ECSP088926A - Compuestos de piridil amida sustituidos como moduladores del receptor h3 de la histamina - Google Patents

Compuestos de piridil amida sustituidos como moduladores del receptor h3 de la histamina

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Publication number
ECSP088926A
ECSP088926A EC2008008926A ECSP088926A ECSP088926A EC SP088926 A ECSP088926 A EC SP088926A EC 2008008926 A EC2008008926 A EC 2008008926A EC SP088926 A ECSP088926 A EC SP088926A EC SP088926 A ECSP088926 A EC SP088926A
Authority
EC
Ecuador
Prior art keywords
alkyl
histamine
piridil
compounds replaced
independently
Prior art date
Application number
EC2008008926A
Other languages
English (en)
Inventor
Kiev S Ly
Neelakandha Mani
Hua Zhong
Frank Villani
Michael A Letavic
Chennagiri R Pandit
John M Keith
John E Mills
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ECSP088926A publication Critical patent/ECSP088926A/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/63—One oxygen atom
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    • C07D213/643—2-Phenoxypyridines; Derivatives thereof
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Pain & Pain Management (AREA)
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  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

Compuestos de piridilamida de Fórmula (I): consta gráfico en donde R1 es -alquilo de C1-4 o cicloalquilo monocíclico saturado; m es 1 ó 2; X es N o CH; Y es N o CRa; Ra es -H, -Z-Ar, -CH2NRbRc, -CN, -CO2alquilo de C1-4, -CO2H o CONRbRc; en donde Rb y Rc son cada uno de manera independiente -H o alquilo de C1-4; y R2 es -H o -Z-Ar; con la condición de que uno de X y Y es N y uno de Ra y R2 es Z-Ar; en donde Z es O o S; y Ar es un grupo fenilo o heteroarilo monocíclico no sustituido o sustituido con uno, dos o tres sustituyentes R3; en donde cada sustituyente R3 se selecciona de manera independiente del grupo que consiste de: halo, -alquilo de C1-4, -OH, -Oalquilo de C1-4, -Salquilo de C1-4, -CN, -CONRdRe y -NO2; en donde Rd y Re son cada uno de manera independiente -H o alquilo de C1-4; son moduladores del receptor H3 de la histamina útiles en el tratamiento de las enfermedades mediadas por el receptor H3 de la histamina
EC2008008926A 2006-05-30 2008-11-28 Compuestos de piridil amida sustituidos como moduladores del receptor h3 de la histamina ECSP088926A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80340706P 2006-05-30 2006-05-30
US82310806P 2006-08-22 2006-08-22

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US (4) US7777031B2 (es)
EP (1) EP2032536B1 (es)
JP (1) JP5285603B2 (es)
KR (1) KR101372941B1 (es)
CN (1) CN101495456B (es)
AR (1) AR061419A1 (es)
AU (1) AU2007256931B2 (es)
BR (1) BRPI0711873A2 (es)
CA (1) CA2653940C (es)
CR (1) CR10544A (es)
EA (1) EA015555B1 (es)
EC (1) ECSP088926A (es)
IL (1) IL195514A (es)
MX (2) MX339668B (es)
MY (1) MY146506A (es)
NI (1) NI200800314A (es)
NO (1) NO341679B1 (es)
NZ (1) NZ573028A (es)
TW (1) TWI393715B (es)
WO (1) WO2007143422A2 (es)
ZA (1) ZA200810855B (es)

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MX339668B (es) 2006-05-30 2016-06-02 Janssen Pharmaceutica N V * Compuestos de piridil amida sustituidos como moduladores del receptor h3 de la histamina.
CN101511807A (zh) * 2006-06-29 2009-08-19 詹森药业有限公司 组胺h3受体的取代的苯甲酰胺调节剂
TW200823204A (en) * 2006-10-17 2008-06-01 Arena Pharm Inc Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO2009067405A1 (en) * 2007-11-20 2009-05-28 Janssen Pharmaceutica N.V. Substituted pyrazinyl amide compounds as modulators of the histamine h3 receptor
WO2009067406A1 (en) * 2007-11-20 2009-05-28 Janssen Pharmaceutica N.V. Substituted pyridyl amide compounds as modulators of the histamine h3 receptor
CN105712977B (zh) * 2007-11-20 2021-06-29 詹森药业有限公司 作为组胺h3受体调节剂的环烷基氧基吡啶化合物和杂环烷基氧基吡啶化合物
WO2009097995A1 (de) * 2008-02-07 2009-08-13 Sanofi-Aventis Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2010000763A2 (en) * 2008-06-30 2010-01-07 Novartis Ag Combination products
WO2010045311A1 (en) * 2008-10-16 2010-04-22 Schering Corporation Methods of using nitrogen-containing heterocycle derivatives
HRP20170776T1 (hr) 2009-03-18 2017-08-11 Janssen Pharmaceutica N.V. Postupak za pripravu modulatora histaminskog h3 receptora
PL2729130T3 (pl) 2011-07-07 2018-02-28 Janssen Sciences Ireland Uc Preparaty kombinowane darunawiru
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules

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