MA41179A - Composés inhibiteurs de parg - Google Patents

Composés inhibiteurs de parg

Info

Publication number
MA41179A
MA41179A MA041179A MA41179A MA41179A MA 41179 A MA41179 A MA 41179A MA 041179 A MA041179 A MA 041179A MA 41179 A MA41179 A MA 41179A MA 41179 A MA41179 A MA 41179A
Authority
MA
Morocco
Prior art keywords
sub
parg
inhibitor compounds
compounds
parg inhibitor
Prior art date
Application number
MA041179A
Other languages
English (en)
Inventor
Niall M Hamilton
James R Hitchin
Colin P Hutton
Allan M Jordan
Alison E Mcgonagle
Kate M Smith
Ian D Waddell
Bohdan Waszkowycz
Original Assignee
Cancer Research Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Research Tech Ltd filed Critical Cancer Research Tech Ltd
Publication of MA41179A publication Critical patent/MA41179A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

La présente invention concerne des composés de la formule i qui fonctionnent en tant qu'inhibiteurs de l'activité enzymatique parg (poly adp-ribose glycohydrolase) : dans ladite formule, r<sub>1a</sub>, r<sub>1b</sub>, r<sub>1c</sub>, r<sub>1d</sub>, r<sub>1e</sub>, w, x<sub>1</sub>, x<sub>2</sub>, x<sub>3</sub>, x<sub>4</sub>, x<sub>5</sub>, x<sub>6</sub>, x<sub>7</sub>, c sont chacun tels que définis dans la description. La présente invention concerne également des procédés de préparation de ces composés, des compositions pharmaceutiques les comprenant et leur utilisation dans le traitement de troubles prolifératifs, tels que le cancer, ainsi que d'autres maladies ou états dans lesquels est impliquée l'activité parg.
MA041179A 2014-12-19 2015-12-16 Composés inhibiteurs de parg MA41179A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB201422771 2014-12-19

Publications (1)

Publication Number Publication Date
MA41179A true MA41179A (fr) 2017-10-24

Family

ID=54937310

Family Applications (1)

Application Number Title Priority Date Filing Date
MA041179A MA41179A (fr) 2014-12-19 2015-12-16 Composés inhibiteurs de parg

Country Status (16)

Country Link
US (4) US10508086B2 (fr)
EP (2) EP3233845B1 (fr)
JP (1) JP6673920B2 (fr)
KR (1) KR102682782B1 (fr)
CN (2) CN107295799B (fr)
AU (1) AU2015365602B2 (fr)
BR (1) BR112017012707B1 (fr)
CA (1) CA2969298C (fr)
ES (1) ES2886471T3 (fr)
IL (1) IL252745B (fr)
MA (1) MA41179A (fr)
MX (1) MX380901B (fr)
RU (1) RU2017125520A (fr)
SG (1) SG11201704843QA (fr)
WO (1) WO2016097749A1 (fr)
ZA (1) ZA201704383B (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA41140A (fr) 2014-12-12 2017-10-17 Cancer Research Tech Ltd Dérivés de 2,4-dioxo-quinazoline-6-sulfonamide en tant qu'inhibiteurs de la parg
MA41179A (fr) 2014-12-19 2017-10-24 Cancer Research Tech Ltd Composés inhibiteurs de parg
WO2020205646A2 (fr) * 2019-03-29 2020-10-08 Board Of Regents, The University Of Texas System Inhibiteurs de parg à petites molécules et leurs procédés d'utilisation
US20220389003A1 (en) * 2019-09-20 2022-12-08 Ideaya Biosciences, Inc. 4-substituted indole and indazole sulfonamido derivatives as parg inhibitors
AU2022359801A1 (en) 2021-10-04 2024-02-01 Forx Therapeutics Ag Parg inhibitory compounds
WO2024074497A1 (fr) 2022-10-03 2024-04-11 Forx Therapeutics Ag Composé inhibiteur de parg
US20250002491A1 (en) 2021-10-04 2025-01-02 Forx Therapeutics Ag N,n-dimethyl-4-(7-(n-(1-methylcyclopropyl)sulfamoyl)-imidazo[1,5-a]pyridin-5-yl)piperazine-1-carboxamide derivatives and the corresponding pyrazolo[1,5-a]pyridine derivatives as parg inhibitors for the treatment of cancer
EP4401721A4 (fr) 2021-10-17 2025-10-15 Univ Of South Alabama Foundation For Research And Commercialization Traitement contre le cancer
US12227484B2 (en) 2022-02-14 2025-02-18 Arase Therapeutics Inc. Inhibitors of PARG
CN116693519A (zh) 2022-03-04 2023-09-05 上海璎黎药业有限公司 一种含五元杂芳环结构化合物、其药物组合物及应用
WO2023175184A1 (fr) 2022-03-17 2023-09-21 Forx Therapeutics Ag Dérivés de 2,4-dioxo-1,4-dihydroquinazoline utilisés comme inhibiteurs de parg pour le traitement du cancer
WO2023175185A1 (fr) 2022-03-17 2023-09-21 Forx Therapeutics Ag Dérivés de 2,4-dioxo-1,4-dihydroquinazoline utilisés en tant qu'inhibiteurs de parg pour le traitement du cancer
AR128846A1 (es) * 2022-03-23 2024-06-19 Ideaya Biosciences Inc Compuestos de indazol sustituidos con piperazina como inhibidores de parg
CN114685283B (zh) * 2022-04-06 2024-02-27 南京艾康生物科技有限公司 一种1-(氟甲基)环丙胺盐酸盐的制备方法
WO2023205914A1 (fr) * 2022-04-28 2023-11-02 Danatlas Pharmaceuticals Co., Ltd. Dérivés hétérocycliques tricycliques, compositions et utilisations de ceux-ci
CA3250037A1 (fr) * 2022-04-28 2023-11-02 Danatlas Pharmaceuticals Co., Ltd. Dérivés hétérocycliques tricycliques, compositions et utilisations de ceux-ci
JP2025522274A (ja) 2022-05-17 2025-07-15 ８５８ セラピューティクス，インコーポレーテッド Ｐａｒｇの阻害剤
CA3260113A1 (fr) * 2022-06-29 2025-06-07 Hangzhou Synrx Therapeutics Biomedical Technology Co., Ltd. Composé contenant de l’azote à cinq chaînons et à six chaînons, et intermédiaire, procédé de préparation et utilisation associée
CN119522220A (zh) * 2022-07-19 2025-02-25 苏州信诺维医药科技股份有限公司 含硫杂芳环化合物、其药物组合物及其用途
EP4311829A1 (fr) 2022-07-28 2024-01-31 Nodus Oncology Limited Dérivés d'hétéroaryl sulfonamide bicyclique substitués pour le traitement du cancer
JP2025533274A (ja) * 2022-10-13 2025-10-03 ハンミ ファーマシューティカルズ カンパニー リミテッド Ｙａｐ－ｔｅａｄ相互作用を阻害するための新規なヘテロ二環式化合物及びそれを含む薬学的組成物
WO2024120519A1 (fr) * 2022-12-09 2024-06-13 捷思英达控股有限公司 Inhibiteur de tead, procédé de préparation associé et utilisation médicale de celui-ci
WO2024173234A1 (fr) * 2023-02-13 2024-08-22 Arase Therapeutics Inc. Inhibiteurs de parg
EP4688159A1 (fr) 2023-04-05 2026-02-11 FoRx Therapeutics AG Composés inhibiteurs de parg
TWI908044B (zh) * 2023-04-27 2025-12-11 大陸商北京丹擎醫藥科技有限公司 三環雜環衍生物及其組合物及其用途
CN121548418A (zh) * 2023-05-23 2026-02-17 康特克斯生物科技美国公司 二环杂芳基化合物
CN119143747A (zh) * 2023-06-16 2024-12-17 上海璎黎药业有限公司 一种杂芳环结构化合物、其药物组合物及应用
WO2025035108A2 (fr) * 2023-08-10 2025-02-13 Arase Therapeutics Inc. Inhibiteurs de parg
WO2025046148A1 (fr) 2023-09-01 2025-03-06 Forx Therapeutics Ag Nouveaux inhibiteurs de parg
WO2025073870A1 (fr) 2023-10-03 2025-04-10 Forx Therapeutics Ag Composé inhibiteur de parg
WO2025093755A1 (fr) 2023-11-01 2025-05-08 Forx Therapeutics Ag Nouveaux inhibiteurs de parg
WO2025098445A1 (fr) * 2023-11-07 2025-05-15 南京同诺康医药科技有限公司 Inhibiteur de parg, son procédé de préparation et son utilisation
WO2025108225A1 (fr) * 2023-11-20 2025-05-30 上海复星医药（集团）股份有限公司 Dérivé tricyclique contenant de l'azote en tant qu'inhibiteur de parg
WO2025133396A1 (fr) 2023-12-22 2025-06-26 Forx Therapeutics Ag Nouveaux inhibiteurs de parg bicyclo hétéroaryles
WO2025229549A1 (fr) * 2024-04-30 2025-11-06 Satyarx Pharma Innovations Pvt Ltd Nouveaux composés hétérocycliques utilisés en tant qu'inhibiteurs de parg
WO2026022150A1 (fr) 2024-07-22 2026-01-29 Forx Therapeutics Ag Composés inhibiteurs de parg
WO2026040953A1 (fr) * 2024-08-19 2026-02-26 上海和誉生物医药科技有限公司 Inhibiteur de parg polycyclique et ses utilisations

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1157858A (fr) 1979-12-03 1983-11-29 Ikuo Ueda Derives de quinazoline
DE4407047A1 (de) 1994-03-03 1995-09-07 Merck Patent Gmbh Acetamide
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
JP4471404B2 (ja) 1996-02-13 2010-06-02 アストラゼネカ ユーケイ リミテッド Ｖｅｇｆインヒビターとしてのキナゾリン誘導体
ATE211134T1 (de) 1996-03-05 2002-01-15 4-anilinochinazolin derivate
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
AU1065400A (en) 1998-11-12 2000-06-05 Bae Systems Electronics Limited Scanning of electromagnetic beams
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
DK1553097T3 (da) 1999-02-10 2010-12-13 Astrazeneca Ab Quinazolinderivat som angiogeneseinhibitor og mellemprodukter dertil
DE19927415A1 (de) * 1999-06-16 2000-12-21 Bayer Ag Indolinylharnstoffderivate
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
NZ522074A (en) 2000-05-31 2004-06-25 Astrazeneca Ab Indole derivatives with vascular damaging activity
UA73993C2 (uk) 2000-06-06 2005-10-17 Астразенека Аб Хіназолінові похідні для лікування пухлин та фармацевтична композиція
JP2004502766A (ja) 2000-07-07 2004-01-29 アンギオジェン・ファーマシューティカルズ・リミテッド 血管損傷剤としてのコルヒノール誘導体
CA2410562A1 (fr) 2000-07-07 2002-01-31 Angiogene Pharmaceuticals Limited Derives de colchinol utiles comme inhibiteurs de l'angiogenese
TW200303304A (en) 2002-02-18 2003-09-01 Astrazeneca Ab Chemical compounds
US7009052B2 (en) 2003-03-20 2006-03-07 Warner Lambert Company Llc Sulfonamide derivatives
GB0322722D0 (en) 2003-09-27 2003-10-29 Glaxo Group Ltd Compounds
TWI332003B (en) 2004-01-30 2010-10-21 Lilly Co Eli Kinase inhibitors
ATE428714T1 (de) 2004-02-24 2009-05-15 Japan Tobacco Inc Kondensierte heterotetracyclische verbindungen und deren verwendung als hcv-polymerase-inhibitor
US20070049593A1 (en) * 2004-02-24 2007-03-01 Japan Tobacco Inc. Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor
CA2560741C (fr) 2004-03-25 2013-08-06 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, et leur preparation et leurs utilisations
US20070032496A1 (en) * 2005-07-26 2007-02-08 Hergenrother Paul J Compounds for the Treatment of Neurodegeneration and Stroke
HRP20130058T1 (hr) * 2006-01-24 2013-02-28 Eli Lilly & Company Indolsulfonamidni modulatori progesteronskih receptora
CA2645583A1 (fr) 2006-03-20 2007-09-27 F. Hoffman-La Roche Ag Procedes d'inhibition des proteines kinase btk et syk
US20100298289A1 (en) 2007-10-09 2010-11-25 Ucb Pharma, S.A. Heterobicyclic compounds as histamine h4-receptor antagonists
CN101903025A (zh) 2007-10-19 2010-12-01 彼帕科学公司 利用苯并吡喃酮-型parp抑制剂治疗癌症的方法和组合物
EP2298767A4 (fr) * 2008-07-17 2011-10-19 Asahi Kasei Pharma Corp Composé hétérocyclique bicyclique azoté
CN101429191B (zh) 2008-11-03 2012-05-23 中国药科大学 取代的四氢异喹啉衍生物的用途
SG182351A1 (en) 2010-01-13 2012-08-30 Glaxosmithkline Llc Compounds and methods
JP5864546B2 (ja) * 2010-05-07 2016-02-17 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ インダゾール
JP2013526484A (ja) 2010-05-07 2013-06-24 グラクソ グループ リミテッド キナーゼ阻害剤としてのアミノ‐キノリン
US8697739B2 (en) 2010-07-29 2014-04-15 Novartis Ag Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof
EP2627648A1 (fr) 2010-09-16 2013-08-21 Novartis AG INHIBITEURS DE LA 17a-HYDROXYLASE/C17,20-LYASE
AR084280A1 (es) 2010-12-17 2013-05-02 Hoffmann La Roche Compuestos heterociclicos nitrogenados sustituidos fusionados en posicion 6,6 y usos de los mismos
EP2471363A1 (fr) 2010-12-30 2012-07-04 Bayer CropScience AG Utilisation d'acides aryl-, hétéroaryl- et benzylsulfonaminés, d'esters d'acide aminé, d'amides d'acide aminé et carbonitrile ou leurs sels pour l'augmentation de la tolérance au stress dans des plantes
WO2012160464A1 (fr) 2011-05-26 2012-11-29 Daiichi Sankyo Company, Limited Composés hétérocycliques en tant qu'inhibiteurs de protéine kinase
WO2013027168A1 (fr) 2011-08-22 2013-02-28 Pfizer Inc. Nouveaux composés hétérocycliques utilisés en tant qu'inhibiteurs de bromodomaine
WO2013067300A1 (fr) 2011-11-04 2013-05-10 Glaxosmithkline Intellectual Property (No. 2) Limited Méthode de traitement
WO2014026327A1 (fr) 2012-08-15 2014-02-20 Merck Sharp & Dohme Corp. Composés d'acide benzoïque à substitution 4-hétéroaryle en tant qu'inhibiteurs de rorgammat et leurs utilisations
US9938236B2 (en) 2012-12-27 2018-04-10 Drexel University Antiviral agents against HBV infection
EP3105210B1 (fr) 2014-02-11 2019-01-30 Bayer Pharma Aktiengesellschaft Benzimidazol-2-amines comme inhibiteurs de midh1
CN106459042B (zh) 2014-04-02 2019-06-28 英特穆恩公司 抗纤维化吡啶酮类
MA41140A (fr) 2014-12-12 2017-10-17 Cancer Research Tech Ltd Dérivés de 2,4-dioxo-quinazoline-6-sulfonamide en tant qu'inhibiteurs de la parg
MA41179A (fr) 2014-12-19 2017-10-24 Cancer Research Tech Ltd Composés inhibiteurs de parg
RU2019117556A (ru) 2016-11-18 2020-12-18 Мерк Шарп И Доум Корп. Индазольные производные, пригодные в качестве ингибиторов диацилглицерид o-ацилтрансферазы 2
WO2020205646A2 (fr) 2019-03-29 2020-10-08 Board Of Regents, The University Of Texas System Inhibiteurs de parg à petites molécules et leurs procédés d'utilisation
US20220389003A1 (en) 2019-09-20 2022-12-08 Ideaya Biosciences, Inc. 4-substituted indole and indazole sulfonamido derivatives as parg inhibitors
AU2022359801A1 (en) 2021-10-04 2024-02-01 Forx Therapeutics Ag Parg inhibitory compounds
AR128846A1 (es) 2022-03-23 2024-06-19 Ideaya Biosciences Inc Compuestos de indazol sustituidos con piperazina como inhibidores de parg

Also Published As

Publication number Publication date
JP6673920B2 (ja) 2020-03-25
CA2969298A1 (fr) 2016-06-23
IL252745A0 (en) 2017-08-31
RU2017125520A (ru) 2019-01-21
EP3233845A1 (fr) 2017-10-25
MX380901B (es) 2025-03-12
KR102682782B1 (ko) 2024-07-12
US20200165208A1 (en) 2020-05-28
HK1245253A1 (zh) 2018-08-24
NZ732394A (en) 2024-01-26
EP3233845B1 (fr) 2021-07-21
KR20170095370A (ko) 2017-08-22
SG11201704843QA (en) 2017-07-28
BR112017012707A2 (pt) 2018-01-02
US20210380539A1 (en) 2021-12-09
CN112979631A (zh) 2021-06-18
US12129236B2 (en) 2024-10-29
MX2017007976A (es) 2018-03-26
US10995073B2 (en) 2021-05-04
US10508086B2 (en) 2019-12-17
RU2017125520A3 (fr) 2019-06-06
CN107295799B (zh) 2021-03-16
CN112979631B (zh) 2024-09-20
CN107295799A (zh) 2017-10-24
EP3907224A1 (fr) 2021-11-10
US20250223266A1 (en) 2025-07-10
IL252745B (en) 2020-03-31
ES2886471T3 (es) 2021-12-20
CA2969298C (fr) 2023-10-17
AU2015365602B2 (en) 2020-02-27
US20180194738A1 (en) 2018-07-12
WO2016097749A1 (fr) 2016-06-23
JP2017538750A (ja) 2017-12-28
AU2015365602A1 (en) 2017-06-29
BR112017012707B1 (pt) 2023-10-24
ZA201704383B (en) 2022-03-30

Similar Documents

Publication Publication Date Title
MA41179A (fr) Composés inhibiteurs de parg
GEAP202416515A (en) Quinoline compounds as inhibitors of kras
MA64509B1 (fr) Composés hétérocycliques utilisés comme immunomodulateurs
MA64121B1 (fr) Composés hétérocycliques utilisés comme immunomodulateurs
MX2023005636A (es) Inhibidores de bcl6 derivados de bencimidazolona.
MA47043A1 (fr) Composés indole carboxamides utiles comme inhibiteurs de kinase
MA38380A1 (fr) Inhibiteurs quinazoline de l&#39;activation des formes mutantes du récepteur de croissance épidermique (egfr)
MA40111B1 (fr) Dérivés du tétrahydronaphtalène inhibant la protéine mcl-1
MA53399B1 (fr) Pyrazoles substitués en tant qu`inhibiteurs de la kallicréine plasmatique humaine
MA38483A1 (fr) Inhibiteurs de l&#39;ido
EA201892666A1 (ru) 3-оксо-2,6-дифенил-2,3-дигидропиридазин-4-карбоксамиды
MX383856B (es) Compuestos y composiciones para inhibir la actividad de shp2.
MA43979B1 (fr) Dérivés de 1h-indazole-3-carboxamide et composés similaires en tant qu&#39;inhibiteurs du facteur d pour le traitement de maladies characterisés par une activité aberrante du système complémentaire, comme p.E. Troubles immunologiques
EP4371562A3 (fr) Dérivés de la 2-quinolone en tant qu&#39;inhibiteurs du récepteur bcl6
MA34969B1 (fr) Composes et compositions en tant qu inibiteurs de trk
TN2014000420A1 (fr) Derives d&#39;indole et d&#39;indazole qui activent la mpk
MA40123A1 (fr) Pyrimidines utilisées en tant qu&#39;inhibiteurs du facteur xia
MA39219A1 (fr) Nouveaux composés inhibiteurs de la kinase lrrk2 utilisés pour le traitement du parkinson, de l’alzheimer et de la sclérose latérale amyotrophique
MA38391A1 (fr) Dérivés de pyridinyl et triazolone pyridinyl de fusion
MA40955B1 (fr) 2-amino-6-(difluorométhyl)-5,5-difluoro-6-phényl-3,4,5,6-tétrahydropyridines comme inhibiteurs de bace1
MA46229B1 (fr) Composés d&#39;hétéroaryle carboxamide en tant qu&#39;inhibiteurs de ripk2
MA43052B1 (fr) Inhibiteurs de la kallicréine plasmatique humaine
EP2563794A4 (fr) Inhibiteurs de l&#39;activité protéine tyrosine kinase et leurs applications au traitement de troubles ophtalmiques
MA37691B1 (fr) 5-amino[1,4]thiazines comme inhibiteurs de bace1
MA37763B1 (fr) Difluoro-hexahydro-cyclopentaoxazinyles et difluoro-hexahydro-benzooxazinyles en tant qu&#39;inhibiteurs de bace1