AR033360A1 - Formas cristalinas de (2s,3s,5s)-2-(2,6-dimetilfenoxiacetil)amin-3-hidroxi-5-(2-(1-tetrahidropirimid-2-onil)-3-metilbutanoil) amin-1,6-difenilhexano (lopinavir) - Google Patents

Formas cristalinas de (2s,3s,5s)-2-(2,6-dimetilfenoxiacetil)amin-3-hidroxi-5-(2-(1-tetrahidropirimid-2-onil)-3-metilbutanoil) amin-1,6-difenilhexano (lopinavir)

Info

Publication number: AR033360A1
Authority: AR; Argentina
Prior art keywords: amin; lopinavir; tetrahydropirimid; methylbutanoil; dimethylphenoxiacetile
Prior art date: 2000-03-30

Application number

ARP010101522A

Other languages

English (en)

Spanish (es)

Inventor

Rodger F Henry

David Lechuga-Ballesteros

Yuping Niu

William Porter

Daniel A Dickman

S Chemburkar

James J Fort

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-30

Filing date

2001-03-29

Publication date

2003-12-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27065762&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR033360(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-02-27 Priority claimed from US09/793,536 external-priority patent/US6608198B2/en

2001-03-29 Application filed by Abbott Lab filed Critical Abbott Lab

2003-12-17 Publication of AR033360A1 publication Critical patent/AR033360A1/es

Links

KJHKTHWMRKYKJE-SUGCFTRWSA-N Kaletra Chemical compound N1([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=2C=CC=CC=2)NC(=O)COC=2C(=CC=CC=2C)C)CC=2C=CC=CC=2)CCCNC1=O KJHKTHWMRKYKJE-SUGCFTRWSA-N 0.000 title abstract 4
229960004525 lopinavir Drugs 0.000 title abstract 4
239000013078 crystal Substances 0.000 title 1
230000002401 inhibitory effect Effects 0.000 abstract 2
-1 2,6-dimethylphenoxyacetyl Chemical group 0.000 abstract 1
208000031886 HIV Infections Diseases 0.000 abstract 1
108010010369 HIV Protease Proteins 0.000 abstract 1
208000037357 HIV infectious disease Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/10—Oxygen or sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Virology (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
AIDS & HIV (AREA)
Engineering & Computer Science (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ARP010101522A 2000-03-30 2001-03-29 Formas cristalinas de (2s,3s,5s)-2-(2,6-dimetilfenoxiacetil)amin-3-hidroxi-5-(2-(1-tetrahidropirimid-2-onil)-3-metilbutanoil) amin-1,6-difenilhexano (lopinavir) AR033360A1 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US53825700A	2000-03-30	2000-03-30
US09/793,536 US6608198B2 (en)	2000-03-30	2001-02-27	Crystalline pharmaceutical

Publications (1)

Publication Number	Publication Date
AR033360A1 true AR033360A1 (es)	2003-12-17

Family

ID=27065762

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
ARP010101522A AR033360A1 (es)	2000-03-30	2001-03-29	Formas cristalinas de (2s,3s,5s)-2-(2,6-dimetilfenoxiacetil)amin-3-hidroxi-5-(2-(1-tetrahidropirimid-2-onil)-3-metilbutanoil) amin-1,6-difenilhexano (lopinavir)
ARP050102702A AR049560A2 (es)	2000-03-30	2005-06-29	Formas cristalinas de (2s,3s,5s)-2-(2,6-dimetilfenoxiacetil) amin 3-hidroxi-5-(2-(1-tetrahidropirimid-2-onil)-3-metilbutanol)amin-1,6-difenilhexano (lopinavir)

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
ARP050102702A AR049560A2 (es)	2000-03-30	2005-06-29	Formas cristalinas de (2s,3s,5s)-2-(2,6-dimetilfenoxiacetil) amin 3-hidroxi-5-(2-(1-tetrahidropirimid-2-onil)-3-metilbutanol)amin-1,6-difenilhexano (lopinavir)

Country Status (22)

Country	Link
EP (1)	EP1268442A2 (pt)
JP (1)	JP2003529592A (pt)
KR (1)	KR100773258B1 (pt)
CN (2)	CN101066952A (pt)
AR (2)	AR033360A1 (pt)
AU (3)	AU5092001A (pt)
BG (1)	BG107165A (pt)
BR (1)	BR0109433A (pt)
CA (1)	CA2403635A1 (pt)
CZ (1)	CZ20023529A3 (pt)
HU (1)	HUP0302675A3 (pt)
IL (1)	IL151551A0 (pt)
MX (1)	MXPA02009559A (pt)
MY (1)	MY128296A (pt)
NO (1)	NO325005B1 (pt)
NZ (1)	NZ521183A (pt)
PE (1)	PE20011232A1 (pt)
PL (1)	PL359727A1 (pt)
SA (2)	SA01220270B1 (pt)
SK (1)	SK14832002A3 (pt)
TW (1)	TWI284640B (pt)
WO (1)	WO2001074787A2 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6608198B2 (en)	2000-03-30	2003-08-19	Abbott Laboratories	Crystalline pharmaceutical
US8025899B2 (en)	2003-08-28	2011-09-27	Abbott Laboratories	Solid pharmaceutical dosage form
EP2393786B1 (en)	2009-02-06	2014-01-22	Hetero Research Foundation	Novel polymorphs of lopinavir
CA2770338A1 (en) *	2009-08-27	2011-03-03	Merck Sharp & Dohme Corp.	Processes for preparing protease inhibitors of hepatitis c virus
CN112830899A (zh) *	2021-01-18	2021-05-25	合肥华方医药科技有限公司	一种洛匹那韦新晶型及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5914332A (en) *	1995-12-13	1999-06-22	Abbott Laboratories	Retroviral protease inhibiting compounds
AU8145198A (en) *	1997-06-16	1999-01-04	Vertex Pharmaceuticals Incorporated	Methods of increasing the bioavailability of stable crystal polymorphs of a compound

2001
- 2001-03-07 MY MYPI20011034A patent/MY128296A/en unknown
- 2001-03-21 BR BR0109433-5A patent/BR0109433A/pt not_active Application Discontinuation
- 2001-03-21 HU HU0302675A patent/HUP0302675A3/hu unknown
- 2001-03-21 IL IL15155101A patent/IL151551A0/xx unknown
- 2001-03-21 WO PCT/US2001/009112 patent/WO2001074787A2/en not_active Ceased
- 2001-03-21 KR KR1020027012849A patent/KR100773258B1/ko not_active Ceased
- 2001-03-21 AU AU5092001A patent/AU5092001A/xx active Pending
- 2001-03-21 EP EP01924250A patent/EP1268442A2/en not_active Withdrawn
- 2001-03-21 PL PL35972701A patent/PL359727A1/xx not_active Application Discontinuation
- 2001-03-21 CN CNA2007101123988A patent/CN101066952A/zh active Pending
- 2001-03-21 NZ NZ521183A patent/NZ521183A/en not_active IP Right Cessation
- 2001-03-21 CN CNB018076882A patent/CN1330639C/zh not_active Expired - Lifetime
- 2001-03-21 CZ CZ20023529A patent/CZ20023529A3/cs unknown
- 2001-03-21 AU AU2001250920A patent/AU2001250920B2/en not_active Revoked
- 2001-03-21 CA CA002403635A patent/CA2403635A1/en not_active Abandoned
- 2001-03-21 MX MXPA02009559A patent/MXPA02009559A/es active IP Right Grant
- 2001-03-21 SK SK1483-2002A patent/SK14832002A3/sk not_active Application Discontinuation
- 2001-03-21 JP JP2001572482A patent/JP2003529592A/ja active Pending
- 2001-03-29 AR ARP010101522A patent/AR033360A1/es not_active Application Discontinuation
- 2001-03-30 PE PE2001000299A patent/PE20011232A1/es not_active Application Discontinuation
- 2001-05-02 TW TW090107717A patent/TWI284640B/zh active
- 2001-08-07 SA SA01220270A patent/SA01220270B1/ar unknown
- 2001-08-07 SA SA06270303A patent/SA06270303B1/ar unknown
2002
- 2002-09-30 NO NO20024679A patent/NO325005B1/no not_active Application Discontinuation
- 2002-10-03 BG BG107165A patent/BG107165A/bg unknown
2005
- 2005-06-29 AR ARP050102702A patent/AR049560A2/es unknown
2006
- 2006-09-27 AU AU2006222711A patent/AU2006222711A1/en not_active Abandoned

Also Published As

Publication number	Publication date
NO325005B1 (no)	2008-01-14
JP2003529592A (ja)	2003-10-07
CN1422259A (zh)	2003-06-04
MXPA02009559A (es)	2003-05-21
PE20011232A1 (es)	2001-12-08
TWI284640B (en)	2007-08-01
NO20024679D0 (no)	2002-09-30
SK14832002A3 (sk)	2003-02-04
KR20030011807A (ko)	2003-02-11
HUP0302675A3 (en)	2004-03-29
IL151551A0 (en)	2003-04-10
MY128296A (en)	2007-01-31
PL359727A1 (en)	2004-09-06
AU2001250920B2 (en)	2006-06-29
CA2403635A1 (en)	2001-10-11
CN101066952A (zh)	2007-11-07
BG107165A (bg)	2003-07-31
HUP0302675A2 (hu)	2003-12-29
SA06270303B1 (ar)	2009-08-02
AU2006222711A1 (en)	2006-10-19
WO2001074787A2 (en)	2001-10-11
BR0109433A (pt)	2004-08-10
SA01220270B1 (ar)	2006-11-14
EP1268442A2 (en)	2003-01-02
AU5092001A (en)	2001-10-15
CN1330639C (zh)	2007-08-08
NZ521183A (en)	2004-03-26
KR100773258B1 (ko)	2007-11-05
WO2001074787A3 (en)	2002-02-07
NO20024679L (no)	2002-09-30
AR049560A2 (es)	2006-08-16
CZ20023529A3 (cs)	2003-02-12

Legal Events

Date	Code	Title	Description
2010-10-29	FC	Refusal

Publication	Publication Date	Title
ATE367394T1 (de)	2007-08-15	Anreicherung in der zelle an phosphonat analoga von hiv protease inhibitor verbindungen und die verbindungen selbst
BR0011130A (pt)	2002-03-19	Inibidores de metaloproteases
ES2177868T3 (es)	2002-12-16	Hidroxietilaminosulfonamidas de alfa- y beta-aminoacidos utiles como inhibidores de proteasas retroviricas.
MY142948A (en)	2011-01-31	Benzophenones as inhibitors of reverse transcriptase
CY1110690T1 (el)	2015-06-10	Ενωσεις 4-οξοκινολινης και χρησιμοποιηση αυτων ως αναστολεις της ενσωματασης του hiv
CO5540347A2 (es)	2005-07-29	Derivados de dipeptido que contiene un grupo 2-tioacilo n-terminal como inhibidores de vasopeptidasa
UY28722A1 (es)	2005-08-31	Peptidos macrociclicos activos contra el virus del a hepatitis c
DE60112957D1 (de)	2005-09-29	Sulfamide als gamma-secretase-inhibitoren
ATE373005T1 (de)	2007-09-15	Thienopyrrole als antivirale mittel
DE60122718D1 (de)	2006-10-12	Strukturen und zusammensetzungen zur erhöhung der stabilität von aktiven peroxiden
BR0109836A (pt)	2003-06-24	Processo de sìntese de perindopril e de seus sais farmaceuticamente aceitáveis
UY27774A1 (es)	2003-11-28	Inhibidores de metaloproteinas de triaril-oxi-aril-espiropirimidina-2,4,6-triona
SE0203825D0 (sv)	2002-12-20	Novel fused heterocycles and uses thereof
ATE499837T1 (de)	2011-03-15	Antimikrobielle zusammensetzungen, die ethanolamid-puffer und biguanid- desinfektionsmittel enthalten
AR049560A2 (es)	2006-08-16	Formas cristalinas de (2s,3s,5s)-2-(2,6-dimetilfenoxiacetil) amin 3-hidroxi-5-(2-(1-tetrahidropirimid-2-onil)-3-metilbutanol)amin-1,6-difenilhexano (lopinavir)
EA200701692A1 (ru)	2007-12-28	Ингибиторы протеазы вич
PE74799A1 (es)	1999-08-13	Combinaciones antivirales
ATE269313T1 (de)	2004-07-15	Tryptase-inhibitoren
MX9700036A (es)	1997-04-30	Combinacion de compuestos, uso en la preparacion de composiciones para tratar infeccion por el vir s de inmunodeficiencia humana, y composiciones obtenidas.
UY27448A1 (es)	2003-03-31	Ésteres de análogos de 3-desoxi-vitamina d3
ES2190456T3 (es)	2003-08-01	Combinacion de inhibidores de la proteasa del vih.
UY27033A1 (es)	2002-06-20	Nuevos compuestos para su uso como inhibidores de la proteasa de vih
NO20024522L (no)	2002-11-25	Sammensetninger med anti-hiv-aktivitet
AR044258A1 (es)	2005-09-07	Intermedios utiles en la sintesis de los inhibidores de las proteasas de vih y procedimientos para preparar los mismos
SE9902271D0 (sv)	1999-06-16	Pharmaceutically active compounds