NO20031701L - Fremgangsmåte og mellomprodukter i fremstilling av 7- substituerte antiöstrogener - Google Patents

Fremgangsmåte og mellomprodukter i fremstilling av 7- substituerte antiöstrogener

Info

Publication number
NO20031701L
NO20031701L NO20031701A NO20031701A NO20031701L NO 20031701 L NO20031701 L NO 20031701L NO 20031701 A NO20031701 A NO 20031701A NO 20031701 A NO20031701 A NO 20031701A NO 20031701 L NO20031701 L NO 20031701L
Authority
NO
Norway
Prior art keywords
group
preparation
intermediates
formula
antiestrogens
Prior art date
Application number
NO20031701A
Other languages
English (en)
Other versions
NO20031701D0 (no
NO326020B1 (no
Inventor
Robert Stevenson
Witton Fraser Kerr
Raymond Anthony Lane
Eve Joanne Brazier
Philip John Hogan
Patrick Dermot David Laffan
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9901292&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20031701(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20031701D0 publication Critical patent/NO20031701D0/no
Publication of NO20031701L publication Critical patent/NO20031701L/no
Publication of NO326020B1 publication Critical patent/NO326020B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Fremgangsmåte for fremstilling av en mellomprodukt-forbindelse med formel (II): hvor X er som definert i beskrivelsen, Rer halogenalkyl, alkyl, alkenyl, cykloalkyl, karboksyalkyl, alkoksykarbonylalkyl, aryl eller arylalkyl; R, R, Rog Rer organiske grupper som definert i beskrivelsen, hvilken fremgangsmåte omfatter aromatisering av en forbindelse med formel (EI): hvor R1, R2, R3, n, X og R5 er som definert i forbindelse med formel (II) og R4 er en gruppe Reller en forløpergruppe derav, og deretter, hvis nødvendig eller ønsket, utførelse av ett eller flere av de følgende trinn: (i) fjerning av hvilke som helst hydroksybeskyttelsesgrupper R; (ii) omdannelse av en forløper gruppe R4 til en gruppe R, eller hvor Rer en gruppe R, omdannelse av den til en annen slik gruppe. Forbindelser som blir oppnådd er anvendelige mellomprodukter for eksempel ved fremstilling av fulvestrant. Nye mellomprodukter er også krevet.
NO20031701A 2000-10-14 2003-04-11 Fremgangsmate for fremstilling av 7-substituerte antiostrogener NO326020B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0025221.3A GB0025221D0 (en) 2000-10-14 2000-10-14 New process
PCT/GB2001/004485 WO2002032922A1 (en) 2000-10-14 2001-10-09 Process and intermediates for the production of 7-substituted antiestrogens

Publications (3)

Publication Number Publication Date
NO20031701D0 NO20031701D0 (no) 2003-04-11
NO20031701L true NO20031701L (no) 2003-05-23
NO326020B1 NO326020B1 (no) 2008-09-01

Family

ID=9901292

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20031701A NO326020B1 (no) 2000-10-14 2003-04-11 Fremgangsmate for fremstilling av 7-substituerte antiostrogener

Country Status (26)

Country Link
US (1) US7947667B2 (no)
EP (2) EP1328538B1 (no)
JP (2) JP4363846B2 (no)
KR (2) KR100864266B1 (no)
CN (1) CN1255425C (no)
AR (2) AR034561A1 (no)
AT (1) ATE403667T1 (no)
AU (3) AU9213201A (no)
BR (1) BR0114649A (no)
CA (1) CA2425572C (no)
CY (1) CY1108398T1 (no)
DE (1) DE60135240D1 (no)
DK (1) DK1328538T3 (no)
EG (1) EG23373A (no)
ES (2) ES2309094T3 (no)
GB (1) GB0025221D0 (no)
IL (2) IL155172A0 (no)
MX (1) MXPA03003302A (no)
MY (2) MY145819A (no)
NO (1) NO326020B1 (no)
NZ (1) NZ525096A (no)
PT (1) PT1328538E (no)
SA (1) SA01220570B1 (no)
SI (1) SI1328538T1 (no)
WO (1) WO2002032922A1 (no)
ZA (1) ZA200302526B (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0025221D0 (en) 2000-10-14 2000-11-29 Astrazeneca Ab New process
GB0123961D0 (en) 2001-10-05 2001-11-28 Astrazeneca Ab Process and intermediates
JP2007506805A (ja) * 2004-07-27 2007-03-22 シコール インコーポレイティド ７α−アルキル化された１９−ノルステロイドの調製方法
US20100174101A1 (en) * 2007-09-24 2010-07-08 Xi'an Liband Pharmaceutical Co., Ltd. Process for the manufacture of 7-alpha-[9-(4,4,5,5,5-penta fluoropentylsulphinyl) nonyl]estra-1,3,5-(10)- triene-3,17-beta-diol
EP2070942A1 (de) 2007-12-13 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Aromatisierung von 19-Nor-androst-4-en-3-onen zu Estra-1,3,5(10)-trienen
CN101525364B (zh) * 2008-03-07 2012-12-12 杭州九源基因工程有限公司 一种氟维司群的晶型及其制备方法
US8063249B1 (en) 2008-04-25 2011-11-22 Olema Pharmaceuticals, Inc. Substituted triphenyl butenes
CN102391341B (zh) * 2011-08-09 2013-05-22 福建省微生物研究所 制备6,7-脱氢-17β-烃酰氧基诺龙的方法
CN102600064A (zh) * 2012-03-31 2012-07-25 西安力邦制药有限公司 氟维司群或其衍生物缓释制剂及其制备方法
EP2909224B1 (en) 2012-10-22 2020-03-18 Intas Pharmaceuticals Limited An improved process for the preparation of fulvestrant
CN103788164A (zh) * 2012-10-31 2014-05-14 正大天晴药业集团股份有限公司 一种氟维司群的制备方法
CN103965280B (zh) * 2014-05-21 2016-04-20 天津孚音生物科技发展有限公司 一种氟维司群中间体的制备方法
WO2015181116A1 (en) 2014-05-26 2015-12-03 Crystal Pharma, S.A.U. Process and intermediades for the preparation of 7-alkylated steroids
CN104387435B (zh) * 2014-12-10 2017-05-10 天津孚音生物科技发展有限公司 一种化合物及其制备方法与应用
KR101640747B1 (ko) 2015-05-20 2016-07-19 이금운 확장 가능형 끼움식 엘이디 조명 등기구
CN107488205A (zh) * 2016-06-13 2017-12-19 重庆圣华曦药业股份有限公司 一种氟维司群有关物质的制备方法及其在制剂中的检测方法
CN110818764A (zh) * 2018-08-07 2020-02-21 重庆圣华曦药业股份有限公司 一种应用加料监测系统制备氟维斯群中间体的方法
CN111018936B (zh) * 2019-11-12 2021-10-29 广州曼翔医药有限公司 一种氟维司群有关物质e的合成方法
CN116041412A (zh) * 2023-01-13 2023-05-02 香港中文大学（深圳） 氟维司群衍生物及其制备方法、应用和治疗乳腺癌的药物
CN116284195B (zh) * 2023-02-08 2025-07-01 湖南欧亚药业有限公司 一种氟维司群的制备方法
CN116535454A (zh) * 2023-04-28 2023-08-04 香港中文大学（深圳） 氟维司群类化合物及其制备方法和应用
WO2025195993A1 (en) 2024-03-18 2025-09-25 Minakem Process for the preparation of fulvestrant

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7305171A (no) * 1973-04-13 1974-10-15
GB8327256D0 (en) * 1983-10-12 1983-11-16 Ici Plc Steroid derivatives
US5595985A (en) * 1989-03-10 1997-01-21 Endorecherche Inc. Combination therapy for prophylaxis and/or treatment of benign prostatic hyperplasia
DE4132182A1 (de) 1991-09-24 1993-03-25 Schering Ag 11(beta)-substituierte 14, 17-ethanoestratriene, verfahren zur herstellung dieser verbindungen, sowie ihre verwendung zur herstellung von arzneimitteln
US5211831A (en) * 1991-11-27 1993-05-18 Mcgean-Rohco, Inc. Process for extending the life of a displacement plating bath
DE19622457A1 (de) * 1996-05-24 1997-11-27 Schering Ag 7alpha-(5-Methylaminopentyl)-estratriene, Verfahren zu deren Herstellung, pharmazeutische Präparate, die diese 7alpha-(5-Methylaminopentyl)-estratriene enthalten sowie deren Verwendung zur Herstellung von Arzneimitteln
US5952319A (en) * 1997-11-26 1999-09-14 Research Triangle Institute Androgenic steroid compounds and a method of making and using the same
ATE334682T1 (de) * 2000-03-31 2006-08-15 Us Gov Health & Human Serv Verfahren zur herstellung von den trans-4-n- butylcyclohexanoicsaüre- und undecanoicsaüreestern von (7-alpha,11-beta)- dimethyl-17 beta -hydroxy-4-estren-3-one und deren medizynische anwendung
GB0025221D0 (en) 2000-10-14 2000-11-29 Astrazeneca Ab New process
GB0123961D0 (en) * 2001-10-05 2001-11-28 Astrazeneca Ab Process and intermediates

Also Published As

Publication number Publication date
GB0025221D0 (en) 2000-11-29
EP1918295A3 (en) 2012-10-17
CN1479746A (zh) 2004-03-03
AU2001292132B2 (en) 2007-01-25
DE60135240D1 (de) 2008-09-18
KR100864266B1 (ko) 2008-10-20
AU2007201740A1 (en) 2007-05-10
EP1328538B1 (en) 2008-08-06
EG23373A (en) 2005-02-28
EP1328538A1 (en) 2003-07-23
NO20031701D0 (no) 2003-04-11
ES2309094T3 (es) 2008-12-16
CY1108398T1 (el) 2014-02-12
CN1255425C (zh) 2006-05-10
NZ525096A (en) 2004-10-29
US7947667B2 (en) 2011-05-24
SI1328538T1 (sl) 2008-12-31
ATE403667T1 (de) 2008-08-15
KR20080056029A (ko) 2008-06-19
AU9213201A (en) 2002-04-29
US20050101583A1 (en) 2005-05-12
IL155172A0 (en) 2003-10-31
MY145819A (en) 2012-04-30
IL155172A (en) 2012-04-30
DK1328538T3 (da) 2008-11-03
BR0114649A (pt) 2004-02-10
EP1918295B1 (en) 2016-04-06
AR034561A1 (es) 2004-03-03
AR082409A2 (es) 2012-12-05
ES2581379T3 (es) 2016-09-05
EP1918295A2 (en) 2008-05-07
AU2007201740B2 (en) 2010-04-08
JP2009215303A (ja) 2009-09-24
NO326020B1 (no) 2008-09-01
MY149146A (en) 2013-07-15
WO2002032922A1 (en) 2002-04-25
PT1328538E (pt) 2008-09-30
SA01220570B1 (ar) 2007-03-18
ZA200302526B (en) 2004-02-16
JP5133937B2 (ja) 2013-01-30
CA2425572C (en) 2010-03-09
JP4363846B2 (ja) 2009-11-11
JP2004511567A (ja) 2004-04-15
MXPA03003302A (es) 2003-08-07
KR20030081319A (ko) 2003-10-17
CA2425572A1 (en) 2002-04-25

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