AR102712A1 - Agonistas parciales del receptor de insulina - Google Patents

Agonistas parciales del receptor de insulina

Info

Publication number
AR102712A1
AR102712A1 ARP150103770A ARP150103770A AR102712A1 AR 102712 A1 AR102712 A1 AR 102712A1 AR P150103770 A ARP150103770 A AR P150103770A AR P150103770 A ARP150103770 A AR P150103770A AR 102712 A1 AR102712 A1 AR 102712A1
Authority
AR
Argentina
Prior art keywords
partial agonists
insulin receptor
receptor partial
insulin
dimers
Prior art date
Application number
ARP150103770A
Other languages
English (en)
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of AR102712A1 publication Critical patent/AR102712A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se divulgan dímeros de insulina y dímeros de análogo de insulina que actúan como agonistas parciales en el receptor de insulina. Composición. Procedimiento para tratar la diabetes. Uso. Compuesto.
ARP150103770A 2014-11-21 2015-11-19 Agonistas parciales del receptor de insulina AR102712A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462082857P 2014-11-21 2014-11-21
US201562242503P 2015-10-16 2015-10-16

Publications (1)

Publication Number Publication Date
AR102712A1 true AR102712A1 (es) 2017-03-22

Family

ID=54838417

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150103770A AR102712A1 (es) 2014-11-21 2015-11-19 Agonistas parciales del receptor de insulina

Country Status (26)

Country Link
US (4) US10017556B2 (es)
EP (4) EP3666792B1 (es)
JP (5) JP6484337B2 (es)
KR (2) KR102101136B1 (es)
CN (2) CN108064173B (es)
AR (1) AR102712A1 (es)
AU (3) AU2015349890B2 (es)
CA (2) CA3014641C (es)
CL (3) CL2017001288A1 (es)
CO (1) CO2017004976A2 (es)
CR (1) CR20170208A (es)
DO (1) DOP2017000124A (es)
EA (1) EA036714B1 (es)
ES (2) ES2946247T3 (es)
GT (1) GT201700104A (es)
IL (1) IL252257A0 (es)
MX (3) MX2017006651A (es)
NI (1) NI201700060A (es)
PE (1) PE20170957A1 (es)
PH (1) PH12017500935A1 (es)
SG (4) SG10201809428UA (es)
SV (1) SV2017005445A (es)
TN (1) TN2017000178A1 (es)
TW (1) TW201625673A (es)
WO (1) WO2016081670A2 (es)
ZA (1) ZA201703238B (es)

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PH12017500935A1 (en) 2014-11-21 2017-11-27 Merck Sharp & Dohme Insulin receptor partial agonists
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US20240294596A1 (en) * 2020-09-09 2024-09-05 Merck Sharp & Dohme Llc Insulin receptor partial agonists
US11638761B2 (en) 2021-07-09 2023-05-02 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy
US11969475B2 (en) 2021-07-09 2024-04-30 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
US11771776B2 (en) 2021-07-09 2023-10-03 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
CN117980006A (zh) 2021-07-09 2024-05-03 达因疗法公司 用于治疗肌养蛋白病的肌肉靶向复合物和制剂
US11672872B2 (en) 2021-07-09 2023-06-13 Dyne Therapeutics, Inc. Anti-transferrin receptor antibody and uses thereof
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TW201625673A (zh) 2016-07-16
BR122024000898A2 (pt) 2024-02-27
JP6931033B2 (ja) 2021-09-01
IL252257A0 (en) 2017-07-31
PE20170957A1 (es) 2017-07-13
CN108064173B (zh) 2021-05-18
AU2018211207A1 (en) 2018-08-16
TN2017000178A1 (en) 2018-10-19
CL2019001144A1 (es) 2019-07-19
KR20190069622A (ko) 2019-06-19
EA036714B1 (ru) 2020-12-10
CR20170208A (es) 2017-07-17
US10017556B2 (en) 2018-07-10
US20190092833A1 (en) 2019-03-28
EA201791117A1 (ru) 2017-11-30
AU2015349890B2 (en) 2018-08-30
EP3660040B1 (en) 2025-06-18
EP3666792A2 (en) 2020-06-17
SV2017005445A (es) 2018-04-04
SG10201809427SA (en) 2018-11-29
EP3660040A2 (en) 2020-06-03
KR102101136B1 (ko) 2020-04-14
EP3660040A3 (en) 2020-07-29
EP3660041B1 (en) 2023-04-19
CA2966765A1 (en) 2016-05-26
JP6703068B2 (ja) 2020-06-03
PH12017500935A1 (en) 2017-11-27
WO2016081670A3 (en) 2016-08-04
BR112017010481A2 (pt) 2018-04-03
AU2018211208B2 (en) 2020-09-10
KR20170084300A (ko) 2017-07-19
AU2018211207B2 (en) 2020-04-09
ES2946247T3 (es) 2023-07-14
DOP2017000124A (es) 2017-08-15
KR102049647B1 (ko) 2019-11-29
AU2015349890A1 (en) 2017-06-01
SG10201809457YA (en) 2018-11-29
NI201700060A (es) 2017-07-18
US20170107268A1 (en) 2017-04-20
CO2017004976A2 (es) 2017-10-10
AU2018211208A1 (en) 2018-08-16
BR122024000903A2 (pt) 2024-02-27
JP2019014735A (ja) 2019-01-31
JP2019011357A (ja) 2019-01-24
EP3221343B1 (en) 2020-09-16
CN108064173A (zh) 2018-05-22
CN112494656B (zh) 2024-01-30
JP2018501203A (ja) 2018-01-18
EP3660041A1 (en) 2020-06-03
SG11201704064TA (en) 2017-06-29
CA3014641A1 (en) 2016-05-26
BR112017010481A8 (pt) 2023-04-11
CL2019001143A1 (es) 2019-07-19
JP6943825B2 (ja) 2021-10-06
MX2017006651A (es) 2017-08-21
CN112494656A (zh) 2021-03-16
US10800827B2 (en) 2020-10-13
MX2020014121A (es) 2021-03-25
EP3666792A3 (en) 2020-07-29
EP3221343A2 (en) 2017-09-27
JP2020097572A (ja) 2020-06-25
US20180291078A1 (en) 2018-10-11
JP2019014734A (ja) 2019-01-31
US10183981B2 (en) 2019-01-22
ZA201703238B (en) 2018-05-30
GT201700104A (es) 2018-11-27
US20170355743A1 (en) 2017-12-14
WO2016081670A2 (en) 2016-05-26
JP6484337B2 (ja) 2019-03-13
CL2017001288A1 (es) 2017-12-15
EP3666792B1 (en) 2024-12-18
CA2966765C (en) 2020-04-14
SG10201809428UA (en) 2018-11-29
ES3004386T3 (en) 2025-03-12
CA3014641C (en) 2020-08-18
MX2020014120A (es) 2021-03-25

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