AR049583A2 - Compuesto derivado de pirazolo-pirimidina, composicion farmaceutica y el uso de dicho compuesto en la fabricacion de medicamentos - Google Patents

Compuesto derivado de pirazolo-pirimidina, composicion farmaceutica y el uso de dicho compuesto en la fabricacion de medicamentos

Info

Publication number: AR049583A2
Authority: AR; Argentina
Prior art keywords: alkyl; cycloalkyl; haloalkyl; optionally substituted; case
Prior art date: 1996-07-24

Application number

ARP050102868A

Other languages

English (en)

Spanish (es)

Inventor

Liqi He

Paul Joseph Gilligan

Argyrios Georgios Arvanitis

Original Assignee

Bristol Myers Squibb Pharma Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-24

Filing date

2005-07-11

Publication date

2006-08-16

1997-07-23 Priority claimed from US08/899,242 external-priority patent/US6124289A/en

2005-07-11 Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co

2006-08-16 Publication of AR049583A2 publication Critical patent/AR049583A2/es

Links

150000001875 compounds Chemical class 0.000 title abstract 8
239000003814 drug Substances 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 15
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 14
125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 14
125000001475 halogen functional group Chemical group 0.000 abstract 11
-1 2,3-dihydrobenzofuranyl Chemical group 0.000 abstract 10
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 10
125000001072 heteroaryl group Chemical group 0.000 abstract 10
125000003118 aryl group Chemical group 0.000 abstract 8
125000000623 heterocyclic group Chemical group 0.000 abstract 7
125000001424 substituent group Chemical group 0.000 abstract 7
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 6
125000000304 alkynyl group Chemical group 0.000 abstract 6
125000004093 cyano group Chemical group *C#N 0.000 abstract 6
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 5
125000001624 naphthyl group Chemical group 0.000 abstract 5
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 4
125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 abstract 4
125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 abstract 4
125000002541 furyl group Chemical group 0.000 abstract 4
125000001544 thienyl group Chemical group 0.000 abstract 4
125000004306 triazinyl group Chemical group 0.000 abstract 4
125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 3
125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 3
125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 3
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
125000003342 alkenyl group Chemical group 0.000 abstract 3
125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 3
125000004076 pyridyl group Chemical group 0.000 abstract 3
125000000714 pyrimidinyl group Chemical group 0.000 abstract 3
125000005329 tetralinyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 abstract 3
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
125000000081 (C5-C8) cycloalkenyl group Chemical group 0.000 abstract 2
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 2
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
125000004966 cyanoalkyl group Chemical group 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
208000035475 disorder Diseases 0.000 abstract 2
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 abstract 1
125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 1
125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 1
PVOAHINGSUIXLS-UHFFFAOYSA-N 1-Methylpiperazine Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 abstract 1
208000017194 Affective disease Diseases 0.000 abstract 1
206010053164 Alcohol withdrawal syndrome Diseases 0.000 abstract 1
208000024827 Alzheimer disease Diseases 0.000 abstract 1
208000000103 Anorexia Nervosa Diseases 0.000 abstract 1
208000019901 Anxiety disease Diseases 0.000 abstract 1
125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 abstract 1
206010013754 Drug withdrawal syndrome Diseases 0.000 abstract 1
208000030814 Eating disease Diseases 0.000 abstract 1
208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
206010019233 Headaches Diseases 0.000 abstract 1
241000725303 Human immunodeficiency virus Species 0.000 abstract 1
208000013016 Hypoglycemia Diseases 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
208000019022 Mood disease Diseases 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
206010033799 Paralysis Diseases 0.000 abstract 1
208000006011 Stroke Diseases 0.000 abstract 1
208000007271 Substance Withdrawal Syndrome Diseases 0.000 abstract 1
208000025865 Ulcer Diseases 0.000 abstract 1
208000029650 alcohol withdrawal Diseases 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 abstract 1
210000004556 brain Anatomy 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
OGEBRHQLRGFBNV-RZDIXWSQSA-N chembl2036808 Chemical compound C12=NC(NCCCC)=NC=C2C(C=2C=CC(F)=CC=2)=NN1C[C@H]1CC[C@H](N)CC1 OGEBRHQLRGFBNV-RZDIXWSQSA-N 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
235000014632 disordered eating Nutrition 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
206010013663 drug dependence Diseases 0.000 abstract 1
206010015037 epilepsy Diseases 0.000 abstract 1
230000035558 fertility Effects 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
231100000869 headache Toxicity 0.000 abstract 1
230000002008 hemorrhagic effect Effects 0.000 abstract 1
230000002218 hypoglycaemic effect Effects 0.000 abstract 1
125000002883 imidazolyl group Chemical group 0.000 abstract 1
230000008629 immune suppression Effects 0.000 abstract 1
125000001041 indolyl group Chemical group 0.000 abstract 1
230000036512 infertility Effects 0.000 abstract 1
208000000509 infertility Diseases 0.000 abstract 1
231100000535 infertility Toxicity 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
208000014674 injury Diseases 0.000 abstract 1
208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 1
125000000842 isoxazolyl group Chemical group 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
125000002971 oxazolyl group Chemical group 0.000 abstract 1
208000028173 post-traumatic stress disease Diseases 0.000 abstract 1
230000000750 progressive effect Effects 0.000 abstract 1
125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 abstract 1
125000003373 pyrazinyl group Chemical group 0.000 abstract 1
125000003226 pyrazolyl group Chemical group 0.000 abstract 1
125000000168 pyrrolyl group Chemical group 0.000 abstract 1
125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
208000011117 substance-related disease Diseases 0.000 abstract 1
125000000335 thiazolyl group Chemical group 0.000 abstract 1
BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 abstract 1
230000008733 trauma Effects 0.000 abstract 1
231100000397 ulcer Toxicity 0.000 abstract 1
230000009385 viral infection Effects 0.000 abstract 1

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Detergent Compositions (AREA)
Coloring (AREA)

ARP050102868A 1996-07-24 2005-07-11 Compuesto derivado de pirazolo-pirimidina, composicion farmaceutica y el uso de dicho compuesto en la fabricacion de medicamentos AR049583A2 (es)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US2329096P	1996-07-24	1996-07-24
US68604796A	1996-07-24	1996-07-24
US08/899,242 US6124289A (en)	1996-07-24	1997-07-23	Azolo triazines and pyrimidines

Publications (1)

Publication Number	Publication Date
AR049583A2 true AR049583A2 (es)	2006-08-16

Family

ID=27362048

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ARP050102868A AR049583A2 (es)	1996-07-24	2005-07-11	Compuesto derivado de pirazolo-pirimidina, composicion farmaceutica y el uso de dicho compuesto en la fabricacion de medicamentos

Country Status (15)

Country	Link
JP (2)	JP4704521B2 (cs)
CN (3)	CN1104432C (cs)
AR (1)	AR049583A2 (cs)
BR (1)	BR9710544A (cs)
CA (1)	CA2259583C (cs)
CZ (1)	CZ299451B6 (cs)
EA (1)	EA004403B1 (cs)
EE (1)	EE04316B1 (cs)
HR (1)	HRP970413A2 (cs)
IL (4)	IL127871A0 (cs)
NO (1)	NO315610B3 (cs)
NZ (1)	NZ333777A (cs)
PL (1)	PL195762B1 (cs)
SI (1)	SI9720045B (cs)
SK (1)	SK286461B6 (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ528207A (en) *	2001-03-13	2006-02-24	Bristol Myers Squibb Pharma Co	4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-A]-1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands
WO2004110454A1 (ja) *	2003-06-13	2004-12-23	Ishihara Sangyo Kaisha, Ltd.	アデノシンＡ2ａ受容体アゴニストの投与が必要な疾患を治療又は予防するための組成物
US7329662B2 (en) *	2003-10-03	2008-02-12	Hoffmann-La Roche Inc.	Pyrazolo-pyridine
GB0519957D0 (en) *	2005-09-30	2005-11-09	Sb Pharmco Inc	Chemical compound
HRP20100516T1 (hr) *	2006-09-20	2010-10-31	Eli Lilly And Company	Tiazolpirazolopirimidini kao antagonisti receptora crf1
CN103694242B (zh) *	2013-12-10	2016-01-06	昆明翔昊科技有限公司	吡唑并嘧啶类化合物及其药物组合物和其在制药中的应用
WO2019036503A1 (en)	2017-08-14	2019-02-21	Spruce Biosciences, Inc.	CORTICOTROPIN RELEASE FACTOR RECEPTOR ANTAGONISTS
CN112028891B (zh) *	2019-07-30	2022-07-05	厦门宝太生物科技股份有限公司	腺苷受体拮抗剂
KR20240023691A (ko)	2020-08-12	2024-02-22	스프루스 바이오사이언시스 인코포레이티드	다낭성 난소 증후군을 치료하기 위한 방법 및 조성물
US11708372B2 (en)	2021-11-19	2023-07-25	Spruce Biosciences, Inc.	Crystalline composition of tildacerfont and methods of use and preparation thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3995039A (en) *	1975-05-27	1976-11-30	Merck & Co., Inc.	Pyrazolo [1,5-a] [1,3,5] triazines
JPS6157587A (ja) *	1984-08-29	1986-03-24	Shionogi & Co Ltd	縮合複素環誘導体および抗潰瘍剤
US4824834A (en) *	1986-10-31	1989-04-25	Otsuka Pharmaceutical Company, Limited	Pyrazolotriazine compounds
JP2691317B2 (ja) *	1989-08-25	1997-12-17	株式会社大塚製薬工場	４―ヒドロキシ―８―（３―低級アルコキシ―４―フェニルスルフィニルフェニル）ピラゾロ〔１，５―ａ〕―１，３，５―トリアジン光学活性体の塩類及びその製造方法
WO1992006096A1 (fr) *	1990-10-09	1992-04-16	Otsuka Pharmaceutical Co., Ltd.	Derive de pyrimidine, production de ce derive et inhibiteur d'androgenes
AU651986B2 (en) *	1991-04-22	1994-08-11	Otsuka Pharmaceutical Factory, Inc.	Pyrazolo{1,5-a}pyrimidine derivative and anti-inflammatory containing the same
US5356897A (en) *	1991-09-09	1994-10-18	Fujisawa Pharmaceutical Co., Ltd.	3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines

1997
- 1997-07-23 EA EA199900158A patent/EA004403B1/ru not_active IP Right Cessation
- 1997-07-23 JP JP50723398A patent/JP4704521B2/ja not_active Expired - Fee Related
- 1997-07-23 CZ CZ0018499A patent/CZ299451B6/cs not_active IP Right Cessation
- 1997-07-23 CN CN97196525A patent/CN1104432C/zh not_active Expired - Lifetime
- 1997-07-23 BR BR9710544A patent/BR9710544A/pt not_active IP Right Cessation
- 1997-07-23 EE EEP199900019A patent/EE04316B1/xx unknown
- 1997-07-23 NZ NZ333777A patent/NZ333777A/en not_active IP Right Cessation
- 1997-07-23 PL PL97331523A patent/PL195762B1/pl unknown
- 1997-07-23 IL IL12787197A patent/IL127871A0/xx unknown
- 1997-07-23 CA CA002259583A patent/CA2259583C/en not_active Expired - Lifetime
- 1997-07-23 SI SI9720045A patent/SI9720045B/sl active Search and Examination
- 1997-07-23 SK SK97-99A patent/SK286461B6/sk not_active IP Right Cessation
- 1997-07-24 HR HRP970413 patent/HRP970413A2/hr not_active Application Discontinuation
1998
- 1998-12-30 IL IL127871A patent/IL127871A/en not_active IP Right Cessation
1999
- 1999-01-21 NO NO19990264A patent/NO315610B3/no not_active IP Right Cessation
2001
- 2001-05-30 CN CN 01120849 patent/CN1250223C/zh not_active Expired - Lifetime
2002
- 2002-04-25 CN CN 02118589 patent/CN1388126A/zh active Pending
- 2002-06-11 IL IL150163A patent/IL150163A/en not_active IP Right Cessation
2004
- 2004-07-23 JP JP2004216483A patent/JP4194539B2/ja not_active Expired - Fee Related
- 2004-10-12 IL IL164513A patent/IL164513A/en not_active IP Right Cessation
2005
- 2005-07-11 AR ARP050102868A patent/AR049583A2/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
IL164513A (en)	2010-04-29
CZ18499A3 (cs)	1999-11-17
JP4704521B2 (ja)	2011-06-15
CN1250223C (zh)	2006-04-12
SK9799A3 (sk)	2005-04-01
EE9900019A (et)	1999-08-16
IL164513A0 (en)	2005-12-18
NO990264L (no)	1999-03-10
NO990264D0 (no)	1999-01-21
PL195762B1 (pl)	2007-10-31
IL127871A0 (en)	1999-10-28
BR9710544A (pt)	1999-08-17
CZ299451B6 (cs)	2008-07-30
EA199900158A1 (ru)	1999-10-28
HRP970413A2 (en)	1998-10-31
IL150163A (en)	2010-12-30
NO315610B1 (no)	2003-09-29
CN1225637A (zh)	1999-08-11
EA004403B1 (ru)	2004-04-29
JP2002513382A (ja)	2002-05-08
CA2259583C (en)	2009-11-17
EE04316B1 (et)	2004-06-15
SI9720045A (sl)	1999-10-31
CN1327793A (zh)	2001-12-26
SK286461B6 (sk)	2008-10-07
SI9720045B (sl)	2008-02-29
JP4194539B2 (ja)	2008-12-10
JP2005097257A (ja)	2005-04-14
IL127871A (en)	2010-04-29
CN1104432C (zh)	2003-04-02
CN1388126A (zh)	2003-01-01
CA2259583A1 (en)	1998-01-29
PL331523A1 (en)	1999-07-19
NO315610B3 (no)	2003-09-29
NZ333777A (en)	2000-07-28

Legal Events

Date	Code	Title	Description
2008-11-03	FA	Abandonment or withdrawal

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