AR070264A1 - Derivados de oxazepinopirimidona heteroarilamida sustituidos - Google Patents

Derivados de oxazepinopirimidona heteroarilamida sustituidos

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Publication number
AR070264A1
AR070264A1 ARP090100241A ARP090100241A AR070264A1 AR 070264 A1 AR070264 A1 AR 070264A1 AR P090100241 A ARP090100241 A AR P090100241A AR P090100241 A ARP090100241 A AR P090100241A AR 070264 A1 AR070264 A1 AR 070264A1
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AR
Argentina
Prior art keywords
group
alkyl
atom
alkoxy
alkyl group
Prior art date
Application number
ARP090100241A
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English (en)
Inventor
Alistair Lochead
Aude Fayol
Mourad Saady
Philippe Yaiche
Julien Vache
Original Assignee
Dupuis Laurent
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dupuis Laurent, Mitsubishi Tanabe Pharma Corp filed Critical Dupuis Laurent
Publication of AR070264A1 publication Critical patent/AR070264A1/es

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
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    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Diabetes (AREA)
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  • Pain & Pain Management (AREA)
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  • Oncology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Medicamento, proceso, intermediarios. utiles para tratar actividad anormal de GSK3beta. Reivindicacion 1: Un derivado de pirimidona representado por la formula (1) o una de sus sales o uno de sus solvatos o uno de sus hidratos: en la que: Y representa dos átomos de hidrogeno, un átomo de azufre, un átomo de oxigeno o un grupo alquilo C1-2 y un átomo de hidrogeno; Z representa un enlace, un átomo de oxígeno, un átomo de nitrogeno sustituido con un átomo de hidrogeno o un grupo alquilo C1-3, un átomo de azufre, un grupo metileno opcionalmente sustituido con uno o dos grupos elegidos entre un grupo alquilo C1-6, un grupo hidroxilo, alcoxi C1-6, alquilo C1-2 perhalogenado o un grupo amino; R1 representa un anillo de 2, 3 o 4-piridina o un anillo de 2, 4 o 5-pirimidina, estando el anillo opcionalmente sustituido con un grupo alquilo C1-6, alcoxi C1-6 o un átomo de halogeno; R2 representa un átomo de hidrogeno, un grupo alquilo C1-6 o un átomo de halogeno; R3 representa un grupo heterocíclico de 4-15 miembros, estando este grupo opcionalmente sustituido con 1 a 4 sustituyentes seleccionados entre un grupo alquilo C1-6, un átomo de halogeno, alquilo C1-2 perhalogenado, alquilo C1-6 halogenado, hidroxilo, alcoxi C1-6, alcoxi C1-6 halogenado, nitro, ciano, amino, un grupo monoalquilamino C1-6, dialquilamino C2-12, S-alquilo C1-6, C(O)O-alquilo C1-6 o un grupo C(O)O-arilo, un grupo heterocíclico de 4-15 miembros, arilo, O-arilo o un grupo S-arilo, estando los grupos mencionados anteriormente opcionalmente sustituidos con 1 a 4 sustituyentes seleccionados entre un grupo alquilo C1-6, un átomo de halogeno, alcoxi C1-6, C(O)O-alquilo C1-6 o un grupo C(O)O-arilo; R4 representa un átomo de hidrogeno o un grupo alquilo C1-6; y n representa 0 a 3. Reivindicacion 4: Un derivado de pirimidona representado por las formulas (3), (4) y (7) en las que R1 y R2 son como se definieron para el compuesto de formula (1) de acuerdo con la reivindicacion 1.
ARP090100241A 2008-01-29 2009-01-27 Derivados de oxazepinopirimidona heteroarilamida sustituidos AR070264A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08290077A EP2085400A1 (en) 2008-01-29 2008-01-29 Substituted heteroarylamide oxazepinopyrimidone derivatives

Publications (1)

Publication Number Publication Date
AR070264A1 true AR070264A1 (es) 2010-03-25

Family

ID=39495097

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090100241A AR070264A1 (es) 2008-01-29 2009-01-27 Derivados de oxazepinopirimidona heteroarilamida sustituidos

Country Status (16)

Country Link
US (1) US8501728B2 (es)
EP (2) EP2085400A1 (es)
JP (1) JP5581220B2 (es)
KR (1) KR20100116591A (es)
CN (1) CN101981039A (es)
AR (1) AR070264A1 (es)
AU (1) AU2009208726A1 (es)
BR (1) BRPI0906714A2 (es)
CA (1) CA2713248A1 (es)
EA (1) EA201070889A1 (es)
IL (1) IL207191A0 (es)
MX (1) MX2010008360A (es)
NZ (1) NZ587066A (es)
TW (1) TW200936141A (es)
WO (1) WO2009095787A1 (es)
ZA (1) ZA201005381B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2085399A1 (en) * 2008-01-29 2009-08-05 Sanofi-Aventis substituted arylamide oxazepinopyrimidone derivatives
EP2090578A1 (en) * 2008-01-29 2009-08-19 Sanofi-Aventis Substituted arylamide diazepinopyrimidone derivatives for the treatment of neurodegenerative diseases caused by abnormal activity of GSK3-beta
EP2090579A1 (en) * 2008-01-29 2009-08-19 Sanofi-Aventis Substituted heteroarylamide diazepinopyrimidone derivatives
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CN104220955B (zh) * 2012-04-02 2017-07-28 富士通株式会社 模块型数据中心

Family Cites Families (10)

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EG13192A (en) 1976-02-10 1982-12-31 Rhone Poulenc Ind Nouveaux derives du dithiole-1,2 leur preparation et les compositions qui les contiennent
US5629322A (en) 1994-11-15 1997-05-13 Merck & Co., Inc. Cyclic amidine analogs as inhibitors of nitric oxide synthase
EP0861238A4 (en) 1995-11-01 2000-03-01 Merck & Co Inc HEXAHYDRO-5-IMINO-1,4-HETEROAZEPINE DERIVATIVES AS INHIBITORS OF NITROGEN OXIDE SYTHASE
US20030096813A1 (en) * 2001-04-20 2003-05-22 Jingrong Cao Compositions useful as inhibitors of GSK-3
DE60206946T2 (de) * 2001-09-21 2006-07-27 Sanofi-Aventis Substituierte 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-on- und 7-pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1h)onderivate gegen neurodegenerative erkrankungen
EP1557417B1 (en) 2003-12-19 2007-03-07 Sanofi-Aventis Substituted 8'-pyri(mi)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-a] pyrimidin-6-one derivatives
EP1790649A1 (en) 2005-11-21 2007-05-30 Sanofi-Aventis Substituted bicyclic pyrimidone derivatives
EP2085399A1 (en) * 2008-01-29 2009-08-05 Sanofi-Aventis substituted arylamide oxazepinopyrimidone derivatives
EP2090578A1 (en) * 2008-01-29 2009-08-19 Sanofi-Aventis Substituted arylamide diazepinopyrimidone derivatives for the treatment of neurodegenerative diseases caused by abnormal activity of GSK3-beta
EP2090579A1 (en) * 2008-01-29 2009-08-19 Sanofi-Aventis Substituted heteroarylamide diazepinopyrimidone derivatives

Also Published As

Publication number Publication date
EP2247598B1 (en) 2012-10-24
TW200936141A (en) 2009-09-01
MX2010008360A (es) 2010-08-30
JP2011510968A (ja) 2011-04-07
EA201070889A1 (ru) 2011-04-29
US8501728B2 (en) 2013-08-06
WO2009095787A1 (en) 2009-08-06
CA2713248A1 (en) 2009-08-06
KR20100116591A (ko) 2010-11-01
US20110015176A1 (en) 2011-01-20
EP2085400A1 (en) 2009-08-05
EP2247598A1 (en) 2010-11-10
ZA201005381B (en) 2011-10-26
NZ587066A (en) 2011-12-22
BRPI0906714A2 (pt) 2015-06-30
IL207191A0 (en) 2010-12-30
AU2009208726A1 (en) 2009-08-06
JP5581220B2 (ja) 2014-08-27
CN101981039A (zh) 2011-02-23

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