BRPI0718714B8 - arilamidas substituídas por tiazol e oxazol, seu uso e composição farmacêutica que as compreende - Google Patents

arilamidas substituídas por tiazol e oxazol, seu uso e composição farmacêutica que as compreende

Info

Publication number
BRPI0718714B8
BRPI0718714B8 BRPI0718714A BRPI0718714A BRPI0718714B8 BR PI0718714 B8 BRPI0718714 B8 BR PI0718714B8 BR PI0718714 A BRPI0718714 A BR PI0718714A BR PI0718714 A BRPI0718714 A BR PI0718714A BR PI0718714 B8 BRPI0718714 B8 BR PI0718714B8
Authority
BR
Brazil
Prior art keywords
thiazole
pharmaceutical composition
oxazole substituted
substituted arylamides
formula
Prior art date
Application number
BRPI0718714A
Other languages
English (en)
Inventor
Chen Li
Feng Lichun
Patrick Dillon Michael
Yang Minmin
Charles Hawley Ronald
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0718714A2 publication Critical patent/BRPI0718714A2/pt
Publication of BRPI0718714B1 publication Critical patent/BRPI0718714B1/pt
Publication of BRPI0718714B8 publication Critical patent/BRPI0718714B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

arilamidas substituídas por tiazol e oxazol. compostos da fórmula l: i ou um sal farmaceuticamente aceitável dos mesmos, em que: r1 é um grupo de fórmula a ou fórmula b; a; b; e x, r2, r3, r4, r5, r6, ra e rb são como definidos aqui. são também fornecidos métodos de usar os compostos para tratar doenças mediadas por um antagonista de receptor p2x3 e/ou p2x2/3 e métodos de preparar os compostos objetos.
BRPI0718714A 2006-11-09 2007-10-31 arilamidas substituídas por tiazol e oxazol, seu uso e composição farmacêutica que as compreende BRPI0718714B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85828306P 2006-11-09 2006-11-09
US60/858,283 2006-11-09
PCT/EP2007/061771 WO2008055840A1 (en) 2006-11-09 2007-10-31 Thiazole and oxazole-substituted arylamides

Publications (3)

Publication Number Publication Date
BRPI0718714A2 BRPI0718714A2 (pt) 2013-11-26
BRPI0718714B1 BRPI0718714B1 (pt) 2020-09-29
BRPI0718714B8 true BRPI0718714B8 (pt) 2021-05-25

Family

ID=39149180

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0718714A BRPI0718714B8 (pt) 2006-11-09 2007-10-31 arilamidas substituídas por tiazol e oxazol, seu uso e composição farmacêutica que as compreende

Country Status (17)

Country Link
US (1) US7786110B2 (pt)
EP (1) EP2091927B1 (pt)
JP (1) JP5084839B2 (pt)
KR (2) KR101152714B1 (pt)
CN (1) CN101528717B (pt)
AR (1) AR063601A1 (pt)
AT (1) ATE517097T1 (pt)
AU (1) AU2007316681B2 (pt)
BR (1) BRPI0718714B8 (pt)
CA (1) CA2668399C (pt)
CL (1) CL2007003192A1 (pt)
ES (1) ES2367455T3 (pt)
IL (1) IL198301A (pt)
MX (1) MX2009004900A (pt)
PE (1) PE20081475A1 (pt)
TW (1) TW200829584A (pt)
WO (1) WO2008055840A1 (pt)

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* Cited by examiner, † Cited by third party
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JP5084839B2 (ja) 2006-11-09 2012-11-28 エフ．ホフマン−ラ ロシュ アーゲー チアゾール及びオキサゾール置換アリールアミド
US8501933B2 (en) * 2006-11-09 2013-08-06 Roche Palo Alto Llc Thiazole and oxazole-substituted arylamides as P2X3 and P2X2/3 antagonists
EP2215048B1 (en) * 2007-10-31 2015-10-28 Merck Sharp & Dohme Corp. P2x3 receptor antagonists for treatment of pain
WO2009058298A1 (en) * 2007-10-31 2009-05-07 Merck & Co., Inc. P2x3, receptor antagonists for treatment of pain
ES2570628T3 (es) * 2007-12-17 2016-05-19 Hoffmann La Roche Nuevas arilamidas con sustitución imidazol
KR101405746B1 (ko) * 2007-12-17 2014-06-10 에프. 호프만-라 로슈 아게 트리아졸 치환된 아릴아미드 유도체 및 ｐ２ｘ３ 및/또는 ｐ２ｘ２／３ 퓨린성 수용체 길항제로서의 용도
BR122019016794B8 (pt) * 2007-12-17 2021-07-27 Hoffmann La Roche derivados de arilamida substituídos por tetrazol, composição farmacêutica que os compreende e seu uso no tratamento de uma condição inflamatória e/ou autoimune
DK2234976T3 (da) * 2007-12-17 2013-06-24 Hoffmann La Roche Nye pyrazol-substituerede arylamider
WO2009110985A2 (en) 2008-02-29 2009-09-11 Renovis, Inc. Amide compounds, compositions and uses thereof
US20110237578A1 (en) * 2008-09-18 2011-09-29 Zhi-Liang Wei Amide compounds, compositions and uses thereof
BRPI0922645A2 (pt) * 2008-12-16 2019-09-24 Hoffmann La Roche "arilamidas tiadiazol substituídas".
CA2754654A1 (en) * 2009-06-22 2010-12-29 F. Hoffmann-La Roche Ag Novel oxazolone and pyrrolidinone-substituted arylamides
EP2445868B1 (en) 2009-06-22 2013-12-18 F.Hoffmann-La Roche Ag Biphenyl amides useful as p2x3 and/or p2x2/3 receptors modulators
WO2011153359A1 (en) * 2010-06-04 2011-12-08 Albany Molecular Research, Inc. Glycine transporter-1 inhibitors, methods of making them, and uses thereof
US8698952B2 (en) 2011-10-31 2014-04-15 Lg Innotek Co., Ltd. Camera module
WO2014086746A1 (de) * 2012-12-07 2014-06-12 Bayer Cropscience Ag N-(isoxazol-3-yl)-arylcarbonsäureamide und ihre verwendung als herbizide
EP2905282A1 (en) * 2014-02-05 2015-08-12 AXXAM S.p.A. Substituted thiazole or oxazole as P2X7 receptor antagonists
US10183937B2 (en) 2014-12-09 2019-01-22 Bayer Aktiengesellschaft 1,3-thiazol-2-yl substituted benzamides
CU24411B1 (es) 2014-12-09 2019-05-03 Bayer Ag Compuesto derivado de benzamida sustituida con 1,3-tiazol-2-ilo útil para el tratamiento de trastornos neurogénicos
KR20160138877A (ko) 2015-05-26 2016-12-06 (주)펠리테크 마이크로파를 이용한 세라믹 발열 하이브리드 건조기
US10138241B2 (en) 2016-09-15 2018-11-27 Boehringer Ingelheim International Gmbh Substituted benzamides as RIPK2 inhibitors
CN109996546B (zh) * 2016-09-30 2023-06-27 阿沙纳生物科学公司 P2x3和/或p2x2/3化合物及方法
WO2020002090A1 (de) 2018-06-25 2020-01-02 Bayer Aktiengesellschaft Substituierte thiazolylpyrrolone sowie deren salze und ihre verwendung als herbizide wirkstoffe
EP3757103A1 (en) * 2019-06-27 2020-12-30 Bayer AG Analogues of 3-(5-methyl-1,3-thiazol-2-yl)-n-{(1r)-1-[2-(trifluoro-methyl)pyrimidin-5-yl]ethyl}benzamide for the treatment of neurogenic diseases
WO2022063205A1 (zh) * 2020-09-24 2022-03-31 中国医药研究开发中心有限公司 芳基甲酰胺类化合物及其制备方法和医药用途

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SA05260265A (ar) * 2004-08-30 2005-12-03 استرازينيكا ايه بي مركبات جديدة
ES2596706T3 (es) * 2006-06-29 2017-01-11 F. Hoffmann-La Roche Ag Arilamidas con sustitución de tetrazol
JP5084839B2 (ja) 2006-11-09 2012-11-28 エフ．ホフマン−ラ ロシュ アーゲー チアゾール及びオキサゾール置換アリールアミド
WO2009058298A1 (en) 2007-10-31 2009-05-07 Merck & Co., Inc. P2x3, receptor antagonists for treatment of pain

Also Published As

Publication number Publication date
TW200829584A (en) 2008-07-16
CA2668399C (en) 2015-01-27
CA2668399A1 (en) 2008-05-15
CN101528717B (zh) 2013-04-24
JP2010509264A (ja) 2010-03-25
AU2007316681A1 (en) 2008-05-15
EP2091927A1 (en) 2009-08-26
ATE517097T1 (de) 2011-08-15
PE20081475A1 (es) 2008-10-18
KR20090086073A (ko) 2009-08-10
BRPI0718714B1 (pt) 2020-09-29
BRPI0718714A2 (pt) 2013-11-26
US20080132494A1 (en) 2008-06-05
WO2008055840A1 (en) 2008-05-15
MX2009004900A (es) 2009-05-19
EP2091927B1 (en) 2011-07-20
IL198301A0 (en) 2010-02-17
AR063601A1 (es) 2009-02-04
IL198301A (en) 2013-06-27
CL2007003192A1 (es) 2008-06-20
US7786110B2 (en) 2010-08-31
KR101152714B1 (ko) 2012-06-18
KR20120034766A (ko) 2012-04-12
JP5084839B2 (ja) 2012-11-28
ES2367455T3 (es) 2011-11-03
AU2007316681B2 (en) 2013-01-24
KR101165936B1 (ko) 2012-07-19
CN101528717A (zh) 2009-09-09

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