AR048573A1 - Compuesto de 8-azoniabiciclo[3.2.1]octano sustituido en la posicion 3, composicion farmceutica que lo comprende y su uso para preparar esta ultima - Google Patents
Compuesto de 8-azoniabiciclo[3.2.1]octano sustituido en la posicion 3, composicion farmceutica que lo comprende y su uso para preparar esta ultimaInfo
- Publication number
- AR048573A1 AR048573A1 ARP040102500A ARP040102500A AR048573A1 AR 048573 A1 AR048573 A1 AR 048573A1 AR P040102500 A ARP040102500 A AR P040102500A AR P040102500 A ARP040102500 A AR P040102500A AR 048573 A1 AR048573 A1 AR 048573A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- pharmaceutical composition
- formula
- prepare
- acetylcholine
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 239000002131 composite material Substances 0.000 title 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 abstract 2
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 abstract 2
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 abstract 2
- 229960004373 acetylcholine Drugs 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 102000005962 receptors Human genes 0.000 abstract 2
- 108020003175 receptors Proteins 0.000 abstract 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- -1 8-azoniabicyclo [3.2.1] octane compound Chemical group 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000018569 Respiratory Tract disease Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Un compuesto de 8-azoniabiciclo[3.2.1]octano sustituido en la posicion 3 de la formula (1) que sigue: en la que R2 y R3 se seleccionan, independientemente, del grupo constituido por grupos alquilos inferiores de cadena lineal o ramificada (C1-6), grupos cicloalquilos (C5-6), cicloalquil-alquilo (C6-10), 2-tienilo, 2-piridilo, fenilo, fenilo sustituido con un grupo alquilo que no tiene más de 4 átomos de C y fenilo sustituido con un grupo alcoxi que no tiene más de 4 átomos de C; y Xö representa un anion asociado con la carga positiva del átomo de N. Composicion farmacéutica para el tratamiento de enfermedades mediadas por los receptores muscarínicos de la acetilcolina, que comprende un compuesto de la formula (1) y un vehículo del mismo farmacéuticamente aceptable. Uso de un compuesto de la formula (1) para preparar una composicion farmacéutica util para inhibir la union de la acetilcolina a sus receptores en un mamífero que lo necesite, mediante la administracion de una cantidad segura y eficaz de dicho compuesto. De esta forma se puede tratar una enfermedad mediada por un receptor muscarínico de la acetilcolina, en el que la acetilcolina se une a dicho receptor, tales como las enfermedades del tracto respiratorio.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48806103P | 2003-07-17 | 2003-07-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR048573A1 true AR048573A1 (es) | 2006-05-10 |
Family
ID=34102742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040102500A AR048573A1 (es) | 2003-07-17 | 2004-07-15 | Compuesto de 8-azoniabiciclo[3.2.1]octano sustituido en la posicion 3, composicion farmceutica que lo comprende y su uso para preparar esta ultima |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20060160844A1 (es) |
| EP (1) | EP1648462A4 (es) |
| JP (1) | JP2007535477A (es) |
| KR (1) | KR20060054317A (es) |
| CN (1) | CN1822840A (es) |
| AR (1) | AR048573A1 (es) |
| AU (1) | AU2004259239A1 (es) |
| BR (1) | BRPI0412679A (es) |
| CA (1) | CA2532379A1 (es) |
| IL (1) | IL172911A0 (es) |
| IS (1) | IS8297A (es) |
| MA (1) | MA27973A1 (es) |
| MX (1) | MXPA06000664A (es) |
| NO (1) | NO20060776L (es) |
| PE (1) | PE20050711A1 (es) |
| RU (1) | RU2006104854A (es) |
| TW (1) | TW200519109A (es) |
| WO (1) | WO2005009440A1 (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200519108A (en) * | 2003-07-17 | 2005-06-16 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists |
| AP2007004239A0 (en) * | 2003-10-14 | 2007-12-31 | Glaxo Group Ltd | Muscarinic acetycholine receptor antagonists |
| BRPI0415281A (pt) * | 2003-10-17 | 2006-12-19 | Glaxo Group Ltd | antagonistas de receptor de acetilcolina muscarìnico |
| PE20050489A1 (es) * | 2003-11-04 | 2005-09-02 | Glaxo Group Ltd | Antagonistas de receptores de acetilcolina muscarinicos |
| US20090253908A1 (en) * | 2004-03-11 | 2009-10-08 | Glaxo Group Limited | Novel m3 muscarinic acetylchoine receptor antagonists |
| WO2005095407A1 (en) * | 2004-03-17 | 2005-10-13 | Glaxo Group Limited | M3 muscarinic acetylcholine receptor antagonists |
| EP1725238A4 (en) * | 2004-03-17 | 2009-04-01 | Glaxo Group Ltd | M 3 MUSCARINACETYLCHOLINE RECEPTOR ANTAGONISTS |
| PE20060259A1 (es) | 2004-04-27 | 2006-03-25 | Glaxo Group Ltd | Compuestos de quinuclidina como antagonistas del receptor de acetilcolina muscarinico |
| JP2007537261A (ja) * | 2004-05-13 | 2007-12-20 | グラクソ グループ リミテッド | ムスカリン性アセチルコリン受容体アンタゴニスト |
| US7932247B2 (en) * | 2004-11-15 | 2011-04-26 | Glaxo Group Limited | M3 muscarinic acetylcholine receptor antagonists |
| WO2006135715A1 (en) * | 2005-06-10 | 2006-12-21 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Benztropinamine analogs as dopamine uptake inhibitors |
| WO2007016639A2 (en) * | 2005-08-02 | 2007-02-08 | Glaxo Group Limited | M3 muscarinic acetylcholine receptor antagonists |
| WO2007022351A2 (en) | 2005-08-18 | 2007-02-22 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
| WO2007025055A2 (en) | 2005-08-24 | 2007-03-01 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Benztropine compounds and uses thereof as dopamine uptake inhibitors |
| AR070563A1 (es) | 2008-02-06 | 2010-04-21 | Glaxo Group Ltd | Compuesto de un biciclo condensado pirazol-piridin-amina, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para el tratamiento de enfermedades respiratorias. |
| UY31637A1 (es) | 2008-02-06 | 2009-08-03 | Farmacoforos duales-antagonistas muscarinicos de pde4 | |
| PE20091553A1 (es) | 2008-02-06 | 2009-10-30 | Glaxo Group Ltd | Farmacoforos duales - antagonistas muscarinicos de pde4 |
| WO2010094643A1 (en) | 2009-02-17 | 2010-08-26 | Glaxo Group Limited | Quinoline derivatives and their uses for rhinitis and urticaria |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2800482A (en) * | 1955-07-01 | 1957-07-23 | Smith Kline French Lab | Olefinic derivatives of 8-alkylnortropanes and the acid and quaternary ammonium salts thereof |
| US2800478A (en) * | 1955-07-01 | 1957-07-23 | Smith Kline French Lab | 3-substituted-8-alkylnortropanes and the acid and quaternary ammonium salts thereof |
| ES2165768B1 (es) * | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| AU2001271027B2 (en) * | 2000-07-11 | 2005-07-07 | Msd K.K. | Ester derivatives |
| US6608055B2 (en) * | 2001-06-22 | 2003-08-19 | Boehringer Ingelheim Pharma Kg | Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition |
| JP2005512974A (ja) * | 2001-10-17 | 2005-05-12 | ユ セ ベ ソシエテ アノニム | キヌクリジン誘導体、その調製方法、及びｍ２及び／又はｍ３ムスカリン受容体阻害剤としてのその使用 |
| US7345060B2 (en) * | 2003-11-21 | 2008-03-18 | Theravance, Inc. | Compounds having β2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
-
2004
- 2004-07-15 PE PE2004000675A patent/PE20050711A1/es not_active Application Discontinuation
- 2004-07-15 TW TW093121064A patent/TW200519109A/zh unknown
- 2004-07-15 AR ARP040102500A patent/AR048573A1/es unknown
- 2004-07-16 RU RU2006104854/04A patent/RU2006104854A/ru not_active Application Discontinuation
- 2004-07-16 KR KR1020067001003A patent/KR20060054317A/ko not_active Withdrawn
- 2004-07-16 AU AU2004259239A patent/AU2004259239A1/en not_active Abandoned
- 2004-07-16 JP JP2006520388A patent/JP2007535477A/ja active Pending
- 2004-07-16 MX MXPA06000664A patent/MXPA06000664A/es unknown
- 2004-07-16 US US10/565,049 patent/US20060160844A1/en not_active Abandoned
- 2004-07-16 BR BRPI0412679-3A patent/BRPI0412679A/pt not_active IP Right Cessation
- 2004-07-16 CN CNA2004800206530A patent/CN1822840A/zh active Pending
- 2004-07-16 EP EP04778510A patent/EP1648462A4/en not_active Withdrawn
- 2004-07-16 CA CA002532379A patent/CA2532379A1/en not_active Abandoned
- 2004-07-16 WO PCT/US2004/023042 patent/WO2005009440A1/en not_active Ceased
-
2005
- 2005-12-29 IL IL172911A patent/IL172911A0/en unknown
-
2006
- 2006-01-06 MA MA28706A patent/MA27973A1/fr unknown
- 2006-02-13 IS IS8297A patent/IS8297A/is unknown
- 2006-02-17 NO NO20060776A patent/NO20060776L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1648462A4 (en) | 2009-04-08 |
| MXPA06000664A (es) | 2006-03-30 |
| RU2006104854A (ru) | 2006-06-27 |
| AU2004259239A1 (en) | 2005-02-03 |
| PE20050711A1 (es) | 2005-09-10 |
| IL172911A0 (en) | 2006-06-11 |
| IS8297A (is) | 2006-02-13 |
| NO20060776L (no) | 2006-04-11 |
| CA2532379A1 (en) | 2005-02-03 |
| BRPI0412679A (pt) | 2006-10-03 |
| MA27973A1 (fr) | 2006-07-03 |
| EP1648462A1 (en) | 2006-04-26 |
| TW200519109A (en) | 2005-06-16 |
| KR20060054317A (ko) | 2006-05-22 |
| CN1822840A (zh) | 2006-08-23 |
| WO2005009440A1 (en) | 2005-02-03 |
| JP2007535477A (ja) | 2007-12-06 |
| US20060160844A1 (en) | 2006-07-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |