271B1 (de)
GR (1) GR3020055T3 (de)
HU (1) HUT61996A (de)
IE (1) IE922093A1 (de)
MX (1) MX9203331A (de)
NO (1) NO922524L (de)
PL (1) PL295021A1 (de)
ZA (1) ZA924787B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2678272B1 (fr) * 1991-06-27 1994-01-14 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
ES2073951T3 (es) * 1992-07-03 1995-08-16 Synthelabo Derivados de 2-amino-n-(((4-(aminocarbonil)pirimidin-2-il)amino)alquil)pirimidina-4-carboxamida, su preparacion y su aplicacion en terapeutica.
US5447916A (en) * 1993-07-30 1995-09-05 Chiron Corporation Peptoid alpha-1 adrenergic receptor ligands
US5889010A (en) * 1995-05-18 1999-03-30 Pfizer Inc. Benzimidazole derivatives having dopaminergic activity
CA2304100A1 (en) 1997-11-07 1999-05-20 Pharmacia & Upjohn Company Process to produce oxazolidinones
TW536538B (en) 1998-02-20 2003-06-11 Ortho Mcneil Pharm Inc Phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia
EP1346983A3 (de) * 1998-02-20 2003-12-03 Ortho-Mcneil Pharmaceutical, Inc. Phthalimido-arylpiperazine als alpha 1A Rezeptor Antagonisten nützlich zur Behandlung von gutartiger Prostatahyperplasie
ZA991319B (en) * 1998-02-20 2000-11-20 Ortho Mcneil Pharm Inc Novel phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia.
JP2002513799A (ja) * 1998-05-06 2002-05-14 デューク・ユニバーシティー 膀胱および下部尿路症候群の治療方法
JP3519302B2 (ja) 1999-02-09 2004-04-12 株式会社東海理化電機製作所 ウエビング巻取装置用プリテンショナー
KR100566188B1 (ko) * 1999-11-27 2006-03-29 동화약품공업주식회사 신규의 5-피리미딘카르복스아미드 유도체 및 그를포함하는 약학적 조성물
KR100566189B1 (ko) * 1999-12-29 2006-03-29 동화약품공업주식회사 신규의 5-피리미딘카르복스아미드 유도체 및 그를포함하는 약학적 조성물
CA2496463A1 (en) * 2002-08-23 2004-03-04 Pfizer Products Inc. Apparatus for dispensing articles
US7410971B2 (en) * 2003-12-26 2008-08-12 Eisai R&D Management Co., Ltd. 1,2-di(cyclic)substituted benzene compounds
CN100526301C (zh) * 2003-12-26 2009-08-12 卫材R&D管理有限公司 1,2-二(环式基)取代苯化合物
MY140489A (en) * 2003-12-26 2009-12-31 Eisai R&D Man Co Ltd 1,2-di (cyclic) substituted benzene compounds
US20060276465A1 (en) * 2003-12-26 2006-12-07 Eisai R&D Management Co., Ltd. 1,2-di(cyclic) substituted benzene compounds
WO2005118537A2 (en) * 2004-05-31 2005-12-15 Ranbaxy Laboratories Limited Arylpiperazine derivatives as adrenergic receptor antagonists
SE0402200D0 (sv) * 2004-09-13 2004-09-13 Astrazeneca Ab New process II
EP1832580A4 (de) 2004-12-20 2009-03-11 Eisai R&D Man Co Ltd Kristall und salz von 1-cyclopropylmethyl-4-[2-(3,3,5,5)-tetramethylcyclohexyl)phenyl]piperazin
US20090163715A1 (en) * 2005-05-25 2009-06-25 Eisai R&D Management Co., Ltd. Intermediate in Production of [2-(3,3,5,5-Tetramethylcyclohexyl)phenyl]Piperazine Compound
MY144974A (en) * 2005-06-14 2011-11-30 Eisai R&D Man Co Ltd 1,2-di(cyclic) substituted benzene derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2143730A (en) * 1932-05-27 1939-01-10 Apex Electrical Mfg Co Clothes washer
DE2143730A1 (de) * 1971-09-01 1973-03-08 Byk Gulden Lomberg Chem Fab Substituierte pyridine, verfahren zu deren herstellung und sie enthaltende arzneimittel
FR2618436B1 (fr) * 1987-07-23 1989-10-27 Synthelabo Derives de piperidine, leur preparation et leur application en therapeutique
FR2620121B1 (fr) * 1987-09-09 1990-01-05 Synthelabo ((pyrimidinyl-2)-aminoalkyl)-1 piperidines, leur preparation et leur application en therapeutique
FR2656609B1 (fr) * 1989-12-28 1992-03-27 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
DE69208955T2 (de) 1996-10-24
ES2087477T3 (es) 1996-07-16
AU645698B2 (en) 1994-01-20
FR2678271A1 (fr) 1992-12-31
ZA924787B (en) 1993-03-31
US5244901A (en) 1993-09-14
FI922983A0 (fi) 1992-06-26
CN1067884A (zh) 1993-01-13
MX9203331A (es) 1992-12-01
CA2072528A1 (en) 1992-12-28
NO922524D0 (no) 1992-06-26
FI922983L (fi) 1992-12-28
PL295021A1 (en) 1993-03-08
GR3020055T3 (en) 1996-08-31
JP3160371B2 (ja) 2001-04-25
IE922093A1 (en) 1992-12-30
CZ9202002A3 (en) 1993-01-13
HUT61996A (en) 1993-03-29
HU9202137D0 (en) 1992-10-28
DE69208955D1 (de) 1996-04-18
EP0522915A1 (de) 1993-01-13
FI922983A7 (fi) 1992-12-28
JPH05186434A (ja) 1993-07-27
EP0522915B1 (de) 1996-03-13
FR2678271B1 (fr) 1995-01-13
DK0522915T3 (da) 1996-07-22
AU1859092A (en) 1993-01-07
KR930000509A (ko) 1993-01-15
NO922524L (no) 1992-12-28

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee