AR111484A1 - Método para preparar un composición con un bajo contenido de oxígeno disuelto, que comprende paracetamol, y opcionalmente uno o más aine, y una composición obtenida de la misma - Google Patents

Método para preparar un composición con un bajo contenido de oxígeno disuelto, que comprende paracetamol, y opcionalmente uno o más aine, y una composición obtenida de la misma

Info

Publication number
AR111484A1
AR111484A1 ARP180101010A ARP180101010A AR111484A1 AR 111484 A1 AR111484 A1 AR 111484A1 AR P180101010 A ARP180101010 A AR P180101010A AR P180101010 A ARP180101010 A AR P180101010A AR 111484 A1 AR111484 A1 AR 111484A1
Authority
AR
Argentina
Prior art keywords
composition
optionally
paracetamol
container
preparing
Prior art date
Application number
ARP180101010A
Other languages
English (en)
Inventor
Thomas Jacobsen
Original Assignee
Hyloris Dev Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hyloris Dev Sa filed Critical Hyloris Dev Sa
Publication of AR111484A1 publication Critical patent/AR111484A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Método para preparar una composición acuosa para administración intravenosa que comprende paracetamol, y opcionalmente uno o más fármacos antiinflamatorios no esteroides (AINE), por lo cual el oxígeno disuelto de la composición en un recipiente cerrado es de 1,0 ppm como máximo, caracterizado dicho método porque comprende enjuagar por lo menos una vez un recipiente para la producción del compuesto con agua de una temperatura de por lo menos 80ºC, calentando de este modo el recipiente y creando un entorno de bajo contenido de oxígeno en dicho recipiente; y en dicho recipiente enjuagado disolver paracetamol en agua par inyectables, donde dicha agua para inyectables está a una temperatura de por lo menos 80ºC, por medio de lo cual opcionalmente uno o más AINE se agregan antes de o después de disolver el paracetamol.
ARP180101010A 2017-04-20 2018-04-20 Método para preparar un composición con un bajo contenido de oxígeno disuelto, que comprende paracetamol, y opcionalmente uno o más aine, y una composición obtenida de la misma AR111484A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2017/059440 WO2018192664A1 (en) 2017-04-20 2017-04-20 METHOD FOR PREPARING A COMPOSITION WITH A LOW DISSOLVED OXYGEN CONTENT, COMPRISING ACETAMINOPHEN, AND OPTIONALLY ONE OR MORE NSAIDs, AND A COMPOSITION OBTAINED THEREOF

Publications (1)

Publication Number Publication Date
AR111484A1 true AR111484A1 (es) 2019-07-17

Family

ID=58645031

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180101010A AR111484A1 (es) 2017-04-20 2018-04-20 Método para preparar un composición con un bajo contenido de oxígeno disuelto, que comprende paracetamol, y opcionalmente uno o más aine, y una composición obtenida de la misma

Country Status (21)

Country Link
US (1) US11413241B2 (es)
EP (1) EP3612157A1 (es)
JP (1) JP6944590B2 (es)
KR (3) KR102625301B1 (es)
CN (2) CN110719773A (es)
AR (1) AR111484A1 (es)
AU (1) AU2018255376B2 (es)
CA (1) CA3060325A1 (es)
CL (1) CL2019002985A1 (es)
CO (1) CO2019011569A2 (es)
EC (1) ECSP19075614A (es)
IL (1) IL270035B2 (es)
MX (1) MX2019012508A (es)
MY (1) MY205384A (es)
PE (1) PE20191793A1 (es)
PH (1) PH12019502385A1 (es)
RU (1) RU2019137019A (es)
SA (1) SA519410340B1 (es)
SG (1) SG11201909726YA (es)
TW (1) TW201841632A (es)
WO (2) WO2018192664A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016008546A1 (en) 2014-07-18 2016-01-21 Everbright Pharmaceuticals S.A.R.L. Aqueous formulation comprising paracetamol and ibuprofen
UY38573A (es) * 2019-03-05 2020-09-30 Grifols Worldwide Operations Ltd Procedimiento de preparación de contenedores de productos hemoderivados
CN115040475A (zh) * 2022-06-23 2022-09-13 杭州浙中医药科技有限公司 一种n-乙酰半胱氨酸口服溶液
KR20260020463A (ko) 2023-06-02 2026-02-11 이울리아 츠에티 이부프로펜을 포함하는 약학 조성물

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2751875B1 (fr) 1996-08-05 1998-12-24 Scr Newpharm Nouvelles formulations liquides stables a base de paracetamol et leur mode de preparation
FR2809619B1 (fr) * 2000-06-06 2004-09-24 Pharmatop Nouvelles formulations aqueuses de principes actifs sensibles a l'oxydation et leur procede d'obtention
US20060100578A1 (en) 2004-09-13 2006-05-11 Tandem Medical, Inc. Medication delivery apparatus and methods for intravenous infusions
WO2009083759A1 (en) 2008-01-03 2009-07-09 Wockhardt Research Centre Oral pharmaceutical suspension comprising paracetamol and ibuprofen
KR20110112279A (ko) 2008-10-14 2011-10-12 에이에프티 파마슈티칼스 리미티드 의약품 및 치료
EP2243477A1 (de) 2009-04-22 2010-10-27 Fresenius Kabi Deutschland GmbH Paracetamol zur parenteralen Verabreichung
US8404748B2 (en) 2009-08-13 2013-03-26 Neogen N.V. Storage-stable formulation of paracetamol in aqueous solution
PL2389923T3 (pl) 2010-05-19 2013-06-28 Uni Pharma Kleon Tsetis Pharmaceutical Laboratories S A Trwały, gotowy do użycia iniekcyjny preparat paracetamolu
LT2635269T (lt) 2010-11-04 2019-09-10 Aft Pharmaceuticals Limited Derinio kompozicija
US9205037B2 (en) 2011-07-20 2015-12-08 Church & Dwight Co., Inc. Single phase depilatory composition
ES2414557B1 (es) * 2012-01-16 2014-06-10 Novocat Farma, S.A. Composición acuosa de paracetamol para inyección
BE1020614A5 (nl) 2012-01-27 2014-01-07 Hubert De Backer Nv Injectiespuit.
US9072661B2 (en) 2012-03-16 2015-07-07 Cumberland Pharmaceuticals Inc. Injectable ibuprofen formulation
CN104302176B (zh) 2012-03-16 2017-03-22 坎伯兰医药品股份有限公司 可注射布洛芬制剂
WO2016008546A1 (en) 2014-07-18 2016-01-21 Everbright Pharmaceuticals S.A.R.L. Aqueous formulation comprising paracetamol and ibuprofen

Also Published As

Publication number Publication date
IL270035A (es) 2019-12-31
PH12019502385A1 (en) 2020-09-14
SA519410340B1 (ar) 2022-03-13
CO2019011569A2 (es) 2021-03-08
CA3060325A1 (en) 2018-10-25
CN121243065A (zh) 2026-01-02
US11413241B2 (en) 2022-08-16
JP2020522564A (ja) 2020-07-30
CN110719773A (zh) 2020-01-21
JP6944590B2 (ja) 2021-10-06
EP3612157A1 (en) 2020-02-26
RU2019137019A (ru) 2021-05-20
KR102625301B1 (ko) 2024-01-15
NZ758429A (en) 2025-05-02
AU2018255376A1 (en) 2019-11-07
WO2018193099A1 (en) 2018-10-25
PE20191793A1 (es) 2019-12-24
US20210338578A1 (en) 2021-11-04
KR20260006041A (ko) 2026-01-12
KR20190137859A (ko) 2019-12-11
AU2018255376B2 (en) 2023-07-06
TW201841632A (zh) 2018-12-01
IL270035B1 (en) 2023-01-01
WO2018192664A1 (en) 2018-10-25
MY205384A (en) 2024-10-18
IL270035B2 (en) 2023-05-01
RU2019137019A3 (es) 2021-07-05
CL2019002985A1 (es) 2020-01-31
SG11201909726YA (en) 2019-11-28
KR20230160413A (ko) 2023-11-23
ECSP19075614A (es) 2019-11-30
MX2019012508A (es) 2020-02-05

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