AR074978A1 - 3-n-aril-1,3,4-oxadiazolonas 5-o-sustituidas para uso en el tratamiento del dolor y procedimiento de obtencion - Google Patents

3-n-aril-1,3,4-oxadiazolonas 5-o-sustituidas para uso en el tratamiento del dolor y procedimiento de obtencion

Info

Publication number: AR074978A1
Authority: AR; Argentina
Prior art keywords: alkyl; aryl; amino; sulfonyl; alkoxy
Prior art date: 2008-12-23

Application number

ARP090105095A

Other languages

English (en)

Spanish (es)

Inventor

Araujo Soares Da Silva Patricio Manuel Vieira

David Alexander Learmonth

Original Assignee

Bial Portela & Ca Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-12-23

Filing date

2009-12-23

Publication date

2011-03-02

2009-12-23 Application filed by Bial Portela & Ca Sa filed Critical Bial Portela & Ca Sa

2011-03-02 Publication of AR074978A1 publication Critical patent/AR074978A1/es

Links

125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 36
125000000041 C6-C10 aryl group Chemical group 0.000 abstract 21
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 15
125000000217 alkyl group Chemical group 0.000 abstract 14
229910006074 SO2NH2 Inorganic materials 0.000 abstract 12
125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 12
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 12
125000003118 aryl group Chemical group 0.000 abstract 10
229910006069 SO3H Inorganic materials 0.000 abstract 9
125000005129 aryl carbonyl group Chemical group 0.000 abstract 9
125000001153 fluoro group Chemical group F* 0.000 abstract 9
125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 9
150000003573 thiols Chemical class 0.000 abstract 9
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 9
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 9
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 8
125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 8
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 8
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 8
125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 7
125000004104 aryloxy group Chemical group 0.000 abstract 7
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 7
125000006719 (C6-C10) aryl (C1-C6) alkyl group Chemical group 0.000 abstract 6
125000003277 amino group Chemical group 0.000 abstract 6
125000004093 cyano group Chemical group *C#N 0.000 abstract 6
125000000524 functional group Chemical group 0.000 abstract 6
229910052739 hydrogen Inorganic materials 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 6
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 6
229920006395 saturated elastomer Polymers 0.000 abstract 6
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
125000001309 chloro group Chemical group Cl* 0.000 abstract 5
-1 fluorosulfonyl Chemical group 0.000 abstract 5
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 4
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 4
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 4
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 4
ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 4
125000004429 atom Chemical group 0.000 abstract 4
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 4
229910052794 bromium Inorganic materials 0.000 abstract 4
229910052801 chlorine Inorganic materials 0.000 abstract 4
239000000460 chlorine Substances 0.000 abstract 4
229910052740 iodine Inorganic materials 0.000 abstract 4
239000011630 iodine Substances 0.000 abstract 4
125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
229910052760 oxygen Inorganic materials 0.000 abstract 3
229910052717 sulfur Inorganic materials 0.000 abstract 3
CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 2
125000005157 alkyl carboxy group Chemical group 0.000 abstract 2
150000001409 amidines Chemical group 0.000 abstract 2
125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 2
125000001246 bromo group Chemical group Br* 0.000 abstract 2
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 2
150000002148 esters Chemical class 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000002346 iodo group Chemical group I* 0.000 abstract 2
229940002612 prodrug Drugs 0.000 abstract 2
239000000651 prodrug Substances 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
125000002947 alkylene group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
239000003940 fatty acid amidase inhibitor Substances 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000005647 linker group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/13—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

ARP090105095A 2008-12-23 2009-12-23 3-n-aril-1,3,4-oxadiazolonas 5-o-sustituidas para uso en el tratamiento del dolor y procedimiento de obtencion AR074978A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US20354908P	2008-12-23	2008-12-23

Publications (1)

Publication Number	Publication Date
AR074978A1 true AR074978A1 (es)	2011-03-02

Family

ID=41722972

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ARP090105095A AR074978A1 (es)	2008-12-23	2009-12-23	3-n-aril-1,3,4-oxadiazolonas 5-o-sustituidas para uso en el tratamiento del dolor y procedimiento de obtencion

Country Status (3)

Country	Link
AR (1)	AR074978A1 (fr)
TW (1)	TW201028406A (fr)
WO (1)	WO2010074587A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2011085216A2 (fr)	2010-01-08	2011-07-14	Ironwood Pharmaceuticals, Inc.	Utilisation d'inhibiteurs de faah pour traiter la maladie de parkinson et le syndrome des jambes sans repos
US20130224151A1 (en)	2010-03-31	2013-08-29	United States Of America	Use of FAAH Inhibitors for Treating Abdominal, Visceral and Pelvic Pain

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS531335B2 (fr)	1971-11-29	1978-01-18
US4076824A (en)	1975-02-03	1978-02-28	Rhone-Poulenc Industries	Anthelmintic oxadiazolinone derivatives
FR2605007A2 (fr) *	1986-05-07	1988-04-15	Rhone Poulenc Agrochimie	Herbicides de type sulfonyluree, leur preparation, les compositions les contenant et leur utilisation
US5236939A (en)	1989-09-23	1993-08-17	Bayer Aktiengesellschaft	Substituted 1,3,4-oxa(thia)diazolinones process for their preparation and their use of combating endoparasites
DE3931843A1 (de)	1989-09-23	1991-04-04	Bayer Ag	Substituierte 1,3,4-oxa(thia)diazolinone verfahren zu ihrer herstellung und ihre verwendung der bekaempfung von endoparasiten
DE19942354A1 (de)	1999-09-04	2001-03-08	Aventis Pharma Gmbh	Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one, ihre Herstellung und Verwendung in Arzneimitteln
TR200401217T4 (tr)	2000-03-07	2004-06-21	Aventis Pharma Deutschland Gmbh	İkameli 3-Fenil-5-Alkoksi-1,3,4-Oksdiazol-2-one (ve) hormona duyarlı lipazın önlenmesinde kullanılması
US7205321B2 (en)	2001-11-15	2007-04-17	Eli Lilly And Company	Peroxisome proliferator activated receptor alpha agonists
DE10208987A1 (de)	2002-02-28	2003-09-11	Aventis Pharma Gmbh	Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxidiazol-2-one, ihre Herstellung und Verwendung in Arzneistoffen
DE10208986A1 (de)	2002-02-28	2003-09-11	Aventis Pharma Gmbh	Verwendung substituierter 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one zur Herstellung von Arzneimitteln mit hemmender Wirkung an der pankreatischen Lipase
MXPA05000053A (es) *	2002-07-12	2005-04-08	Aventis Pharma Gmbh	Benzoilureas heterociclicamente sustituidas, metodo para su produccion y su uso como medicamentos.
JP2011507952A (ja) *	2007-12-27	2011-03-10	バイアル−ポルテラアンドシーエー，エス．エー．	医療用途用５−ｏ−置換３−ｎ−フェニル−１、３、４−オキサジアゾロン類

2009
- 2009-12-23 TW TW098144465A patent/TW201028406A/zh unknown
- 2009-12-23 AR ARP090105095A patent/AR074978A1/es unknown
- 2009-12-23 WO PCT/PT2009/000079 patent/WO2010074587A2/fr not_active Ceased

Also Published As

Publication number	Publication date
WO2010074587A2 (fr)	2010-07-01
WO2010074587A3 (fr)	2010-11-11
TW201028406A (en)	2010-08-01

Legal Events

Date	Code	Title	Description
2013-01-16	FB	Suspension of granting procedure

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