DK1131410T3 - Gensplejsede vævskonstruktioner og fremgangsmåde til fremstilling og anvendelse deraf - Google Patents

Gensplejsede vævskonstruktioner og fremgangsmåde til fremstilling og anvendelse deraf

Info

Publication number
DK1131410T3
DK1131410T3 DK99962807T DK99962807T DK1131410T3 DK 1131410 T3 DK1131410 T3 DK 1131410T3 DK 99962807 T DK99962807 T DK 99962807T DK 99962807 T DK99962807 T DK 99962807T DK 1131410 T3 DK1131410 T3 DK 1131410T3
Authority
DK
Denmark
Prior art keywords
tissue constructs
processes
preparation
tissue structures
cultured
Prior art date
Application number
DK99962807T
Other languages
English (en)
Inventor
Michael P Murphy
Vincent Ronfard
Original Assignee
Organogenesis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organogenesis Inc filed Critical Organogenesis Inc
Application granted granted Critical
Publication of DK1131410T3 publication Critical patent/DK1131410T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0697Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698Skin equivalents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/90Serum-free medium, which may still contain naturally-sourced components
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/09Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/094Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/13Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323Adult fibroblasts

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Prostheses (AREA)
DK99962807T 1998-11-19 1999-11-19 Gensplejsede vævskonstruktioner og fremgangsmåde til fremstilling og anvendelse deraf DK1131410T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10924798P 1998-11-19 1998-11-19
US33963299A 1999-06-24 1999-06-24
PCT/US1999/027505 WO2000029553A1 (en) 1998-11-19 1999-11-19 Bioengineered tissue constructs and methods for producing and using them

Publications (1)

Publication Number Publication Date
DK1131410T3 true DK1131410T3 (da) 2005-10-31

Family

ID=26806787

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99962807T DK1131410T3 (da) 1998-11-19 1999-11-19 Gensplejsede vævskonstruktioner og fremgangsmåde til fremstilling og anvendelse deraf

Country Status (15)

Country Link
US (2) US7824913B2 (da)
EP (3) EP2295540A1 (da)
JP (2) JP2002530069A (da)
CN (2) CN102051343A (da)
AT (1) ATE305967T1 (da)
AU (3) AU769637B2 (da)
BR (1) BR9915476A (da)
CA (1) CA2351396C (da)
DE (1) DE69927600T2 (da)
DK (1) DK1131410T3 (da)
ES (2) ES2402739T3 (da)
HK (1) HK1040740A1 (da)
IL (1) IL143243A0 (da)
PT (1) PT1612265E (da)
WO (1) WO2000029553A1 (da)

Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2295540A1 (en) * 1998-11-19 2011-03-16 Organogenesis, Inc. Bioengineered tissue constructs and methods for producing and using them
US20020090725A1 (en) * 2000-11-17 2002-07-11 Simpson David G. Electroprocessed collagen
US7615373B2 (en) * 1999-02-25 2009-11-10 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering
US20040018226A1 (en) * 1999-02-25 2004-01-29 Wnek Gary E. Electroprocessing of materials useful in drug delivery and cell encapsulation
US20020081732A1 (en) * 2000-10-18 2002-06-27 Bowlin Gary L. Electroprocessing in drug delivery and cell encapsulation
EP1309361A1 (en) * 2000-08-08 2003-05-14 Bioamide, Inc. Scaffolds for tissue engineered hair
EP1315756A2 (en) * 2000-09-01 2003-06-04 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed fibrin-based matrices and tissues
WO2002022185A2 (en) * 2000-09-18 2002-03-21 Organogenesis Inc. Method for treating a patient using a cultured connective tissue construct
EP1832300A3 (en) * 2000-09-18 2008-02-27 Organogenesis Inc. Method for treating a patient using a cultured connective tissue construct
WO2002025272A1 (en) * 2000-09-21 2002-03-28 Shiseido Company, Ltd. Method of evaluating the degree of maturity of corneous cells
FR2828206B1 (fr) * 2001-08-03 2004-09-24 Centre Nat Rech Scient Utilisation d'inhibiteurs des lysyl oxydases pour la culture cellulaire et le genie tissulaire
JP4822635B2 (ja) * 2001-09-05 2011-11-24 株式会社 資生堂 人工毛球部及びその製造方法、並びに、人工毛球部を用いた薬剤の評価方法
JP4183619B2 (ja) * 2001-10-15 2008-11-19 独立行政法人科学技術振興機構 正常再生組織の形成方法と正常再生組織並びに感受性等の検定方法
FR2833610B1 (fr) * 2001-12-14 2007-01-26 Natural Implant Construits cellulaires cultives in vitro, preparation et utilisations
DE10162814B4 (de) * 2001-12-19 2005-06-23 Henkel Kgaa Rekonstruiertes Haarfollikelmodell
US20050089512A1 (en) * 2001-12-19 2005-04-28 Kordula Schlotmann Skin/hair equivalent with reconstructed papillae
DE10220472A1 (de) * 2002-05-07 2003-11-27 Hans-Guenther Machens Bioartifizielle Haut
AU2003250664A1 (en) * 2002-07-16 2004-02-02 Biogentis Inc. Method for preparing engineered tissue
GB0304918D0 (en) * 2003-03-05 2003-04-09 Celltran Ltd Cell culture
US20040175366A1 (en) * 2003-03-07 2004-09-09 Acell, Inc. Scaffold for cell growth and differentiation
US20040176855A1 (en) * 2003-03-07 2004-09-09 Acell, Inc. Decellularized liver for repair of tissue and treatment of organ deficiency
AU2004253508A1 (en) 2003-06-25 2005-01-13 Acell, Inc. Conditioned matrix compositions for tissue restoration
US8043614B2 (en) 2004-03-09 2011-10-25 Ahlfors Jan-Eric W Autogenic living scaffolds and living tissue matrices: methods and uses thereof
EP1688484B1 (en) * 2003-10-06 2017-06-28 Shiseido Company, Ltd. Method of preparing hair papilla cell preparation, composition and method for regenerating hair follicle and animal having regenerated hair follicle
JP2005218445A (ja) * 2004-01-09 2005-08-18 Technology Seed Incubation Co Ltd 培養皮膚細胞とこれを原料として用いた移植用材及び遺伝子解析用材並びに培養皮膚細胞の製造方法
WO2006048783A2 (en) 2004-03-09 2006-05-11 Ahlfors Jan-Eric W Autogenic living scaffolds and living tissue matrices: methods and uses thereof
JP2007528252A (ja) * 2004-03-09 2007-10-11 ジャン−エリック ダブリュー. アルフォース, オートジェネシス生体足場および生体組織マトリックス;方法およびその使用
US7597885B2 (en) 2004-03-26 2009-10-06 Aderans Research Institute, Inc. Tissue engineered biomimetic hair follicle graft
US20090181092A1 (en) * 2004-07-16 2009-07-16 Spinal Restoration, Inc. Methods for Treating Joints and Discs with a Carrier Matrix and Cells
US8206448B2 (en) 2004-10-29 2012-06-26 Spinal Restoration, Inc. Injection of fibrin sealant using reconstituted components in spinal applications
US7597687B2 (en) 2004-10-29 2009-10-06 Spinal Restoration, Inc. Injection of fibrin sealant including an anesthetic in spinal applications
US8796015B2 (en) 2004-11-09 2014-08-05 Proxy Biomedical Limited Tissue scaffold
CA2608708C (en) * 2005-05-16 2014-04-22 Purdue Research Foundation Engineered extracellular matrix having a specified fibril area fraction
TW200731982A (en) * 2005-10-17 2007-09-01 Aderans Res Inst Inc Method of delivering cells to the skin
DK1948259T3 (da) 2005-10-26 2017-04-10 Genesis Tech Ltd Acellulær bioabsorberbare vævsregenereringsmatrixer produceret ved inkubering af acellulære blodprodukter
US20070148138A1 (en) * 2005-11-22 2007-06-28 Aderans Research Institute, Inc. Hair follicle graft from tissue engineered skin
US20090317441A1 (en) * 2006-02-07 2009-12-24 Bilbo Patrick R Bioengineered tissue constructs and cardiac uses thereof
EP1986731A4 (en) * 2006-02-09 2012-11-07 Aderans Res Inst Inc APPARATUS AND METHODS FOR DELIVERING FLUID AND MATERIAL TO A SUBJECT
JP5386180B2 (ja) 2006-02-28 2014-01-15 ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク 真皮細胞のコンパクト凝集のための方法
JP2009528856A (ja) * 2006-03-03 2009-08-13 オルガノジェネシス インク. 口腔組織の再生および修復
GB0605450D0 (en) * 2006-03-17 2006-04-26 Intercytex Ltd Cell co-culture
WO2007136634A1 (en) * 2006-05-16 2007-11-29 Purdue Research Foundation Three dimensional purified collagen matrices
US20070269476A1 (en) * 2006-05-16 2007-11-22 Voytik-Harbin Sherry L Engineered extracellular matrices control stem cell behavior
FR2903702B1 (fr) * 2006-07-13 2012-10-19 Oreal Equivalent d'epiderme capable de se pigmenter obtenu a partir de cellules de la matrice, procede de preparation et utilisation
CA2663722C (en) 2006-09-21 2014-12-09 Purdue Research Foundation Collagen preparation and method of isolation
EP2082030A2 (en) * 2006-10-20 2009-07-29 Keracure, Inc. Devices with cells cultured on flexible supports
US8709081B2 (en) 2006-10-23 2014-04-29 Stemedica Cell Technologies, Inc. Cellular scaffold
US8105380B2 (en) * 2006-10-23 2012-01-31 Stemedica Cell Technologies, Inc. Cellular scaffold
BRPI0717388A2 (pt) * 2006-10-23 2013-10-15 Cook Biotech Inc Materiais ecm processados com melhores perfis de componentes
US20100183572A1 (en) 2007-02-28 2010-07-22 Takeshi Nakajima Cell capable of expressing lacritin at high level
US7985537B2 (en) 2007-06-12 2011-07-26 Aderans Research Institute, Inc. Methods for determining the hair follicle inductive properties of a composition
WO2009043052A1 (en) * 2007-09-27 2009-04-02 Columbia University Methods and systems for forming biocompatible materials
AU2008329653A1 (en) * 2007-11-28 2009-06-04 Organogenesis, Inc. Bioengineered tissue constructs and methods for production and use
GB2468102B (en) * 2007-12-10 2012-12-05 Purdue Research Foundation Collagen-based matrices with stem cells
US8613776B2 (en) * 2007-12-27 2013-12-24 The Trustees Of Columbia University In The City Of New York Systems and methods for forming patterned extracellular matrix materials
WO2009097559A1 (en) * 2008-01-30 2009-08-06 Histogen, Inc. Extracellular matrix compositions
US8524494B2 (en) 2008-01-30 2013-09-03 Histogen, Inc. Low oxygen tension and BFGF generates a multipotent stem cell from a fibroblast in vitro
KR101610985B1 (ko) 2008-11-14 2016-04-08 히스토젠, 인코포레이티드 암 치료를 위한 세포외 기질 조성물
US20100166822A1 (en) * 2008-12-31 2010-07-01 Howmedica Osteonics Corp. Adhesive cartilage implant
EP2438155B1 (en) 2009-06-04 2016-08-10 The General Hospital Corporation Bioartificial lung
US8986377B2 (en) 2009-07-21 2015-03-24 Lifecell Corporation Graft materials for surgical breast procedures
US8652500B2 (en) 2009-07-22 2014-02-18 Acell, Inc. Particulate tissue graft with components of differing density and methods of making and using the same
US8298586B2 (en) 2009-07-22 2012-10-30 Acell Inc Variable density tissue graft composition
US20110046639A1 (en) * 2009-08-24 2011-02-24 Konstantinos Giotis Method of direct hair implantation
BR112012013303A2 (pt) * 2009-12-04 2016-03-01 Euclid Systems Corp composições farmacêuticas e respectivos usos
EP2524034A1 (en) * 2010-01-14 2012-11-21 Organogenesis, Inc. Bioengineered tissue constructs and methods for producing and using thereof
US20120100110A1 (en) * 2010-04-20 2012-04-26 International Stem Cell Corporation Physiological methods for isolation of high purity cell populations
CA2802880C (en) * 2010-06-18 2019-09-24 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Hair follicle neogenesis
FR2976001B1 (fr) 2011-05-30 2014-10-31 Oreal Modele de cuir chevelu reconstruit et procede de screening de molecules actives
GB201112922D0 (en) * 2011-07-27 2011-09-14 Univ Durham Micro-organ
HK1200483A1 (en) * 2011-09-12 2015-08-07 奥加诺沃公司 Engineered tissues for in vitro research uses, arrays thereof, and methods of making the same
MX2014005723A (es) * 2011-11-11 2014-11-25 Essential Pharmaceuticals Llc Kit que comprende factores labiles y de reemplazo de suero.
EP3400900B1 (en) 2012-01-13 2020-05-20 LifeCell Corporation Methods of manufacturing breast prostheses
CA2866563A1 (en) * 2012-03-07 2013-09-12 Fibrocell Technologies, Inc. Topical dermal formulations and methods of personalized treatment of skin
USD690004S1 (en) 2012-03-16 2013-09-17 Aderans Research Institute, Inc. Holder for a device for delivering cellular material and physiologic fluids
WO2013163358A1 (en) 2012-04-24 2013-10-31 Harvard Bioscience, Inc. Engineered tissue scaffolds and supports therefor
ES2647979T3 (es) 2012-06-21 2017-12-27 Lifecell Corporation Prótesis implantable que tiene fijaciones tisulares acelulares
CA2884311C (en) 2012-10-04 2021-02-16 Lifecell Corporation Surgical template and delivery device
DE102012223061A1 (de) 2012-12-13 2014-06-18 Henkel Ag & Co. Kgaa Altershautmodell
EP2943231A4 (en) 2013-01-09 2016-12-07 Harvard Apparatus Regenerative Tech Inc SYNTHETIC SCAFFOLD
DK2956543T3 (da) 2013-02-12 2019-01-02 Replicel Life Sciences Inc Sammensætninger og fremgangsmåder til behandling og reparation af sener
JP6469655B2 (ja) 2013-05-03 2019-02-13 ザ ヘンリー エム. ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド 代用皮膚および毛包新生の方法
CN103497892B (zh) * 2013-09-03 2015-12-02 中山大学 一种细胞培养基材及其制备方法和应用
US9878071B2 (en) 2013-10-16 2018-01-30 Purdue Research Foundation Collagen compositions and methods of use
TW201538730A (zh) 2014-02-12 2015-10-16 Replicel Life Sciences Inc 用於治療骨骼、關節及軟骨之組合物及方法
WO2015138999A1 (en) 2014-03-14 2015-09-17 The General Hospital Corporation Lung bioreactor
JP6218238B2 (ja) * 2014-07-10 2017-10-25 国立大学法人大阪大学 人工皮膚及びその製造方法
EP3185922B1 (en) 2014-08-27 2025-04-02 Purdue Research Foundation Collagen-based therapeutic delivery systems
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
US11919941B2 (en) 2015-04-21 2024-03-05 Purdue Research Foundation Cell-collagen-silica composites and methods of making and using the same
AU2016265286B2 (en) 2015-05-15 2021-01-21 Lifecell Corporation Tissue matrices for plastic surgery
US11802265B2 (en) * 2015-06-25 2023-10-31 Auckland Uniservices Ltd Tissue culture apparatus and method
US20180228599A1 (en) * 2015-08-06 2018-08-16 The Johns Hopkins University Tissue-derived scaffolds for corneal reconstruction
EP3337427A1 (en) 2015-08-21 2018-06-27 Lifecell Corporation Breast treatment device
DE102015119880B4 (de) * 2015-11-17 2018-05-24 Technische Universität Berlin Verfahren zur Herstellung von Haarfollikeln und de novo Papillen sowie deren Verwendung für in vitro Tests und in vivo Implantate
US10624992B2 (en) 2016-05-16 2020-04-21 The General Hospital Corporation Human airway stem cells in lung epithelial engineering
JP6840774B2 (ja) 2016-05-16 2021-03-10 ザ ジェネラル ホスピタル コーポレイション 肺上皮エンジニアリングにおけるヒト気道幹細胞
US11045579B2 (en) 2016-08-31 2021-06-29 Lifecell Corporation Breast treatment device
MX380950B (es) * 2016-09-23 2025-03-12 Univ Mexico Nac Autonoma Metodo para preparar un suplemento a partir de cultivos de celulas mesenquimales de gelatina de wharton y usos del mismo.
CN106544281B (zh) * 2016-12-07 2019-07-02 哈尔滨工业大学 一种基于蛋白质和多糖构筑生物体保护层的制备方法
ES3040675T3 (en) 2017-01-31 2025-11-04 Geniphys Inc Methods and compositions for matrix preparation
EP3615568A4 (en) 2017-04-25 2021-01-20 Purdue Research Foundation TISSUE RESTORATION THREE-DIMENSIONAL (3D) ARTIFICIAL MUSCLE
CN109663148A (zh) * 2018-12-17 2019-04-23 太阳雨林(厦门)生物医药有限公司 一种细胞外基质高分子材料生物复合血管
WO2020227095A1 (en) 2019-05-03 2020-11-12 Lifecell Corporation Breast treatment device
EP3986425A1 (en) 2019-06-18 2022-04-27 United Therapeutics Corporation Mitochondrial treatment of organs for transplantation
CN111100838B (zh) * 2019-12-27 2023-05-09 广东博溪生物科技有限公司 低温保存运输培养基
EP4096635A4 (en) 2020-01-27 2024-02-21 GeniPhys, Inc. BIOLOGICAL FILLER FOR TISSUE RESTORATION AND REGENERATION
WO2022061222A1 (en) * 2020-09-18 2022-03-24 University Of Virginia Patent Foundation 3d-printed modular microchip with an integrated impeller pump to model inter-organ communication
US20260061101A1 (en) * 2022-08-05 2026-03-05 The Texas A&M University System Fabricated engineered skin dermis compositions and methods thereof
CN119979445B (zh) * 2025-04-10 2025-09-09 四川大学 一种培养基、口腔黏膜上皮细胞模型,及其制备方法和用途

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485096A (en) * 1982-02-26 1984-11-27 Massachusetts Institute Of Technology Tissue-equivalent and method for preparation thereof
DE3317550C2 (de) 1983-05-13 1985-08-22 Stephan Priv.Doz.Dr.rer.nat.Dr.med.habil. 8000 München Nees Verfahren zum Züchten einer lückenlosen Zellschicht und Vorrichtung zur Durchführung dieses Verfahrens
US5484432A (en) * 1985-09-27 1996-01-16 Laser Biotech, Inc. Collagen treatment apparatus
US5026649A (en) 1986-03-20 1991-06-25 Costar Corporation Apparatus for growing tissue cultures in vitro
US5266480A (en) 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US5032508A (en) 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5510254A (en) 1986-04-18 1996-04-23 Advanced Tissue Sciences, Inc. Three dimensional cell and tissue culture system
US4963489A (en) 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
EP0282746A1 (en) * 1987-02-19 1988-09-21 Takeda Chemical Industries, Ltd. Method for producing artificial cultured tissue
JPS6410983A (en) * 1987-02-19 1989-01-13 Takeda Chemical Industries Ltd Artificial tissue and production thereof
FR2612939B1 (fr) * 1987-03-26 1989-06-23 Cird Equivalent de peau
US4835102A (en) 1987-03-31 1989-05-30 Eugene Bell Tissue equivalent test systems
JPH051280Y2 (da) 1987-10-12 1993-01-13
CA2018228C (en) 1989-06-05 1996-02-27 Nancy L. Parenteau Cell culture systems and media
IL95429A (en) * 1989-09-15 1997-09-30 Organogenesis Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production
US5800537A (en) 1992-08-07 1998-09-01 Tissue Engineering, Inc. Method and construct for producing graft tissue from an extracellular matrix
IL102929A (en) * 1992-08-24 1996-11-14 Interpharm Lab Ltd Serum-free medium for mammalian cells
US5374515A (en) 1992-11-13 1994-12-20 Organogenesis, Inc. In vitro cornea equivalent model
US5827641A (en) * 1992-11-13 1998-10-27 Parenteau; Nancy L. In vitro cornea equivalent model
US5366893A (en) 1993-01-13 1994-11-22 Becton, Dickinson And Company Culture vessel
JPH07178A (ja) * 1993-06-11 1995-01-06 New Japan Chem Co Ltd 細胞培養用担体
US5891617A (en) 1993-09-15 1999-04-06 Organogenesis Inc. Cryopreservation of harvested skin and cultured skin or cornea equivalents by slow freezing
US5518878A (en) 1993-09-15 1996-05-21 Organogenesis Inc. Cryopreservation of cultured skin or cornea equivalents with agitation
US5731417A (en) * 1994-04-25 1998-03-24 Becton, Dickinson And Company Cell culture substrates and method of making
CA2189421A1 (en) * 1994-05-11 1995-11-23 Organogenesis Inc. Collagen from cell cultures
US5716404A (en) 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US5618718A (en) 1994-12-30 1997-04-08 Universite Laval Production of a contractile smooth muscle
US5695998A (en) 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
US5830708A (en) * 1995-06-06 1998-11-03 Advanced Tissue Sciences, Inc. Methods for production of a naturally secreted extracellular matrix
US5665391A (en) * 1995-10-12 1997-09-09 Spectral Diagnostics Inc. Cultured, full-thickness integument substitutes based on three-dimensional matrix membranes
US5689961A (en) 1996-01-30 1997-11-25 Organogenesis Inc. Ice seeding apparatus for cryopreservation systems
US5766937A (en) 1996-02-15 1998-06-16 Becton Dickinson And Company Culture vessel and assembly
AU2808397A (en) * 1996-04-26 1997-11-19 Case Western Reserve University Skin regeneration using mesenchymal stem cells
EP2295540A1 (en) * 1998-11-19 2011-03-16 Organogenesis, Inc. Bioengineered tissue constructs and methods for producing and using them
US6733530B1 (en) * 1999-08-02 2004-05-11 Eric Sun-Yin Chan Material and method for engraftment of a composite biocompatible skin graft on the neodermis of artificial skin
CN100345452C (zh) * 2003-10-16 2007-10-24 华为技术有限公司 一种确定移动通信系统中用于加密同步的计数器检查发起时机的方法

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AU1917100A (en) 2000-06-05
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CA2351396A1 (en) 2000-05-25
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JP2010187680A (ja) 2010-09-02
EP2295540A1 (en) 2011-03-16
EP1612265A3 (en) 2006-03-01
ES2402739T3 (es) 2013-05-08
AU2004201787A1 (en) 2004-05-27
ATE305967T1 (de) 2005-10-15
US20080108134A1 (en) 2008-05-08
PT1612265E (pt) 2013-03-14
EP1131410B1 (en) 2005-10-05
WO2000029553A9 (en) 2000-11-09
DE69927600T2 (de) 2006-07-06
WO2000029553A1 (en) 2000-05-25
EP1612265B1 (en) 2013-01-16
EP1612265A2 (en) 2006-01-04
US7824913B2 (en) 2010-11-02
US20020172705A1 (en) 2002-11-21
HK1040740A1 (zh) 2002-06-21
IL143243A0 (en) 2002-04-21
JP5484975B2 (ja) 2014-05-07
DE69927600D1 (de) 2005-11-10
AU2010201787A1 (en) 2010-05-27
JP2002530069A (ja) 2002-09-17
AU2010201787B2 (en) 2012-09-13
AU769637B2 (en) 2004-01-29
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ES2249928T3 (es) 2006-04-01

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