AR070642A1 - Procedimiento de sintesis del (7- metoxi-1 naftil) acetonitrilo y aplicacion a la sintesis de la agomelatina - Google Patents

Procedimiento de sintesis del (7- metoxi-1 naftil) acetonitrilo y aplicacion a la sintesis de la agomelatina

Info

Publication number: AR070642A1
Authority: AR; Argentina
Prior art keywords: formula; synthesis; compound; naftil; agomelatin
Prior art date: 2007-08-03

Application number

ARP080103344A

Other languages

English (en)

Spanish (es)

Inventor

Thierry Dubuffet

Jean-Paul Hermet

Jean-Pierre Lecouve

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-08-03

Filing date

2008-08-01

Publication date

2010-04-28

2008-08-01 Application filed by Servier Lab filed Critical Servier Lab

2010-04-28 Publication of AR070642A1 publication Critical patent/AR070642A1/es

Links

230000015572 biosynthetic process Effects 0.000 title abstract 5
238000003786 synthesis reaction Methods 0.000 title abstract 5
238000000034 method Methods 0.000 title abstract 4
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 title 3
ZITFWUUYPONCCK-UHFFFAOYSA-N 1,2,3,4,5,6-hexachlorocyclohexane;naphthalen-1-yl n-methylcarbamate Chemical compound ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl.C1=CC=C2C(OC(=O)NC)=CC=CC2=C1 ZITFWUUYPONCCK-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 6
WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 3
IWXCQSJYXQESCP-UHFFFAOYSA-N 7-methoxynaphthalene-1-carboxylic acid Chemical compound C1=CC=C(C(O)=O)C2=CC(OC)=CC=C21 IWXCQSJYXQESCP-UHFFFAOYSA-N 0.000 abstract 1
YJYPHIXNFHFHND-UHFFFAOYSA-N agomelatine Chemical compound C1=CC=C(CCNC(C)=O)C2=CC(OC)=CC=C21 YJYPHIXNFHFHND-UHFFFAOYSA-N 0.000 abstract 1
229960002629 agomelatine Drugs 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
239000003638 chemical reducing agent Substances 0.000 abstract 1
230000008878 coupling Effects 0.000 abstract 1
238000010168 coupling process Methods 0.000 abstract 1
238000005859 coupling reaction Methods 0.000 abstract 1
238000007333 cyanation reaction Methods 0.000 abstract 1
239000007787 solid Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/14—Preparation of carboxylic acid nitriles by reaction of cyanides with halogen-containing compounds with replacement of halogen atoms by cyano groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Toxicology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ARP080103344A 2007-08-03 2008-08-01 Procedimiento de sintesis del (7- metoxi-1 naftil) acetonitrilo y aplicacion a la sintesis de la agomelatina AR070642A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0705688A FR2919606B1 (fr)	2007-08-03	2007-08-03	Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'agomelatine.

Publications (1)

Publication Number	Publication Date
AR070642A1 true AR070642A1 (es)	2010-04-28

Family

ID=38926411

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ARP080103344A AR070642A1 (es)	2007-08-03	2008-08-01	Procedimiento de sintesis del (7- metoxi-1 naftil) acetonitrilo y aplicacion a la sintesis de la agomelatina

Country Status (34)

Country	Link
US (2)	US8252951B2 (fr)
EP (1)	EP2176214B1 (fr)
JP (1)	JP5250626B2 (fr)
KR (1)	KR101179173B1 (fr)
CN (1)	CN101772484B (fr)
AP (1)	AP2611A (fr)
AR (1)	AR070642A1 (fr)
AU (1)	AU2008316406B2 (fr)
BR (1)	BRPI0815126A2 (fr)
CA (1)	CA2695234C (fr)
CL (1)	CL2008002272A1 (fr)
CY (1)	CY1115094T1 (fr)
DK (1)	DK2176214T3 (fr)
EA (1)	EA016333B1 (fr)
ES (1)	ES2467690T3 (fr)
FR (1)	FR2919606B1 (fr)
GE (1)	GEP20125586B (fr)
HR (1)	HRP20140407T1 (fr)
JO (1)	JO2992B1 (fr)
MA (1)	MA31740B1 (fr)
MY (1)	MY160226A (fr)
NZ (1)	NZ583064A (fr)
PA (1)	PA8792101A1 (fr)
PE (1)	PE20090881A1 (fr)
PL (1)	PL2176214T3 (fr)
PT (1)	PT2176214E (fr)
RS (1)	RS53250B (fr)
SA (1)	SA08290480B1 (fr)
SI (1)	SI2176214T1 (fr)
TW (1)	TWI352074B (fr)
UA (1)	UA94837C2 (fr)
UY (1)	UY31229A1 (fr)
WO (1)	WO2009053545A2 (fr)
ZA (1)	ZA201001184B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2011154140A2 (fr)	2010-06-10	2011-12-15	Gador S.A.	Nouveau procédé de préparation de n-[2-(7-méthoxy-1-naphtyl)-éthyl]acétamide et nouvelle forme cristalline
WO2013054273A2 (fr)	2011-10-11	2013-04-18	Ranbaxy Laboratories Limited	Procédé pour la préparation d'agomélatine
CN103130673B (zh) *	2011-11-28	2017-05-03	重庆医药工业研究院有限责任公司	一种阿戈美拉晶型i的制备方法
EP2785681A1 (fr)	2011-12-01	2014-10-08	Ranbaxy Laboratories Limited	Procédé de préparation d'agomélatine
ITMI20121444A1 (it)	2012-08-27	2014-02-28	Procos Spa	Processo per la produzione di agomelatine
CN104788342A (zh) *	2015-04-07	2015-07-22	湖南大学	一种由芳香甲醇制备芳香腈类化合物的方法
CN107098828A (zh) *	2017-05-09	2017-08-29	枣阳市残联福利生物化工厂	一种高效合成甲氧基萘乙腈的工艺
CN107382773A (zh) *	2017-06-19	2017-11-24	太仓弘杉环保科技有限公司	一种合成7‑甲氧基萘乙腈的方法
CN107162933A (zh) *	2017-06-19	2017-09-15	太仓大唐化纤厂	一种合成阿戈美拉汀重要中间体7‑甲氧基萘乙腈的方法
CN107353229B (zh) *	2017-08-08	2019-04-30	许昌恒生制药有限公司	一种阿戈美拉汀中间体的制备方法
CN112574065B (zh) *	2020-12-30	2022-10-28	宁波职业技术学院	一种(苯-1,3,5-三酰基)三乙腈的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH02202864A (ja) *	1989-01-31	1990-08-10	Hitachi Ltd	２，３―ジシアノ―６―ナフチルメタノール誘導体およびその製法
FR2658818B1 (fr)	1990-02-27	1993-12-31	Adir Cie	Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2696453B1 (fr) *	1992-10-02	1994-12-23	Adir	Nouveaux arylalkyl(thio)amides, leur procédé de préparation, et les compositions pharmaceutiques qui les contiennent.
FR2726268B1 (fr) *	1994-10-26	1996-12-06	Adir	Nouvelles o-arylmethyl n-(thio)acyl hydroxylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent
FR2784375B1 (fr) *	1998-10-12	2000-11-24	Adir	Nouveaux derives cycliques a chaine cycloalkylenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2866335B1 (fr) *	2004-02-13	2006-05-26	Servier Lab	Nouveau procede de synthese de l'agomelatine

2007
- 2007-08-03 FR FR0705688A patent/FR2919606B1/fr not_active Expired - Fee Related
2008
- 2008-07-16 UY UY31229A patent/UY31229A1/es not_active Application Discontinuation
- 2008-07-24 PE PE2008001252A patent/PE20090881A1/es active IP Right Grant
- 2008-08-01 US US12/733,034 patent/US8252951B2/en not_active Expired - Fee Related
- 2008-08-01 MY MYPI2010000320A patent/MY160226A/en unknown
- 2008-08-01 CL CL2008002272A patent/CL2008002272A1/es unknown
- 2008-08-01 TW TW097129371A patent/TWI352074B/zh not_active IP Right Cessation
- 2008-08-01 AP AP2010005145A patent/AP2611A/xx active
- 2008-08-01 HR HRP20140407AT patent/HRP20140407T1/hr unknown
- 2008-08-01 WO PCT/FR2008/001146 patent/WO2009053545A2/fr not_active Ceased
- 2008-08-01 CN CN200880101738XA patent/CN101772484B/zh not_active Expired - Fee Related
- 2008-08-01 GE GEAP200811699A patent/GEP20125586B/en unknown
- 2008-08-01 SI SI200831201T patent/SI2176214T1/sl unknown
- 2008-08-01 EA EA201000257A patent/EA016333B1/ru not_active IP Right Cessation
- 2008-08-01 PA PA20088792101A patent/PA8792101A1/es unknown
- 2008-08-01 CA CA2695234A patent/CA2695234C/fr not_active Expired - Fee Related
- 2008-08-01 BR BRPI0815126-1A2A patent/BRPI0815126A2/pt not_active Application Discontinuation
- 2008-08-01 PL PL08842551T patent/PL2176214T3/pl unknown
- 2008-08-01 NZ NZ583064A patent/NZ583064A/en not_active IP Right Cessation
- 2008-08-01 UA UAA201002246A patent/UA94837C2/ru unknown
- 2008-08-01 RS RS20140155A patent/RS53250B/sr unknown
- 2008-08-01 PT PT88425517T patent/PT2176214E/pt unknown
- 2008-08-01 AU AU2008316406A patent/AU2008316406B2/en not_active Ceased
- 2008-08-01 DK DK08842551.7T patent/DK2176214T3/da active
- 2008-08-01 JP JP2010519488A patent/JP5250626B2/ja active Active
- 2008-08-01 ES ES08842551.7T patent/ES2467690T3/es active Active
- 2008-08-01 EP EP08842551.7A patent/EP2176214B1/fr active Active
- 2008-08-01 AR ARP080103344A patent/AR070642A1/es not_active Application Discontinuation
- 2008-08-01 KR KR1020107004649A patent/KR101179173B1/ko not_active Expired - Fee Related
- 2008-08-02 SA SA08290480A patent/SA08290480B1/ar unknown
- 2008-08-03 JO JOP/2008/0348A patent/JO2992B1/ar active
2010
- 2010-02-18 ZA ZA2010/01184A patent/ZA201001184B/en unknown
- 2010-03-01 MA MA32661A patent/MA31740B1/fr unknown
2012
- 2012-07-30 US US13/561,421 patent/US8436206B2/en not_active Expired - Fee Related
2014
- 2014-05-21 CY CY20141100356T patent/CY1115094T1/el unknown

Also Published As

Publication number	Publication date
UA94837C2 (ru)	2011-06-10
AP2010005145A0 (en)	2010-02-28
ES2467690T3 (es)	2014-06-12
MA31740B1 (fr)	2010-10-01
GEP20125586B (en)	2012-07-25
WO2009053545A3 (fr)	2009-07-23
EA201000257A1 (ru)	2010-08-30
RS53250B (sr)	2014-08-29
JO2992B1 (ar)	2016-09-05
MY160226A (en)	2017-02-28
CA2695234A1 (fr)	2009-04-30
AU2008316406B2 (en)	2011-04-07
PL2176214T3 (pl)	2014-06-30
PA8792101A1 (es)	2009-09-17
PE20090881A1 (es)	2009-07-18
US20120330062A1 (en)	2012-12-27
CL2008002272A1 (es)	2009-02-06
AP2611A (en)	2013-03-05
EP2176214B1 (fr)	2014-03-05
SA08290480B1 (ar)	2012-02-07
TW200925141A (en)	2009-06-16
US20100137628A1 (en)	2010-06-03
US8252951B2 (en)	2012-08-28
CN101772484A (zh)	2010-07-07
CN101772484B (zh)	2013-09-18
AU2008316406A1 (en)	2009-04-30
SI2176214T1 (sl)	2014-06-30
CY1115094T1 (el)	2016-12-14
JP5250626B2 (ja)	2013-07-31
KR101179173B1 (ko)	2012-09-03
PT2176214E (pt)	2014-04-14
DK2176214T3 (da)	2014-06-10
UY31229A1 (es)	2008-09-30
TWI352074B (en)	2011-11-11
HK1145830A1 (en)	2011-05-06
HRP20140407T1 (hr)	2014-06-06
FR2919606A1 (fr)	2009-02-06
ZA201001184B (en)	2011-04-28
CA2695234C (fr)	2013-02-05
FR2919606B1 (fr)	2010-09-17
KR20100039899A (ko)	2010-04-16
BRPI0815126A2 (pt)	2015-02-03
EA016333B1 (ru)	2012-04-30
US8436206B2 (en)	2013-05-07
NZ583064A (en)	2011-07-29
EP2176214A2 (fr)	2010-04-21
JP2010535746A (ja)	2010-11-25
WO2009053545A2 (fr)	2009-04-30

Legal Events

Date	Code	Title	Description
2015-02-20	FG	Grant, registration
2021-12-06	FD	Application declared void or lapsed, e.g., due to non-payment of fee

Publication	Publication Date	Title
CL2008002272A1 (es)	2009-02-06	Procedimiento para preparar (7-metoxi-1-naftil)-acetonitrilo a partir del derivado de acido que se reduce y se transforma a nitrilo; util en la sintesis de agomelatina.
BR112012028369A2 (pt)	2017-03-21	processo de preparo de aminoácidos ou ésteres saturados, compreendendo uma etapa de metástase.
CO6120163A1 (es)	2010-01-29	Nuevo procedimeinto de sintesis de la agomelatina
AR061256A1 (es)	2008-08-13	Proceso para convertir compuestos de nitrilo acidos carboxilicos y los esteres correspondientes
CL2012001145A1 (es)	2012-09-14	Método para liberar un polisacárido capsular a partir de células tipo 5 o tipo 8 de staphilococcus aureus, que comprende la etapa de tratar las células con un ácido; proceso para purificar dicho polisacárido; composición que comprende estos polisacáridos.
AR078030A1 (es)	2011-10-12	Procedimiento para la preparacion de aldehidos c10 alfa, beta-insaturados
CL2009001684A1 (es)	2010-07-19	Procedimiento de sintesis de agomelatina por reduccion de un grupo nitrilo en presencia de anhidrido acetico.
CO6160240A2 (es)	2010-05-20	Proceso de sintesis de macrolida
AR076027A1 (es)	2011-05-11	Metodos e intermediarios para la preparacion de agentes farmaceuticos
MY152981A (en)	2014-12-15	Method for the synthesis of an omega-amino acid or ester starting from a monounsaturated fatty acid or ester
AR072143A1 (es)	2010-08-11	Procedimiento para la preparacion de un producto intermedio para la sintesis de etexilato de dabigatran
CL2011001626A1 (es)	2012-01-20	Metodo para producir un ester y amidas que comprende hacer reaccionar un acido graso o un acido graso amidificado con ozono y un alcohol a una temperatura entre -80 y 80 grados celsius
EP1967507A3 (fr)	2008-10-29	Procédé amélioré pour la conversion d'alcanes en acides carboxyliques insaturés
MY148547A (en)	2013-04-30	Method for producing fatty acid alkyl ester and/or glycerin
CL2011000296A1 (es)	2011-11-04	Proceso de preparación del ester metílico del ácido 4-oxo-octahidro-indol-1-carboxílico y compuestos intermediarios utilizados.
AR078916A1 (es)	2011-12-14	Procedimiento para la purificacion de paliperidona
AR088763A1 (es)	2014-07-02	Proceso para producir un producto acrilato
BR112014032741A2 (pt)	2017-06-27	lipase em esterificação de ácidos graxos de cadeia curta
BR112013003992A2 (pt)	2016-07-12	método de produção
AR074887A1 (es)	2011-02-23	Procedimiento de sintesis de la agomelatina
BRPI0500333A (pt)	2006-09-12	processo catalìtico para esterificação de ácidos graxos
AR047162A1 (es)	2006-01-11	Un procedimiento para catalizar una reaccion de defi usando un catalizador basado en un metal del grupo 4 (de acuerdo con la iupac)
AR066054A1 (es)	2009-07-22	Proceso para preparar galantamina
PE20140503A1 (es)	2014-05-14	Medio para la lixiviacion de cobre de minerales refractarios
EP2450343A4 (fr)	2013-01-09	Procédé de production de la thréo-3-(3,4-dihydroxyphényle)-l-sérine