BRPI0809130A8 - Composições combinadas hairpin-antissenso e métodos para modulação da expressão - Google Patents

Composições combinadas hairpin-antissenso e métodos para modulação da expressão

Info

Publication number
BRPI0809130A8
BRPI0809130A8 BRPI0809130A BRPI0809130A BRPI0809130A8 BR PI0809130 A8 BRPI0809130 A8 BR PI0809130A8 BR PI0809130 A BRPI0809130 A BR PI0809130A BR PI0809130 A BRPI0809130 A BR PI0809130A BR PI0809130 A8 BRPI0809130 A8 BR PI0809130A8
Authority
BR
Brazil
Prior art keywords
methods
nucleotide sequence
target
expression
antisense compositions
Prior art date
Application number
BRPI0809130A
Other languages
English (en)
Inventor
John Shanklin
Tam Nguyen
Original Assignee
Brookhaven Science Ass Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brookhaven Science Ass Llc filed Critical Brookhaven Science Ass Llc
Publication of BRPI0809130A2 publication Critical patent/BRPI0809130A2/pt
Publication of BRPI0809130A8 publication Critical patent/BRPI0809130A8/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3519—Fusion with another nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Nutrition Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

composições combinadas hairpin-antissenso e métodos para modulação da expressão. é descrito um constructo de nucleotídeos que compreende uma sequência de nucleotídeos que forma uma haste e uma alça, em que a alça compreende uma sequência de nucleotídeos que modula a expressão de um alvo, em que a haste compreende uma sequência de nucleotídeos que modula a expressão de um alvo, e em que o alvo modulado pela sequência de nucleotídeos na alça e o alvo modulado pela sequência de nucleotídeos na haste podem ser iguais ou diferentes. vetores, métodos de regulação de expressão-alvo, métodos de fornecimento de uma célula, e métodos de tratamento de condições que compreendem a sequência de nucleotídeos também são descritos.
BRPI0809130A 2007-03-21 2008-03-20 Composições combinadas hairpin-antissenso e métodos para modulação da expressão BRPI0809130A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89621207P 2007-03-21 2007-03-21
US60/896,212 2007-03-21
PCT/US2008/057704 WO2008116094A2 (en) 2007-03-21 2008-03-20 Combined hairpin-antisense compositions and methods for modulating expression

Publications (2)

Publication Number Publication Date
BRPI0809130A2 BRPI0809130A2 (pt) 2014-08-26
BRPI0809130A8 true BRPI0809130A8 (pt) 2021-11-03

Family

ID=39766774

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0809130A BRPI0809130A8 (pt) 2007-03-21 2008-03-20 Composições combinadas hairpin-antissenso e métodos para modulação da expressão

Country Status (13)

Country Link
US (2) US8796442B2 (pt)
EP (1) EP2129680B1 (pt)
JP (1) JP5759673B2 (pt)
AR (3) AR066194A1 (pt)
AU (1) AU2008228814B2 (pt)
BR (1) BRPI0809130A8 (pt)
CA (1) CA2681323A1 (pt)
DK (1) DK2129680T3 (pt)
ES (1) ES2538217T3 (pt)
HU (1) HUE027018T2 (pt)
PL (1) PL2129680T3 (pt)
PT (1) PT2129680E (pt)
WO (1) WO2008116094A2 (pt)

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Also Published As

Publication number Publication date
PL2129680T3 (pl) 2015-10-30
US20140342453A1 (en) 2014-11-20
ES2538217T3 (es) 2015-06-18
AR080722A2 (es) 2012-05-02
PT2129680E (pt) 2015-08-28
WO2008116094A3 (en) 2008-11-20
AR066194A1 (es) 2009-08-05
WO2008116094A2 (en) 2008-09-25
EP2129680A2 (en) 2009-12-09
HUE027018T2 (en) 2016-08-29
JP2010521973A (ja) 2010-07-01
EP2129680B1 (en) 2015-05-06
US9193972B2 (en) 2015-11-24
AU2008228814A1 (en) 2008-09-25
JP5759673B2 (ja) 2015-08-05
CA2681323A1 (en) 2008-09-25
AR098140A2 (es) 2016-05-04
DK2129680T3 (en) 2015-08-10
EP2129680A4 (en) 2010-10-20
BRPI0809130A2 (pt) 2014-08-26
US20080311658A1 (en) 2008-12-18
AU2008228814B2 (en) 2014-03-06
US8796442B2 (en) 2014-08-05

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