CO2017004976A2 - Agonistas parciales del receptor de insulina - Google Patents

Agonistas parciales del receptor de insulina

Info

Publication number
CO2017004976A2
CO2017004976A2 CONC2017/0004976A CO2017004976A CO2017004976A2 CO 2017004976 A2 CO2017004976 A2 CO 2017004976A2 CO 2017004976 A CO2017004976 A CO 2017004976A CO 2017004976 A2 CO2017004976 A2 CO 2017004976A2
Authority
CO
Colombia
Prior art keywords
partial agonists
insulin receptor
receptor partial
insulin
dimers
Prior art date
Application number
CONC2017/0004976A
Other languages
English (en)
Inventor
Ravi Nargund
Songnian Lin
Lin Yan
Pei Huo
Dmitri Pissarnitski
Danqing Feng
Yuping Zhu
Ahmet Kekec
B Christina Madsen-Duggan
Zhi-Cai Shi
Zhicai Wu
Yingjun Mu
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of CO2017004976A2 publication Critical patent/CO2017004976A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se divulgan dímeros de insulina y dímeros de análogo de insulina que actúan como agonistas parciales en el receptor de insulina.
CONC2017/0004976A 2014-11-21 2017-05-18 Agonistas parciales del receptor de insulina CO2017004976A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462082857P 2014-11-21 2014-11-21
US201562242503P 2015-10-16 2015-10-16
PCT/US2015/061445 WO2016081670A2 (en) 2014-11-21 2015-11-19 Insulin receptor partial agonists

Publications (1)

Publication Number Publication Date
CO2017004976A2 true CO2017004976A2 (es) 2017-10-10

Family

ID=54838417

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2017/0004976A CO2017004976A2 (es) 2014-11-21 2017-05-18 Agonistas parciales del receptor de insulina

Country Status (26)

Country Link
US (4) US10017556B2 (es)
EP (4) EP3666792B1 (es)
JP (5) JP6484337B2 (es)
KR (2) KR102049647B1 (es)
CN (2) CN112494656B (es)
AR (1) AR102712A1 (es)
AU (3) AU2015349890B2 (es)
CA (2) CA3014641C (es)
CL (3) CL2017001288A1 (es)
CO (1) CO2017004976A2 (es)
CR (1) CR20170208A (es)
DO (1) DOP2017000124A (es)
EA (1) EA036714B1 (es)
ES (2) ES3004386T3 (es)
GT (1) GT201700104A (es)
IL (1) IL252257A0 (es)
MX (3) MX2017006651A (es)
NI (1) NI201700060A (es)
PE (1) PE20170957A1 (es)
PH (1) PH12017500935A1 (es)
SG (4) SG11201704064TA (es)
SV (1) SV2017005445A (es)
TN (1) TN2017000178A1 (es)
TW (1) TW201625673A (es)
WO (1) WO2016081670A2 (es)
ZA (1) ZA201703238B (es)

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Publication number Publication date
US20170355743A1 (en) 2017-12-14
IL252257A0 (en) 2017-07-31
US20170107268A1 (en) 2017-04-20
CN108064173A (zh) 2018-05-22
JP2019011357A (ja) 2019-01-24
JP2019014734A (ja) 2019-01-31
ZA201703238B (en) 2018-05-30
SG10201809427SA (en) 2018-11-29
CL2019001144A1 (es) 2019-07-19
BR112017010481A8 (pt) 2023-04-11
GT201700104A (es) 2018-11-27
SG10201809428UA (en) 2018-11-29
US10800827B2 (en) 2020-10-13
WO2016081670A3 (en) 2016-08-04
EP3666792B1 (en) 2024-12-18
EP3660040A2 (en) 2020-06-03
ES3004386T3 (en) 2025-03-12
TW201625673A (zh) 2016-07-16
JP6943825B2 (ja) 2021-10-06
US20180291078A1 (en) 2018-10-11
CA2966765A1 (en) 2016-05-26
EP3666792A3 (en) 2020-07-29
EP3221343B1 (en) 2020-09-16
SV2017005445A (es) 2018-04-04
CA3014641C (en) 2020-08-18
US10017556B2 (en) 2018-07-10
JP2019014735A (ja) 2019-01-31
JP2020097572A (ja) 2020-06-25
KR102049647B1 (ko) 2019-11-29
CN112494656A (zh) 2021-03-16
EA036714B1 (ru) 2020-12-10
CR20170208A (es) 2017-07-17
EP3221343A2 (en) 2017-09-27
TN2017000178A1 (en) 2018-10-19
BR112017010481A2 (pt) 2018-04-03
KR20190069622A (ko) 2019-06-19
EP3666792A2 (en) 2020-06-17
EP3660041B1 (en) 2023-04-19
BR122024000898A2 (pt) 2024-02-27
KR102101136B1 (ko) 2020-04-14
US20190092833A1 (en) 2019-03-28
PE20170957A1 (es) 2017-07-13
MX2020014121A (es) 2021-03-25
NI201700060A (es) 2017-07-18
AR102712A1 (es) 2017-03-22
AU2018211207A1 (en) 2018-08-16
AU2018211208A1 (en) 2018-08-16
JP6484337B2 (ja) 2019-03-13
EA201791117A1 (ru) 2017-11-30
CN108064173B (zh) 2021-05-18
ES2946247T3 (es) 2023-07-14
SG11201704064TA (en) 2017-06-29
EP3660041A1 (en) 2020-06-03
AU2018211208B2 (en) 2020-09-10
AU2015349890A1 (en) 2017-06-01
DOP2017000124A (es) 2017-08-15
MX2020014120A (es) 2021-03-25
CN112494656B (zh) 2024-01-30
JP2018501203A (ja) 2018-01-18
MX2017006651A (es) 2017-08-21
CA3014641A1 (en) 2016-05-26
BR122024000903A2 (pt) 2024-02-27
CL2019001143A1 (es) 2019-07-19
AU2018211207B2 (en) 2020-04-09
EP3660040A3 (en) 2020-07-29
SG10201809457YA (en) 2018-11-29
JP6931033B2 (ja) 2021-09-01
EP3660040B1 (en) 2025-06-18
PH12017500935A1 (en) 2017-11-27
CA2966765C (en) 2020-04-14
JP6703068B2 (ja) 2020-06-03
CL2017001288A1 (es) 2017-12-15
WO2016081670A2 (en) 2016-05-26
AU2015349890B2 (en) 2018-08-30
US10183981B2 (en) 2019-01-22
KR20170084300A (ko) 2017-07-19

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