DK45080A - Fremgangsmaade til fremstilling af anthracyclinglycosider - Google Patents

Fremgangsmaade til fremstilling af anthracyclinglycosider

Info

Publication number: DK45080A
Authority: DK; Denmark
Prior art keywords: compounds; preparation; anthracycling; lycosides; procedure
Prior art date: 1979-02-02

Application number

DK45080A

Other languages

English (en)

Inventor

G Cassinelli

F Arcamone

A D Marco

Original Assignee

Erba Farmitalia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-02-02

Filing date

1980-02-01

Publication date

1980-08-03

1980-02-01 Application filed by Erba Farmitalia filed Critical Erba Farmitalia

1980-08-03 Publication of DK45080A publication Critical patent/DK45080A/da

Links

238000000034 method Methods 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
229930190071 lycoside Natural products 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 abstract 2
125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
229960000975 daunorubicin Drugs 0.000 abstract 1
STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 abstract 1
229960004679 doxorubicin Drugs 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Furan Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

DK45080A 1979-02-02 1980-02-01 Fremgangsmaade til fremstilling af anthracyclinglycosider DK45080A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB7903700		1979-02-02

Publications (1)

Publication Number	Publication Date
DK45080A true DK45080A (da)	1980-08-03

Family

ID=10502917

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK45080A DK45080A (da)	1979-02-02	1980-02-01	Fremgangsmaade til fremstilling af anthracyclinglycosider

Country Status (6)

Country	Link
US (1)	US4254110A (da)
EP (1)	EP0014425B1 (da)
JP (1)	JPS55133370A (da)
AT (1)	ATE1150T1 (da)
DE (1)	DE3060481D1 (da)
DK (1)	DK45080A (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4314999A (en) *	1978-07-31	1982-02-09	Proter S.P.A.	N-Acyl derivatives of glucosamine having antitumor chemotherapeutic acitivity
JPS57106694A (en) *	1980-11-01	1982-07-02	Erba Carlo Spa	Anthracycline glycoside
GB2196626B (en) *	1986-10-15	1990-09-19	Erba Farmitalia	Antitumor anthracycline glycosides, their preparation, intermediates thereof, and compositions and use therefor
FR2660561B1 (fr) *	1990-04-06	1994-05-13	Technomed International	Sonde rectale.
US7388083B2 (en) *	2005-03-07	2008-06-17	Solux Corporation	Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
US8802830B2 (en)	2005-12-20	2014-08-12	Solux Corporation	Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en)	2008-01-08	2013-01-22	Solux Corporation	Method of aralkylation of 4′-hydroxyl group of anthracylins

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL130756C (da) *	1964-03-02
GB1550879A (en) *	1976-12-22	1979-08-22	Farmaceutici Italia	Antitumour glycosides
GB1542920A (en) *	1976-12-22	1979-03-28	Farmaceutici Italia	Antitumour glycosides
US4181795A (en) *	1978-05-22	1980-01-01	Purdue Research Foundation	Daunosamine synthesis

1980
- 1980-01-28 US US06/115,725 patent/US4254110A/en not_active Expired - Lifetime
- 1980-01-29 AT AT80100447T patent/ATE1150T1/de not_active IP Right Cessation
- 1980-01-29 EP EP80100447A patent/EP0014425B1/en not_active Expired
- 1980-01-29 DE DE8080100447T patent/DE3060481D1/de not_active Expired
- 1980-02-01 JP JP1015980A patent/JPS55133370A/ja active Granted
- 1980-02-01 DK DK45080A patent/DK45080A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP0014425A1 (en)	1980-08-20
ATE1150T1 (de)	1982-06-15
DE3060481D1 (en)	1982-07-22
JPS55133370A (en)	1980-10-17
US4254110A (en)	1981-03-03
EP0014425B1 (en)	1982-06-02
JPS6321671B2 (da)	1988-05-09

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Legal Events

Date	Code	Title	Description
1989-10-09	AHB	Application shelved due to non-payment