BRPI0113286B8 - pirazóis substituídos e composição farmacêutica compreendendo os mesmos. - Google Patents

pirazóis substituídos e composição farmacêutica compreendendo os mesmos.

Info

Publication number
BRPI0113286B8
BRPI0113286B8 BRPI0113286A BR0113286A BRPI0113286B8 BR PI0113286 B8 BRPI0113286 B8 BR PI0113286B8 BR PI0113286 A BRPI0113286 A BR PI0113286A BR 0113286 A BR0113286 A BR 0113286A BR PI0113286 B8 BRPI0113286 B8 BR PI0113286B8
Authority
BR
Brazil
Prior art keywords
same
substituted pyrazoles
pharmaceutical composition
pyrazoles
substituted
Prior art date
Application number
BRPI0113286A
Other languages
English (en)
Other versions
BR0113286B1 (pt
BR0113286A (pt
Inventor
A Pio Barbara
A Grice Cheryl
R Butler Christopher
A Sehon Clark
J Gustin Darin
Khatuya Haripada
Cai Hui
P Edwards James
Wei Jianmei
L Tays Kevin
P Meduna Steven
Original Assignee
Johnson & Johnson
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson & Johnson, Ortho Mcneil Pharm Inc filed Critical Johnson & Johnson
Publication of BR0113286A publication Critical patent/BR0113286A/pt
Publication of BR0113286B1 publication Critical patent/BR0113286B1/pt
Publication of BRPI0113286B8 publication Critical patent/BRPI0113286B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

"pirazóis substituídos". são descritos pirazóis substituídos, processos para produção dos mesmos, composições contendo os mesmos, e métodos empregando os mesmos para tratar, por exemplo, doenças autoimunes mediadas por catepsina s.
BRPI0113286A 2000-08-14 2001-08-10 pirazóis substituídos e composição farmacêutica compreendendo os mesmos. BRPI0113286B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22517800P 2000-08-14 2000-08-14
US09/927,324 US6953793B2 (en) 2000-08-14 2001-08-10 Substituted pyrazoles
PCT/US2001/025290 WO2002014315A2 (en) 2000-08-14 2001-08-10 Substituted pyrazoles

Publications (3)

Publication Number Publication Date
BR0113286A BR0113286A (pt) 2003-09-09
BR0113286B1 BR0113286B1 (pt) 2013-04-16
BRPI0113286B8 true BRPI0113286B8 (pt) 2021-05-25

Family

ID=26919364

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0113286A BRPI0113286B8 (pt) 2000-08-14 2001-08-10 pirazóis substituídos e composição farmacêutica compreendendo os mesmos.

Country Status (19)

Country Link
US (2) US6953793B2 (pt)
EP (1) EP1309593B1 (pt)
JP (1) JP5049447B2 (pt)
KR (1) KR100837193B1 (pt)
AT (1) ATE320427T1 (pt)
AU (2) AU2001286454B2 (pt)
BR (1) BRPI0113286B8 (pt)
CA (1) CA2419552C (pt)
CZ (1) CZ307185B6 (pt)
DE (1) DE60118004T2 (pt)
DK (1) DK1309593T3 (pt)
ES (1) ES2261463T3 (pt)
HU (1) HU230538B1 (pt)
MX (1) MXPA03001422A (pt)
NZ (1) NZ524191A (pt)
PL (1) PL213103B1 (pt)
PT (1) PT1309593E (pt)
RU (1) RU2317988C2 (pt)
WO (1) WO2002014315A2 (pt)

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Also Published As

Publication number Publication date
JP2004511440A (ja) 2004-04-15
CZ307185B6 (cs) 2018-03-07
CA2419552C (en) 2010-10-12
PT1309593E (pt) 2006-08-31
KR20030060876A (ko) 2003-07-16
HU230538B1 (hu) 2016-11-28
WO2002014315A3 (en) 2002-06-13
BR0113286B1 (pt) 2013-04-16
DE60118004T2 (de) 2006-11-16
AU2001286454B2 (en) 2006-09-14
CZ2003429A3 (cs) 2003-12-17
AU8645401A (en) 2002-02-25
HK1055422A1 (en) 2004-01-09
US20030078419A1 (en) 2003-04-24
HUP0303108A2 (hu) 2004-01-28
NZ524191A (en) 2004-11-26
PL360696A1 (en) 2004-09-20
RU2003107016A (ru) 2004-11-27
CA2419552A1 (en) 2002-02-21
US6953793B2 (en) 2005-10-11
EP1309593A2 (en) 2003-05-14
PL213103B1 (pl) 2013-01-31
DE60118004D1 (de) 2006-05-11
KR100837193B1 (ko) 2008-06-13
HUP0303108A3 (en) 2012-10-29
JP5049447B2 (ja) 2012-10-17
MXPA03001422A (es) 2004-01-26
ATE320427T1 (de) 2006-04-15
WO2002014315A2 (en) 2002-02-21
BR0113286A (pt) 2003-09-09
EP1309593B1 (en) 2006-03-15
US20050245576A1 (en) 2005-11-03
ES2261463T3 (es) 2006-11-16
RU2317988C2 (ru) 2008-02-27
DK1309593T3 (da) 2006-07-17

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