AR059176A1 - Compuesto de indol, composicion farmaceutica que lo comprende, metodo para prepararlo y su uso para preparar dicha composicion y para la manufactura de un medicamento para el tratamiento o prevencion de leiomiomas y endometriosis. - Google Patents

Compuesto de indol, composicion farmaceutica que lo comprende, metodo para prepararlo y su uso para preparar dicha composicion y para la manufactura de un medicamento para el tratamiento o prevencion de leiomiomas y endometriosis.

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Publication number
AR059176A1
AR059176A1 ARP070100303A ARP070100303A AR059176A1 AR 059176 A1 AR059176 A1 AR 059176A1 AR P070100303 A ARP070100303 A AR P070100303A AR P070100303 A ARP070100303 A AR P070100303A AR 059176 A1 AR059176 A1 AR 059176A1
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AR
Argentina
Prior art keywords
alkyl
haloalkyl
alkenyl
cycloalkyl
heteroaryl
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Application number
ARP070100303A
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English (en)
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Lilly Co Eli
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Publication date
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Publication of AR059176A1 publication Critical patent/AR059176A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Oncology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)

Abstract

Un compuesto de indol de la formula (1): en donde n es 1 o 2; R1 se selecciona de: alquilo C1-6, alquenilo C2-6, alquinilo C2-6, hidroxialquilo C1-6, haloalquilo C1-6, alquilarilo C1-6, alquilheteroarilo C1-6, cicloalquilo C3-8, alquilcicloalquilo C1-6, alquilheterociclilo C1-6, arilo, heteroarilo, alquilo C1-6-O-R9, alquilo C0-6 C(S)R9, alquilo C0-6COR9, -C(O)NR9R10, -SOnR11, en donde cada uno de los cicloalquilo, heterociclilo, arilo, y heteroarilo se enlistan ya sea singularmente o en combinacion con una porcion alquilo son opcionalmente substituidos, con un grupo seleccionado de: halo, -CN, -OH, oxo, alquilo C1-3, haloalquilo C1-3, alquilciano C1-3, alquenilo C2-5, alquilo C0-C3 NO-2, -O-alquilo C1-3, hidroxialquilo C1-3, alquilo C0-3NR12R13, alquilo C0-3C(O)R12, alquilo C0-3C(O)OR12, -C(O)NR12R1 3, -C(S)NR12R13, -CH2OR12, -SR12, -S(O)nR12, -S(O)nNR12R13, -N(R9)C(O)NR12R13, -N(R12)C(O)OR13, -N(R12)S(O)nR13, -N(R12)S(O)nNR12R13, -C=N-OR12, y -cicloCN4R9; con la condicion de que arilo y heteroarilo no son di o tri substituidos con substituyentes alcoxi; R2 se selecciona de H, halo, -CN, alquilo C1-6, haloalquilo C1-8, cicloalquilo C3-8, alquenilo C2-6, alquinilo C2-6, en donde el cicloalquilo es opcionalmente substituido con un grupo seleccionado de: halo, -CN, -OH, oxo, alquilo C1-3, haloalquilo C1-3, cianoalquilo C1-3, alquenilo C2-5, alquilo C0-3-NO-2, -O-alquilo C1-3, y hidroxialquilo C1-3; R3 se selecciona de un arilo opcionalmente substituido o un heteroarilo opcionalmente substituido; en donde el arilo substituido y el heteroarilo substituido se substituye con un grupo seleccionado de: halo, -CN, -OH, oxo, alquilo C1-3, haloalquilo C1-3, alquilciano C1-3, alquenilo C2-5, alquilo C0-3 NO-2, -O-alquilo C1-3, hidroxialquilo C1-3, alquilo C0-3NR12R13, alquilo C0-3C(O)R12, alquilo C0-C3C(O)OR12, -C(O)NR12R13, -C(S)NR12R13, -CH2OR12, -SR12, -S(O)nR12, -S(O)nNR12R13, -N(R9)C(O)NR12R13, -N(R12)C(O)OR13, -N(R12)S(O)nR13, - N(R12)S(O)nNR12R13, y -C=N-OR12; R4, R5, y R7 son cada uno independientemente seleccionados de: H, halo, -OH, -CN, alquilo C1-6, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6, -O-alquilo C1-6, -O-haloalquilo C1-6; R6 se selecciona de: alquilo C1- 6, haloalquilo C1-6, alquilheterociclilo C1-6, alquilheteroarilo C0-6, cicloalquilo C3-8, alquilcicloalquilo C1-6, alquenilo C2-6, heterociclilo, alquilo C0-6NR9R10, y -N(H)C(O)R9, en donde cada uno de los cicloalquilo, heterociclilo, y heteroarilo se enlistan ya sea singularmente o en combinacion con una porcion alquilo son opcionalmente substituidos con uno o más grupos seleccionados de halo, -CN, -OH, oxo, alquilo C1-3, haloalquilo C1-3, alquilciano C1-3, alquenilo C2-5, alquilo C0-3NO2, -O- alquilo C1-3, y hidroxialquilo C1-3; R8 se selecciona de: H, alquilo C1-4, haloalquilo C1-4; R9 y R10 son individualmente seleccionados de: H, alquilo C1-6, haloalquilo C1-6, alquilheterociclilo C0-6, alquilcicloalquilo C1-6 alquilarilo C1-6, alquilheteroarilo C0-6, hidroxialquilo C1-6, alquenilo C2-6, cicloalquilo C3-8, o R9 y R10 junto con el átomo al cual se enlazan forman un anillo cíclico de 4 hasta 7 miembros que contiene 0-2 heteroátomos y en donde cada uno de los anillo cíclicos, heterociclilo, cicloalquilo, arilo, y heteroarilo se enlistan ya sea singularmente o con una porcion alquilo son opcionalmente substituidos; R11 se selecciona de: alquilo C1-6, -NR9R10, alquilcicloalquilo C0-6, arilo, heteroarilo en donde cada uno de los cicloalquilo, arilo, y heteroarilo se enlistan ya sea singularmente o en combinacion con una porcion alquilo son opcionalmente substituidos con un grupo seleccionado de: halo, -CN, -OH, oxo, alquilo C1-3, haloalquilo C1-3, cianoalquilo C1-3, alquenilo C2-5, alquilo C0-3NO2-, -O- alquilo C1-3, e hidroxialquilo C1-3; R12 y R13 son individualmente seleccionados de: H, alquilo C1-6, haloalquilo C1-6, alquilcicloalquilo C1-6, alquilarilo C1-6, alquilheteroarilo C0-6, hidroxialquilo C1-6, alquenilo C2-6, y cicloalquilo C3-8; o una sal farmacéuticamente aceptable del mismo. Método para su preparacion, composiciones farmacéuticas que lo comprenden, y su uso para prepararlas. El compuesto es util para modular la actividad del receptor de progesterona, en especial sirve para tratar y/o prevenir leiomiomas o las secuelas patologicas debido a endometriosis en un mamífero.
ARP070100303A 2006-01-24 2007-01-24 Compuesto de indol, composicion farmaceutica que lo comprende, metodo para prepararlo y su uso para preparar dicha composicion y para la manufactura de un medicamento para el tratamiento o prevencion de leiomiomas y endometriosis. AR059176A1 (es)

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US76163706P 2006-01-24 2006-01-24

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AR059176A1 true AR059176A1 (es) 2008-03-12

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US (1) US7932284B2 (es)
EP (1) EP1979314B1 (es)
JP (1) JP4912414B2 (es)
KR (1) KR101126895B1 (es)
CN (1) CN101374808B (es)
AR (1) AR059176A1 (es)
AU (1) AU2007208109B2 (es)
BR (1) BRPI0706411A2 (es)
CA (1) CA2637933C (es)
CR (1) CR10236A (es)
DK (1) DK1979314T3 (es)
DO (1) DOP2007000018A (es)
EA (1) EA014470B1 (es)
EC (1) ECSP088641A (es)
ES (1) ES2399112T3 (es)
HR (1) HRP20130058T1 (es)
IL (1) IL192021A (es)
MA (1) MA30207B1 (es)
MY (1) MY146494A (es)
NO (1) NO20083553L (es)
NZ (1) NZ568910A (es)
PE (1) PE20071245A1 (es)
PT (1) PT1979314E (es)
SI (1) SI1979314T1 (es)
SV (1) SV2008002986A (es)
TN (1) TNSN08311A1 (es)
TW (1) TWI368613B (es)
UA (1) UA94600C2 (es)
WO (1) WO2007087488A2 (es)
ZA (1) ZA200805757B (es)

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