AR068552A1 - Polipeptidos y polinucleotidos del fago omegamru y sus usos para detectar, apuntar e inhibir celulas microbianas metanogenicas - Google Patents
Polipeptidos y polinucleotidos del fago omegamru y sus usos para detectar, apuntar e inhibir celulas microbianas metanogenicasInfo
- Publication number
- AR068552A1 AR068552A1 ARP080104172A ARP080104172A AR068552A1 AR 068552 A1 AR068552 A1 AR 068552A1 AR P080104172 A ARP080104172 A AR P080104172A AR P080104172 A ARP080104172 A AR P080104172A AR 068552 A1 AR068552 A1 AR 068552A1
- Authority
- AR
- Argentina
- Prior art keywords
- polypeptides
- phage
- omegamru
- cells
- microbial cells
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
- C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
- C12N9/641—Cysteine endopeptidases (3.4.22)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/13—Tumour cells, irrespective of tissue of origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/10—Detection of antigens from microorganism in sample from host
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/20—Reduction of greenhouse gas [GHG] emissions in agriculture, e.g. CO2
- Y02P60/22—Methane [CH4], e.g. from rice paddies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
Abstract
Composiciones y métodos para la administracion de moléculas inhibidoras en células microbianas, en particular, células metanogenas. Específicamente, se refiere al omegamru fago recientemente identificado, que incluye la induccion del fago, partículas del fago, y el genoma del fago, y también polipéptidos del fago, así como también polinucleotidos que codifican estos polipéptidos. También se refiere a vectores de expresion y células huésped para la produccion de estos polipéptidos, a métodos para detectar, apuntar, e inhibir células microbianas, especialmente células metanogenas, utilizando el fago revelado, polipéptidos, polinucleotidos, vectores de expresion, y células huésped, también posee composiciones farmacéuticas que comprenden el fago omegamru.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97510407P | 2007-09-25 | 2007-09-25 | |
| US98984107P | 2007-11-22 | 2007-11-22 | |
| US98984007P | 2007-11-22 | 2007-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR068552A1 true AR068552A1 (es) | 2009-11-18 |
Family
ID=40511642
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080104173A AR068553A1 (es) | 2007-09-25 | 2008-09-25 | Vacunas y componentes de vacuna para la inhibicion de celulas microbianas |
| ARP080104171A AR068551A1 (es) | 2007-09-25 | 2008-09-25 | Peptidos y polipeptidos permeabilizantes celulares para celulas microbianas |
| ARP080104172A AR068552A1 (es) | 2007-09-25 | 2008-09-25 | Polipeptidos y polinucleotidos del fago omegamru y sus usos para detectar, apuntar e inhibir celulas microbianas metanogenicas |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080104173A AR068553A1 (es) | 2007-09-25 | 2008-09-25 | Vacunas y componentes de vacuna para la inhibicion de celulas microbianas |
| ARP080104171A AR068551A1 (es) | 2007-09-25 | 2008-09-25 | Peptidos y polipeptidos permeabilizantes celulares para celulas microbianas |
Country Status (17)
| Country | Link |
|---|---|
| US (7) | US8586709B2 (es) |
| EP (5) | EP2203466B1 (es) |
| JP (5) | JP5552053B2 (es) |
| CN (4) | CN107129524B (es) |
| AR (3) | AR068553A1 (es) |
| AU (4) | AU2008305846A1 (es) |
| BR (5) | BRPI0817299A8 (es) |
| CA (3) | CA2700164C (es) |
| CL (3) | CL2008002859A1 (es) |
| DK (3) | DK3327030T3 (es) |
| ES (3) | ES2587595T3 (es) |
| MX (3) | MX2010003328A (es) |
| NZ (1) | NZ745324A (es) |
| RU (1) | RU2528854C2 (es) |
| UY (3) | UY31361A1 (es) |
| WO (3) | WO2009041831A1 (es) |
| ZA (1) | ZA201001933B (es) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8586709B2 (en) * | 2007-09-25 | 2013-11-19 | Pastoral Greenhouse Research Limited | Cell-permeabilising peptides and polypeptides for microbial cells |
| GB0815484D0 (en) | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
| DK2445515T3 (en) * | 2009-06-26 | 2016-07-04 | Univ Leuven Kath | antimicrobial agents |
| KR101701890B1 (ko) | 2009-06-26 | 2017-02-02 | 뤼산도 아게 | 항균제 |
| EP2470660A4 (en) | 2009-08-27 | 2013-03-20 | Pastoral Greenhouse Gas Res Ltd | COMPLETE GENOME SEQUENCE OF THE METHANOGEN METHOBOBROVIBACTERIUM RUMINANTIUM |
| EA037276B1 (ru) * | 2010-04-27 | 2021-03-03 | Лисандо Аг | Способы устранения или уменьшения бактериальной биопленки |
| TWI678374B (zh) * | 2012-09-19 | 2019-12-01 | 韓商傑姆維克斯&凱爾有限公司 | 穿膜胜肽以及包含該胜肽之共軛物及組成物(三) |
| EP2840140B2 (en) * | 2012-12-12 | 2023-02-22 | The Broad Institute, Inc. | Crispr-Cas based method for mutation of prokaryotic cells |
| WO2014204578A1 (en) | 2013-06-21 | 2014-12-24 | The General Hospital Corporation | Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing |
| CN112301024A (zh) | 2013-03-15 | 2021-02-02 | 通用医疗公司 | 使用RNA引导的FokI核酸酶(RFN)提高RNA引导的基因组编辑的特异性 |
| US10760064B2 (en) | 2013-03-15 | 2020-09-01 | The General Hospital Corporation | RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci |
| CN106459995B (zh) | 2013-11-07 | 2020-02-21 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
| JP6823593B2 (ja) * | 2014-11-06 | 2021-02-03 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーE.I.Du Pont De Nemours And Company | Rna誘導型エンドヌクレアーゼの細胞へのペプチド媒介輸送 |
| CN104789675A (zh) * | 2015-04-15 | 2015-07-22 | 江苏师范大学 | 一种检测荷斯坦奶牛瘤胃微生物的方法 |
| WO2016178207A1 (en) * | 2015-05-04 | 2016-11-10 | Ramot At Tel-Aviv University Ltd. | Methods and kits for fragmenting dna |
| US9512446B1 (en) | 2015-08-28 | 2016-12-06 | The General Hospital Corporation | Engineered CRISPR-Cas9 nucleases |
| US9926546B2 (en) | 2015-08-28 | 2018-03-27 | The General Hospital Corporation | Engineered CRISPR-Cas9 nucleases |
| EP3484996B1 (en) * | 2016-07-14 | 2020-09-09 | Basf Se | Fermentation medium comprising chelating agent |
| JP7234114B2 (ja) * | 2016-12-29 | 2023-03-07 | イルミナ インコーポレイテッド | 細胞区画内の生体分子への直交アクセスおよび細胞区画内の生体分子のタグ付けのための分析システム |
| US12473535B2 (en) | 2017-01-05 | 2025-11-18 | Shenzhen Mindray Bio-Medical Electronics Co., Ltd. | Method for preparing reticulocyte simulating particles and platelet simulating particles, and reference control |
| US10745439B2 (en) * | 2017-03-20 | 2020-08-18 | Regents Of The University Of Minnesota | Kinase substrates and methods of use thereof |
| WO2019147743A1 (en) | 2018-01-26 | 2019-08-01 | Massachusetts Institute Of Technology | Structure-guided chemical modification of guide rna and its applications |
| EP3592140A1 (en) * | 2018-03-19 | 2020-01-15 | Regeneron Pharmaceuticals, Inc. | Transcription modulation in animals using crispr/cas systems |
| EP3880698A4 (en) | 2018-11-14 | 2022-11-30 | RubrYc Therapeutics, Inc. | MANIPULATED CD25 POLYPEPTIDES AND USES THEREOF |
| EP3880227A4 (en) | 2018-11-14 | 2022-11-09 | RubrYc Therapeutics, Inc. | ANTI-CD25 ANTIBODIES |
| CN109627301B (zh) * | 2019-02-18 | 2022-08-05 | 浙江新银象生物工程有限公司 | Nisin固体稳定剂开发及应用 |
| CA3171721A1 (en) * | 2020-03-19 | 2021-09-23 | Fritz Eichenseher | A stabilized protein of interest |
| US20230072496A1 (en) * | 2020-04-10 | 2023-03-09 | Liberty Biosecurity, Llc | Polypeptide compositions and uses thereof |
| CN112143747B (zh) * | 2020-09-09 | 2022-09-13 | 昆明理工大学 | 一种噬菌体裂解酶及其基因、基因重组表达载体与应用 |
| HUE067496T2 (hu) | 2020-12-08 | 2024-10-28 | Ruminant Biotech Corp Ltd | Az állatoknak szánt anyagok bejuttatására szolgáló eszközök és módszerek fejlesztése |
| CN112961217B (zh) * | 2021-03-19 | 2022-11-08 | 江苏元本生物科技有限公司 | 一种靶向Siglec-15的噬菌体多肽 |
| CN113121705B (zh) * | 2021-04-19 | 2023-03-24 | 成都英普博集生物科技有限公司 | 用于制备短肽混合物的融合蛋白、目的多肽、短肽混合物的制备方法及应用 |
| EP4554616A1 (en) * | 2022-07-11 | 2025-05-21 | Arkea Bio Corp. | Compositions and methods for reducing methane emissions in ruminant populations |
| CN115417927A (zh) * | 2022-09-08 | 2022-12-02 | 南京松天盛科生物科技有限公司 | 小鼠腹水致敏物及其应用 |
| EP4612293A1 (en) * | 2022-11-03 | 2025-09-10 | Helix Nanotechnologies Inc | Ruminal and methanogen vaccines and uses thereof |
| CN115938486B (zh) * | 2022-12-06 | 2023-11-10 | 内蒙古农业大学 | 基于图神经网络的抗菌性乳酸菌株筛选方法 |
| WO2025207521A1 (en) * | 2024-03-25 | 2025-10-02 | Silage Labs, Inc. | Bacteria expressing lysins for inhibition of methanogenesis |
| WO2025219570A1 (en) | 2024-04-17 | 2025-10-23 | Johannes Kepler Universität Linz | Composition for inhibiting protein translocation and methods using the same |
| WO2025233675A1 (en) * | 2024-05-10 | 2025-11-13 | Institut Pasteur | Use of talosaminidase to regulate populations of archaeal methanogens in industrial, agricultural and medical settings |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US159861A (en) * | 1875-02-16 | Improvement in brooms | ||
| NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
| CA1221635A (fr) * | 1983-05-03 | 1987-05-12 | Andre Speecke | Composition a activite pharmaceutique amelioree et utilisation de celle-ci pour des usages veterinaires |
| GB8815968D0 (en) * | 1988-07-05 | 1988-08-10 | Pfizer Ltd | Veterinary devices |
| JPH05219927A (ja) * | 1992-02-14 | 1993-08-31 | Gumma Pref Gov | 飼料の混合装置及び混合飼料の製造方法 |
| WO1995011995A1 (en) | 1993-10-26 | 1995-05-04 | Affymax Technologies N.V. | Arrays of nucleic acid probes on biological chips |
| JP3651915B2 (ja) * | 1993-06-30 | 2005-05-25 | 財団法人神奈川科学技術アカデミー | シグナル配列ペプチドをコードするdna断片の探索法及びそのためのベクター |
| ZA948204B (en) | 1993-10-19 | 1995-06-12 | Commw Scient Ind Res Org | Method for improving utilisation of nutrients by ruminant or ruminant-like animals |
| NZ278977A (en) | 1994-01-20 | 1997-03-24 | Pastoral Agric Res Inst Nz Ltd | Sustained release bolus for ruminants |
| EP0739198B1 (en) | 1994-01-20 | 2003-09-17 | Agresearch Limited | Device for administration of beneficial materials to ruminants |
| US6015880A (en) | 1994-03-16 | 2000-01-18 | California Institute Of Technology | Method and substrate for performing multiple sequential reactions on a matrix |
| AUPN353695A0 (en) | 1995-06-14 | 1995-07-06 | Commonwealth Scientific And Industrial Research Organisation | Immunogenic preparation and method for improving the productivity of ruminant animals |
| WO1998007830A2 (en) * | 1996-08-22 | 1998-02-26 | The Institute For Genomic Research | COMPLETE GENOME SEQUENCE OF THE METHANOGENIC ARCHAEON, $i(METHANOCOCCUS JANNASCHII) |
| US5985907A (en) * | 1998-08-12 | 1999-11-16 | Health Research, Inc. | Method for inhibiting growth of methanogens |
| AU2002306849A1 (en) | 2001-03-21 | 2002-10-08 | Elitra Pharmaceuticals, Inc. | Identification of essential genes in microorganisms |
| AU2002326949A1 (en) | 2001-09-18 | 2003-05-12 | The Board Of Regents Of The University Of Nebraska | Method for the inhibition of methanogenesis |
| US7314974B2 (en) * | 2002-02-21 | 2008-01-01 | Monsanto Technology, Llc | Expression of microbial proteins in plants for production of plants with improved properties |
| US20060068386A1 (en) * | 2002-03-04 | 2006-03-30 | Alexei Slesarev | Complete genome and protein sequence of the hyperthermophile methanopyrus kandleri av19 and monophyly of archael methanogens and methods of use thereof |
| SE523209C2 (sv) * | 2002-05-14 | 2004-04-06 | Akzo Nobel Nv | Förfarande för att reducera metanbildningen från matspjälkningsaktiviteter hos djur |
| EP1861490A4 (en) | 2005-03-23 | 2010-11-17 | Univ St Louis | USE OF ARCHAEA FOR MODULATING NUTRITIONAL FUNCTIONALITY OF GASTROINTESTINAL BIOZOOSIS |
| US8586709B2 (en) * | 2007-09-25 | 2013-11-19 | Pastoral Greenhouse Research Limited | Cell-permeabilising peptides and polypeptides for microbial cells |
| CN101434924A (zh) * | 2008-12-17 | 2009-05-20 | 中南大学 | 一种分离严格厌氧产甲烷古菌的方法 |
| EP2470660A4 (en) * | 2009-08-27 | 2013-03-20 | Pastoral Greenhouse Gas Res Ltd | COMPLETE GENOME SEQUENCE OF THE METHANOGEN METHOBOBROVIBACTERIUM RUMINANTIUM |
| CN101864362B (zh) * | 2010-05-19 | 2012-05-09 | 江苏加德绿色能源有限公司 | 一种复合微生物菌剂及其应用 |
| DE102011119230B4 (de) * | 2011-11-23 | 2013-07-11 | Audi Ag | Kraftwagen-Blinkleuchte und Verfahren zum Betreiben einer Blinkleuchte |
| JP2016511630A (ja) * | 2012-12-21 | 2016-04-21 | ダニスコ・ユーエス・インク | 代案の下流メバロン酸経路を使用するイソプレン、イソプレノイド、およびイソプレノイド前駆体の生成 |
-
2008
- 2008-09-25 US US12/678,925 patent/US8586709B2/en active Active
- 2008-09-25 BR BRPI0817299A patent/BRPI0817299A8/pt not_active Application Discontinuation
- 2008-09-25 EP EP08834203.5A patent/EP2203466B1/en active Active
- 2008-09-25 EP EP08833501A patent/EP2203470A4/en not_active Ceased
- 2008-09-25 UY UY31361A patent/UY31361A1/es active IP Right Grant
- 2008-09-25 WO PCT/NZ2008/000248 patent/WO2009041831A1/en not_active Ceased
- 2008-09-25 DK DK17206527.8T patent/DK3327030T3/da active
- 2008-09-25 CN CN201611216760.1A patent/CN107129524B/zh active Active
- 2008-09-25 CA CA2700164A patent/CA2700164C/en active Active
- 2008-09-25 CN CN200880109156.6A patent/CN101932595B/zh active Active
- 2008-09-25 US US12/678,976 patent/US9296789B2/en active Active
- 2008-09-25 EP EP17206527.8A patent/EP3327030B1/en active Active
- 2008-09-25 CL CL2008002859A patent/CL2008002859A1/es unknown
- 2008-09-25 BR BR122021010729-7A patent/BR122021010729B1/pt active IP Right Grant
- 2008-09-25 WO PCT/NZ2008/000249 patent/WO2009041832A2/en not_active Ceased
- 2008-09-25 ES ES08834203.5T patent/ES2587595T3/es active Active
- 2008-09-25 DK DK08834203.5T patent/DK2203466T3/en active
- 2008-09-25 AU AU2008305846A patent/AU2008305846A1/en not_active Abandoned
- 2008-09-25 CN CN2008801094507A patent/CN102015755A/zh active Pending
- 2008-09-25 EP EP08834643.2A patent/EP2203467B1/en active Active
- 2008-09-25 NZ NZ745324A patent/NZ745324A/en unknown
- 2008-09-25 ES ES17206527T patent/ES2895908T3/es active Active
- 2008-09-25 MX MX2010003328A patent/MX2010003328A/es active IP Right Grant
- 2008-09-25 DK DK08834643.2T patent/DK2203467T3/en active
- 2008-09-25 BR BRPI0817312-5A patent/BRPI0817312B1/pt active IP Right Grant
- 2008-09-25 MX MX2010003321A patent/MX2010003321A/es active IP Right Grant
- 2008-09-25 BR BR122020023381-8A patent/BR122020023381B1/pt active IP Right Grant
- 2008-09-25 UY UY31360A patent/UY31360A1/es not_active Application Discontinuation
- 2008-09-25 RU RU2010116163/10A patent/RU2528854C2/ru not_active IP Right Cessation
- 2008-09-25 AR ARP080104173A patent/AR068553A1/es active IP Right Grant
- 2008-09-25 JP JP2010526840A patent/JP5552053B2/ja not_active Expired - Fee Related
- 2008-09-25 EP EP21181143.5A patent/EP3936516A1/en not_active Withdrawn
- 2008-09-25 US US12/678,936 patent/US8592556B2/en active Active
- 2008-09-25 MX MX2010003319A patent/MX340736B/es active IP Right Grant
- 2008-09-25 JP JP2010526841A patent/JP6067209B2/ja active Active
- 2008-09-25 BR BR122021010737-8A patent/BR122021010737B1/pt active IP Right Grant
- 2008-09-25 AU AU2008304018A patent/AU2008304018A1/en not_active Abandoned
- 2008-09-25 CA CA2700129A patent/CA2700129C/en active Active
- 2008-09-25 WO PCT/NZ2008/000247 patent/WO2009041830A2/en not_active Ceased
- 2008-09-25 CL CL2008002860A patent/CL2008002860A1/es unknown
- 2008-09-25 CL CL2008002861A patent/CL2008002861A1/es unknown
- 2008-09-25 CA CA2700162A patent/CA2700162C/en active Active
- 2008-09-25 JP JP2010526839A patent/JP5558356B2/ja not_active Expired - Fee Related
- 2008-09-25 AR ARP080104171A patent/AR068551A1/es unknown
- 2008-09-25 ES ES08834643.2T patent/ES2625144T3/es active Active
- 2008-09-25 AU AU2008304019A patent/AU2008304019A1/en not_active Abandoned
- 2008-09-25 UY UY31359A patent/UY31359A1/es not_active Application Discontinuation
- 2008-09-25 AR ARP080104172A patent/AR068552A1/es unknown
- 2008-09-25 CN CN200880109364.6A patent/CN101918431B/zh active Active
-
2010
- 2010-03-18 ZA ZA2010/01933A patent/ZA201001933B/en unknown
-
2013
- 2013-10-25 US US14/063,640 patent/US20140220636A1/en not_active Abandoned
-
2014
- 2014-07-04 JP JP2014139171A patent/JP2015042166A/ja active Pending
- 2014-08-08 AU AU2014210649A patent/AU2014210649B2/en active Active
-
2016
- 2016-03-28 US US15/082,373 patent/US10590170B2/en active Active
- 2016-10-05 JP JP2016197575A patent/JP2017046704A/ja active Pending
-
2020
- 2020-02-10 US US16/786,665 patent/US10995120B2/en active Active
-
2021
- 2021-04-08 US US17/226,028 patent/US11926647B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR068552A1 (es) | Polipeptidos y polinucleotidos del fago omegamru y sus usos para detectar, apuntar e inhibir celulas microbianas metanogenicas | |
| AR077992A1 (es) | Secuencia del genoma completo del metanogeno methanobrevibacter ruminantium | |
| EA201290295A1 (ru) | Специфичные к рецептору меланокортина-1 линейные пептиды | |
| CR20190319A (es) | ANTICUERPOS CONTRA EL INHIBIDOR DEL ACTIVADOR DE PLASMINÓGENO TIPO 1 (PAI-1) Y USOS DE LOS MISMOS (Divisional 2016-0117) | |
| CL2015001353A1 (es) | Molécula que contiene el dominio de fibronectina de tipo iii (fn3) biespecífico, donde el primer dominio se une al receptor del factor de crecimiento epidérmico (egrf) y el segundo al factor de crecimiento de hepatocitos (c-met); dominio de fn3; polinucleótido que la codifica; vector; célula huésped; método de producción; composición farmacéutica que la comprende; y uso para tratar el cáncer. | |
| PY1147875A (es) | Polipéptidos de enlace de los receptores de quimiocina | |
| DOP2015000039A (es) | Inhibidores de glucosilceramida sintasa | |
| BR112018001660A2 (pt) | células exterminadoras naturais e linhagens de células exterminadoras naturais modificadas possuindo citotoxicidade aumentada | |
| CL2015001790A1 (es) | Compuestos derivados de 3,4-dihidroisoquinolina sustituidos, inhibidores de prmt5; composicion farmaceutica; kit farmaceutico; metodo de inhibicion de prmt5; metodo para tratar la expresion de un gen; metodo para alterar la transcripcion; metodo de tratamiento de un trastorno tal como cancer, diabetes y obesisdad, entre otros. | |
| MX2016001044A (es) | Aav variante y composiciones, metodos y usos para transferencia genica a celulas, organos y tejidos. | |
| CL2012003745A1 (es) | Compuestos derivados de aminopirazoloquinazolinas, como inhibidores frente a la actividad fosforilante del receptor igf-1 localizado en membranas celulares; preparacion farmaceutica que los contiene; y su uso en el tratamiento y/o prevencion de cancer, infecciones, enfermedades inflamatorias y autoinmunitarias. | |
| DOP2013000209A (es) | Inhibidores de glucosilceramida sintasa | |
| CL2011000957A1 (es) | Compuesto derivados de isoindolina sustituidos, inhibidores de citosinas tnf-a; composicion farmaceutica; utiles en el tratamiento del cancer. | |
| CL2012002250A1 (es) | Compuestos heterociclicos fusionados derivados de pirimidinonas, inhibidores potentes de cdc7; composicion farmaceutica; y su uso en la prevencion o el tratamiento del cancer. | |
| EP2361988A4 (en) | MOLECULAR MARKER FOR CANCER STYLE CELL | |
| IN2015DN03029A (es) | ||
| BR112012029975A2 (pt) | peptídeo como medicamento, em particular para o tratamento do câncer. | |
| WO2011138328A3 (en) | Use of inhibitory molecules for the treatment of pulmonary hypertension | |
| BR112015021708A2 (pt) | Inibidor de polipetídeo do tnfa, polinucleotídeo isolado, estrutura de expressão de ácido nucleico, célula de planta, composição farmacêutica e método de produção de um inibidor de polipeptídeo do tnfa | |
| GT201500071A (es) | Antiandrògenos para el tratamiento del cancer de prostata residente a la castracion no metastàsico3 | |
| BR112014027981A2 (pt) | compostos do tipo fumagilol e métodos de produção e utilização dos mesmos | |
| MX351599B (es) | Polimeros cationicos con base en glucogeno. | |
| CL2011001427A1 (es) | Compuestos derivados de 4-azetidinil-1-heteroaril-ciclohexanol; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como epoc, aterosclerosis, artritis reumatoide, entre otras. | |
| MX2011008885A (es) | Composiciones, sintesis y metodos para usar derivados de arilpiperazina. | |
| PH12015500515A1 (en) | Beta-glucosidase from magnaporthe grisea |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |