AR061027A1 - Inhibidores del virus del papiloma humano y las composiciones farmaceuticas que los contienen - Google Patents
Inhibidores del virus del papiloma humano y las composiciones farmaceuticas que los contienenInfo
- Publication number
- AR061027A1 AR061027A1 ARP070102162A ARP070102162A AR061027A1 AR 061027 A1 AR061027 A1 AR 061027A1 AR P070102162 A ARP070102162 A AR P070102162A AR P070102162 A ARP070102162 A AR P070102162A AR 061027 A1 AR061027 A1 AR 061027A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- alkyl
- inhibitors
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 230000002378 acidificating effect Effects 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- -1 halogenalkylthio Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- 229940124686 HPV inhibitor Drugs 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Inhibidores de VPH de formula (1):en la que G1 representa un enlace o una cadena hidrocarbonada eventualmente sustituida por uno o dos grupos alquilo, G2 los grupos de formulas (2) en los que R representa un H, alquilo, halogenoalquilo, o un radical profármaco tal como carbamato, acetilo o dialquilaminometilo, G representa un enlace o una cadena hidrocarbonada eventualmente sustituida por uno o dos alquilo, W representa un oxigeno o un azufre, R1 y R2 representan cada uno un grupo elegido entre un hidrogeno, un halogeno, un hidroxilo, tio, alcoxi, halogenalcoxi, alquiltio, halogenalquiltio, amino, monoalquilamino, dialquilamino, cicloalquilo, alquilo o halogenalquilo, R3 representa un ácido o un radical profármaco de la funcion ácido o bien un bioisostero de la funcion ácido, A representa un arilo, cicloalquilo, cicloalquenilo o un heterociclo, cada uno eventualmente sustituido, y B representa un arilo o un heterociclo de 6 eslabones, cada uno eventualmente sustituido, así como sus sales farmacéuticamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0604496A FR2901273B1 (fr) | 2006-05-19 | 2006-05-19 | Inhibiteurs du virus du papillome humain et les compositions pharmaceutiques les contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR061027A1 true AR061027A1 (es) | 2008-07-30 |
Family
ID=37575135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070102162A AR061027A1 (es) | 2006-05-19 | 2007-05-18 | Inhibidores del virus del papiloma humano y las composiciones farmaceuticas que los contienen |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US8207373B2 (es) |
| EP (1) | EP2024350B1 (es) |
| JP (1) | JP5399237B2 (es) |
| CN (1) | CN101466693B (es) |
| AR (1) | AR061027A1 (es) |
| BR (1) | BRPI0711208A2 (es) |
| CA (1) | CA2652469C (es) |
| DK (1) | DK2024350T3 (es) |
| ES (1) | ES2436772T3 (es) |
| FR (1) | FR2901273B1 (es) |
| MX (1) | MX2008014771A (es) |
| PT (1) | PT2024350E (es) |
| WO (1) | WO2007135106A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2923825B1 (fr) * | 2007-11-20 | 2013-05-03 | Anaconda Pharma | Nouveaux inhibiteurs du virus du papillome humain et les compositions pharmaceutiques les contenant. |
| FR2990134B1 (fr) * | 2012-05-07 | 2014-11-21 | Anaconda Pharma | Composition pharmaceutique d'un inhibiteur du virus du papillome |
| FR3000490B1 (fr) * | 2012-12-27 | 2015-03-13 | Anaconda Pharma | Procede de synthese d'une hydrazine utile dans le traitement du virus du papillome |
| ES2796276T3 (es) * | 2015-02-05 | 2020-11-26 | Ab Science | Compuestos con actividad antitumoral |
| WO2017009751A1 (en) | 2015-07-15 | 2017-01-19 | Pfizer Inc. | Pyrimidine derivatives |
| CN105582083A (zh) * | 2015-09-08 | 2016-05-18 | 石友爱 | 一种治疗鲍温样丘疹病的中药 |
| WO2018157842A1 (zh) * | 2017-03-02 | 2018-09-07 | 中国科学院上海药物研究所 | 2-(取代苯氨基)苯甲酸类fto抑制剂治疗白血病的用途 |
| CN109748903B (zh) * | 2017-11-01 | 2021-08-10 | 北京协和制药二厂 | 吡法齐明的制备方法 |
| EP3594205A1 (en) | 2018-07-09 | 2020-01-15 | Abivax | Phenyl-n-aryl derivatives for treating a rna virus infection |
| EP3594206A1 (en) | 2018-07-09 | 2020-01-15 | Abivax | Phenyl-n-quinoline derivatives for treating a rna virus infection |
| JP2020127293A (ja) * | 2019-02-05 | 2020-08-20 | ファナック株式会社 | ロータコアの製造装置及びロータコアの製造方法、並びにロータ構造 |
| CN110041223B (zh) * | 2019-06-03 | 2021-10-22 | 西北师范大学 | 以肼类化合物为原料氧化合成偶氮类化合物的方法 |
| PL3999493T3 (pl) | 2019-07-19 | 2024-04-22 | Abivax | Pochodne arylo-N-arylowe do leczenia zakażenia wirusem RNA |
| CN114276273B (zh) * | 2021-12-29 | 2024-06-21 | 维思普新材料（苏州）有限公司 | 一种基于四苯基肼类衍生物的有机电致发光材料及其电子器件 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4292429A (en) * | 1978-03-08 | 1981-09-29 | Ciba-Geigy Corporation | Imidazole urea and amido compounds |
| SK13332001A3 (sk) * | 1999-03-19 | 2002-02-05 | Vertex Pharmaceuticals Incorporated | Inhibítory IMPDH enzýmu a ich použitie |
| WO2004108673A2 (en) * | 2003-06-09 | 2004-12-16 | Boehringer Ingelheim International Gmbh | Inhibitors of papilloma virus |
-
2006
- 2006-05-19 FR FR0604496A patent/FR2901273B1/fr not_active Expired - Fee Related
-
2007
- 2007-05-18 CA CA2652469A patent/CA2652469C/fr not_active Expired - Fee Related
- 2007-05-18 EP EP07729287.8A patent/EP2024350B1/fr not_active Not-in-force
- 2007-05-18 ES ES07729287.8T patent/ES2436772T3/es active Active
- 2007-05-18 WO PCT/EP2007/054843 patent/WO2007135106A1/fr not_active Ceased
- 2007-05-18 US US12/300,998 patent/US8207373B2/en not_active Expired - Fee Related
- 2007-05-18 BR BRPI0711208-4A patent/BRPI0711208A2/pt not_active IP Right Cessation
- 2007-05-18 MX MX2008014771A patent/MX2008014771A/es active IP Right Grant
- 2007-05-18 JP JP2009511485A patent/JP5399237B2/ja not_active Expired - Fee Related
- 2007-05-18 PT PT77292878T patent/PT2024350E/pt unknown
- 2007-05-18 DK DK07729287.8T patent/DK2024350T3/da active
- 2007-05-18 AR ARP070102162A patent/AR061027A1/es not_active Application Discontinuation
- 2007-05-18 CN CN2007800218616A patent/CN101466693B/zh not_active Expired - Fee Related
-
2012
- 2012-05-08 US US13/466,530 patent/US9452991B2/en active Active
-
2016
- 2016-09-26 US US15/276,208 patent/US9974779B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP5399237B2 (ja) | 2014-01-29 |
| US9974779B2 (en) | 2018-05-22 |
| CA2652469C (fr) | 2016-05-03 |
| ES2436772T3 (es) | 2014-01-07 |
| FR2901273A1 (fr) | 2007-11-23 |
| US9452991B2 (en) | 2016-09-27 |
| CN101466693A (zh) | 2009-06-24 |
| CA2652469A1 (fr) | 2007-11-29 |
| US8207373B2 (en) | 2012-06-26 |
| CN101466693B (zh) | 2012-12-12 |
| US20120220633A1 (en) | 2012-08-30 |
| DK2024350T3 (da) | 2013-12-09 |
| PT2024350E (pt) | 2013-12-11 |
| WO2007135106A1 (fr) | 2007-11-29 |
| US20170079968A1 (en) | 2017-03-23 |
| FR2901273B1 (fr) | 2010-12-24 |
| BRPI0711208A2 (pt) | 2011-03-22 |
| JP2009537595A (ja) | 2009-10-29 |
| EP2024350B1 (fr) | 2013-09-18 |
| US20180021318A9 (en) | 2018-01-25 |
| EP2024350A1 (fr) | 2009-02-18 |
| MX2008014771A (es) | 2008-11-28 |
| US20090209586A1 (en) | 2009-08-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed, e.g., due to non-payment of fee |