AR044647A1 - Suspensiones orales estables de azitromicina en forma no dihidratada - Google Patents
Suspensiones orales estables de azitromicina en forma no dihidratadaInfo
- Publication number
- AR044647A1 AR044647A1 ARP040101979A ARP040101979A AR044647A1 AR 044647 A1 AR044647 A1 AR 044647A1 AR P040101979 A ARP040101979 A AR P040101979A AR P040101979 A ARP040101979 A AR P040101979A AR 044647 A1 AR044647 A1 AR 044647A1
- Authority
- AR
- Argentina
- Prior art keywords
- azithromycin
- suspension
- conversion
- oral suspension
- oral
- Prior art date
Links
- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 title abstract 7
- 229960004099 azithromycin Drugs 0.000 title abstract 7
- 239000000725 suspension Substances 0.000 title abstract 3
- 229940100692 oral suspension Drugs 0.000 abstract 5
- 238000006243 chemical reaction Methods 0.000 abstract 4
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 239000008135 aqueous vehicle Substances 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 229940059096 powder for oral suspension Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Polvo para suspensión oral, y a una suspensión oral preparada a partir del mismo, que comprende azitromicina en forma no dihidratada y un excipiente que estabiliza la conversión de azitromicina, donde dicho excipiente reduce la conversión de la forma de azitromicina, cuando se pone en suspensión, a otra forma de azitromicina. Procedimiento para reducir la conversión de una forma de azitromicina en forma no dihidratada, en una suspensión oral, añadiendo un excipiente reductor de la tensión superficial que reduce la tensión superficial del vehículo acuoso. Procedimiento para reducir la conversión de una azitromicina en forma no dihidratada en una suspensión oral no aromatizada, elevando la viscosidad de la suspensión oral, y en una suspensión oral aromatizada disminuyendo la viscosidad de la suspensión oral.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48783703P | 2003-07-15 | 2003-07-15 | |
| US10/636,013 US20050013835A1 (en) | 2003-07-15 | 2003-08-06 | Stable non-dihydrate azithromycin oral suspensions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR044647A1 true AR044647A1 (es) | 2005-09-21 |
Family
ID=33479339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040101979A AR044647A1 (es) | 2003-07-15 | 2004-06-08 | Suspensiones orales estables de azitromicina en forma no dihidratada |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20050013835A1 (es) |
| EP (1) | EP1498141B1 (es) |
| JP (1) | JP4208759B2 (es) |
| KR (1) | KR20060041229A (es) |
| AR (1) | AR044647A1 (es) |
| AT (1) | ATE423573T1 (es) |
| AU (1) | AU2004255032A1 (es) |
| BR (1) | BRPI0412541A (es) |
| CA (1) | CA2464831A1 (es) |
| DE (1) | DE602004019603D1 (es) |
| IL (1) | IL172491A0 (es) |
| MX (1) | MXPA06000272A (es) |
| NO (1) | NO20060611L (es) |
| RU (1) | RU2325149C2 (es) |
| TW (1) | TW200501966A (es) |
| WO (1) | WO2005004920A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2591744A1 (en) * | 2004-12-21 | 2006-06-29 | Pfizer Products Inc. | Stable non-dihydrate azithromycin oral suspensions |
| US20090318375A1 (en) * | 2005-06-08 | 2009-12-24 | Hanmi Pharm Co., Ltd | Crystalline Azithromycin L-Malate Monohydrate and Pharmaceutical Composition Containing Same |
| WO2011130707A2 (en) * | 2010-04-15 | 2011-10-20 | Chromocell Corporation | Compounds, compositions, and methods for reducing or eliminating bitter taste |
| MX346673B (es) * | 2010-04-15 | 2017-03-29 | Chromocell Corp | Compuestos, composiciones y metodos para reducir o eliminar el sabor amargo. |
| WO2013088274A1 (en) | 2011-12-14 | 2013-06-20 | Wockhardt Limited | Anhydrous amorphous azithromycin composition free of azithromycin dihydrate |
| JP5825088B2 (ja) * | 2011-12-21 | 2015-12-02 | ライオン株式会社 | 液体口腔用組成物 |
| JP6456849B2 (ja) * | 2013-03-01 | 2019-01-23 | ハーキュリーズ・インコーポレーテッドＨｅｒｃｕｌｅｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | 高められた性能及び改善された加工性を有する医薬組成物 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4474768A (en) * | 1982-07-19 | 1984-10-02 | Pfizer Inc. | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
| MX12213A (es) * | 1987-07-09 | 1993-05-01 | Pfizer | Metodo de preparacion de dihidrato de azitromicina cristalino |
| WO1989002271A1 (en) * | 1987-09-10 | 1989-03-23 | Pfizer | Azithromycin and derivatives as antiprotozoal agents |
| TW271400B (es) * | 1992-07-30 | 1996-03-01 | Pfizer | |
| US5605889A (en) * | 1994-04-29 | 1997-02-25 | Pfizer Inc. | Method of administering azithromycin |
| DE69524214T3 (de) * | 1994-05-06 | 2008-05-15 | Pfizer Inc. | Azithromycin enthaltende arzneiverabreichungsformen mit gesteuerter wirkstoffabgabe |
| AUPP437698A0 (en) * | 1998-06-30 | 1998-07-23 | Baumgart, Karl | Methods for treatment of coronary, carotid and other vascular disease |
| US6245903B1 (en) * | 1998-08-21 | 2001-06-12 | Apotex, Inc. | Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof |
| US6365574B2 (en) * | 1998-11-30 | 2002-04-02 | Teva Pharmaceutical Industries Ltd. | Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof |
| US6383527B1 (en) * | 1999-03-04 | 2002-05-07 | Nps Pharmaceuticals, Inc. | Compositions comprising valerian extracts, isovaleric acid or derivatives thereof with a NSAID |
| US6703372B1 (en) * | 1999-06-29 | 2004-03-09 | Biochemie S.A. | Macrolides |
| IT1313610B1 (it) * | 1999-08-09 | 2002-09-09 | S I F I Societa Ind Farmaceuti | Processo per la preparazione di formulazioni acquose per uso oftalmico |
| IL141438A0 (en) * | 2000-02-23 | 2002-03-10 | Pfizer Prod Inc | Method of increasing the bioavailability and tissue penetration of azithromycin |
| RU2188018C2 (ru) * | 2000-06-20 | 2002-08-27 | Нестерук Владимир Викторович | Композиционный состав антибактериального лекарственного средства |
| DE60209704T2 (de) * | 2001-05-22 | 2006-11-16 | Pfizer Products Inc., Groton | Neue kristallforme von azithromycin |
| US6861413B2 (en) * | 2001-05-22 | 2005-03-01 | Pfizer Inc. | Stable non-dihydrate azithromycin oral suspensions |
| WO2003032922A2 (en) * | 2001-10-18 | 2003-04-24 | Teva Pharmaceutical Industries Ltd. | Stabilized azithromycin compositions |
| NZ532707A (en) * | 2001-12-21 | 2006-07-28 | Pfizer Prod Inc | Directly compressible formulations of azithromycin |
| GB0214277D0 (en) * | 2002-06-20 | 2002-07-31 | Biochemie Gmbh | Organic compounds |
| GB0224197D0 (en) * | 2002-10-17 | 2002-11-27 | Biochemie Gmbh | Organic compounds |
-
2003
- 2003-08-06 US US10/636,013 patent/US20050013835A1/en not_active Abandoned
-
2004
- 2004-04-21 CA CA002464831A patent/CA2464831A1/en not_active Abandoned
- 2004-04-22 JP JP2004126485A patent/JP4208759B2/ja not_active Expired - Fee Related
- 2004-04-28 AT AT04252475T patent/ATE423573T1/de not_active IP Right Cessation
- 2004-04-28 DE DE602004019603T patent/DE602004019603D1/de not_active Expired - Fee Related
- 2004-04-28 EP EP04252475A patent/EP1498141B1/en not_active Expired - Lifetime
- 2004-04-30 TW TW093112334A patent/TW200501966A/zh unknown
- 2004-05-12 AU AU2004255032A patent/AU2004255032A1/en not_active Abandoned
- 2004-05-12 MX MXPA06000272A patent/MXPA06000272A/es unknown
- 2004-05-12 KR KR1020067000835A patent/KR20060041229A/ko not_active Ceased
- 2004-05-12 RU RU2005140740/15A patent/RU2325149C2/ru not_active IP Right Cessation
- 2004-05-12 BR BRPI0412541-0A patent/BRPI0412541A/pt not_active IP Right Cessation
- 2004-05-12 WO PCT/IB2004/001610 patent/WO2005004920A1/en not_active Ceased
- 2004-06-08 AR ARP040101979A patent/AR044647A1/es unknown
-
2005
- 2005-12-11 IL IL172491A patent/IL172491A0/en unknown
-
2006
- 2006-02-08 NO NO20060611A patent/NO20060611L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0412541A (pt) | 2006-09-19 |
| RU2005140740A (ru) | 2006-08-10 |
| NO20060611L (no) | 2006-04-10 |
| IL172491A0 (en) | 2006-04-10 |
| DE602004019603D1 (de) | 2009-04-09 |
| EP1498141B1 (en) | 2009-02-25 |
| KR20060041229A (ko) | 2006-05-11 |
| JP4208759B2 (ja) | 2009-01-14 |
| EP1498141A1 (en) | 2005-01-19 |
| RU2325149C2 (ru) | 2008-05-27 |
| AU2004255032A1 (en) | 2005-01-20 |
| US20050013835A1 (en) | 2005-01-20 |
| MXPA06000272A (es) | 2006-04-07 |
| ATE423573T1 (de) | 2009-03-15 |
| TW200501966A (en) | 2005-01-16 |
| WO2005004920A1 (en) | 2005-01-20 |
| CA2464831A1 (en) | 2005-01-15 |
| JP2005035973A (ja) | 2005-02-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |