AR018246A1 - Compuestos inositil-glicanos con actividad del tipo de la insulina, procedimiento para su preparacion, composicion farmaceutica que los contiene, procedimiento para la preparacion de dicha composicion farmaceutica, y el uso de dichos compuestos para la preparacion de un medicamento - Google Patents
Compuestos inositil-glicanos con actividad del tipo de la insulina, procedimiento para su preparacion, composicion farmaceutica que los contiene, procedimiento para la preparacion de dicha composicion farmaceutica, y el uso de dichos compuestos para la preparacion de un medicamentoInfo
- Publication number
- AR018246A1 AR018246A1 ARP970105573A ARP970105573A AR018246A1 AR 018246 A1 AR018246 A1 AR 018246A1 AR P970105573 A ARP970105573 A AR P970105573A AR P970105573 A ARP970105573 A AR P970105573A AR 018246 A1 AR018246 A1 AR 018246A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- procedure
- compounds
- inositol
- alkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- 239000008194 pharmaceutical composition Substances 0.000 title 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 abstract 3
- 229960000367 inositol Drugs 0.000 abstract 3
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 229910019142 PO4 Inorganic materials 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 2
- 239000010452 phosphate Substances 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 230000002608 insulinlike Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/04—Disaccharides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compuestos inositol-glicanos con actividad del tipo de la insulina que comprenden la formula (I): A-Z-R y/o una sal fisiologicamente tolerable delcompuesto de la formula (I) y/o una forma esteroisomera del compuesto de la formula (I), en la que: Are presenta el resto:H-P(O)(OH)-, H-P(S)(OH)-, HO-P(S)(OH)-, HS-P(S)(OH)-, alquilo C1-4-P(O)(OH)-, alquilo C1-4-P(S)(OH)-, S(O)2(OR1), S(O)(OR1), NH2-C(O)-, R1R2N-, R1R2N-C(O)-NH-, R1O-SO2-NH-, alquiloC1-4-SO2-, alquilo C1-4-S(O)- o R1-S-, en dondeR1 y R2, independientemente entre sí, significan un átomo de hidrogeno o alquilo C1-4, Z representa2 a 6 restos azucar, 2 a 6 restos azucar, sustituidos una a seis veces, independientemente entre sí, con : metilo, resto azucar, resto diazucar, -SO2-OH,-C (O)-NR1R2,-C(O)-alquilo C1-4, -P(O)(H)OH, -P(O)(OH)2, -P(S)(H)(OH), -P(S)(OH)2, -P(S)(SH)(OH), -P(O)(OH)-O-CH2-CH2-NR1R2 o el enlace glicosídico entrelos restos azucar 2 a 6 reemplazado una a seis veces por -CH2 o -S-, y en donde R1 y R2,independien temente entre sí, significan un átomo de hidrogenoo alquilo C1-4; R representa:1) inositol, 2) inositol,fosfato,3) isonositol-tiofosfato, 4) inositol-ciclofosfato, 5)inositol-ciclotiofosfato, 6) un resto delgrupo definido en R 2) a 5),sustituido un a o dos veces, independientemente entre sí, con: fosfato o tiofosfato, 7) un resto del grupo definido en R 2 a 5)monosustituido con: un resto ciclofosfato o un resto ciclotiofosfato, u 8) inositol, estando sustituidos dos grupos OHvecinos con: -CH2- CO2-NH-;procedimiento para su preparacion, preparacion farmacéutica que los contiene, procedimiento para la preparacion de dicha preparacion farmacéutica,y el uso de dichos compuestos para la preparacion de un medicamento.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19649350A DE19649350A1 (de) | 1996-11-28 | 1996-11-28 | Inositolglykane mit insulinartiger Wirkung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR018246A1 true AR018246A1 (es) | 2001-11-14 |
Family
ID=7813041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970105573A AR018246A1 (es) | 1996-11-28 | 1997-11-26 | Compuestos inositil-glicanos con actividad del tipo de la insulina, procedimiento para su preparacion, composicion farmaceutica que los contiene, procedimiento para la preparacion de dicha composicion farmaceutica, y el uso de dichos compuestos para la preparacion de un medicamento |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6004938A (es) |
| EP (1) | EP0845475B1 (es) |
| JP (1) | JP4299378B2 (es) |
| CN (1) | CN1136224C (es) |
| AR (1) | AR018246A1 (es) |
| AT (1) | ATE290541T1 (es) |
| AU (1) | AU728637B2 (es) |
| BR (1) | BR9706041C1 (es) |
| CA (1) | CA2222103C (es) |
| CZ (1) | CZ294886B6 (es) |
| DE (2) | DE19649350A1 (es) |
| DK (1) | DK0845475T3 (es) |
| ES (1) | ES2237784T3 (es) |
| HU (1) | HUP9702242A3 (es) |
| PL (1) | PL188604B1 (es) |
| PT (1) | PT845475E (es) |
| RU (1) | RU2178794C2 (es) |
| TR (1) | TR199701432A2 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7312196B2 (en) * | 1997-01-08 | 2007-12-25 | Amylin Pharmaceuticals, Inc. | Formulations for amylin agonist peptides |
| GB9814039D0 (en) * | 1998-06-29 | 1998-08-26 | Univ London | Materials and methods relating to the prevention or treatment of ischaemia-reperfusion injury |
| ATE390434T1 (de) * | 2000-05-12 | 2008-04-15 | Rodaris Pharmaceuticals Ltd | Inositolphosphoglycanderivate und ihre medizinische verwendung |
| US6953781B2 (en) | 2000-05-12 | 2005-10-11 | Rodaris Pharmaceuticals Limited | Compounds and their uses |
| AU6042601A (en) * | 2000-05-12 | 2001-11-20 | Rodaris Pharmaceuticals Limited | Compounds and their uses |
| WO2001085746A1 (en) * | 2000-05-12 | 2001-11-15 | Rodaris Pharmaceuticals Limited | Inositol phosphoglycan derivatives and their medical uses |
| US6716826B2 (en) | 2000-05-12 | 2004-04-06 | Rodaris Pharmaceuticals Limited | Compounds and their uses |
| US6939857B2 (en) | 2000-05-12 | 2005-09-06 | Rodaris Pharmaceuticals Limited | Compounds and their uses |
| US6759390B2 (en) | 2000-05-12 | 2004-07-06 | Manuel Martin-Lomas | Compounds and their uses |
| GB0015627D0 (en) * | 2000-06-26 | 2000-08-16 | Rademacher Group Limited | Phosphoglycan messengers and their medical uses |
| FR2828206B1 (fr) * | 2001-08-03 | 2004-09-24 | Centre Nat Rech Scient | Utilisation d'inhibiteurs des lysyl oxydases pour la culture cellulaire et le genie tissulaire |
| US7084115B2 (en) * | 2002-04-29 | 2006-08-01 | Oxyplus, Inc. | Inositol pyrophosphates, and methods of use thereof |
| WO2004005532A2 (en) * | 2002-07-10 | 2004-01-15 | Massachusetts Institute Of Technology | Solid-phase and solution-phase synthesis of glycosylphosphatidylinositol glycans |
| TWI254635B (en) * | 2002-08-05 | 2006-05-11 | Yamanouchi Pharma Co Ltd | Azulene derivative and salt thereof |
| CN100369610C (zh) * | 2002-10-09 | 2008-02-20 | 中国药科大学 | 一种防治糖尿病的植物提取物及其制备方法与药物用途 |
| US7745423B2 (en) * | 2004-07-06 | 2010-06-29 | NormOxys, Inc | Calcium/sodium salt of inositol tripyrophosphate as an allosteric effector of hemoglobin |
| US20060106000A1 (en) * | 2004-07-06 | 2006-05-18 | Claude Nicolau | Use of inositol-tripyrophosphate in treating tumors and diseases |
| US20070135389A1 (en) * | 2004-07-06 | 2007-06-14 | Claude Nicolau | Tumor eradication by inositol-tripyrophosphate |
| FR2878850B1 (fr) * | 2004-12-02 | 2008-10-31 | Cis Bio Internat Sa | Derives de l'inositol-1-phosphate |
| WO2008080064A1 (en) * | 2006-12-21 | 2008-07-03 | Trustees Of Tufts College | Synthetic lipophilic inositol glycans for treatment of cancer and glucose-metabolism disorders |
| JP2010514772A (ja) * | 2006-12-29 | 2010-05-06 | ノームオクシス インコーポレイテッド | シクリトールおよびその誘導体ならびにその治療用途 |
| CN101784193A (zh) * | 2007-05-01 | 2010-07-21 | 诺尔姆奥克西斯公司 | 促红细胞生成素互补或替代 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4446064A (en) * | 1980-12-19 | 1984-05-01 | The University Of Virginia Alumni Patents Foundation | Insulin mediator substance |
| DE3326473A1 (de) * | 1983-07-22 | 1985-01-31 | Hoechst Ag, 6230 Frankfurt | Pharmazeutisches mittel zur behandlung des diabetes mellitus |
| DE3326472A1 (de) * | 1983-07-22 | 1985-02-14 | Hoechst Ag, 6230 Frankfurt | Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus |
| US4906468A (en) * | 1986-04-11 | 1990-03-06 | The Rockefeller University | Insulin activity messengers, their antibodies, and thereof |
| YU66892A (sh) * | 1991-08-20 | 1995-10-24 | Hoechst Ag. | Fosfoinositolglikan - peptid sa delovanjem kao insulin |
| ATE184611T1 (de) * | 1991-11-29 | 1999-10-15 | Hoechst Ag | Peptide mit insulinartiger wirkung |
| JPH06293790A (ja) * | 1993-04-08 | 1994-10-21 | Kyowa Hakko Kogyo Co Ltd | 生理活性物質イノシトールグリカン |
| US5652221A (en) * | 1994-11-07 | 1997-07-29 | The University Of Virginia Patent Foundation | Method of treating defective glucose metabolism using synthetic insulin substances |
-
1996
- 1996-11-28 DE DE19649350A patent/DE19649350A1/de not_active Withdrawn
-
1997
- 1997-11-13 DE DE59712220T patent/DE59712220D1/de not_active Expired - Fee Related
- 1997-11-13 ES ES97119835T patent/ES2237784T3/es not_active Expired - Lifetime
- 1997-11-13 AT AT97119835T patent/ATE290541T1/de not_active IP Right Cessation
- 1997-11-13 EP EP97119835A patent/EP0845475B1/de not_active Expired - Lifetime
- 1997-11-13 PT PT97119835T patent/PT845475E/pt unknown
- 1997-11-13 DK DK97119835T patent/DK0845475T3/da active
- 1997-11-25 CA CA002222103A patent/CA2222103C/en not_active Expired - Fee Related
- 1997-11-26 HU HU9702242A patent/HUP9702242A3/hu unknown
- 1997-11-26 AR ARP970105573A patent/AR018246A1/es active IP Right Grant
- 1997-11-26 TR TR97/01432A patent/TR199701432A2/xx unknown
- 1997-11-26 AU AU45382/97A patent/AU728637B2/en not_active Ceased
- 1997-11-26 US US08/979,865 patent/US6004938A/en not_active Expired - Fee Related
- 1997-11-26 CN CNB971229589A patent/CN1136224C/zh not_active Expired - Fee Related
- 1997-11-27 BR BR9706041-0A patent/BR9706041C1/pt active Search and Examination
- 1997-11-27 CZ CZ19973775A patent/CZ294886B6/cs not_active IP Right Cessation
- 1997-11-27 JP JP32550897A patent/JP4299378B2/ja not_active Expired - Fee Related
- 1997-11-27 RU RU97120547/04A patent/RU2178794C2/ru not_active IP Right Cessation
- 1997-11-28 PL PL97323407A patent/PL188604B1/pl not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE19649350A1 (de) | 1998-06-04 |
| HK1008786A1 (en) | 1999-05-21 |
| EP0845475B1 (de) | 2005-03-09 |
| PT845475E (pt) | 2005-06-30 |
| ATE290541T1 (de) | 2005-03-15 |
| HUP9702242A1 (hu) | 1998-12-28 |
| JP4299378B2 (ja) | 2009-07-22 |
| DK0845475T3 (da) | 2005-06-27 |
| JPH10158291A (ja) | 1998-06-16 |
| ES2237784T3 (es) | 2005-08-01 |
| HUP9702242A3 (en) | 1999-01-28 |
| CA2222103A1 (en) | 1998-05-28 |
| CZ294886B6 (cs) | 2005-04-13 |
| RU2178794C2 (ru) | 2002-01-27 |
| CA2222103C (en) | 2007-08-28 |
| US6004938A (en) | 1999-12-21 |
| EP0845475A1 (de) | 1998-06-03 |
| DE59712220D1 (de) | 2005-04-14 |
| CN1136224C (zh) | 2004-01-28 |
| BR9706041A (pt) | 1999-11-23 |
| HU9702242D0 (en) | 1998-03-02 |
| BR9706041C1 (pt) | 2000-06-06 |
| CN1184112A (zh) | 1998-06-10 |
| CZ377597A3 (cs) | 1998-06-17 |
| MX9709207A (es) | 1998-05-31 |
| TR199701432A2 (xx) | 1998-06-22 |
| AU4538297A (en) | 1998-06-04 |
| PL188604B1 (pl) | 2005-03-31 |
| AU728637B2 (en) | 2001-01-11 |
| PL323407A1 (en) | 1998-06-08 |
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