AR031867A1 - Compuestos derivados de fenoxibencilamina como ssri, su uso en la preparacion de medicamentos, procedimiento de preparacion del compuesto e intermediarios utiles - Google Patents

Compuestos derivados de fenoxibencilamina como ssri, su uso en la preparacion de medicamentos, procedimiento de preparacion del compuesto e intermediarios utiles

Info

Publication number: AR031867A1
Authority: AR; Argentina
Prior art keywords: alkyl; compounds; preparation; heterocyclic ring; independently substituted
Prior art date: 2000-08-31

Application number

ARP010104114A

Other languages

English (en)

Spanish (es)

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-31

Filing date

2001-08-29

Publication date

2003-10-08

2000-08-31 Priority claimed from GB0021593A external-priority patent/GB0021593D0/en

2001-03-21 Priority claimed from GB0107116A external-priority patent/GB0107116D0/en

2001-08-29 Application filed by Pfizer filed Critical Pfizer

2003-10-08 Publication of AR031867A1 publication Critical patent/AR031867A1/es

Links

150000001875 compounds Chemical class 0.000 title abstract 7
239000012896 selective serotonin reuptake inhibitor Substances 0.000 title abstract 3
229940124834 selective serotonin reuptake inhibitor Drugs 0.000 title abstract 3
239000003814 drug Substances 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
229910052757 nitrogen Inorganic materials 0.000 abstract 5
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 3
125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
229910052731 fluorine Inorganic materials 0.000 abstract 3
125000005842 heteroatom Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
229910052760 oxygen Inorganic materials 0.000 abstract 3
229910052717 sulfur Inorganic materials 0.000 abstract 3
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
208000035475 disorder Diseases 0.000 abstract 2
239000011737 fluorine Substances 0.000 abstract 2
125000001153 fluoro group Chemical group F* 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical compound C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 abstract 1
125000001963 4 membered heterocyclic group Chemical group 0.000 abstract 1
125000001960 7 membered carbocyclic group Chemical group 0.000 abstract 1
208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
101100516563 Caenorhabditis elegans nhr-6 gene Proteins 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
201000001880 Sexual dysfunction Diseases 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
101710164184 Synaptic vesicular amine transporter Proteins 0.000 abstract 1
102100034333 Synaptic vesicular amine transporter Human genes 0.000 abstract 1
MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical group [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
208000015802 attention deficit-hyperactivity disease Diseases 0.000 abstract 1
125000002393 azetidinyl group Chemical group 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical class C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000004438 haloalkoxy group Chemical group 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
229910052740 iodine Inorganic materials 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
YXMXAXHPRPWBJB-UHFFFAOYSA-N n-phenoxy-1-phenylmethanamine Chemical compound C=1C=CC=CC=1CNOC1=CC=CC=C1 YXMXAXHPRPWBJB-UHFFFAOYSA-N 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
208000028173 post-traumatic stress disease Diseases 0.000 abstract 1
206010036596 premature ejaculation Diseases 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
230000009103 reabsorption Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
231100000872 sexual dysfunction Toxicity 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
201000009032 substance abuse Diseases 0.000 abstract 1
231100000736 substance abuse Toxicity 0.000 abstract 1
208000011117 substance-related disease Diseases 0.000 abstract 1
239000011593 sulfur Chemical group 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/39—Heterocyclic compounds having sulfur as a ring hetero atom having oxygen in the same ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/06—Six-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Reproductive Health (AREA)
Addiction (AREA)
Gynecology & Obstetrics (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Hydrogenated Pyridines (AREA)
Quinoline Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ARP010104114A 2000-08-31 2001-08-29 Compuestos derivados de fenoxibencilamina como ssri, su uso en la preparacion de medicamentos, procedimiento de preparacion del compuesto e intermediarios utiles AR031867A1 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB0021593A GB0021593D0 (en)	2000-08-31	2000-08-31	Diphenyl ether compounds useful in therapy
GB0107116A GB0107116D0 (en)	2001-03-21	2001-03-21	Novel compounds

Publications (1)

Publication Number	Publication Date
AR031867A1 true AR031867A1 (es)	2003-10-08

Family

ID=26244953

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ARP010104114A AR031867A1 (es)	2000-08-31	2001-08-29	Compuestos derivados de fenoxibencilamina como ssri, su uso en la preparacion de medicamentos, procedimiento de preparacion del compuesto e intermediarios utiles

Country Status (32)

Country	Link
EP (1)	EP1313701A1 (fr)
JP (1)	JP2004507523A (fr)
KR (1)	KR20030029889A (fr)
CN (1)	CN1449380A (fr)
AP (1)	AP2001002265A0 (fr)
AR (1)	AR031867A1 (fr)
AU (1)	AU2001278650A1 (fr)
BG (1)	BG107544A (fr)
BR (1)	BR0113610A (fr)
CA (1)	CA2420969A1 (fr)
CZ (1)	CZ2003467A3 (fr)
DO (1)	DOP2001000242A (fr)
DZ (1)	DZ3414A1 (fr)
EA (1)	EA200300206A1 (fr)
EE (1)	EE200300084A (fr)
HN (1)	HN2001000191A (fr)
HR (1)	HRP20030141A2 (fr)
HU (1)	HUP0303385A2 (fr)
IL (1)	IL154343A0 (fr)
IS (1)	IS6704A (fr)
MA (1)	MA26945A1 (fr)
MX (1)	MXPA03001848A (fr)
NO (1)	NO20030842L (fr)
NZ (1)	NZ523951A (fr)
OA (1)	OA12372A (fr)
PA (1)	PA8526701A1 (fr)
PE (1)	PE20020346A1 (fr)
PL (1)	PL360743A1 (fr)
SK (1)	SK2012003A3 (fr)
TN (1)	TNSN01131A1 (fr)
UY (1)	UY26924A1 (fr)
WO (1)	WO2002018333A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6403597B1 (en) *	1997-10-28	2002-06-11	Vivus, Inc.	Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation
US6436938B1 (en) *	2001-01-22	2002-08-20	Pfizer Inc.	Combination treatment for depression
US20020107244A1 (en) *	2001-02-02	2002-08-08	Howard Harry R.	Combination treatment for depression
US20020183306A1 (en) *	2001-05-30	2002-12-05	Pfizer Inc.	Combination treatment for sleep disorders including sleep apnea
GB0318706D0 (en) *	2003-08-08	2003-09-10	Pfizer Ltd	Selective serotonin reuptake inhibitors in the treatment of disease
AU2005214167B2 (en)	2004-02-13	2008-08-07	Warner-Lambert Company Llc	Androgen receptor modulators
CA2563291A1 (fr)	2004-04-13	2005-10-27	Warner-Lambert Company Llc	Derives de 4-cyanophenoxy-alkylcarboxyle comme modulateurs androgenes
BRPI0509980A (pt)	2004-04-22	2007-10-16	Warner Lambert Co	moduladores de androgênio
BRPI0513020A (pt)	2004-07-08	2008-04-22	Warner Lambert Co	moduladores de andrÈgenio, seus usos, composição farmacêutica, formulação farmacêutica tópica e artigo de fabricação
US20090105349A1 (en) *	2004-08-18	2009-04-23	Warner-Lambert Company Llc	Androgen modulators
EP1791807A1 (fr) *	2004-09-10	2007-06-06	Pfizer Products Incorporated	Ligands de diphenyl ether therapeutiques
TW200724139A (en)	2005-05-05	2007-07-01	Warner Lambert Co	Androgen modulators
WO2007010350A1 (fr) *	2005-07-19	2007-01-25	Pfizer Products Inc.	Synthèse d’éthers diphényliques à usage thérapeutique
WO2007047397A2 (fr)	2005-10-13	2007-04-26	Smithkline Beecham Corporation	Nouveaux composes heterocycliques
US20100048713A1 (en) *	2006-01-06	2010-02-25	Aarhus Universitet	Compounds acting on the serotonin transporter
US20080045508A1 (en) *	2006-06-29	2008-02-21	Brett Allison	Substituted aminomethyl benzamide compounds
CN101511775A (zh)	2006-06-29	2009-08-19	詹森药业有限公司	丁基和丁炔基苄基胺化合物
WO2008002820A2 (fr) *	2006-06-29	2008-01-03	Janssen Pharmaceutica N.V.	Composés de benzylamine substituée
WO2010059393A1 (fr) *	2008-10-30	2010-05-27	Janssen Pharmaceutica Nv	Modulateurs du récepteur de la sérotonine
WO2010059390A1 (fr)	2008-10-30	2010-05-27	Janssen Pharmaceutica Nv	Modulateurs du récepteur de la sérotonine
KR101043200B1 (ko) *	2010-11-08	2011-06-21	성시민	호흡용 공기탱크의 공기 충전장치
CN103329114B (zh)	2011-01-27	2015-11-25	惠普发展公司，有限责任合伙企业	与便携设备连接的计算设备
CN113543852A (zh)	2019-03-06	2021-10-22	第一三共株式会社	吡咯并吡唑衍生物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA923283B (en) *	1991-05-29	1993-01-27	Akzo Nv	Phenoxyphenyl derivatives
WO1995005376A1 (fr) *	1993-08-19	1995-02-23	Warner-Lambert Company	Derives de 2(5h)furanone, 2(5h)thiophenone et 2(5h)pyrrolone substitues, leur preparation et leur utilisation en tant qu'antagonistes de l'endotheline
CZ293595A3 (cs) *	1995-11-09	1999-12-15	Farmak A. S.	Deriváty N,N-dimethyl-2-(arylthio)benzylaminu, jejich soli, způsoby jejich přípravy a jejich použití v léčivých přípravcích
WO1999047497A2 (fr) *	1998-03-13	1999-09-23	Merck Frosst Canada & Co.	Acides carboxyliques et acylsulfonamides, compositions contenant ces composes et methodes de traitement
HUP0105488A3 (en) *	1999-02-23	2005-07-28	Pfizer Prod Inc	Monoamine reuptake inhibitors for treatment of cns disorders and pharmaceutical compositions containing the compounds
GB0007884D0 (en) *	2000-03-31	2000-05-17	Pfizer Ltd	Diphenyl ether compounds useful in therapy

2001
- 2001-08-22 CN CN01814846A patent/CN1449380A/zh active Pending
- 2001-08-22 MX MXPA03001848A patent/MXPA03001848A/es active IP Right Grant
- 2001-08-22 EA EA200300206A patent/EA200300206A1/ru unknown
- 2001-08-22 SK SK201-2003A patent/SK2012003A3/sk unknown
- 2001-08-22 EP EP01956734A patent/EP1313701A1/fr not_active Withdrawn
- 2001-08-22 IL IL15434301A patent/IL154343A0/xx unknown
- 2001-08-22 CA CA002420969A patent/CA2420969A1/fr not_active Abandoned
- 2001-08-22 OA OA1200300056A patent/OA12372A/en unknown
- 2001-08-22 NZ NZ523951A patent/NZ523951A/en unknown
- 2001-08-22 JP JP2002523451A patent/JP2004507523A/ja active Pending
- 2001-08-22 HU HU0303385A patent/HUP0303385A2/hu unknown
- 2001-08-22 DZ DZ013414A patent/DZ3414A1/fr active
- 2001-08-22 PL PL36074301A patent/PL360743A1/xx not_active Application Discontinuation
- 2001-08-22 WO PCT/IB2001/001521 patent/WO2002018333A1/fr not_active Ceased
- 2001-08-22 EE EEP200300084A patent/EE200300084A/xx unknown
- 2001-08-22 AP APAP/P/2001/002265A patent/AP2001002265A0/en unknown
- 2001-08-22 AU AU2001278650A patent/AU2001278650A1/en not_active Abandoned
- 2001-08-22 CZ CZ2003467A patent/CZ2003467A3/cs unknown
- 2001-08-22 KR KR10-2003-7003011A patent/KR20030029889A/ko not_active Ceased
- 2001-08-22 BR BR0113610-0A patent/BR0113610A/pt not_active IP Right Cessation
- 2001-08-22 HR HR20030141A patent/HRP20030141A2/hr not_active Application Discontinuation
- 2001-08-24 PA PA20018526701A patent/PA8526701A1/es unknown
- 2001-08-28 HN HN2001000191A patent/HN2001000191A/es unknown
- 2001-08-28 PE PE2001000862A patent/PE20020346A1/es not_active Application Discontinuation
- 2001-08-29 AR ARP010104114A patent/AR031867A1/es unknown
- 2001-08-29 DO DO2001000242A patent/DOP2001000242A/es unknown
- 2001-08-30 TN TNTNSN01131A patent/TNSN01131A1/fr unknown
- 2001-08-31 UY UY26924A patent/UY26924A1/es not_active Application Discontinuation
2003
- 2003-01-30 IS IS6704A patent/IS6704A/is unknown
- 2003-02-07 BG BG107544A patent/BG107544A/bg unknown
- 2003-02-21 MA MA27049A patent/MA26945A1/fr unknown
- 2003-02-24 NO NO20030842A patent/NO20030842L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO20030842D0 (no)	2003-02-24
JP2004507523A (ja)	2004-03-11
NZ523951A (en)	2004-09-24
KR20030029889A (ko)	2003-04-16
HN2001000191A (es)	2002-03-11
CA2420969A1 (fr)	2002-03-07
IL154343A0 (en)	2003-09-17
MA26945A1 (fr)	2004-12-20
EP1313701A1 (fr)	2003-05-28
UY26924A1 (es)	2002-03-22
BR0113610A (pt)	2003-06-24
HUP0303385A2 (hu)	2004-03-01
CZ2003467A3 (cs)	2004-04-14
OA12372A (en)	2006-04-17
PA8526701A1 (es)	2003-07-28
BG107544A (bg)	2003-10-31
AP2001002265A0 (en)	2001-09-30
AU2001278650A1 (en)	2002-03-13
DZ3414A1 (fr)	2002-03-07
WO2002018333A1 (fr)	2002-03-07
IS6704A (is)	2003-01-30
EA200300206A1 (ru)	2003-06-26
PE20020346A1 (es)	2002-05-08
PL360743A1 (en)	2004-09-20
SK2012003A3 (en)	2004-06-08
HRP20030141A2 (en)	2003-04-30
TNSN01131A1 (fr)	2005-11-10
CN1449380A (zh)	2003-10-15
NO20030842L (no)	2003-04-28
MXPA03001848A (es)	2003-06-04
DOP2001000242A (es)	2002-05-15
EE200300084A (et)	2005-02-15

Legal Events

Date	Code	Title	Description
2011-12-16	FB	Suspension of granting procedure

Publication	Publication Date	Title
AR031867A1 (es)	2003-10-08	Compuestos derivados de fenoxibencilamina como ssri, su uso en la preparacion de medicamentos, procedimiento de preparacion del compuesto e intermediarios utiles
AR035617A1 (es)	2004-06-16	Compuestos derivados de fenetanolamina, combinaciones y formulaciones farmaceuticas de los mismos, proceso para su preparacion, su uso en la preparacion de medicamentos para el tratamiento o profilaxis de una condicion clinica para la cual se indica un agonista beta2 adreno-receptor e intermediarios
ECSP034563A (es)	2003-06-25	Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti-inflamatorios y analgesicos
AR036114A1 (es)	2004-08-11	Tetrahidroimidazol[1,2-a]pirazinas y tetrahidrotriazol[4,3-a]pirazinas como inhibidores de la dipeptidil peptidasa utiles para el tratamiento o la prevencion de la diabetes
AR069510A1 (es)	2010-01-27	Arilo y heteroarilo imidazo[1,5-a]pirazinas fusionadas como inhibidores de la fosfodiesterasa 10
UY28026A1 (es)	2004-04-30	4-piperazinilbencenosulfonilindoles y usos de los mismos.
AR035479A1 (es)	2004-06-02	Derivados de eteres biarilicos y sus sales, composiciones farmaceuticas que los comprenden y procedimientos para el tratamiento de trastornos o afecciones
AR063454A1 (es)	2009-01-28	Derivados acetamida de diazepan como inhibidores selectivos de 11 beta - hsd1. procesos de obtencion y composiciones farmaceuticas.
CR8859A (es)	2007-03-02	Derivados de piridina
MXPA05011710A (es)	2006-01-23	Derivados de pirimidina con actividad de crf.
AR036659A1 (es)	2004-09-22	Compuestos derivados de fenil-piperazina, fenil-piperidina y fenil-tetrahidropiridina como inhibidores de la reabsorcion de la serotonina, una composicion farmaceutica y utilizacion de los mismos para la preparacion de medicamentos
DE60330910D1 (de)	2010-02-25	Verbindungen mit selektiverinhibierender wirkung für gsk3
PA8621901A1 (es)	2006-03-24	Derivados de sulfonamida para el tratamiento de enfermedades
AR053344A1 (es)	2007-05-02	Antagonistas del cgrp,procedimiento para su preparacion,composiciones farmaceuticas que los contienen y usos para el tratamiento de la migrana y otras enfermedades
UY27322A1 (es)	2003-02-28	Nuevos derivados de indol con afinidad por el receptor 5-ht6
AR015448A1 (es)	2001-05-02	COMBINACIoN DE UN INHIBIDOR DE REABSORCIoN DE 5-HT CON UN ANTAGONISTA O AGONISTA PARCIAL DE H5-HT1B, PROCESO PARA SU PREPARACIoN, FORMULACIoN FARMACÉUTICA QUE LA CONTIENE, SU USO PARA PREPARAR MEDICAMENTOS PARA TRATAR TRASTORNOS AFECTIVOS Y KIT QUE CONTIENE DICHA COMBINACIoN
AR035818A1 (es)	2004-07-14	Fenil-heterociclil-eteres con actividad como inhibidores selectivos de recaptacion de serotonina, composiciones farmaceuticas y su uso en la fabricacion de medicamentos
AR053092A1 (es)	2007-04-25	Compuestos derivados de acido fenoxiacetico y compuestos intermediarios de sintesis
AR038404A1 (es)	2005-01-12	Derivados de nicotinamida utiles como inhibidores de pde4, procedimiento para la preparacion del compuesto y composicion farmaceutica que lo incluye
AR050698A1 (es)	2006-11-15	Compuesto de benzazepina, composicion farmaceutica que lo comprende, su uso para la fabricacion de un medicamento y procedimiento para la preparacion de dicho compuesto
AR013503A1 (es)	2000-12-27	Una combinacion de un inhibidor de la monoamina oxidasa y un antagonista o agonista parcial selectivo de h5-ht(1b), formulacion farmaceutica, usos ymetodo de preparacion
ECSP088257A (es)	2008-04-28	Derivados de amida
AR035451A1 (es)	2004-05-26	Derivados de beta-carbolina, su uso para la fabricacion de un medicamento para el tratamiento de la depresion, ansiedad y desordenes bipolares, una composicion farmaceutica y una combinacion.
PE20060630A1 (es)	2006-08-03	Amidas sustituidas de acido tienopirrolcarboxilico, amidas del acido pirrolotiazolcarboxilico y analogos relacionados como inhibidores de la caseina cinasa ie
ECSP088602A (es)	2008-08-29	Compuestos con efectos medicinales debido a la interacción con el receptor de glucocorticoides