AR010904A1 - Benzotiadiazoles sustituidos comoantagonista del receptor endotelial, procedimiento para prepararlos, medicamentos y composiciones farmaceuticas quelas contienen. - Google Patents
Benzotiadiazoles sustituidos comoantagonista del receptor endotelial, procedimiento para prepararlos, medicamentos y composiciones farmaceuticas quelas contienen.Info
- Publication number
- AR010904A1 AR010904A1 ARP980101123A ARP980101123A AR010904A1 AR 010904 A1 AR010904 A1 AR 010904A1 AR P980101123 A ARP980101123 A AR P980101123A AR P980101123 A ARP980101123 A AR P980101123A AR 010904 A1 AR010904 A1 AR 010904A1
- Authority
- AR
- Argentina
- Prior art keywords
- hal
- atoms
- nha
- naa
- independently represent
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 108091007231 endothelial receptors Proteins 0.000 title 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 3
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 206010008118 cerebral infarction Diseases 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- FNQJDLTXOVEEFB-UHFFFAOYSA-N 1,2,3-benzothiadiazole Chemical class C1=CC=C2SN=NC2=C1 FNQJDLTXOVEEFB-UHFFFAOYSA-N 0.000 abstract 1
- -1 1H-tetrazol-5-yl Chemical group 0.000 abstract 1
- 201000006474 Brain Ischemia Diseases 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 101100295741 Gallus gallus COR4 gene Proteins 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020852 Hypertonia Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000001647 Renal Insufficiency Diseases 0.000 abstract 1
- 206010063897 Renal ischaemia Diseases 0.000 abstract 1
- 208000032851 Subarachnoid Hemorrhage Diseases 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- 201000006370 kidney failure Diseases 0.000 abstract 1
- 208000031225 myocardial ischemia Diseases 0.000 abstract 1
- KIWSYRHAAPLJFJ-DNZSEPECSA-N n-[(e,2z)-4-ethyl-2-hydroxyimino-5-nitrohex-3-enyl]pyridine-3-carboxamide Chemical compound [O-][N+](=O)C(C)C(/CC)=C/C(=N/O)/CNC(=O)C1=CC=CN=C1 KIWSYRHAAPLJFJ-DNZSEPECSA-N 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Benzotiadiazoles sustituidos de formula I, en donde X representa O o S, R1 representa H, Hal, OH, OA, A, NO2, NH2, NHA, NAA, NHCOR4, NHCOR6, NHSO2R4,NHSO2R6, S(O)mR6, SO3H, SO3H, SO2NR4R4 o formilo, R2, R2 representan independientemente A,(CH2)nHet, CH2COAr, CH2COHet o OAr, R2 también representaH, R3 representa COOR4, CN, 1H-tetrazol-5-ilo o CONHSO2R5, R4, R4 representan independientemente H o A, R5 representa A o Ar, R6 representa fenilo o naftilono sustituido o mono, di o trisustituido con A, NH2, NHA, NAA, NO2, CN o Hal, R7, R7 representan independientemente H o alquilo de 1 a 6 átomos de C, A, Arepresentan independientemente alquilo de 1 a 6 átomos de C, en donde uno o dos grupos de CH2 pueden estar remplazados por átomos deO o S o por prupos-CR7=CR7 y/o 1 a 7 átomos de H pueden estar reemplazados por F, o bencilo , Ar representa fenilo o naftilo no sustituido o mono, di o trisustituido con A, OR4,NH2, NHA, NAA, NO2, CN, Hal, NHCOR4, NHCOR6, NHSO2R4, NHSO2R6, COOR4,OPh,CONH2,CONHA,CONAA,COR4,CONHSO2R4,CONHSO2R6,O(CH2)nCOOR4,O(CH2)nOR4,SO3H,SO2NR4R4,S(O)mR6 o S(O)mR4, Het representa un heterociclo saturado, insaturado o aromatio de uno o dos nucleos, que contienen de 1 a 4 átomos de N, O y/o S, quese encuentra unido a traves del N o C y que puede no estar sustituido o estar mono, di o trisustituido con Hal,A,R3,NHA,NAA,NO2 y/o =O,Hal representa fluor,cloro, bromo o yodo, m es 0, 1 o 2 y n es 1 o 2, siendo R3 distinto de COOA cuando R2 representaCH2COAr y R2 representa H, y sus sales. Procedimiento parapreparar dichos compuestos y composiciones farmaceuticas que los contienen, que son utiles para combatir la hipertonia, la insuficiencia cardíaca, lainsuficiencia renal, el infarto cerebral,la enfermedad coronaria,la isquemia renal, cerebral y de miocardio, la hemorragia subaracnoidal, las inflamaciones,
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19710831A DE19710831A1 (de) | 1997-03-15 | 1997-03-15 | Endothelin-Rezeptor-Antagonisten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR010904A1 true AR010904A1 (es) | 2000-07-12 |
Family
ID=7823513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980101123A AR010904A1 (es) | 1997-03-15 | 1998-03-13 | Benzotiadiazoles sustituidos comoantagonista del receptor endotelial, procedimiento para prepararlos, medicamentos y composiciones farmaceuticas quelas contienen. |
Country Status (5)
| Country | Link |
|---|---|
| AR (1) | AR010904A1 (es) |
| AU (1) | AU6826498A (es) |
| DE (1) | DE19710831A1 (es) |
| WO (1) | WO1998041515A1 (es) |
| ZA (1) | ZA982111B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6432432B1 (en) | 1999-03-05 | 2002-08-13 | Arch Chemicals, Inc. | Chemical method of making a suspension, emulsion or dispersion of pyrithione particles |
| AR037097A1 (es) | 2001-10-05 | 2004-10-20 | Novartis Ag | Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento |
| DE10155076A1 (de) * | 2001-11-09 | 2003-05-22 | Merck Patent Gmbh | Verwendung von Endothelin-Rezeptor-Antagonisten zur Behandlung von Tumorerkrankungen |
| DE102005047647A1 (de) | 2005-10-05 | 2007-04-12 | Merck Patent Gmbh | a,a'-Dihydroxyketonderivate und deren Verwendung als UV-Filter |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4659862A (en) * | 1984-05-03 | 1987-04-21 | E. I. Du Pont De Nemours And Company | Process of preparing nitrodihydroaryl carbonyl compounds |
| PT617001E (pt) * | 1993-03-19 | 2000-06-30 | Merck & Co Inc | Derivados do acido fenoxifenilacetico |
| US5686478A (en) * | 1993-07-20 | 1997-11-11 | Merck & Co. Inc. | Endothelin antagonists |
| DE19509950A1 (de) * | 1995-03-18 | 1996-09-19 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
| DE19530032A1 (de) * | 1995-08-16 | 1997-02-20 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
| DE19607096A1 (de) * | 1996-02-24 | 1997-08-28 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
-
1997
- 1997-03-15 DE DE19710831A patent/DE19710831A1/de not_active Withdrawn
-
1998
- 1998-03-04 AU AU68264/98A patent/AU6826498A/en not_active Abandoned
- 1998-03-04 WO PCT/EP1998/001205 patent/WO1998041515A1/de not_active Ceased
- 1998-03-12 ZA ZA982111A patent/ZA982111B/xx unknown
- 1998-03-13 AR ARP980101123A patent/AR010904A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE19710831A1 (de) | 1998-09-17 |
| ZA982111B (en) | 1998-09-14 |
| AU6826498A (en) | 1998-10-12 |
| WO1998041515A1 (de) | 1998-09-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6409116B2 (ja) | プロテインキナーゼ阻害剤としてのアミノピリダジノン化合物 | |
| JP2007505138A5 (es) | ||
| ES8505659A1 (es) | Un procedimiento para la preparacion de inhibidores biciclicos de la tromboxano sintetasa. | |
| CO6170405A2 (es) | Composicion plaguicida que comprende fluopicolida y un compuesto insecticida | |
| ZA200605526B (en) | Substituted azole derivatives, compositions and methods of use | |
| AR030211A1 (es) | Compuestos derivados de amino-pirazol, composicion farmaceutica que lo comprende y su uso en el tratamiento de enfermedades mediadas por la actividad de la quinasa proteinica | |
| AR068054A1 (es) | Compuestos de pirrolopirimidina | |
| KR940007021A (ko) | 흥분성 아미노산 수용체 길항물질 | |
| AR035974A1 (es) | Derivados de diarilmetil piperazina, procesos para su preparacion, uso de estos derivados para la elaboracion de medicamentos y composicion farmaceutica | |
| AR036041A1 (es) | Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen | |
| AR019777A1 (es) | Derivados de la diacilhidrazina, un procedimiento para su preparacion, el empleo de los mismos en la elaboracion de medicamentos, las composicionesfarmaceuticas que los contienen y un procedimiento para preparar estas composiciones farmaceuticas | |
| HRP20231608T1 (hr) | Derivati piridinil sulfonamida, njihovi farmaceutski pripravci i njihove uporabe | |
| AR010904A1 (es) | Benzotiadiazoles sustituidos comoantagonista del receptor endotelial, procedimiento para prepararlos, medicamentos y composiciones farmaceuticas quelas contienen. | |
| KR920012051A (ko) | 비페닐릴 화합물 | |
| RU2005105564A (ru) | Производные бензимидазола и их применение в качестве пролекарств ингибиторов протонного насоса | |
| AR115007A1 (es) | Derivados de triazolona o sales de los mismos y composiciones farmacéuticas que comprenden los mismos | |
| BR112017022757B1 (pt) | Derivados do pirazol, seus usos e composição farmacêutica | |
| JP2011504489A5 (es) | ||
| JP2021514399A5 (es) | ||
| EP0317953A3 (en) | N-(1-thienylcycloalkyl)alkenylamines for treatment of neurotoxic injury | |
| ES2036137B1 (es) | Procedimiento para la preparacion de la nueva 1-(3-clorofenil)-4-hidroximetil-7,8-dimetoxi-5h-2,3-benzodiacepina y de sus sales de adicion acida. | |
| KR890011834A (ko) | 술폰아미드 및 이것을 활성성분으로서 함유하는 제초제 | |
| ES2102870T3 (es) | Benzopiranos y composiciones farmaceuticas que los contienen. | |
| AR010909A1 (es) | Derivados sustituidos de 8-(aza u oxa o tia)-3-aza-ciclopenta[a]inden como antagonistas del receptor endotelial, procedimiento para prepararlos ,procedimiento para obtener composiciones farmaceuticas a base de los derivados, medicamentos y composiciones farmaceuticas que los contienen. | |
| SE8008254L (sv) | Cyklopropankarboxylsyraester-derivat |