AR016751A1 - Metodo para inhibir la liberacion del peptido beta-amiloide en una celula, composicion farmaceutica y compuestos utiles en dicho metodo - Google Patents
Metodo para inhibir la liberacion del peptido beta-amiloide en una celula, composicion farmaceutica y compuestos utiles en dicho metodoInfo
- Publication number
- AR016751A1 AR016751A1 ARP970105393A ARP970105393A AR016751A1 AR 016751 A1 AR016751 A1 AR 016751A1 AR P970105393 A ARP970105393 A AR P970105393A AR P970105393 A ARP970105393 A AR P970105393A AR 016751 A1 AR016751 A1 AR 016751A1
- Authority
- AR
- Argentina
- Prior art keywords
- beta
- release
- inhibiting
- cell
- pharmaceutical composition
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 102000013455 Amyloid beta-Peptides Human genes 0.000 abstract 2
- 108010090849 Amyloid beta-Peptides Proteins 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75544296A | 1996-11-22 | 1996-11-22 | |
| US80852897A | 1997-02-28 | 1997-02-28 | |
| US80752897A | 1997-02-28 | 1997-02-28 | |
| US80742797A | 1997-02-28 | 1997-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR016751A1 true AR016751A1 (es) | 2001-08-01 |
Family
ID=27505670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970105393A AR016751A1 (es) | 1996-11-22 | 1997-11-18 | Metodo para inhibir la liberacion del peptido beta-amiloide en una celula, composicion farmaceutica y compuestos utiles en dicho metodo |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0942924A2 (id) |
| JP (1) | JP2001503782A (id) |
| KR (1) | KR20000069064A (id) |
| CN (1) | CN1238779A (id) |
| AR (1) | AR016751A1 (id) |
| AU (1) | AU5356198A (id) |
| BR (1) | BR9713400A (id) |
| CA (1) | CA2267634A1 (id) |
| CO (1) | CO4910156A1 (id) |
| CZ (1) | CZ122899A3 (id) |
| EA (1) | EA199900490A1 (id) |
| HR (1) | HRP970627A2 (id) |
| HU (1) | HUP0100270A3 (id) |
| ID (1) | ID22044A (id) |
| IL (1) | IL129083A0 (id) |
| NO (1) | NO992368L (id) |
| NZ (1) | NZ334690A (id) |
| PE (1) | PE16999A1 (id) |
| TR (3) | TR199902937T2 (id) |
| WO (1) | WO1998022494A2 (id) |
| YU (1) | YU46097A (id) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19616486C5 (de) | 1996-04-25 | 2016-06-30 | Royalty Pharma Collection Trust | Verfahren zur Senkung des Blutglukosespiegels in Säugern |
| US6191166B1 (en) * | 1997-11-21 | 2001-02-20 | Elan Pharmaceuticals, Inc. | Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis |
| US6635632B1 (en) | 1996-12-23 | 2003-10-21 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| DE19823831A1 (de) | 1998-05-28 | 1999-12-02 | Probiodrug Ges Fuer Arzneim | Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen |
| US6958330B1 (en) | 1998-06-22 | 2005-10-25 | Elan Pharmaceuticals, Inc. | Polycyclic α-amino-ε-caprolactams and related compounds |
| US6552013B1 (en) | 1998-06-22 | 2003-04-22 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| WO1999067219A1 (en) * | 1998-06-22 | 1999-12-29 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| CA2325389A1 (en) * | 1998-06-22 | 1999-12-29 | James E. Audia | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| AU4710499A (en) * | 1998-06-22 | 2000-01-10 | Elan Pharmaceuticals, Inc. | Cyclic amino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use ofsuch compounds |
| DE19828113A1 (de) * | 1998-06-24 | 2000-01-05 | Probiodrug Ges Fuer Arzneim | Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV |
| DE19828114A1 (de) | 1998-06-24 | 2000-01-27 | Probiodrug Ges Fuer Arzneim | Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV |
| DE19834591A1 (de) | 1998-07-31 | 2000-02-03 | Probiodrug Ges Fuer Arzneim | Verfahren zur Steigerung des Blutglukosespiegels in Säugern |
| US6486350B1 (en) | 1998-09-30 | 2002-11-26 | Elan Pharmaceuticals Inc. | Biological reagents and methods for determining the mechanism in the generation of β-amyloid peptide |
| US6737038B1 (en) | 1998-11-12 | 2004-05-18 | Bristol-Myers Squibb Company | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging |
| KR20010080709A (ko) | 1998-12-10 | 2001-08-22 | 프리돌린 클라우스너, 롤란드 비. 보레르 | 프로콜라겐 ｃ-프로티나제 저해제 |
| US6723711B2 (en) | 1999-05-07 | 2004-04-20 | Texas Biotechnology Corporation | Propanoic acid derivatives that inhibit the binding of integrins to their receptors |
| US6972296B2 (en) | 1999-05-07 | 2005-12-06 | Encysive Pharmaceuticals Inc. | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
| BR0010349B1 (pt) * | 1999-05-07 | 2011-10-04 | derivados de ácido propanóico que inibem a ligação de integrinas aos seus receptores. | |
| DE19926233C1 (de) | 1999-06-10 | 2000-10-19 | Probiodrug Ges Fuer Arzneim | Verfahren zur Herstellung von Thiazolidin |
| DE19940130A1 (de) | 1999-08-24 | 2001-03-01 | Probiodrug Ges Fuer Arzneim | Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung |
| WO2001034639A2 (en) * | 1999-11-09 | 2001-05-17 | Eli Lilly And Company | β-AMINOACID COMPOUNDS USEFUL FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS |
| HU229042B1 (en) | 2000-03-31 | 2013-07-29 | Prosidion Ltd | Method for the improvement of islet signaling in diabetes mellitus and for its prevention |
| US6878363B2 (en) | 2000-05-17 | 2005-04-12 | Bristol-Myers Squibb Pharma Company | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging |
| EP1268450A1 (en) | 2000-06-01 | 2003-01-02 | Bristol-Myers Squibb Pharma Company | Lactams substituted by cyclic succinates as inhibitors of a-beta protein production |
| FR2832152A1 (fr) * | 2001-11-09 | 2003-05-16 | Aventis Pharma Sa | Utilisation de derives de 2-amino-thiazoline comme inhibiteurs de no-synthase inductible |
| GB0016681D0 (en) | 2000-07-06 | 2000-08-23 | Merck Sharp & Dohme | Therapeutic compounds |
| US6432944B1 (en) | 2000-07-06 | 2002-08-13 | Bristol-Myers Squibb Company | Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives |
| US7132104B1 (en) | 2000-10-27 | 2006-11-07 | Probiodrug Ag | Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders |
| US6890905B2 (en) | 2001-04-02 | 2005-05-10 | Prosidion Limited | Methods for improving islet signaling in diabetes mellitus and for its prevention |
| DE10150203A1 (de) | 2001-10-12 | 2003-04-17 | Probiodrug Ag | Peptidylketone als Inhibitoren der DPIV |
| US20030130199A1 (en) | 2001-06-27 | 2003-07-10 | Von Hoersten Stephan | Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents |
| US7368421B2 (en) | 2001-06-27 | 2008-05-06 | Probiodrug Ag | Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis |
| AR039059A1 (es) | 2001-08-06 | 2005-02-09 | Sanofi Aventis | Compuesto derivado de acilaminotiazol, su utilizacion, procedimientos para prepararlo, composicion farmaceutica que lo comprende, y compuestos intermediarios |
| FR2840899B1 (fr) * | 2002-06-12 | 2005-02-25 | Sanofi Synthelabo | Derives d'acylaminothiazole, leur preparation et leur utilisation en therapeutique |
| US6844316B2 (en) | 2001-09-06 | 2005-01-18 | Probiodrug Ag | Inhibitors of dipeptidyl peptidase I |
| DE10143840A1 (de) * | 2001-09-06 | 2003-03-27 | Probiodrug Ag | Neue Inhibitoren der Dipeptidylpeptidase I |
| DK1446393T3 (da) | 2001-11-09 | 2006-07-10 | Aventis Pharma Sa | Derivater af 2-amino-thiazolin og fremstilling heraf som inhibitorer af inducerbar NO-syntase |
| JP2005527504A (ja) | 2002-02-28 | 2005-09-15 | プロシディオン・リミテッド | グルタミニルを基礎するｄｐｉｖ阻害剤 |
| CA2851462A1 (en) | 2003-01-08 | 2004-07-29 | University Of Washington | Antibacterial agents |
| KR20110059664A (ko) | 2003-05-05 | 2011-06-02 | 프로비오드룩 아게 | 글루타미닐 및 글루타메이트 사이클라제의 이펙터의 용도 |
| JP4806628B2 (ja) | 2003-05-05 | 2011-11-02 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤 |
| EP1666068A4 (en) * | 2003-09-24 | 2010-08-04 | Santen Pharmaceutical Co Ltd | REMEDY FOR EYE DISEASES ACCOMPANIED BY OPTICAL NERVE INJURIES |
| BRPI0415409A (pt) | 2003-10-15 | 2006-12-05 | Probiodrug Ag | uso de efetuadores de ciclases de glutaminila e glutamato |
| JP5539864B2 (ja) | 2007-06-12 | 2014-07-02 | アカオゲン，インコーポレーテッド | 抗菌剤 |
| EP2062909A1 (en) * | 2007-11-21 | 2009-05-27 | SOLVAY (Société Anonyme) | Peptide production and purification process |
| BG110141A (en) | 2008-05-23 | 2009-12-31 | "Софарма" Ад | GALANTAMINE DERIVATIVES, METHODS FOR THEIR PREPARATION AND USE |
| WO2013170165A1 (en) | 2012-05-10 | 2013-11-14 | Achaogen, Inc. | Antibacterial agents |
| WO2017004560A1 (en) * | 2015-07-02 | 2017-01-05 | The Regents Of The University Of California | Methods and compositions for amyloid aggregates |
| EP4274559A4 (en) * | 2021-01-05 | 2024-12-11 | Southern Research Institute | PROGRAMMED DEATH-LIGAND-1 MODULATORS |
| WO2024076635A2 (en) * | 2022-10-05 | 2024-04-11 | Buck Institute For Research On Aging | Suppressors of site iq electron leak and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU661270B2 (en) * | 1990-03-05 | 1995-07-20 | Cephalon, Inc. | Chymotrypsin-like proteases and their inhibitors |
| WO1995013084A1 (en) * | 1992-05-11 | 1995-05-18 | Miles Inc. | Cathepsin d is an amyloidogenic protease in alzheimer's disease |
| NZ264143A (en) * | 1993-08-09 | 1996-11-26 | Lilly Co Eli | Use of an aspartyl protease inhibitor to inhibit beta-amyloid peptide production |
| JPH09505281A (ja) * | 1993-10-01 | 1997-05-27 | メレルファーマスーティカルズ インコーポレイテッド | β−アミロイド蛋白質製造の阻害剤類 |
| US6017887A (en) * | 1995-01-06 | 2000-01-25 | Sibia Neurosciences, Inc. | Peptide, peptide analog and amino acid analog protease inhibitors |
| US5804560A (en) * | 1995-01-06 | 1998-09-08 | Sibia Neurosciences, Inc. | Peptide and peptide analog protease inhibitors |
| WO1996039194A1 (en) * | 1995-06-06 | 1996-12-12 | Athena Neurosciences, Inc. | Novel cathepsin and methods and compositions for inhibition thereof |
-
1997
- 1997-11-18 AR ARP970105393A patent/AR016751A1/es not_active Application Discontinuation
- 1997-11-19 HR HR08/808,528A patent/HRP970627A2/hr not_active Application Discontinuation
- 1997-11-20 PE PE1997001056A patent/PE16999A1/es not_active Application Discontinuation
- 1997-11-21 AU AU53561/98A patent/AU5356198A/en not_active Abandoned
- 1997-11-21 WO PCT/US1997/020804 patent/WO1998022494A2/en not_active Ceased
- 1997-11-21 ID IDW990394A patent/ID22044A/id unknown
- 1997-11-21 TR TR1999/02937T patent/TR199902937T2/xx unknown
- 1997-11-21 TR TR1999/02938T patent/TR199902938T2/xx unknown
- 1997-11-21 TR TR1999/01133T patent/TR199901133T2/xx unknown
- 1997-11-21 BR BR9713400-7A patent/BR9713400A/pt not_active IP Right Cessation
- 1997-11-21 CO CO97068215A patent/CO4910156A1/es unknown
- 1997-11-21 KR KR1019997004486A patent/KR20000069064A/ko not_active Withdrawn
- 1997-11-21 CA CA002267634A patent/CA2267634A1/en not_active Abandoned
- 1997-11-21 EP EP97950601A patent/EP0942924A2/en not_active Withdrawn
- 1997-11-21 NZ NZ334690A patent/NZ334690A/en unknown
- 1997-11-21 EA EA199900490A patent/EA199900490A1/ru unknown
- 1997-11-21 CN CN97199803A patent/CN1238779A/zh active Pending
- 1997-11-21 YU YU46097A patent/YU46097A/sh unknown
- 1997-11-21 IL IL12908397A patent/IL129083A0/xx unknown
- 1997-11-21 CZ CZ991228A patent/CZ122899A3/cs unknown
- 1997-11-21 JP JP52375698A patent/JP2001503782A/ja active Pending
- 1997-11-21 HU HU0100270A patent/HUP0100270A3/hu unknown
-
1999
- 1999-05-14 NO NO992368A patent/NO992368L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TR199901133T2 (xx) | 1999-07-21 |
| HRP970627A2 (en) | 1998-08-31 |
| CO4910156A1 (es) | 2000-04-24 |
| JP2001503782A (ja) | 2001-03-21 |
| WO1998022494A3 (en) | 1998-11-26 |
| NO992368D0 (no) | 1999-05-14 |
| HUP0100270A3 (en) | 2001-09-28 |
| CZ122899A3 (cs) | 1999-10-13 |
| KR20000069064A (ko) | 2000-11-25 |
| WO1998022494A2 (en) | 1998-05-28 |
| BR9713400A (pt) | 2000-01-25 |
| ID22044A (id) | 1999-08-26 |
| YU46097A (sh) | 2000-10-30 |
| EP0942924A2 (en) | 1999-09-22 |
| NO992368L (no) | 1999-06-21 |
| CN1238779A (zh) | 1999-12-15 |
| PE16999A1 (es) | 1999-02-19 |
| EA199900490A1 (ru) | 2000-02-28 |
| NZ334690A (en) | 2001-09-28 |
| HUP0100270A2 (hu) | 2001-08-28 |
| TR199902938T2 (xx) | 2002-06-21 |
| TR199902937T2 (xx) | 2001-01-22 |
| AU5356198A (en) | 1998-06-10 |
| CA2267634A1 (en) | 1998-05-28 |
| IL129083A0 (en) | 2000-02-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR016751A1 (es) | Metodo para inhibir la liberacion del peptido beta-amiloide en una celula, composicion farmaceutica y compuestos utiles en dicho metodo | |
| BR9714517A (pt) | Cicloalquila, lactama, lactona e compostos correlatos, composições farmacêuticas compreendendo os mesmos e processos para inibir liberação de peptìdeo beta-amilóide e/ou sua sìntese por uso de tais compostos | |
| EA199900778A1 (ru) | ГЕТЕРОЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ И ИХ ИСПОЛЬЗОВАНИЕ ДЛЯ ИНГИБИРОВАНИЯ β-АМИЛОИДНОГО ПЕПТИДА | |
| DE69733272D1 (de) | N-(aryl/heteroarylacetyl)aminosäureester, diese enthaltende pharmazeutische zusammensetzungen und methoden zur inhibierung der beta-amyloidfreisetzung und/oder deren synthese unter verwendung dieser verbindungen | |
| PE20020802A1 (es) | COMPUESTO DE LACTAMA COMO INHIBIDOR DE LA LIBERACION DEL PEPTIDO ß-AMILOIDE | |
| ES2178000T3 (es) | Composiciones y metodos para tratar infecciones usando analogos de indolicidina. | |
| MX9505182A (es) | Composicion terapeutica para aplicacion topica, que contiene un antagonista de la substancia p. | |
| BR9502707A (pt) | Composto composição farmacêutica e método para o tratamento de uma afecção | |
| ES2176600T3 (es) | Derivado de la propiofenona y procedimientos para su preparacion. | |
| BG101841A (bg) | Инхибитори на клетъчна адхезия | |
| BR9714064A (pt) | Composição farmacêutica | |
| BG104599A (en) | Inhibition of raf kinase using symmetrical and unsymmetrical substituted diphenyl ureas | |
| TR199701073T1 (xx) | Protein kinaz C inhibit�rleri. | |
| NZ223400A (en) | Dental composition containing kappa-caseino-glycopeptides | |
| BR9808429A (pt) | Composição farmacêutica e processo para a sua preparação. | |
| BR9811099A (pt) | Inibidores de urocinase | |
| ID29393A (id) | Komposisi pengobatan kanker dan metoda penggunaan minyak-minyak esensil tanaman alamiah | |
| BRPI0113286B8 (pt) | pirazóis substituídos e composição farmacêutica compreendendo os mesmos. | |
| BR0008922A (pt) | Compostos úteis como agentes antiinflamatórios | |
| ATE264692T1 (de) | Verwendung von no synthase hemmern und fängern von reaktiven sauerstoffsformen zur behandlung von ischämie | |
| MX9710252A (es) | Utilizacion de al menos un peptido en una composicion cosmetica o para la preparacion de un medicamento. | |
| ES2221950T3 (es) | Dihidrobenzofurano y compuestos relacionados utiles como agentes anti-inflamatorios. | |
| DK1207870T3 (da) | Farmaceutiske præparater, der indeholder N-palmitoylethanolamid og anvendelse deraf | |
| ES2170143T3 (es) | Composiciones que comprenden halofantrina en una forma especial. | |
| ES2124983T3 (es) | Utilizacion de un antagonista de substancia p para el tratamiento de las manchas rojas cutaneas de origen neurogeno. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |