AR036384A1 - Una proteina de fusion que tiene actividad de eritropoyetina in vivo aumentada - Google Patents

Una proteina de fusion que tiene actividad de eritropoyetina in vivo aumentada

Info

Publication number
AR036384A1
AR036384A1 ARP020103279A ARP020103279A AR036384A1 AR 036384 A1 AR036384 A1 AR 036384A1 AR P020103279 A ARP020103279 A AR P020103279A AR P020103279 A ARP020103279 A AR P020103279A AR 036384 A1 AR036384 A1 AR 036384A1
Authority
AR
Argentina
Prior art keywords
increased
fusion protein
activity
erythropoyetin
vivid
Prior art date
Application number
ARP020103279A
Other languages
English (en)
Inventor
Dong-Eok Lee
Myung-Suk Oh
Bo-Sup Chung
Ji-Sook Park
Ki-Wan Kim
Original Assignee
Cheil Jedang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cheil Jedang Corp filed Critical Cheil Jedang Corp
Publication of AR036384A1 publication Critical patent/AR036384A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Una proteína de fusión que tiene actividad de eritropoyetina in vivo aumentada en donde un fragmento de péptido del extremo carboxilo terminal de tromboyetina es fusionado con el extremo carboxilo terminal de la eritropoyetina humana. Esta proteína de fusión tiene una vida media in vivo muy aumentada debido al contenido aumentado de carbohidratos sin pérdidas de la actividad inherente de la eritropoyetina, y no provoca ninguna antigenicidad cuando se aplica al cuerpo humano.
ARP020103279A 2001-11-29 2002-08-30 Una proteina de fusion que tiene actividad de eritropoyetina in vivo aumentada AR036384A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR10-2001-0074975A KR100467750B1 (ko) 2001-11-29 2001-11-29 생체내 에리스로포이에틴 활성이 증진된 융합단백질

Publications (1)

Publication Number Publication Date
AR036384A1 true AR036384A1 (es) 2004-09-01

Family

ID=36821313

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020103279A AR036384A1 (es) 2001-11-29 2002-08-30 Una proteina de fusion que tiene actividad de eritropoyetina in vivo aumentada

Country Status (23)

Country Link
US (1) US7098318B2 (es)
EP (1) EP1319712B1 (es)
JP (1) JP3860097B2 (es)
KR (1) KR100467750B1 (es)
CN (1) CN100390201C (es)
AR (1) AR036384A1 (es)
AT (1) ATE460483T1 (es)
AU (1) AU2002300359B2 (es)
BR (1) BRPI0203394B1 (es)
CA (1) CA2394572C (es)
DE (2) DE60235603D1 (es)
ES (1) ES2339426T3 (es)
FR (1) FR2832716B1 (es)
GB (1) GB2382580B (es)
IT (1) ITMI20021803A1 (es)
MX (1) MXPA02008131A (es)
MY (1) MY122935A (es)
NZ (1) NZ520442A (es)
RU (1) RU2225220C1 (es)
SG (1) SG117416A1 (es)
TW (1) TWI237056B (es)
WO (1) WO2003046013A1 (es)
ZA (1) ZA200206172B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7345019B1 (en) * 1999-04-13 2008-03-18 The Kenneth S. Warren Institute, Inc. Modulation of excitable tissue function by peripherally administered erythropoietin
US20030072737A1 (en) * 2000-12-29 2003-04-17 Michael Brines Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs
US7767643B2 (en) 2000-12-29 2010-08-03 The Kenneth S. Warren Institute, Inc. Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs
CN1897959A (zh) * 2003-09-29 2007-01-17 沃伦药品公司 用于治疗和预防脓毒病和粘连形成的组织保护细胞因子
US7625564B2 (en) 2006-01-27 2009-12-01 Novagen Holding Corporation Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US7553941B2 (en) * 2006-02-03 2009-06-30 Modigene Inc Long-acting polypeptides and methods of producing same
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8067548B2 (en) 2007-07-26 2011-11-29 Novagen Holding Corporation Fusion proteins having mutated immunoglobulin hinge region
CN101863982A (zh) * 2009-04-17 2010-10-20 哈药集团生物工程有限公司 一种用于升高血小板的融合蛋白及其制备方法
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
US12203113B2 (en) 2009-07-09 2025-01-21 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
CN103864913A (zh) * 2012-12-18 2014-06-18 联亚生技开发股份有限公司 重组蛋白
US20160024181A1 (en) 2013-03-13 2016-01-28 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
KR102527180B1 (ko) 2014-12-10 2023-04-27 옵코 바이오로직스 리미티드 장기간 작용성 ctp-변형된 성장 호르몬 폴리펩타이드의 제조 방법
KR102662956B1 (ko) 2015-06-19 2024-05-03 옵코 바이오로직스 리미티드 장기-작용성 응고 인자 및 그의 제조 방법
EP4303228B1 (en) 2016-07-11 2026-05-27 OPKO Biologics Ltd. Long-acting coagulation factor vii and methods of producing same

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE122010000006I2 (de) * 1989-02-21 2012-06-21 Univ Washington Modifizierte formen von fortpflanzungshormonen.
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
AU646822B2 (en) * 1989-10-13 1994-03-10 Kirin-Amgen Inc. Erythropoietin isoforms
US5856298A (en) * 1989-10-13 1999-01-05 Amgen Inc. Erythropoietin isoforms
KR960701650A (ko) * 1993-04-29 1996-03-28 찰스 엠. 브룩 에리트로포이에틴 유사체 조성물 및 방법(Eythropoietin analog compositions and methods)
IL110669A (en) * 1993-08-17 2008-11-26 Kirin Amgen Inc Erythropoietin analogs
GB2285446B (en) * 1994-01-03 1999-07-28 Genentech Inc Thrombopoietin
ITFI940106A1 (it) * 1994-05-27 1995-11-27 Menarini Ricerche Sud Spa Molecola ibrida di formula gm-csf-l-epo o epo-l-gm-csf per la stimolaz ione eritropoietica
WO1996023888A1 (en) * 1995-02-03 1996-08-08 G.D. Searle & Co. NOVEL c-MPL LIGANDS
US6242570B1 (en) * 1997-07-10 2001-06-05 Beth Israel Deaconess Medical Center Production and use of recombinant protein multimers with increased biological activity
WO1999002709A1 (en) * 1997-07-10 1999-01-21 Beth Israel Deaconess Medical Center Recombinant erythropoietin / immunoglobulin fusion proteins
ATE375363T1 (de) * 1997-07-14 2007-10-15 Bolder Biotechnology Inc Derivate des wachstumshormons und verwandte proteine
US6342220B1 (en) * 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
AU3538799A (en) * 1998-04-30 1999-11-23 Kirin Brewery Company, Limited Human thrombopoietin mutants
DK1088084T3 (da) * 1998-06-15 2007-01-29 Gtc Biotherapeutics Inc Erythropoietin analog-humant serumalbumin fusionsprotein
ATE407697T1 (de) * 1999-07-13 2008-09-15 Bolder Biotechnology Inc Erythropoietin immunglobulin fusionsproteine
CA2391080A1 (en) * 1999-11-12 2001-05-25 Merck Patent Gesellschaft Mit Beschraenkter Haftung Erythropoietin forms with improved properties

Also Published As

Publication number Publication date
FR2832716B1 (fr) 2004-12-03
MY122935A (en) 2006-05-31
DE60235603D1 (de) 2010-04-22
US20030124115A1 (en) 2003-07-03
BR0203394A (pt) 2004-05-11
ES2339426T3 (es) 2010-05-20
GB2382580B (en) 2003-10-08
JP2003169671A (ja) 2003-06-17
NZ520442A (en) 2003-10-31
EP1319712A2 (en) 2003-06-18
WO2003046013A1 (en) 2003-06-05
US7098318B2 (en) 2006-08-29
MXPA02008131A (es) 2004-12-13
RU2225220C1 (ru) 2004-03-10
GB0218252D0 (en) 2002-09-11
DE10235248A1 (de) 2003-06-12
EP1319712B1 (en) 2010-03-10
GB2382580A (en) 2003-06-04
AU2002300359B2 (en) 2004-12-23
ZA200206172B (en) 2003-04-03
CN100390201C (zh) 2008-05-28
SG117416A1 (en) 2005-12-29
TWI237056B (en) 2005-08-01
JP3860097B2 (ja) 2006-12-20
KR20030044272A (ko) 2003-06-09
CA2394572A1 (en) 2003-05-29
FR2832716A1 (fr) 2003-05-30
BRPI0203394B1 (pt) 2015-12-01
CN1421461A (zh) 2003-06-04
CA2394572C (en) 2007-08-14
DE10235248B4 (de) 2004-12-23
RU2002123438A (ru) 2004-03-27
ITMI20021803A1 (it) 2003-05-30
EP1319712A3 (en) 2003-11-12
KR100467750B1 (ko) 2005-01-24
ATE460483T1 (de) 2010-03-15

Similar Documents

Publication Publication Date Title
MY122935A (en) Fusion protein having enhanced in vivo activity of erythropoietin
ECSP064643A (es) Proteinas de fusion de glp-1
ATE473011T1 (de) Modifizierte transferrin-fusionsproteine mit doppelten transferrin-amino- oder carboxy- terminalen domänen
ES2077666T3 (es) Proteina de union a fibronectina y su preparacion.
ES2059547T3 (es) Expresion y secrecion mejoradas de proteinas heterologas en levadura, empleando secuencia conductora de factor alfa truncado.
ATE353916T1 (de) Chimärische natriuretische peptide
BR9407377A (pt) Toxina hibrida
HRP20050354B1 (es)
BR0212256A (pt) Proteìnas de fusão de transferrina modificadas
EA200100216A1 (ru) Композиции на основе слитого белка ов и способы их применения
ATE411082T1 (de) Neue verwendung von kurzkettigen carbonsäuren
EP1270642A4 (en) BRANCHED POLYALKYLENE GLYCLE
ATE317441T1 (de) Cathepsin-02-protease
NO20023774D0 (no) Ökning av antistoffbaserte fusjonsproteiners halveringstid i blodomlöpet
DK1088084T3 (da) Erythropoietin analog-humant serumalbumin fusionsprotein
ATE328101T1 (de) Strukturprotein von adeno-assoziiertem virus mit veränderten chromatographischen eigenschaften
WO2001004265A3 (en) C-terminal protein tagging
EP1400550A4 (en) BRANCHED POLYALKYLENE GLYCLE
AR025660A1 (es) PRECURSOR DE HIRUDINA, PROCEDIMIENTO PAA LA PREPARACIoN DE LEU-HIRUDINA Y SU EMPLEO PARA LA PREPARACIoN DE LEU-HIRUDINA.
DE59901061D1 (de) Anschlussstutzen mit dichtwulst
ES2310055T3 (es) Quinasa humana dependiente de ciclina (hpnqalre).
EA200000875A1 (ru) Белки, взаимодействующие с каспазой-8
DE59608073D1 (de) Antikörper gegen ein, einen histidin-anteil aufweisendes fusionspolypeptid
DE69014115D1 (de) Stabilisierte, starke grf-analoga.
EA200400393A1 (ru) Антитела против каспазы-8, их получение и применение

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed, e.g., due to non-payment of fee