ECSP099638A - Nuevo compuesto de adenina - Google Patents

Nuevo compuesto de adenina

Info

Publication number
ECSP099638A
ECSP099638A EC2009009638A ECSP099638A ECSP099638A EC SP099638 A ECSP099638 A EC SP099638A EC 2009009638 A EC2009009638 A EC 2009009638A EC SP099638 A ECSP099638 A EC SP099638A EC SP099638 A ECSP099638 A EC SP099638A
Authority
EC
Ecuador
Prior art keywords
substituted
alkyl
heterocycle
saturated
heteroaryl
Prior art date
Application number
EC2009009638A
Other languages
English (en)
Inventor
Yoshiaki Isobe
Tomoaki Nakamura
Original Assignee
Astrazeneca Ab
Dainippon Sumitomo Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39765921&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP099638(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab, Dainippon Sumitomo Pharma Co filed Critical Astrazeneca Ab
Publication of ECSP099638A publication Critical patent/ECSP099638A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P27/14—Decongestants or antiallergics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • AIDS & HIV (AREA)

Abstract

Un compuesto nuevo de adenina representado por la fórmula (1): donde A representa un carbociclo aromático (no)sustituido o heterociclo aromático (no)sustituido ; L1 y L2 cada uno independientemente representa alquileno de cadena lineal o ramificada, etc.; R1 representa halógeno, alquilo (no)sustituido, alquenilo (no)sustituido, alquinilo (no)sustituido, cicloalquilo (no)sustituido, arilo (no)sustituido, o heteroarilo (no)sustituido; R2 y R3 cada uno independientemente representa hidrógeno, o alquilo (no)sustituido, alquenilo (no)sustituido, alquinilo (no)sustituido, cicloalquilo (no)sustituido, heterociclo saturado (no)sustituido, arilo (no)sustituido, o heteroarilo (no)sustituido, o R2 se combina junto con L2 o R3 para formar un heterociclo saturado (no)sustituido que contiene nitrógeno de 4 a 8 miembros; X es oxígeno, azufre, SO, SO2, NR7, NR7CO donde R7 es hidrógeno o alquilo, o una única unión; siempre que X sea una única unión cuando R1 es halógeno, o una sal aceptable para uso farmacéutico del mismo. El compuesto y la sal son útiles como un medicamento.
EC2009009638A 2007-03-20 2009-09-18 Nuevo compuesto de adenina ECSP099638A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2007071713 2007-03-20

Publications (1)

Publication Number Publication Date
ECSP099638A true ECSP099638A (es) 2009-10-30

Family

ID=39765921

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2009009638A ECSP099638A (es) 2007-03-20 2009-09-18 Nuevo compuesto de adenina

Country Status (21)

Country Link
US (2) US20100093998A1 (es)
EP (1) EP2133353A4 (es)
JP (1) JPWO2008114817A1 (es)
KR (1) KR20090125774A (es)
CN (1) CN101679433A (es)
AR (1) AR065784A1 (es)
AU (1) AU2008227500A1 (es)
BR (1) BRPI0809134A2 (es)
CA (1) CA2680397A1 (es)
CL (1) CL2008000789A1 (es)
CO (1) CO6220972A2 (es)
EC (1) ECSP099638A (es)
IL (1) IL200831A0 (es)
MX (1) MX2009010024A (es)
NZ (1) NZ579744A (es)
PE (1) PE20081887A1 (es)
RU (1) RU2009138471A (es)
TW (1) TW200902018A (es)
UY (1) UY30966A1 (es)
WO (1) WO2008114817A1 (es)
ZA (1) ZA200906253B (es)

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US7989459B2 (en) * 2006-02-17 2011-08-02 Pharmacopeia, Llc Purinones and 1H-imidazopyridinones as PKC-theta inhibitors
US8138172B2 (en) * 2006-07-05 2012-03-20 Astrazeneca Ab 8-oxoadenine derivatives acting as modulators of TLR7
TW200831105A (en) 2006-12-14 2008-08-01 Astrazeneca Ab Novel compounds
AR065372A1 (es) * 2007-02-19 2009-06-03 Smithkline Beecham Corp Derivados de purina
ES2373616T3 (es) * 2007-03-19 2012-02-07 Astrazeneca Ab Compuestos de 8-oxo-adenina 9 sustituidos como moduladores del receptor de tipo toll (tlr7).
ES2457316T3 (es) 2007-03-19 2014-04-25 Astrazeneca Ab Compuestos 8-oxo-adenina 9 sustituidos como moduladores del receptor similares a toll (TLR7)
JPWO2008114819A1 (ja) 2007-03-20 2010-07-08 大日本住友製薬株式会社 新規アデニン化合物
AR065784A1 (es) * 2007-03-20 2009-07-01 Dainippon Sumitomo Pharma Co Derivados de 8-oxo adenina,medicamentos que los contienen y usos como agentes terapeuticos para enfermedades alergicas, antivirales o antibacterianas.
HRP20120895T1 (hr) 2007-05-08 2012-11-30 Astrazeneca Ab Imidazokinolini sa imuno-modulacijskim svojstvima
CA2691444C (en) 2007-06-29 2016-06-14 Gilead Sciences, Inc. Purine derivatives and their use as modulators of toll-like receptor 7
PE20091236A1 (es) 2007-11-22 2009-09-16 Astrazeneca Ab Derivados de pirimidina como immunomoduladores de tlr7
PE20091156A1 (es) 2007-12-17 2009-09-03 Astrazeneca Ab Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo
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UY30966A1 (es) 2008-10-31
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WO2008114817A1 (ja) 2008-09-25
US20110028715A1 (en) 2011-02-03
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RU2009138471A (ru) 2011-04-27
IL200831A0 (en) 2010-05-17
MX2009010024A (es) 2009-10-12
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AR065784A1 (es) 2009-07-01
ZA200906253B (en) 2010-01-27

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