AR082409A2 - Proceso para preparar un compuesto intermediario derivado de estradiol 7-sustituido y compuesto que se usa en dicho proceso - Google Patents

Proceso para preparar un compuesto intermediario derivado de estradiol 7-sustituido y compuesto que se usa en dicho proceso

Info

Publication number
AR082409A2
AR082409A2 ARP110102734A ARP110102734A AR082409A2 AR 082409 A2 AR082409 A2 AR 082409A2 AR P110102734 A ARP110102734 A AR P110102734A AR P110102734 A ARP110102734 A AR P110102734A AR 082409 A2 AR082409 A2 AR 082409A2
Authority
AR
Argentina
Prior art keywords
group
compound
estradiol
prepare
replaced
Prior art date
Application number
ARP110102734A
Other languages
English (en)
Inventor
Farser Kerr
Eve J Brazier
Phillip J Hogan
Anthony Lane
David Laffan
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9901292&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR082409(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR082409A2 publication Critical patent/AR082409A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Un proceso para preparar un compuesto intermediario de fórmula (1) donde X es S; n es 9; R es hidrógeno o un grupo protector de hidroxi, R1 es -(CH2)3CF2CF3; R2 es hidrógeno, alquilo C1-6 o hidroxi; R3 es hidrógeno, alquilo C1-6, alquenilo C2-6 o alquinilo C2-6; R4 es hidroxi, alcanoiloxi C1-10, carboxi-alcanoiloxi C1-10 o aroiloxi (tal como benzoiloxi); R5 es alquilo C1-6; cuyo proceso comprende la aromatización de un compuesto de fórmula (2) donde R1, R2, R3, n, X y R5 son como se definen para la fórmula (1) y R4’ es un grupo R4 o un grupo precursor del mismo, y por lo tanto si resulta necesario o deseable, llevar a cabo uno o más de los siguientes pasos: (i) eliminar uno o varios grupos protectores R; (ii) convertir un grupo precursor R4’ en un grupo R4, o donde R4’ es un grupo R4, convertirlo en un grupo diferente.
ARP110102734A 2000-10-14 2011-07-28 Proceso para preparar un compuesto intermediario derivado de estradiol 7-sustituido y compuesto que se usa en dicho proceso AR082409A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0025221.3A GB0025221D0 (en) 2000-10-14 2000-10-14 New process

Publications (1)

Publication Number Publication Date
AR082409A2 true AR082409A2 (es) 2012-12-05

Family

ID=9901292

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP010104814A AR034561A1 (es) 2000-10-14 2001-10-12 Proceso para preparar un compuesto intermediario derivado de estradiol 7-sustituido y compuesto que se usa en dicho proceso
ARP110102734A AR082409A2 (es) 2000-10-14 2011-07-28 Proceso para preparar un compuesto intermediario derivado de estradiol 7-sustituido y compuesto que se usa en dicho proceso

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP010104814A AR034561A1 (es) 2000-10-14 2001-10-12 Proceso para preparar un compuesto intermediario derivado de estradiol 7-sustituido y compuesto que se usa en dicho proceso

Country Status (26)

Country Link
US (1) US7947667B2 (es)
EP (2) EP1328538B1 (es)
JP (2) JP4363846B2 (es)
KR (2) KR20080056029A (es)
CN (1) CN1255425C (es)
AR (2) AR034561A1 (es)
AT (1) ATE403667T1 (es)
AU (3) AU9213201A (es)
BR (1) BR0114649A (es)
CA (1) CA2425572C (es)
CY (1) CY1108398T1 (es)
DE (1) DE60135240D1 (es)
DK (1) DK1328538T3 (es)
EG (1) EG23373A (es)
ES (2) ES2581379T3 (es)
GB (1) GB0025221D0 (es)
IL (2) IL155172A0 (es)
MX (1) MXPA03003302A (es)
MY (2) MY145819A (es)
NO (1) NO326020B1 (es)
NZ (1) NZ525096A (es)
PT (1) PT1328538E (es)
SA (1) SA01220570B1 (es)
SI (1) SI1328538T1 (es)
WO (1) WO2002032922A1 (es)
ZA (1) ZA200302526B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0025221D0 (en) 2000-10-14 2000-11-29 Astrazeneca Ab New process
GB0123961D0 (en) 2001-10-05 2001-11-28 Astrazeneca Ab Process and intermediates
US7790910B2 (en) 2004-07-27 2010-09-07 Sicor Inc. Process for the preparation of 7α-alkylated 19-norsteroids
WO2009039700A1 (en) * 2007-09-24 2009-04-02 Xi'an Libang Pharmaceutical Co., Ltd. Process for the manufacture of 7-alpha-[9-(4,4,5,5,5-penta fluoropentvlsulphinvl) nonvllestra-l,3,5-(10)- triene-3,17-beta-diol
EP2070942A1 (de) * 2007-12-13 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Aromatisierung von 19-Nor-androst-4-en-3-onen zu Estra-1,3,5(10)-trienen
CN101525364B (zh) * 2008-03-07 2012-12-12 杭州九源基因工程有限公司 一种氟维司群的晶型及其制备方法
US8063249B1 (en) 2008-04-25 2011-11-22 Olema Pharmaceuticals, Inc. Substituted triphenyl butenes
CN102391341B (zh) * 2011-08-09 2013-05-22 福建省微生物研究所 制备6,7-脱氢-17β-烃酰氧基诺龙的方法
CN102600064A (zh) * 2012-03-31 2012-07-25 西安力邦制药有限公司 氟维司群或其衍生物缓释制剂及其制备方法
CA2884806A1 (en) 2012-10-22 2014-05-01 Intas Pharmaceuticals Limited An improved process for the preparation of fulvestrant
CN103788164A (zh) * 2012-10-31 2014-05-14 正大天晴药业集团股份有限公司 一种氟维司群的制备方法
CN103965280B (zh) * 2014-05-21 2016-04-20 天津孚音生物科技发展有限公司 一种氟维司群中间体的制备方法
WO2015181116A1 (en) 2014-05-26 2015-12-03 Crystal Pharma, S.A.U. Process and intermediades for the preparation of 7-alkylated steroids
CN104387435B (zh) * 2014-12-10 2017-05-10 天津孚音生物科技发展有限公司 一种化合物及其制备方法与应用
KR101640747B1 (ko) 2015-05-20 2016-07-19 이금운 확장 가능형 끼움식 엘이디 조명 등기구
CN107488205A (zh) * 2016-06-13 2017-12-19 重庆圣华曦药业股份有限公司 一种氟维司群有关物质的制备方法及其在制剂中的检测方法
CN110818764A (zh) * 2018-08-07 2020-02-21 重庆圣华曦药业股份有限公司 一种应用加料监测系统制备氟维斯群中间体的方法
CN111018936B (zh) * 2019-11-12 2021-10-29 广州曼翔医药有限公司 一种氟维司群有关物质e的合成方法
CN116041412A (zh) * 2023-01-13 2023-05-02 香港中文大学（深圳） 氟维司群衍生物及其制备方法、应用和治疗乳腺癌的药物
CN116284195B (zh) * 2023-02-08 2025-07-01 湖南欧亚药业有限公司 一种氟维司群的制备方法
CN116535454A (zh) * 2023-04-28 2023-08-04 香港中文大学（深圳） 氟维司群类化合物及其制备方法和应用
WO2025195993A1 (en) 2024-03-18 2025-09-25 Minakem Process for the preparation of fulvestrant

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7305171A (es) * 1973-04-13 1974-10-15
GB8327256D0 (en) 1983-10-12 1983-11-16 Ici Plc Steroid derivatives
US5595985A (en) * 1989-03-10 1997-01-21 Endorecherche Inc. Combination therapy for prophylaxis and/or treatment of benign prostatic hyperplasia
DE4132182A1 (de) * 1991-09-24 1993-03-25 Schering Ag 11(beta)-substituierte 14, 17-ethanoestratriene, verfahren zur herstellung dieser verbindungen, sowie ihre verwendung zur herstellung von arzneimitteln
US5211831A (en) * 1991-11-27 1993-05-18 Mcgean-Rohco, Inc. Process for extending the life of a displacement plating bath
DE19622457A1 (de) * 1996-05-24 1997-11-27 Schering Ag 7alpha-(5-Methylaminopentyl)-estratriene, Verfahren zu deren Herstellung, pharmazeutische Präparate, die diese 7alpha-(5-Methylaminopentyl)-estratriene enthalten sowie deren Verwendung zur Herstellung von Arzneimitteln
US5952319A (en) * 1997-11-26 1999-09-14 Research Triangle Institute Androgenic steroid compounds and a method of making and using the same
EP1272196B1 (en) * 2000-03-31 2006-08-02 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Methods of making the 4-n-butylcyclohexanoic and the undecanoic acid esters of (7 alpha,11 beta)-dimethyl-17 beta-hydroxy-4-estren-3-one and their medical use
GB0025221D0 (en) 2000-10-14 2000-11-29 Astrazeneca Ab New process
GB0123961D0 (en) * 2001-10-05 2001-11-28 Astrazeneca Ab Process and intermediates

Also Published As

Publication number Publication date
MY145819A (en) 2012-04-30
EP1918295B1 (en) 2016-04-06
CY1108398T1 (el) 2014-02-12
MY149146A (en) 2013-07-15
US20050101583A1 (en) 2005-05-12
SA01220570B1 (ar) 2007-03-18
AU9213201A (en) 2002-04-29
WO2002032922A1 (en) 2002-04-25
CN1255425C (zh) 2006-05-10
AU2007201740A1 (en) 2007-05-10
NO20031701L (no) 2003-05-23
NO326020B1 (no) 2008-09-01
CA2425572C (en) 2010-03-09
DK1328538T3 (da) 2008-11-03
US7947667B2 (en) 2011-05-24
BR0114649A (pt) 2004-02-10
JP2004511567A (ja) 2004-04-15
ES2309094T3 (es) 2008-12-16
GB0025221D0 (en) 2000-11-29
EP1328538A1 (en) 2003-07-23
CA2425572A1 (en) 2002-04-25
AR034561A1 (es) 2004-03-03
JP5133937B2 (ja) 2013-01-30
JP4363846B2 (ja) 2009-11-11
CN1479746A (zh) 2004-03-03
MXPA03003302A (es) 2003-08-07
IL155172A0 (en) 2003-10-31
EP1328538B1 (en) 2008-08-06
IL155172A (en) 2012-04-30
KR20030081319A (ko) 2003-10-17
AU2001292132B2 (en) 2007-01-25
KR100864266B1 (ko) 2008-10-20
ZA200302526B (en) 2004-02-16
EP1918295A2 (en) 2008-05-07
ES2581379T3 (es) 2016-09-05
NO20031701D0 (no) 2003-04-11
AU2007201740B2 (en) 2010-04-08
DE60135240D1 (de) 2008-09-18
SI1328538T1 (sl) 2008-12-31
NZ525096A (en) 2004-10-29
KR20080056029A (ko) 2008-06-19
JP2009215303A (ja) 2009-09-24
ATE403667T1 (de) 2008-08-15
EP1918295A3 (en) 2012-10-17
PT1328538E (pt) 2008-09-30
EG23373A (en) 2005-02-28

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