AR130077A1 - Substratos escindibles por proteasas, y métodos de uso de los mismos - Google Patents
Substratos escindibles por proteasas, y métodos de uso de los mismosInfo
- Publication number
- AR130077A1 AR130077A1 ARP230102011A ARP230102011A AR130077A1 AR 130077 A1 AR130077 A1 AR 130077A1 AR P230102011 A ARP230102011 A AR P230102011A AR P230102011 A ARP230102011 A AR P230102011A AR 130077 A1 AR130077 A1 AR 130077A1
- Authority
- AR
- Argentina
- Prior art keywords
- cleavable
- protease
- seq
- substrate
- acid sequence
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
- C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24024—Gelatinase A (3.4.24.24), i.e. matrix metalloproteinase 2 or MMP2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24035—Gelatinase B (3.4.24.35), i.e. matrix metalloprotease 9 or MMP9
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/2408—Membrane-type matrix metalloproteinase-1 (3.4.24.80)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Se divulgan polipéptidos aislados que incluyen un resto escindible que es substrato para al menos una proteasa (por ej., MT-SP1 y/o una MMP) y polipéptidos aislados que incluyen un substrato que tiene un primer resto escindible que es escindible por una primera proteasa y un segundo resto escindible que es escindible por una segunda proteasa. Se divulgan moléculas activables que incluyen los polipéptidos aislados. Se divulgan métodos para preparar y usar los polipéptidos aislados y las moléculas activables que incluyen los polipéptidos aislados en una variedad de aplicaciones terapéuticas, de diagnóstico y profilácticas. Reivindicación 1: Un polipéptido aislado que comprende un substrato, caracterizado porque el substrato comprende un primer resto escindible (CM1) que es escindible por al menos una primera proteasa, y un segundo resto escindible (CM2) que es escindible por una segunda proteasa, y en donde el CM1 comprende la secuencia de aminoácidos de PXGL, en donde X es W, Y, F, R, K, Q, A, o M, opcionalmente en donde el CM1 comprende la secuencia de aminoácidos de PXGL, en donde X es W, Y, F, R, K, Q, o M. Reivindicación 57: Un polipéptido aislado que comprende un substrato, caracterizado porque el substrato comprende: APRG (SEQ ID Nº 382), o un primer resto escindible (CM1) que escindible por una primera proteasa y un segundo resto escindible (CM2) que es escindible por una segunda proteasa, y en donde el substrato comprende un núcleo APR y el substrato comprende la secuencia de aminoácidos de APRSL (SEQ ID Nº 669), APRSY (SEQ ID Nº 39), APRSM (SEQ ID Nº 383), APRGL (SEQ ID Nº 672), APRGY (SEQ ID Nº 384), o APRGM (SEQ ID Nº 385). Reivindicación 89: Un polipéptido aislado que comprende un substrato escindible por una MMP y una serina proteasa, caracterizado porque el substrato comprende una secuencia de aminoácidos seleccionada entre las SEQ ID Nº 9 - 24, 37 - 73, 83 - 353, 383 - 385, y 560 - 695, opcionalmente en donde el substrato comprende una secuencia de aminoácidos seleccionada entre las SEQ ID Nº 9 - 24, 37 - 73, 83 - 353, 383 - 385, y 560 - 683. Reivindicación 90: Un polipéptido aislado que comprende un substrato, caracterizado porque el substrato comprende un primer resto escindible (CM1) que es escindible por una primera proteasa, y un segundo resto escindible (CM2) que es escindible por una segunda proteasa, y en donde el substrato comprende una secuencia de aminoácidos con una o más mutaciones de un aminoácido o dos aminoácidos de una cualquiera de las SEQ ID Nº 9 - 24, 37 - 73, 83 - 353, 383 - 385, y 560 - 695, opcionalmente en donde el substrato comprende una secuencia de aminoácidos con una o más mutaciones de uno o dos aminoácidos de cualquiera de las SEQ ID Nº 9 - 24, 37 - 73, 83 - 353, 383 - 385, y 560 - 683. Reivindicación 91: Un polipéptido aislado que comprende un resto escindible (CM) caracterizado porque comprende una secuencia de aminoácidos con una o más mutaciones de uno o dos aminoácidos de cualquiera de las SEQ ID Nº 382, en donde el CM es un substrato para una proteasa. Reivindicación 115: El método de la reivindicación 114, caracterizado porque la enfermedad es cáncer, una infección, un trastorno inflamatorio, un trastorno cardiovascular, un trastorno neurodegenerativo o un trastorno autoinmunitario.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263370026P | 2022-08-01 | 2022-08-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR130077A1 true AR130077A1 (es) | 2024-10-30 |
Family
ID=87801206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP230102011A AR130077A1 (es) | 2022-08-01 | 2023-07-31 | Substratos escindibles por proteasas, y métodos de uso de los mismos |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12617856B2 (es) |
| EP (1) | EP4565250A1 (es) |
| JP (1) | JP2025525754A (es) |
| AR (1) | AR130077A1 (es) |
| TW (1) | TW202424183A (es) |
| WO (1) | WO2024030850A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20260015425A1 (en) | 2022-08-01 | 2026-01-15 | Cytomx Therapeutics, Inc. | Protease-cleavable substrates and methods of use thereof |
| WO2025151752A1 (en) | 2024-01-10 | 2025-07-17 | Xilio Development, Inc. | Masked il-2 cytokines and methods of use thereof |
| WO2025240659A2 (en) | 2024-05-14 | 2025-11-20 | Cytomx Therapeutics, Inc. | Activatable constructs, compositions and methods |
| WO2026020161A1 (en) | 2024-07-19 | 2026-01-22 | Cytomx Therapeutics, Inc. | Activatable il-12 constructs and related compositions and methods |
| WO2026035650A2 (en) | 2024-08-05 | 2026-02-12 | Cytomx Therapeutics, Inc. | Cleavable polypeptides and methods of use thereof |
| WO2026112598A1 (en) | 2024-11-25 | 2026-05-28 | Modernatx, Inc. | Messenger rna encoding masked proteins and compositions and uses thereof |
| CN119241656B (zh) * | 2024-12-09 | 2025-04-18 | 青岛农业大学 | 小分子活性肽、组合物及其在制备具有抗氧化降血糖功效的产品中的应用 |
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| WO2024030845A1 (en) | 2022-08-01 | 2024-02-08 | Cytomx Therapeutics, Inc. | Protease-cleavable moieties and methods of use thereof |
-
2023
- 2023-07-31 AR ARP230102011A patent/AR130077A1/es unknown
- 2023-07-31 TW TW112128640A patent/TW202424183A/zh unknown
- 2023-07-31 WO PCT/US2023/071310 patent/WO2024030850A1/en not_active Ceased
- 2023-07-31 EP EP23761347.6A patent/EP4565250A1/en active Pending
- 2023-07-31 JP JP2025503386A patent/JP2025525754A/ja active Pending
-
2025
- 2025-03-17 US US19/081,340 patent/US12617856B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2024030850A1 (en) | 2024-02-08 |
| US12617856B2 (en) | 2026-05-05 |
| TW202424183A (zh) | 2024-06-16 |
| US20250215095A1 (en) | 2025-07-03 |
| EP4565250A1 (en) | 2025-06-11 |
| JP2025525754A (ja) | 2025-08-07 |
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