AR045016A1 - Derivados de 5-carbamimidoi-2-metilsulfaniltiofen-3-sulfonil como inhibidores conjugados de la cascada de complemento y su uso en el tratamiento de enfermedades. - Google Patents

Derivados de 5-carbamimidoi-2-metilsulfaniltiofen-3-sulfonil como inhibidores conjugados de la cascada de complemento y su uso en el tratamiento de enfermedades.

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Publication number
AR045016A1
AR045016A1 ARP040102366A ARP040102366A AR045016A1 AR 045016 A1 AR045016 A1 AR 045016A1 AR P040102366 A ARP040102366 A AR P040102366A AR P040102366 A ARP040102366 A AR P040102366A AR 045016 A1 AR045016 A1 AR 045016A1
Authority
AR
Argentina
Prior art keywords
complement cascade
metilsulfaniltiofen
carbamimidoi
sulfonil
diseases
Prior art date
Application number
ARP040102366A
Other languages
English (en)
Original Assignee
Dimensional Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dimensional Pharm Inc filed Critical Dimensional Pharm Inc
Publication of AR045016A1 publication Critical patent/AR045016A1/es

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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
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  • Health & Medical Sciences (AREA)
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  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
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Abstract

Inhibidores conjugados de la cascada de complemento, y a un método para tratar a un paciente utilizando un inhibidor conjugado de la cascada de complemento. Reivindicación 1: Una composición que comprende un inhibidor conjugado del complemento. Reivindicación 2: La composición de la reivindicación 1 que presenta un grupo de fórmulas: (D-L)n-P o D-Ln-Pn', en los cuales: D se selecciona independientemente en cada aparición de compuestos que son inhibidores de la cascada de complemento; L es un grupo conector opcional (en cada aparición) seleccionado independientemente en cada aparición; n es 1, 2, 3, 4, 5 ó 6; n' es 1, 2, 3 ó 4; y P se selecciona independientemente en cada aparición de compuestos que mejoran las propiedades farmacocinéticas de D.
ARP040102366A 2003-07-03 2004-07-05 Derivados de 5-carbamimidoi-2-metilsulfaniltiofen-3-sulfonil como inhibidores conjugados de la cascada de complemento y su uso en el tratamiento de enfermedades. AR045016A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48485403P 2003-07-03 2003-07-03
US57137404P 2004-05-14 2004-05-14
US10/869,430 US7482376B2 (en) 2003-07-03 2004-06-16 Conjugated complement cascade inhibitors

Publications (1)

Publication Number Publication Date
AR045016A1 true AR045016A1 (es) 2005-10-12

Family

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ARP040102366A AR045016A1 (es) 2003-07-03 2004-07-05 Derivados de 5-carbamimidoi-2-metilsulfaniltiofen-3-sulfonil como inhibidores conjugados de la cascada de complemento y su uso en el tratamiento de enfermedades.

Country Status (14)

Country Link
US (1) US7482376B2 (es)
EP (1) EP1644046A2 (es)
JP (1) JP2007535474A (es)
KR (1) KR20060032994A (es)
AR (1) AR045016A1 (es)
AU (1) AU2004253474B2 (es)
BR (1) BRPI0412298A (es)
CA (1) CA2530480A1 (es)
HR (1) HRP20060007A2 (es)
MX (1) MXPA06000277A (es)
MY (1) MY138732A (es)
NZ (1) NZ544407A (es)
TW (1) TW200510397A (es)
WO (1) WO2005002627A2 (es)

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KR20050040832A (ko) 2001-10-29 2005-05-03 넥타르 테라퓨틱스 에이엘, 코포레이션 단백질 키나아제 ｃ 억제제의 중합체 공액
DE60219677T2 (de) 2001-10-30 2008-05-15 Nektar Therapeutics Al, Corp., Huntsville Wasserlösliche polymerkonjugate von retinoesäure
UA80131C2 (en) * 2002-05-28 2007-08-27 Dimensional Pharm Inc Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions
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TW200510397A (en) 2005-03-16
MXPA06000277A (es) 2006-07-03
HRP20060007A2 (en) 2006-08-31
AU2004253474B2 (en) 2010-12-23
US20050004031A1 (en) 2005-01-06
EP1644046A2 (en) 2006-04-12
NZ544407A (en) 2009-03-31
WO2005002627A2 (en) 2005-01-13
KR20060032994A (ko) 2006-04-18
WO2005002627A3 (en) 2005-07-28
JP2007535474A (ja) 2007-12-06
MY138732A (en) 2009-07-31
BRPI0412298A (pt) 2006-09-19
US7482376B2 (en) 2009-01-27
AU2004253474A1 (en) 2005-01-13

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