ES2196772T3 - Compuestos amino ciclicos. - Google Patents

Compuestos amino ciclicos.

Info

Publication number
ES2196772T3
ES2196772T3 ES99906508T ES99906508T ES2196772T3 ES 2196772 T3 ES2196772 T3 ES 2196772T3 ES 99906508 T ES99906508 T ES 99906508T ES 99906508 T ES99906508 T ES 99906508T ES 2196772 T3 ES2196772 T3 ES 2196772T3
Authority
ES
Spain
Prior art keywords
group
groups
alkyl
alkoxy
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99906508T
Other languages
English (en)
Inventor
Fumitoshi Asai
Atsuhiro Sugidachi
Toshihiko Ikeda
Haruo Iwabuchi
Yoshiaki Kuroki
Teruhiko Inoue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Ube Corp
Original Assignee
Sankyo Co Ltd
Ube Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd, Ube Industries Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of ES2196772T3 publication Critical patent/ES2196772T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Lubricants (AREA)
  • Cosmetics (AREA)

Abstract

Un compuesto amino cíclico representado por la fórmula siguiente: **(Fórmula)** en la que: R1 representa un grupo fenilo que puede estar opcionalmente sustituido por al menos un sustituyente seleccionado entre el grupo que consiste en átomos de halógeno, grupos alquilo de C1-C4, grupos (alquilo de C1-C4) sustituidos con flúor, grupos alcoxi de C1-C4, grupos (alcoxi de C1-C4) sustituidos con flúor, grupos ciano y grupos nitro; R2 representa un grupo acilo alifático de C1-C8 que puede estar opcionalmente sustituido por al menos un sustituyente seleccionado entre el grupo que consiste en átomos de halógeno, grupos alcoxi de C1-C4 y grupos ciano, un grupo benzoilo que puede estar opcionalmente sustituido por al menos un sustituyente seleccionado entre el grupo que consiste en átomos de halógeno, grupos alquilo de C1-C4 y grupos alcoxi de C1-C4, o un grupo (alcoxi de C1-C4)carbonilo; y R3 representa un grupo amino cíclico saturado que tiene en total entre 2 y 8 átomos de carbono en uno o más anillos, teniendo el mayor anillo que contiene nitrógeno entre 3 y 7 átomos en el anillo, estando sustituido dicho grupo amino cíclico saturado por un grupo de fórmula -S-X-R4 en la que R4 y X son tal como se definen a continuación, estando unido dicho grupo amino cíclico saturado a través de un átomo de nitrógeno del anillo del mismo al átomo de carbono adyacente al que están unidos los sustituyentes R1 y R2, y conteniendo de forma opcional dicho grupo amino cíclico saturado un heteroátomo adicional en el anillo seleccionado entre el grupo que consiste en átomos de oxígeno, nitrógeno y azufre, R4 representa un grupo fenilo que puede estar opcionalmente sustituido por al menos un sustituyente seleccionado entre el grupo que consiste en átomos de halógeno, grupos alquilo de C1-C4, grupos alcoxi de C1-C4, grupo nitros y grupos ciano, un grupo alquilo de C1-C6 que puede estar opcionalmente sustituido por al menos un sustituyente seleccionado entre el grupo que consiste en grupos amino, grupos hidroxilo, grupos carboxilo, grupos (alcoxi de C1-C4)carbonilo, sustituyentes de fórmula -NH-A1 (en la que, A1 representa un residuo de un a-amino ácido) y sustituyentes de fórmula -CO-A2 (en la que, A2 representa un residuo de un a-amino ácido), o un grupo cicloalquilo de C3-C8, y X representa un átomo de azufre, un grupo sulfinilo o un grupo sulfonilo, y dicho grupo amino cíclico puede estar adicionalmente sustituido por un grupo de fórmula =CR5R6, en la que R5 y R6 son iguales o diferentes y cada uno de ellos representa de forma independiente un átomo de hidrógeno, un grupo alquilo de C1-C4, un grupo carboxilo, un grupo (alcoxi de C1-C4)carbonilo, un grupo carbamoilo, un grupo (alquilo de C1-C4) carbamoilo o un grupo di-(alquilo de C1-C4) carbamoilo; o una sal farmacológicamente aceptable del mismo.
ES99906508T 1998-02-27 1999-02-26 Compuestos amino ciclicos. Expired - Lifetime ES2196772T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4692198 1998-02-27

Publications (1)

Publication Number Publication Date
ES2196772T3 true ES2196772T3 (es) 2003-12-16

Family

ID=12760807

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99906508T Expired - Lifetime ES2196772T3 (es) 1998-02-27 1999-02-26 Compuestos amino ciclicos.

Country Status (23)

Country Link
US (1) US6610708B1 (es)
EP (1) EP1063230B1 (es)
KR (1) KR100567950B1 (es)
CN (1) CN100369896C (es)
AT (1) ATE238279T1 (es)
AU (1) AU737303B2 (es)
BR (1) BRPI9908319B8 (es)
CA (1) CA2322171C (es)
CZ (1) CZ300821B6 (es)
DE (1) DE69907166T2 (es)
DK (1) DK1063230T3 (es)
ES (1) ES2196772T3 (es)
HU (1) HU225741B1 (es)
ID (1) ID25589A (es)
IL (1) IL138068A (es)
MX (1) MXPA00008439A (es)
NO (1) NO317882B1 (es)
NZ (1) NZ506574A (es)
PL (1) PL200666B1 (es)
PT (1) PT1063230E (es)
RU (1) RU2203887C2 (es)
TR (1) TR200002505T2 (es)
WO (1) WO1999043648A1 (es)

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CN101233108A (zh) * 2005-05-27 2008-07-30 第一三共株式会社 具有取代烷基的环胺衍生物
RU2312660C2 (ru) * 2005-07-25 2007-12-20 Государственное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия" Федерального агентства по здравоохранению и социальному развитию (ГОУ ВПО ПГФА Росздрава) 4-ацетил-3-гидрокси-1-(2-гидроксиэтиламиноэтил)-5-фенил-3-пирролин-2-он, проявляющий антикоагулянтную активность
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CA2322171A1 (en) 1999-09-02
HUP0100950A2 (hu) 2001-08-28
US6610708B1 (en) 2003-08-26
HU225741B1 (en) 2007-07-30
AU737303B2 (en) 2001-08-16
BRPI9908319B1 (pt) 2012-01-10
EP1063230A1 (en) 2000-12-27
ATE238279T1 (de) 2003-05-15
KR20010041367A (ko) 2001-05-15
HUP0100950A3 (en) 2002-12-28
NO317882B1 (no) 2004-12-27
NO20004279D0 (no) 2000-08-25
PT1063230E (pt) 2003-07-31
CZ300821B6 (cs) 2009-08-19
ID25589A (id) 2000-10-19
IL138068A (en) 2005-11-20
CN100369896C (zh) 2008-02-20
RU2203887C2 (ru) 2003-05-10
DE69907166T2 (de) 2004-02-05
CZ20003119A3 (cs) 2001-01-17
TR200002505T2 (tr) 2000-12-21
EP1063230A4 (en) 2001-12-12
WO1999043648A1 (en) 1999-09-02
PL200666B1 (pl) 2009-01-30
NO20004279L (no) 2000-10-26
MXPA00008439A (es) 2002-04-24
DE69907166D1 (de) 2003-05-28
CN1298389A (zh) 2001-06-06
IL138068A0 (en) 2001-10-31
DK1063230T3 (da) 2003-07-14
PL342573A1 (en) 2001-06-18
NZ506574A (en) 2003-06-30
AU2641399A (en) 1999-09-15
CA2322171C (en) 2009-10-27
KR100567950B1 (ko) 2006-04-05
BRPI9908319B8 (pt) 2021-07-06
BRPI9908319A (pt) 2000-11-07
EP1063230B1 (en) 2003-04-23

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