AR060095A1 - Derivados de himbacina monociclicos y biciclicos utiles como antogonistas de los receptores de trombina - Google Patents

Derivados de himbacina monociclicos y biciclicos utiles como antogonistas de los receptores de trombina

Info

Publication number: AR060095A1
Authority: AR; Argentina
Prior art keywords: alkyl; group; hydrogen; ring; aminoalkyl
Prior art date: 2006-03-29

Application number

ARP070101263A

Other languages

English (en)

Spanish (es)

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-03-29

Filing date

2007-03-27

Publication date

2008-05-21

2007-03-27 Application filed by Schering Corp filed Critical Schering Corp

2008-05-21 Publication of AR060095A1 publication Critical patent/AR060095A1/es

Links

102000003790 Thrombin receptors Human genes 0.000 title 1
108090000166 Thrombin receptors Proteins 0.000 title 1
FMPNFDSPHNUFOS-LPJDIUFZSA-N himbacine Chemical class C(/[C@@H]1[C@H]2CCCC[C@@H]2C[C@@H]2C(=O)O[C@H]([C@H]12)C)=C\[C@H]1CCC[C@H](C)N1C FMPNFDSPHNUFOS-LPJDIUFZSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 31
229910052739 hydrogen Inorganic materials 0.000 abstract 20
239000001257 hydrogen Substances 0.000 abstract 20
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 18
125000004103 aminoalkyl group Chemical group 0.000 abstract 16
125000003545 alkoxy group Chemical group 0.000 abstract 13
125000000753 cycloalkyl group Chemical group 0.000 abstract 11
229910052736 halogen Inorganic materials 0.000 abstract 10
150000002367 halogens Chemical class 0.000 abstract 10
125000001072 heteroaryl group Chemical group 0.000 abstract 8
-1 methylenedioxy group Chemical group 0.000 abstract 8
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 7
125000004429 atom Chemical group 0.000 abstract 7
229910052757 nitrogen Inorganic materials 0.000 abstract 7
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 6
125000003710 aryl alkyl group Chemical group 0.000 abstract 6
125000001188 haloalkyl group Chemical group 0.000 abstract 6
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 6
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 6
229910052760 oxygen Inorganic materials 0.000 abstract 6
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
125000003342 alkenyl group Chemical group 0.000 abstract 5
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 5
125000004446 heteroarylalkyl group Chemical group 0.000 abstract 5
125000000623 heterocyclic group Chemical group 0.000 abstract 5
125000002102 aryl alkyloxo group Chemical group 0.000 abstract 4
125000004104 aryloxy group Chemical group 0.000 abstract 4
125000005842 heteroatom Chemical group 0.000 abstract 4
229910052717 sulfur Inorganic materials 0.000 abstract 4
125000000304 alkynyl group Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 3
229910052799 carbon Inorganic materials 0.000 abstract 3
125000000592 heterocycloalkyl group Chemical group 0.000 abstract 3
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 3
239000001301 oxygen Substances 0.000 abstract 3
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000003302 alkenyloxy group Chemical group 0.000 abstract 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 2
150000001721 carbon Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 2
125000003709 fluoroalkyl group Chemical group 0.000 abstract 2
125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 2
125000002950 monocyclic group Chemical group 0.000 abstract 2
125000004434 sulfur atom Chemical group 0.000 abstract 2
125000004950 trifluoroalkyl group Chemical group 0.000 abstract 2
125000006345 2,2,2-trifluoroethoxymethyl group Chemical group [H]C([H])(*)OC([H])([H])C(F)(F)F 0.000 abstract 1
DBTDEFJAFBUGPP-UHFFFAOYSA-N Methanethial Chemical compound S=C DBTDEFJAFBUGPP-UHFFFAOYSA-N 0.000 abstract 1
150000001204 N-oxides Chemical class 0.000 abstract 1
102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 abstract 1
108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 abstract 1
229910006069 SO3H Inorganic materials 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000005083 alkoxyalkoxy group Chemical group 0.000 abstract 1
125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000002431 aminoalkoxy group Chemical group 0.000 abstract 1
125000005127 aryl alkoxy alkyl group Chemical group 0.000 abstract 1
125000005160 aryl oxy alkyl group Chemical group 0.000 abstract 1
235000010290 biphenyl Nutrition 0.000 abstract 1
239000004305 biphenyl Substances 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
125000004858 cycloalkoxyalkyl group Chemical group 0.000 abstract 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
125000004980 cyclopropylene group Chemical group 0.000 abstract 1
125000004990 dihydroxyalkyl group Chemical group 0.000 abstract 1
125000004428 fluoroalkoxy group Chemical group 0.000 abstract 1
125000004994 halo alkoxy alkyl group Chemical group 0.000 abstract 1
125000000262 haloalkenyl group Chemical group 0.000 abstract 1
125000004447 heteroarylalkenyl group Chemical group 0.000 abstract 1
125000005114 heteroarylalkoxy group Chemical group 0.000 abstract 1
125000005326 heteroaryloxy alkyl group Chemical group 0.000 abstract 1
125000005113 hydroxyalkoxy group Chemical group 0.000 abstract 1
125000001041 indolyl group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
125000005359 phenoxyalkyl group Chemical group 0.000 abstract 1
125000003884 phenylalkyl group Chemical group 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000006413 ring segment Chemical group 0.000 abstract 1
102200012954 rs121918642 Human genes 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
239000011593 sulfur Chemical group 0.000 abstract 1
125000005309 thioalkoxy group Chemical group 0.000 abstract 1
125000004001 thioalkyl group Chemical group 0.000 abstract 1
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1

Classifications

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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Neurology (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Ophthalmology & Optometry (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Hematology (AREA)
Endocrinology (AREA)
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Hospice & Palliative Care (AREA)
Gynecology & Obstetrics (AREA)
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Vascular Medicine (AREA)
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ARP070101263A 2006-03-29 2007-03-27 Derivados de himbacina monociclicos y biciclicos utiles como antogonistas de los receptores de trombina AR060095A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US78696106P	2006-03-29	2006-03-29

Publications (1)

Publication Number	Publication Date
AR060095A1 true AR060095A1 (es)	2008-05-21

Family

ID=38561631

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ARP070101263A AR060095A1 (es)	2006-03-29	2007-03-27	Derivados de himbacina monociclicos y biciclicos utiles como antogonistas de los receptores de trombina

Country Status (12)

Country	Link
US (1)	US7888377B2 (de)
EP (1)	EP1999111B1 (de)
JP (1)	JP2009534308A (de)
KR (1)	KR20080104352A (de)
CN (1)	CN101460463A (de)
AR (1)	AR060095A1 (de)
AU (1)	AU2007243657A1 (de)
CA (1)	CA2647933A1 (de)
MX (1)	MX2008012574A (de)
TW (1)	TW200811107A (de)
WO (1)	WO2007126771A2 (de)
ZA (1)	ZA200808247B (de)

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* Cited by examiner, † Cited by third party
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US8227412B2 (en) *	2007-03-29	2012-07-24	Tsopanoglou Nikos E	Bioactive parstatin peptides and methods of use
ES2532902T3 (es)	2010-04-16	2015-04-01	Sanofi	Piridil-vinil-pirroles tricíclicos como inhibidores de PAR1
PL2558462T3 (pl)	2010-04-16	2015-03-31	Sanofi Sa	Pirydylo-winylo-pirazolo-chinoliny jako inhibitory PAR1
WO2012149285A1 (en) *	2011-04-28	2012-11-01	Claire Mitchell	Method for treatment of macular degeneration by modulating p2y12 or p2x7 receptors
EP3024550A4 (de)	2013-07-22	2016-12-07	Merck Sharp & Dohme	Co-kristall aus dem par-1-rezeptor-antagonisten vorapaxar und aspirin
CN105777681B (zh) *	2014-12-17	2019-03-01	博瑞生物医药（苏州）股份有限公司	喜巴辛类似物及其中间体的制备方法
CN105949116A (zh) *	2016-06-08	2016-09-21	青岛理工大学	酰基哌嗪类化合物及其制备方法和用途
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- 2007-03-27 US US11/728,672 patent/US7888377B2/en active Active
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- 2007-03-27 WO PCT/US2007/007497 patent/WO2007126771A2/en not_active Ceased
- 2007-03-27 KR KR1020087023799A patent/KR20080104352A/ko not_active Withdrawn
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- 2007-03-27 CN CNA2007800202800A patent/CN101460463A/zh active Pending
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Publication number	Publication date
AU2007243657A1 (en)	2007-11-08
EP1999111B1 (de)	2013-12-18
US20070232635A1 (en)	2007-10-04
WO2007126771A2 (en)	2007-11-08
ZA200808247B (en)	2009-11-25
KR20080104352A (ko)	2008-12-02
JP2009534308A (ja)	2009-09-24
CN101460463A (zh)	2009-06-17
EP1999111A2 (de)	2008-12-10
US7888377B2 (en)	2011-02-15
WO2007126771A3 (en)	2007-12-21
CA2647933A1 (en)	2007-11-08
MX2008012574A (es)	2008-10-10
TW200811107A (en)	2008-03-01

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JP2009534358A5 (de)	2011-03-10
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