AR031098A1 - Compuestos de hidroxifenil urea sustituidos con sulfonamidas, composiciones farmaceuticas que los comprenden, y uso de los mismos en la fabricacion de medicamentos para tratar una enfermedad mediada por una quimioquina - Google Patents

Compuestos de hidroxifenil urea sustituidos con sulfonamidas, composiciones farmaceuticas que los comprenden, y uso de los mismos en la fabricacion de medicamentos para tratar una enfermedad mediada por una quimioquina

Info

Publication number: AR031098A1
Authority: AR; Argentina
Prior art keywords: alkyl; heteroaryl; heterocycle; optionally substituted; aryl
Prior art date: 2000-03-16

Application number

ARP010101183A

Other languages

English (en)

Spanish (es)

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-16

Filing date

2001-03-14

Publication date

2003-09-10

2001-03-14 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

2003-09-10 Publication of AR031098A1 publication Critical patent/AR031098A1/es

Links

239000003814 drug Substances 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
230000001404 mediated effect Effects 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical class NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title 1
201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 25
125000001072 heteroaryl group Chemical group 0.000 abstract 9
125000000623 heterocyclic group Chemical group 0.000 abstract 8
229910052739 hydrogen Inorganic materials 0.000 abstract 8
239000001257 hydrogen Substances 0.000 abstract 8
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 8
125000003118 aryl group Chemical group 0.000 abstract 7
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 6
229910052757 nitrogen Inorganic materials 0.000 abstract 5
229910052760 oxygen Inorganic materials 0.000 abstract 5
229910052717 sulfur Inorganic materials 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 4
125000005842 heteroatom Chemical group 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
125000001424 substituent group Chemical group 0.000 abstract 3
125000000027 (C1-C10) alkoxy group Chemical group 0.000 abstract 2
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
125000005018 aryl alkenyl group Chemical group 0.000 abstract 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
239000001301 oxygen Substances 0.000 abstract 2
125000003107 substituted aryl group Chemical group 0.000 abstract 2
239000011593 sulfur Chemical group 0.000 abstract 2
MTFFANYLEXKMTD-UHFFFAOYSA-N 1-hydroxy-1-phenylurea Chemical class NC(=O)N(O)C1=CC=CC=C1 MTFFANYLEXKMTD-UHFFFAOYSA-N 0.000 abstract 1
125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
102000004890 Interleukin-8 Human genes 0.000 abstract 1
108090001007 Interleukin-8 Proteins 0.000 abstract 1
229910003813 NRa Inorganic materials 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000002877 alkyl aryl group Chemical group 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
150000001540 azides Chemical class 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
229910002091 carbon monoxide Inorganic materials 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
125000004447 heteroarylalkenyl group Chemical group 0.000 abstract 1
125000005114 heteroarylalkoxy group Chemical group 0.000 abstract 1
125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
125000004366 heterocycloalkenyl group Chemical group 0.000 abstract 1
XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 abstract 1
229940096397 interleukin-8 Drugs 0.000 abstract 1
230000002969 morbid Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/47—Y being a hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes

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Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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ARP010101183A 2000-03-16 2001-03-14 Compuestos de hidroxifenil urea sustituidos con sulfonamidas, composiciones farmaceuticas que los comprenden, y uso de los mismos en la fabricacion de medicamentos para tratar una enfermedad mediada por una quimioquina AR031098A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US18984800P	2000-03-16	2000-03-16

Publications (1)

Publication Number	Publication Date
AR031098A1 true AR031098A1 (es)	2003-09-10

Family

ID=22699008

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ARP010101183A AR031098A1 (es)	2000-03-16	2001-03-14	Compuestos de hidroxifenil urea sustituidos con sulfonamidas, composiciones farmaceuticas que los comprenden, y uso de los mismos en la fabricacion de medicamentos para tratar una enfermedad mediada por una quimioquina

Country Status (23)

Country	Link
EP (1)	EP1263427A4 (fr)
JP (1)	JP2003526664A (fr)
KR (1)	KR20020091130A (fr)
CN (1)	CN1424910A (fr)
AP (1)	AP2002002606A0 (fr)
AR (1)	AR031098A1 (fr)
AU (1)	AU2001250873A1 (fr)
BG (1)	BG107013A (fr)
BR (1)	BR0108749A (fr)
CA (1)	CA2403062A1 (fr)
CO (1)	CO5280089A1 (fr)
CZ (1)	CZ20023075A3 (fr)
DZ (1)	DZ3317A1 (fr)
EA (1)	EA200200981A1 (fr)
HU (1)	HUP0300470A3 (fr)
MA (1)	MA25659A1 (fr)
MX (1)	MXPA02009094A (fr)
NO (1)	NO20024367L (fr)
OA (1)	OA12231A (fr)
PL (1)	PL366034A1 (fr)
SK (1)	SK13282002A3 (fr)
WO (1)	WO2001068084A1 (fr)
ZA (1)	ZA200207325B (fr)

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AR030689A1 (es) *	2000-03-14	2003-09-03	Smithkline Beecham Corp	Compuestos de 3-aminosulfonil-2-hidroxifenil urea, composiciones farmaceuticas que los comprenden, y uso de dichos compuestos en la manufactura de medicamentos para tratar enfermedades mediadas por quimioquinas
WO2005113534A2 (fr)	2004-05-12	2005-12-01	Schering Corporation	Antagonistes de chimiokines cxcr1 et cxcr2
AU2007240365B2 (en) *	2006-04-21	2011-12-15	Glaxosmithkline Llc	IL-8 receptor antagonists
US8097626B2 (en) *	2006-04-21	2012-01-17	Glaxosmithkline Llc	IL-8 receptor antagonists
CR20160557A (es) *	2014-05-29	2017-01-20	Glaxosmithkline Ip Dev Ltd	Compuestos derivados de 1-(ciclopent-2-en-1-il)-3-(2-hidroxi-3-(arilsulfonil)fenil)urea como inhibidores cxcr2
EP3174851A1 (fr) *	2014-07-31	2017-06-07	GlaxoSmithKline Intellectual Property Management Limited	Utilisation d'antagonistes de cxcr2 pour la prévention et/ou le traitement de la neuropathie périphérique chimio-induite (npci)
CN111727184B (zh)	2018-01-11	2022-06-28	深圳嘉科生物科技有限公司	Cxcr2拮抗剂
US12577235B2 (en)	2019-07-11	2026-03-17	Shenzhen Optimum Biological Technology Co., Ltd	Crystalline form of CXCR2 antagonist and application thereof

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EP0809492A4 (fr) *	1995-02-17	2007-01-24	Smithkline Beecham Corp	Antagonistes des recepteurs d'il-8
PL330850A1 (en) *	1996-06-27	1999-06-07	Smithkline Beecham Corp	Antagonists of il-8 receptors
US6214881B1 (en) *	1996-08-21	2001-04-10	Smithkline Beecham Corporation	IL-8 receptor antagonists
KR100642184B1 (ko) *	1998-09-23	2006-11-10	암젠 인크	아릴술폰아닐리드 우레아
UY25842A1 (es) *	1998-12-16	2001-04-30	Smithkline Beecham Corp	Antagonistas de receptores de il-8

2001
- 2001-03-14 CO CO01020681A patent/CO5280089A1/es not_active Application Discontinuation
- 2001-03-14 AR ARP010101183A patent/AR031098A1/es unknown
- 2001-03-16 BR BR0108749-5A patent/BR0108749A/pt not_active Application Discontinuation
- 2001-03-16 KR KR1020027012102A patent/KR20020091130A/ko not_active Withdrawn
- 2001-03-16 HU HU0300470A patent/HUP0300470A3/hu unknown
- 2001-03-16 SK SK1328-2002A patent/SK13282002A3/sk unknown
- 2001-03-16 EP EP01924195A patent/EP1263427A4/fr not_active Withdrawn
- 2001-03-16 CA CA002403062A patent/CA2403062A1/fr not_active Abandoned
- 2001-03-16 EA EA200200981A patent/EA200200981A1/ru unknown
- 2001-03-16 CN CN01806605A patent/CN1424910A/zh active Pending
- 2001-03-16 WO PCT/US2001/008672 patent/WO2001068084A1/fr not_active Ceased
- 2001-03-16 JP JP2001566648A patent/JP2003526664A/ja not_active Withdrawn
- 2001-03-16 PL PL01366034A patent/PL366034A1/xx not_active Application Discontinuation
- 2001-03-16 AU AU2001250873A patent/AU2001250873A1/en not_active Abandoned
- 2001-03-16 OA OA1200200289A patent/OA12231A/en unknown
- 2001-03-16 CZ CZ20023075A patent/CZ20023075A3/cs unknown
- 2001-03-16 MX MXPA02009094A patent/MXPA02009094A/es active IP Right Grant
- 2001-03-16 AP APAP/P/2002/002606A patent/AP2002002606A0/fr unknown
- 2001-03-16 DZ DZ013317A patent/DZ3317A1/fr active
2002
- 2002-08-20 BG BG107013A patent/BG107013A/bg unknown
- 2002-09-12 ZA ZA200207325A patent/ZA200207325B/en unknown
- 2002-09-12 NO NO20024367A patent/NO20024367L/no unknown
- 2002-09-12 MA MA26815A patent/MA25659A1/fr unknown

Also Published As

Publication number	Publication date
EP1263427A4 (fr)	2005-08-24
CO5280089A1 (es)	2003-05-30
AP2002002606A0 (fr)	2002-09-30
EA200200981A1 (ru)	2003-02-27
PL366034A1 (en)	2005-01-24
BR0108749A (pt)	2004-06-29
CZ20023075A3 (cs)	2003-05-14
NO20024367L (no)	2002-10-22
ZA200207325B (en)	2003-10-17
MXPA02009094A (es)	2003-03-12
BG107013A (bg)	2003-05-30
SK13282002A3 (sk)	2003-02-04
DZ3317A1 (fr)	2001-09-20
HUP0300470A2 (hu)	2003-06-28
CN1424910A (zh)	2003-06-18
JP2003526664A (ja)	2003-09-09
WO2001068084A1 (fr)	2001-09-20
HUP0300470A3 (en)	2005-05-30
EP1263427A1 (fr)	2002-12-11
CA2403062A1 (fr)	2001-09-20
MA25659A1 (fr)	2002-12-31
NO20024367D0 (no)	2002-09-12
AU2001250873A1 (en)	2001-09-24
KR20020091130A (ko)	2002-12-05
OA12231A (en)	2003-11-07

Legal Events

Date	Code	Title	Description
2004-05-21	FB	Suspension of granting procedure

Publication	Publication Date	Title
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DK0510526T3 (da)	1997-05-26	Anvendelse af sulfonamider som lægemiddel og nye sulfonamider
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ES2137998T3 (es)	2000-01-01	Nuevos derivados de aminoacidos, procedimiento para su preparacion y composiciones farmaceuticas que contienen estos compuestos.
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AR038818A1 (es)	2005-01-26	Compuesto de piperidina, uso del mismo para preparar un medicamento, composicion farmaceutica que lo comprende y procedimiento para su preparacion
CO5280059A1 (es)	2003-05-30	Derivados de 2-ox-1-pirrolidina, procewo para prepararlos y sus aplicaciones
EE03872B1 (et)	2002-10-15	Arüülglütsiinamiidi derivaadid, meetod nende valmistamiseks ja neid ühendeid sisaldavad farmatseutilised preparaadid
AR003936A1 (es)	1998-09-30	Compuestos triciclicos y composiciones farmaceuticas y el uso de dichos compuestos para la fabricacion de un medicamento util para inhibir elcrecimiento anormal de celulas.
AR060545A1 (es)	2008-06-25	Compuestos de benzoaxol y benzotiazol 6-0- sustituidos y metodos de inhibicion de la senalizacion de csf-1r. composiciones farmaceuticas
AR037089A1 (es)	2004-10-20	Derivado de 1,2 benzotiazepina o 1,2,5-benzotiadiazepina,proceso para su preparacion, composicion farmaceutica que lo comprende, y su uso en la fabricacion de un medicamento para la produccion de un efecto inhibidor de transporte ileal de acidos biliares
AR032165A1 (es)	2003-10-29	Carboxamidas heterociclicas, composiciones farmaceuticas, uso de dichas carboxamidas para preparar un medicamento como agentes antivirales y el uso in vitro para inhibir una dna polimerasa viral
AR012315A1 (es)	2000-10-18	Derivados de ditiolan y el uso de los mismos en la fabricacion de un medicamento.
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