AR044178A1 - Derivados de piperidinil- y piperazinil-alquilcarbamatos, su preparacion y su aplicacion en terapeutica - Google Patents

Derivados de piperidinil- y piperazinil-alquilcarbamatos, su preparacion y su aplicacion en terapeutica

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Publication number
AR044178A1
AR044178A1 ARP040101538A ARP040101538A AR044178A1 AR 044178 A1 AR044178 A1 AR 044178A1 AR P040101538 A ARP040101538 A AR P040101538A AR P040101538 A ARP040101538 A AR P040101538A AR 044178 A1 AR044178 A1 AR 044178A1
Authority
AR
Argentina
Prior art keywords
group
cycloalkyl
integer equal
alkyl
alkylene
Prior art date
Application number
ARP040101538A
Other languages
English (en)
Inventor
Ahmed Abouabdellah
Philippe Burnier
Christian Hoornaert
Jean Jeunesse
Frederic Puech
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR044178A1 publication Critical patent/AR044178A1/es

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    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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Abstract

Compuestos caracterizados porque responden a la fórmula general (1), en la cual: A representa un átomo de nitrógeno o un grupo CR2 en el cual R2 representa un átomo de hidrógeno, de flúor o un grupo hidroxilo, ciano, trifluorometilo, alquilo-C1-6, alcoxi-C1-6; n representa un número entero igual a 2 ó 3 y m representa un número entero igual a 2 cuando A representa un átomo de nitrógeno; n representa un número entero igual a 1, 2 ó 3 y m un número entero igual a 1 ó 2 cuando A representa un grupo CR2; B representa un enlace covalente o un grupo alquileno-C1-8; R1 representa un grupo elegido entre un fenilo, piridinilo, piridazinilo, pirimidinilo, pirazinilo, triazinilo, oxazolilo, isoxazolilo, tiazolilo, isotiazolilo, imidazolilo, oxadiazolilo, tiadiazolilo, triazolilo, naftilo, quinolinilo, tetrahidroquinolinilo, isoquinolinilo, tetrahidroisoquinolinilo, ftalazinilo, quinazolinilo, quinoxalinilo, naftiridinilo, cinolinilo, imidazopirimidinilo, tienopirimidinilo, benzofuranilo, benzotienilo, bencimidazolilo, benzoxazolilo, bencisoxazolilo, benzotiazolilo, bencisotiazolilo, indazolilo, pirrolopiridinilo, furopiridinilo, dihidrofuropiridinilo, tienopiridinilo, dihidrotienopiridinilo, imidazopiridinilo, pirazolopiridinilo, oxazolopiridinilo, isoxazolopiridinilo, tiazolopiridinilo; el grupo R1 está sustituido eventualmente por uno o varios grupos R' y/o R''; R' representa un átomo de halógeno o un grupo ciano, nitro, hidroxilo, alquilo-C1-6, alcoxi-C1-6, tioalquilo-C1-6, fluoroalquilo-C1-6, fluoroalcoxi-C1-6, fluorotioalquilo-C1-6, cicloalquilo-C3-7, cicloalquilo-(C3-7)-alquileno-(C1-6), azetidinilo, piperidinilo, pirrolidinilo, morfolinilo, piperazinilo, azepinilo, NH2, NHR6, NR6R7, NR6COR7, NR6SO2R7, COR6, CO2R6, SO2R6, SO2NR6R7 o -O-(alquileno-C1-6)-O-; R'' representa un fenilo, imidazolilo, piridazinilo, pirazinilo o pirimidinilo; el o los grupos R'' están eventualmente sustituidos por uno o varios grupos R' idénticos o diferentes entre sí; R3 representa un grupo de fórmula general CHR4CONHR5 en la cual: R4 representa un átomo de hidrógeno o un grupo alquilo-C1-6; y R5 representa un átomo de hidrógeno o un grupo alquilo-C1-6, cicloalquilo-C3-7, cicloalquilo-(C3-7)-alquileno-(C1-6); R6 y R7 representan independientemente entre sí un grupo alquilo-C1-6, en estado de base, de sal de adición con un ácido, de hidrato o de solvato.
ARP040101538A 2003-05-07 2004-05-06 Derivados de piperidinil- y piperazinil-alquilcarbamatos, su preparacion y su aplicacion en terapeutica AR044178A1 (es)

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EP3022179B1 (en) * 2013-07-18 2017-11-15 Fondazione Istituto Italiano Di Tecnologia Phenyl carbamates and their use as inhibitors of the fatty acid amide hydrolase (faah) enzyme and modulators of the d3 dopamine receptor (d3dr)
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UA81808C2 (en) 2008-02-11
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US7214798B2 (en) 2007-05-08
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EP1633735B1 (fr) 2011-11-30
US20060089344A1 (en) 2006-04-27
CA2521700A1 (en) 2004-11-18
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AU2004236006B2 (en) 2010-03-11
TW200505895A (en) 2005-02-16
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