BR0109836A - Processo de sìntese de perindopril e de seus sais farmaceuticamente aceitáveis - Google Patents

Processo de sìntese de perindopril e de seus sais farmaceuticamente aceitáveis

Info

Publication number
BR0109836A
BR0109836A BR0109836-5A BR0109836A BR0109836A BR 0109836 A BR0109836 A BR 0109836A BR 0109836 A BR0109836 A BR 0109836A BR 0109836 A BR0109836 A BR 0109836A
Authority
BR
Brazil
Prior art keywords
perindopril
pharmaceutically acceptable
acceptable salts
synthesis process
formula
Prior art date
Application number
BR0109836-5A
Other languages
English (en)
Other versions
BRPI0109836B1 (pt
Inventor
Pascal Langlois
Hugues Turbe
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8848925&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0109836(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of BR0109836A publication Critical patent/BR0109836A/pt
Publication of BRPI0109836B1 publication Critical patent/BRPI0109836B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"PROCESSO DE SìNTESE DE PERINDOPRIL E DE SEUS SAIS FARMACEUTICAMENTE ACEITáVEIS". A invenção refere-se a um processo de síntese industrial do perindopril de fórmula (I) e de seus sais farmaceuticamente aceitáveis.
BRPI0109836-5A 2000-04-06 2001-04-05 Processo de síntese de perindopril e de seus sais farmaceuticamente aceitáveis BRPI0109836B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0004379A FR2807431B1 (fr) 2000-04-06 2000-04-06 Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
PCT/FR2001/001026 WO2001058868A1 (fr) 2000-04-06 2001-04-05 Procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables

Publications (2)

Publication Number Publication Date
BR0109836A true BR0109836A (pt) 2003-06-24
BRPI0109836B1 BRPI0109836B1 (pt) 2015-08-04

Family

ID=8848925

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0109836-5A BRPI0109836B1 (pt) 2000-04-06 2001-04-05 Processo de síntese de perindopril e de seus sais farmaceuticamente aceitáveis

Country Status (34)

Country Link
US (1) US6835843B2 (pt)
EP (1) EP1268424B1 (pt)
JP (1) JP3939553B2 (pt)
KR (1) KR100507616B1 (pt)
CN (1) CN1296355C (pt)
AP (1) AP1385A (pt)
AT (1) ATE369338T1 (pt)
AU (2) AU4847001A (pt)
BG (1) BG65984B1 (pt)
BR (1) BRPI0109836B1 (pt)
CA (1) CA2405486C (pt)
CY (1) CY1108522T1 (pt)
CZ (1) CZ302575B6 (pt)
DE (1) DE60129800T2 (pt)
DK (1) DK1268424T3 (pt)
EA (1) EA005079B1 (pt)
EE (1) EE05032B1 (pt)
ES (1) ES2291307T3 (pt)
FR (1) FR2807431B1 (pt)
GE (1) GEP20063797B (pt)
HR (1) HRP20020876B1 (pt)
HU (1) HU227674B1 (pt)
ME (1) ME00441B (pt)
MX (1) MXPA02009706A (pt)
NO (1) NO324174B1 (pt)
NZ (1) NZ521454A (pt)
OA (1) OA12242A (pt)
PL (1) PL204471B1 (pt)
PT (1) PT1268424E (pt)
RS (1) RS50808B (pt)
SK (1) SK286921B6 (pt)
UA (1) UA75070C2 (pt)
WO (1) WO2001058868A1 (pt)
ZA (1) ZA200207419B (pt)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2827860B1 (fr) 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
ATE365714T1 (de) * 2002-01-30 2007-07-15 Servier Lab Verfahren zur herstellung von hochreinem perindopril und zwischenverbindungen nützlich in der synthese
JP2005256847A (ja) * 2002-02-28 2005-09-22 Nsk Ltd 車輪用軸受ユニット
GB2395195A (en) * 2002-11-18 2004-05-19 Cipla Ltd Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors
ATE307801T1 (de) * 2003-02-28 2005-11-15 Servier Lab Verfahren zur synthese des (2s,3as,7as)- perhydroindol-2-carbonsäures und seiner estern, verwendung in der synthese von perindopril
EP1603558B1 (en) 2003-02-28 2008-05-21 Les Laboratoires Servier S.A. Process for preparation of perindopril and salts thereof
DE60301774T2 (de) * 2003-02-28 2006-07-20 Les Laboratoires Servier Verfahren zur Synthese von (2S,3aS,7aS)-1-((S)-Alanyl)-octahydro-1H-indol-2-carbonsäurederivaten und Verwendung in der Synthese von Perindopril
SI1403275T1 (sl) * 2003-02-28 2006-02-28 Servier Lab Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
EP1319668B1 (fr) * 2003-03-12 2004-10-27 Les Laboratoires Servier Nouveau procédé de synthèse de dérivés de l'acide (2S, 3aS, 7aS)-1-[(S)]-alanyl]-octahydro-1H-indole-2-carboxylique et application à la synthèse du perindopril
EP1323729B1 (fr) * 2003-03-12 2004-11-03 Les Laboratoires Servier Nouveau procédé de synthèse de l'acide (2S, 3aS, 7aS)-perhydroindole-2-carboxylique et de ses esters, et application à la synthèse du perindopril
DK1321471T3 (da) * 2003-03-12 2005-08-29 Servier Lab Ny syntesefremgangsmåde til perindopril og farmaceutisk acceptable salte heraf
WO2004099138A2 (en) * 2003-05-12 2004-11-18 Cipla Limited Process for the preparation of perindopril
DK1636185T3 (da) 2003-06-24 2012-05-07 Servier Lab Nye krystalformer af Perindopril erbumin
SI1367063T1 (sl) * 2003-07-31 2006-10-31 Servier Lab Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
ES2271497T3 (es) * 2003-07-31 2007-04-16 Les Laboratoires Servier Nuevo procedimiento de sintesis de perindopril y de sus sales farmaceuticamente aceptables.
DK1675827T3 (da) * 2003-10-21 2010-04-19 Servier Lab Ny fremgangsmåde til fremstilling af krystallint perindopril erbumin
SI1420029T1 (sl) * 2003-12-10 2008-08-31 Servier Lab Postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
PT1729739T (pt) * 2004-03-29 2016-12-01 Servier Lab Processo para a preparação de uma composição farmacêutica sólida
GB2413128A (en) * 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
SI21800A (sl) * 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
ES2255872B1 (es) * 2004-12-31 2007-08-16 Quimica Sintetica, S.A. Procedimiento para la preparacion de perindopril erbumina.
PT1679072E (pt) * 2005-01-06 2008-12-22 Ipca Lab Ltd Processo para a síntese de derivados de ácido (2s,3as,7as)-1-(s)-alanil-octa-hidro-1h-indole-2-carboxílico e utilização na síntese de perindopril
US7291745B2 (en) * 2005-03-21 2007-11-06 Glenmark Pharmaceuticals Limited Process for the preparation of perindopril
JP2006290825A (ja) * 2005-04-13 2006-10-26 Shiono Chemical Co Ltd アルファ型ペリンドプリルエルブミンの製造法
DE102005058166A1 (de) * 2005-12-05 2007-06-06 Hexal Ag Matrixkontrolliertes transdermales System mit Amin-Salzen der ACE-Hemmer-Dicarbonsäuren
WO2007085933A2 (en) * 2006-01-25 2007-08-02 Glenmark Pharmaceuticals Limited Process for the preparation of n-[1-(s)-ethoxycarbonyl-1-butyl]-(s)-alanine-dmt complex and its use in the preparation of perindopril
WO2008114270A1 (en) * 2007-03-22 2008-09-25 Aarti Healthcare Limited Process for the preparation of perindopril erbumine salt and novel polymorph (s) thereof
FR2961105B1 (fr) * 2010-06-15 2013-02-08 Servier Lab Utilisation de l'association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion de l'angiotensine pour le traitement de l'insuffisance cardiaque
EP2906536B1 (en) * 2012-10-10 2018-03-14 Piramal Enterprises Limited An improved process for preparation of perindopril intermediate
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
PH12018502155B1 (en) 2016-04-20 2024-03-27 Servier Lab Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid
CN107098949B (zh) * 2017-04-20 2021-03-16 上药东英（江苏）药业有限公司 一种制备培哚普利叔丁胺盐的绿色合成新工艺

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
DE3302125A1 (de) * 1983-01-22 1984-07-26 Boehringer Ingelheim KG, 6507 Ingelheim Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2620700B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides

Also Published As

Publication number Publication date
BG107249A (bg) 2003-07-31
PT1268424E (pt) 2007-10-16
ES2291307T3 (es) 2008-03-01
CA2405486A1 (fr) 2001-08-16
EP1268424A1 (fr) 2003-01-02
CA2405486C (fr) 2008-07-29
WO2001058868A1 (fr) 2001-08-16
DK1268424T3 (da) 2007-12-17
AP2002002630A0 (en) 2002-09-30
FR2807431A1 (fr) 2001-10-12
HRP20020876A2 (en) 2004-02-29
UA75070C2 (uk) 2006-03-15
CN1296355C (zh) 2007-01-24
HRP20020876B1 (en) 2010-10-31
YU73802A (sh) 2006-01-16
OA12242A (en) 2003-12-08
MXPA02009706A (es) 2004-09-06
AU2001248470B2 (en) 2005-01-20
EA200201057A1 (ru) 2003-06-26
ATE369338T1 (de) 2007-08-15
DE60129800T2 (de) 2008-06-05
EA005079B1 (ru) 2004-10-28
HK1053309A1 (en) 2003-10-17
HU0101336D0 (en) 2001-06-28
US20030069431A1 (en) 2003-04-10
JP3939553B2 (ja) 2007-07-04
NO20024808L (no) 2002-10-04
HUP0101336A2 (hu) 2002-02-28
NZ521454A (en) 2004-03-26
BRPI0109836B1 (pt) 2015-08-04
AU4847001A (en) 2001-08-20
AP1385A (en) 2005-04-08
ZA200207419B (en) 2003-09-16
PL346555A1 (en) 2001-09-10
SK14182002A3 (sk) 2003-02-04
HUP0101336A3 (en) 2003-03-28
ME00441B (me) 2011-10-10
NO20024808D0 (no) 2002-10-04
HU227674B1 (hu) 2011-11-28
EE05032B1 (et) 2008-06-16
DE60129800D1 (de) 2007-09-20
CZ20023291A3 (cs) 2003-02-12
CY1108522T1 (el) 2014-04-09
US6835843B2 (en) 2004-12-28
EP1268424B1 (fr) 2007-08-08
CZ302575B6 (cs) 2011-07-20
BG65984B1 (bg) 2010-08-31
CN1420867A (zh) 2003-05-28
NO324174B1 (no) 2007-09-03
GEP20063797B (en) 2006-04-25
FR2807431B1 (fr) 2002-07-19
SK286921B6 (sk) 2009-07-06
KR20030013381A (ko) 2003-02-14
KR100507616B1 (ko) 2005-08-10
RS50808B (sr) 2010-08-31
JP2003531825A (ja) 2003-10-28
EE200200575A (et) 2004-04-15
PL204471B1 (pl) 2010-01-29

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 04/08/2015, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 18A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2508 DE 29-01-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.