AR034703A1 - Metodos y composiciones para preparar emamectina. - Google Patents
Metodos y composiciones para preparar emamectina.Info
- Publication number
- AR034703A1 AR034703A1 ARP020101764A ARP020101764A AR034703A1 AR 034703 A1 AR034703 A1 AR 034703A1 AR P020101764 A ARP020101764 A AR P020101764A AR P020101764 A ARP020101764 A AR P020101764A AR 034703 A1 AR034703 A1 AR 034703A1
- Authority
- AR
- Argentina
- Prior art keywords
- monooxygenases
- methods
- prepare
- avermectin
- emamectine
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 102000008109 Mixed Function Oxygenases Human genes 0.000 abstract 6
- 108010074633 Mixed Function Oxygenases Proteins 0.000 abstract 6
- 239000005660 Abamectin Substances 0.000 abstract 3
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 abstract 2
- 239000005894 Emamectin Substances 0.000 abstract 1
- 108090000854 Oxidoreductases Proteins 0.000 abstract 1
- 102000004316 Oxidoreductases Human genes 0.000 abstract 1
- 108091007187 Reductases Proteins 0.000 abstract 1
- 230000001464 adherent effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- CXEGAUYXQAKHKJ-NSBHKLITSA-N emamectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](NC)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 CXEGAUYXQAKHKJ-NSBHKLITSA-N 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
Se describe la familia de monooxigenasa P450, cada miembro de las cuales oxida regioselectivamente avermectina a 4''ceto-avermectina. Las monooxigenasas P450 encuentran uso en los métodos y formulaciones para preparar emamectina a partir de avermectina. Asimismo, se describen métodos para purificar las monooxigenasas P450 de la invención, los agentes adherentes que se deben específicamente a las monooxigenasas P450 de la invención, y células genéticamente manipuladas que expresan las monooxigenasas P450 de la invención. Asimismo se describen ferrodoxinas y ferrodoxinas reductasas que son activas con las monooxigenasas P450 .
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29114901P | 2001-05-16 | 2001-05-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR034703A1 true AR034703A1 (es) | 2004-03-17 |
Family
ID=23119055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020101764A AR034703A1 (es) | 2001-05-16 | 2002-05-14 | Metodos y composiciones para preparar emamectina. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20030068788A1 (es) |
| EP (1) | EP1389239A2 (es) |
| JP (1) | JP2004529651A (es) |
| KR (1) | KR20040005963A (es) |
| CN (1) | CN1514880A (es) |
| AR (1) | AR034703A1 (es) |
| AU (1) | AU2002342337B2 (es) |
| BR (1) | BR0209813A (es) |
| CA (1) | CA2446130A1 (es) |
| CZ (1) | CZ20033078A3 (es) |
| HU (1) | HUP0400008A2 (es) |
| IL (1) | IL158764A0 (es) |
| MX (1) | MXPA03010381A (es) |
| PL (1) | PL367195A1 (es) |
| RU (1) | RU2003135646A (es) |
| WO (1) | WO2002092801A2 (es) |
| ZA (1) | ZA200307737B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003087381A1 (en) * | 2002-04-12 | 2003-10-23 | Mercian Corporation | Expression system of actinomycete-origin cytochrome p-450 in escherichia coli |
| EP1705247A4 (en) | 2003-11-27 | 2008-08-20 | Mercian Corp | DNA ACCOMPANYING HYDROXYLATION OF A MAKROLIDE COMPOUND |
| CN1977046A (zh) | 2004-07-20 | 2007-06-06 | 卫材R&D管理有限公司 | 编码参与普拉地内酯生物合成的多肽的dna |
| AU2006203345B1 (en) * | 2006-07-06 | 2007-12-13 | Wyeth | Biocatalytic oxidation process and use thereof |
| JPWO2008096695A1 (ja) * | 2007-02-05 | 2010-05-20 | メルシャン株式会社 | ビタミンｄ類の水酸化に関連するｄｎａ |
| CA2924541A1 (en) * | 2013-09-19 | 2015-03-26 | Firmenich Sa | Method for producing fragrant alcohols |
| JP6522551B2 (ja) * | 2016-06-10 | 2019-05-29 | 長谷川香料株式会社 | （−）−ロタンドンの製造方法 |
| GB201807815D0 (en) | 2018-05-14 | 2018-06-27 | Hypha Discovery Ltd | Hydroxylation techniques |
| GB201819209D0 (en) | 2018-11-26 | 2019-01-09 | Hypha Discovery Ltd | Biocatalytic techniques |
| CN110305818A (zh) * | 2019-08-15 | 2019-10-08 | 齐鲁制药（内蒙古）有限公司 | 一种阿维菌素菌种选育方法 |
| GB201917077D0 (en) | 2019-11-22 | 2020-01-08 | Hypha Discovery Ltd | Biocatalytic techniques |
| CN118755844B (zh) * | 2024-07-17 | 2025-06-20 | 中国农业科学院蔬菜花卉研究所 | 一种田间害螨对阿维菌素抗性的基因突变位点及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4427663A (en) * | 1982-03-16 | 1984-01-24 | Merck & Co., Inc. | 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof |
| US4874749A (en) * | 1987-07-31 | 1989-10-17 | Merck & Co., Inc. | 4"-Deoxy-4-N-methylamino avermectin Bla/Blb |
| WO1993012236A1 (en) * | 1991-12-16 | 1993-06-24 | E.I. Du Pont De Nemours And Company | Constitutive expression of p450soy and ferredoxin-soy in streptomyces, and biotransformation of chemicals by recombinant organisms |
| US5399717A (en) * | 1993-09-29 | 1995-03-21 | Merck & Co., Inc. | Glycosidation route to 4"-epi-methylamino-4"-deoxyavermectin B1 |
| US6117659A (en) * | 1997-04-30 | 2000-09-12 | Kosan Biosciences, Inc. | Recombinant narbonolide polyketide synthase |
| US6265202B1 (en) * | 1998-06-26 | 2001-07-24 | Regents Of The University Of Minnesota | DNA encoding methymycin and pikromycin |
| GB9926887D0 (en) * | 1999-11-12 | 2000-01-12 | Novartis Ag | Organic compounds |
| JP2002058490A (ja) * | 2000-08-22 | 2002-02-26 | Kyowa Hakko Kogyo Co Ltd | 新規チトクロームｐ４５０ |
-
2002
- 2002-05-14 AR ARP020101764A patent/AR034703A1/es unknown
- 2002-05-14 US US10/145,415 patent/US20030068788A1/en not_active Abandoned
- 2002-05-15 HU HU0400008A patent/HUP0400008A2/hu unknown
- 2002-05-15 AU AU2002342337A patent/AU2002342337B2/en not_active Ceased
- 2002-05-15 BR BR0209813-0A patent/BR0209813A/pt not_active IP Right Cessation
- 2002-05-15 IL IL15876402A patent/IL158764A0/xx unknown
- 2002-05-15 KR KR10-2003-7014879A patent/KR20040005963A/ko not_active Withdrawn
- 2002-05-15 RU RU2003135646/13A patent/RU2003135646A/ru not_active Application Discontinuation
- 2002-05-15 EP EP02743025A patent/EP1389239A2/en not_active Withdrawn
- 2002-05-15 CA CA002446130A patent/CA2446130A1/en not_active Abandoned
- 2002-05-15 CZ CZ20033078A patent/CZ20033078A3/cs unknown
- 2002-05-15 MX MXPA03010381A patent/MXPA03010381A/es unknown
- 2002-05-15 CN CNA02810000XA patent/CN1514880A/zh active Pending
- 2002-05-15 WO PCT/EP2002/005363 patent/WO2002092801A2/en not_active Ceased
- 2002-05-15 PL PL02367195A patent/PL367195A1/xx not_active Application Discontinuation
- 2002-05-15 JP JP2002589669A patent/JP2004529651A/ja active Pending
-
2003
- 2003-10-03 ZA ZA200307737A patent/ZA200307737B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20033078A3 (cs) | 2004-02-18 |
| MXPA03010381A (es) | 2004-03-16 |
| JP2004529651A (ja) | 2004-09-30 |
| HUP0400008A2 (hu) | 2004-04-28 |
| US20030068788A1 (en) | 2003-04-10 |
| IL158764A0 (en) | 2004-05-12 |
| WO2002092801A3 (en) | 2003-11-27 |
| ZA200307737B (en) | 2004-04-21 |
| BR0209813A (pt) | 2004-06-01 |
| RU2003135646A (ru) | 2005-05-10 |
| KR20040005963A (ko) | 2004-01-16 |
| AU2002342337B2 (en) | 2006-01-05 |
| WO2002092801A2 (en) | 2002-11-21 |
| CA2446130A1 (en) | 2002-11-21 |
| PL367195A1 (en) | 2005-02-21 |
| EP1389239A2 (en) | 2004-02-18 |
| CN1514880A (zh) | 2004-07-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |