AR080722A2 - Metodo para regular la expresion de un blanco con una construccion de nucleotidos y para tratar un acondicion patologica - Google Patents

Metodo para regular la expresion de un blanco con una construccion de nucleotidos y para tratar un acondicion patologica

Info

Publication number
AR080722A2
AR080722A2 ARP110100994A ARP110100994A AR080722A2 AR 080722 A2 AR080722 A2 AR 080722A2 AR P110100994 A ARP110100994 A AR P110100994A AR P110100994 A ARP110100994 A AR P110100994A AR 080722 A2 AR080722 A2 AR 080722A2
Authority
AR
Argentina
Prior art keywords
expression
nucleotide sequence
blank
pathological condition
regulate
Prior art date
Application number
ARP110100994A
Other languages
English (en)
Inventor
John Shanklin
Tam Nguyen
Original Assignee
Brookhaven Science Ass Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brookhaven Science Ass Llc filed Critical Brookhaven Science Ass Llc
Publication of AR080722A2 publication Critical patent/AR080722A2/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3519—Fusion with another nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Nutrition Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Se describe un método para regular la expresion de un blanco, que comprende proveer a una célula la construccion de nucleotido que comprende: una secuencia de nucleotido que forma un tronco y un giro; en donde el giro comprende una primera secuencia de nucleotido que modula la expresion de un blanco; en donde el tronco comprende una segunda secuencia de nucleotido que modula la expresion de un blanco; y en donde el blanco modulado por la primera secuencia de nucleotido y el blanco modulado por la segunda secuencia de nucleotido pueden ser iguales o diferentes; y cultivar dicha célula. Se describe también un método para tratar una condicion patologica vectores, métodos para regular la expresion del blanco, para preparar una construccion para regular un blanco, composiciones farmacéuticas y células que comprende la construccion de nucleotido utilizada en los métodos.
ARP110100994A 2007-03-21 2011-03-23 Metodo para regular la expresion de un blanco con una construccion de nucleotidos y para tratar un acondicion patologica AR080722A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89621207P 2007-03-21 2007-03-21

Publications (1)

Publication Number Publication Date
AR080722A2 true AR080722A2 (es) 2012-05-02

Family

ID=39766774

Family Applications (3)

Application Number Title Priority Date Filing Date
ARP080101204A AR066194A1 (es) 2007-03-21 2008-03-25 Composiciones antisentido en horquilla combinadas y metodos para modular la expresion de un gen blanco en celulas
ARP110100994A AR080722A2 (es) 2007-03-21 2011-03-23 Metodo para regular la expresion de un blanco con una construccion de nucleotidos y para tratar un acondicion patologica
ARP140103952A AR098140A2 (es) 2007-03-21 2014-10-21 Método para regular la expresión de un blanco con una construcción de nucleótidos y para tratar una condición patológica; método para preparar dicha construcción composición médica y célula que la contiene

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP080101204A AR066194A1 (es) 2007-03-21 2008-03-25 Composiciones antisentido en horquilla combinadas y metodos para modular la expresion de un gen blanco en celulas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP140103952A AR098140A2 (es) 2007-03-21 2014-10-21 Método para regular la expresión de un blanco con una construcción de nucleótidos y para tratar una condición patológica; método para preparar dicha construcción composición médica y célula que la contiene

Country Status (13)

Country Link
US (2) US8796442B2 (es)
EP (1) EP2129680B1 (es)
JP (1) JP5759673B2 (es)
AR (3) AR066194A1 (es)
AU (1) AU2008228814B2 (es)
BR (1) BRPI0809130A8 (es)
CA (1) CA2681323A1 (es)
DK (1) DK2129680T3 (es)
ES (1) ES2538217T3 (es)
HU (1) HUE027018T2 (es)
PL (1) PL2129680T3 (es)
PT (1) PT2129680E (es)
WO (1) WO2008116094A2 (es)

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Also Published As

Publication number Publication date
PL2129680T3 (pl) 2015-10-30
US20140342453A1 (en) 2014-11-20
ES2538217T3 (es) 2015-06-18
PT2129680E (pt) 2015-08-28
WO2008116094A3 (en) 2008-11-20
AR066194A1 (es) 2009-08-05
WO2008116094A2 (en) 2008-09-25
EP2129680A2 (en) 2009-12-09
HUE027018T2 (en) 2016-08-29
JP2010521973A (ja) 2010-07-01
EP2129680B1 (en) 2015-05-06
US9193972B2 (en) 2015-11-24
AU2008228814A1 (en) 2008-09-25
JP5759673B2 (ja) 2015-08-05
CA2681323A1 (en) 2008-09-25
AR098140A2 (es) 2016-05-04
DK2129680T3 (en) 2015-08-10
EP2129680A4 (en) 2010-10-20
BRPI0809130A8 (pt) 2021-11-03
BRPI0809130A2 (pt) 2014-08-26
US20080311658A1 (en) 2008-12-18
AU2008228814B2 (en) 2014-03-06
US8796442B2 (en) 2014-08-05

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