AR240832A1 - Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-propan-1,1-difosfonato disodico. - Google Patents

Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-propan-1,1-difosfonato disodico.

Info

Publication number
AR240832A1
AR240832A1 AR301204A AR30120485A AR240832A1 AR 240832 A1 AR240832 A1 AR 240832A1 AR 301204 A AR301204 A AR 301204A AR 30120485 A AR30120485 A AR 30120485A AR 240832 A1 AR240832 A1 AR 240832A1
Authority
AR
Argentina
Prior art keywords
disodic
diphosphonate
propan
hydroxy
amino
Prior art date
Application number
AR301204A
Other languages
English (en)
Spanish (es)
Other versions
AR240832A2 (es
Original Assignee
Ciba Geigy Ag Y Henkel Kommand
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4263070&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR240832(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ciba Geigy Ag Y Henkel Kommand filed Critical Ciba Geigy Ag Y Henkel Kommand
Application granted granted Critical
Publication of AR240832A1 publication Critical patent/AR240832A1/es
Publication of AR240832A2 publication Critical patent/AR240832A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AR301204A 1984-08-06 1985-08-06 Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-propan-1,1-difosfonato disodico. AR240832A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH376884 1984-08-06

Publications (2)

Publication Number Publication Date
AR240832A1 true AR240832A1 (es) 1991-02-28
AR240832A2 AR240832A2 (es) 1991-02-28

Family

ID=4263070

Family Applications (4)

Application Number Title Priority Date Filing Date
AR301204A AR240832A1 (es) 1984-08-06 1985-08-06 Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-propan-1,1-difosfonato disodico.
AR89314300A AR244697A1 (es) 1984-08-06 1989-06-29 Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-1,1-difosfonato disodico
AR89314298A AR244698A1 (es) 1984-08-06 1989-06-29 Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-1,1-difosfonato disodico.
AR89314299A AR244696A1 (es) 1984-08-06 1989-06-29 Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-1,1-difosfonato disodico.

Family Applications After (3)

Application Number Title Priority Date Filing Date
AR89314300A AR244697A1 (es) 1984-08-06 1989-06-29 Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-1,1-difosfonato disodico
AR89314298A AR244698A1 (es) 1984-08-06 1989-06-29 Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-1,1-difosfonato disodico.
AR89314299A AR244696A1 (es) 1984-08-06 1989-06-29 Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-1,1-difosfonato disodico.

Country Status (26)

Country Link
US (2) US4639338A (fr)
EP (1) EP0177443B1 (fr)
JP (1) JPS6143196A (fr)
KR (1) KR940000817B1 (fr)
AR (4) AR240832A1 (fr)
AT (1) ATE47396T1 (fr)
AU (1) AU591066B2 (fr)
CA (1) CA1255694A (fr)
CY (1) CY1570A (fr)
DD (1) DD239597A5 (fr)
DE (1) DE3573783D1 (fr)
DK (1) DK167282B1 (fr)
DO (1) DOP1990004769A (fr)
ES (2) ES8701188A1 (fr)
FI (1) FI79712C (fr)
GR (1) GR851910B (fr)
HK (1) HK42591A (fr)
HU (1) HU193124B (fr)
IE (1) IE58077B1 (fr)
IL (1) IL75990A (fr)
MX (1) MX9203373A (fr)
NO (1) NO165401C (fr)
PH (1) PH24854A (fr)
PT (1) PT80916B (fr)
SG (1) SG91390G (fr)
ZA (1) ZA855892B (fr)

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CH664158A5 (fr) * 1984-07-18 1988-02-15 Symphar Sa Derives propylidenediphosphonates-1,3 substitues en position 2, leur procede de preparation et compositions pharmaceutiques les contenant.
DE3770982D1 (de) * 1986-04-24 1991-08-01 Fujisawa Pharmaceutical Co Diphosphonsaeure-verbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel.
US4963681A (en) * 1987-07-06 1990-10-16 Norwich Eaton Pharmaceuticals, Inc. Process for synthesis of aminomethylene phosphonoalkylphosphinates
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PH26923A (en) * 1989-03-08 1992-12-03 Ciba Geigy N-substituted amino alkanediphosphonic acids
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
PH27186A (en) * 1989-09-07 1993-04-16 Ciba Geigy Ag Double-coated granules of disodium pamidronate
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
EP0541037A3 (en) * 1991-11-06 1997-02-26 Takeda Chemical Industries Ltd Squalene synthetase inhibitory composition and use thereof
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
TW237386B (fr) 1992-04-15 1995-01-01 Ciba Geigy
US6406714B1 (en) 1992-12-02 2002-06-18 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids
US5358941A (en) * 1992-12-02 1994-10-25 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids with lactose
JP3266395B2 (ja) * 1993-11-24 2002-03-18 富士写真フイルム株式会社 有機薬品の晶析方法
TW390813B (en) * 1994-04-29 2000-05-21 Merck & Co Inc Wet granulation formulation for bisphosphonic acids
US20010007863A1 (en) * 1998-06-18 2001-07-12 Merck & Co., Inc. Wet granulation formulation for bisphosphonic acids
GB9408775D0 (en) * 1994-05-04 1994-06-22 Ciba Geigy Ag Use of certain methanebisphosphonic acid derivatives to prevent prothesis loosening and prothesis migration
DE19719680A1 (de) 1997-05-09 1998-11-19 Boehringer Mannheim Gmbh Verwendung von Diphosphonsäuren zur präventiven Behandlung von Spätfolgen bei Harnblasenerweiterung oder Harnblasenersatz
ES2231919T3 (es) * 1997-07-15 2005-05-16 Gador S.A. Forma cristalina de sal monosodica monohidrato del acido n,n-dimetil-3-amino-1-hidroxipropano-1,1-difosfonico.
IL141423A (en) * 1998-08-27 2005-09-25 Teva Pharma Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
EP1702924A3 (fr) * 1998-08-27 2007-07-18 Teva Pharmaceutical Industries Ltd Formes de type hydrate du sel de sodium de l'alendronate, procédés de préparation et compositions pharmaceutiques
EP0998933A1 (fr) 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Procédé pour la préparation de compositions pharmaucetiques contenant des diphosphonates pour administration orale
EP0998932A1 (fr) 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Forme d'administration pharmaceutique contenant des diphosphonates ou leurs sels et méthode pour la fabriquer
WO2000034293A1 (fr) * 1998-12-10 2000-06-15 Aesgen, Inc. Methode de preparation du pamidronate
US6160165A (en) 1998-12-10 2000-12-12 Aesgen, Inc. Method for preparation of disodium pamidronate
US6794536B1 (en) * 1998-12-10 2004-09-21 Aesqen, Inc. Method for preparation of disodium pamidronate
US6143919A (en) * 1999-05-18 2000-11-07 3M Innovative Properties Company Polymerizable acidic compounds and methods of preparation
US6315566B1 (en) 1999-05-18 2001-11-13 3M Innovative Properties Company Dental materials
US6963008B2 (en) * 1999-07-19 2005-11-08 Teva Pharmaceutical Industries Ltd. Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
ES2153794B1 (es) * 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
KR100343232B1 (ko) * 1999-12-10 2002-07-10 김재윤 결정성 파미드론산 이나트륨염 수화물과 그의 제조방법
KR20030043931A (ko) * 2000-09-18 2003-06-02 에프. 에이취. 펄딩 앤드 컴파니 리미티드 디포스포네이트 용액
US7560490B2 (en) * 2001-01-23 2009-07-14 Gador S.A. Composition comprising bisphosphonates for prevention and/or treatment of metabolic diseases of bones, process for preparing such composition and use thereof
EP1390044A4 (fr) 2001-05-02 2005-03-23 Sicor Inc Pamidronate disodique injectable
CA2372450A1 (fr) * 2001-05-10 2001-09-19 Pharmaceutical Partners Of Canada Inc. Preparation injectable liquide de pamidronate disodique
ITMI20012751A1 (it) * 2001-12-21 2003-06-21 Lyogen Ltd Sale monosodico dell'acido pamidronico e procedimento per la sua preparazione
CA2470495A1 (fr) * 2001-12-24 2003-07-17 Teva Pharmaceutical Industries Ltd. Forme posologique avec pastille noyau de principe actif enrobee dans un corps annulaire comprime de poudre ou de substance granulaire, et procede et outils pour la production de cette forme posologique
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
EP2316468A1 (fr) 2002-02-22 2011-05-04 Shire LLC Système de distribution et méthodes de protection et d'administration de dextroamphetamine
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
ES2291749T5 (es) * 2002-12-20 2011-07-21 F. Hoffmann-La Roche Ag Formulación de altas dosis de ibandronato.
US20050119230A1 (en) * 2003-09-18 2005-06-02 Alexandra Glausch Pharmaceutical products comprising bisphosphonated
AU2003286309A1 (en) * 2003-12-04 2005-06-24 Mustafa Nevzat Ilac Sanayii A.S. Method for producing pure disodium pamidronate
DK2283825T3 (da) 2004-05-24 2022-06-27 Theramex Hq Uk Ltd Enterisk fast oral doseringsform af en bisfosfonat indeholdende et chelateringsmiddel
US7687482B2 (en) * 2006-03-17 2010-03-30 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods
EP1802641B8 (fr) * 2004-10-08 2012-03-07 The Board Of Trustees Of The University Of Illinois Composes de bisphosphonate et methodes de traitement de maladies de resorption osseuse, de cancers, de douleurs osseuses, de troubles immunitaires et de maladies infectieuses
US8012949B2 (en) * 2004-10-08 2011-09-06 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS
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CN105920023A (zh) 2009-09-01 2016-09-07 杜克大学 双膦酸类组合物及其治疗心力衰竭的方法
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CH664158A5 (fr) * 1984-07-18 1988-02-15 Symphar Sa Derives propylidenediphosphonates-1,3 substitues en position 2, leur procede de preparation et compositions pharmaceutiques les contenant.

Also Published As

Publication number Publication date
HU193124B (en) 1987-08-28
JPH058717B2 (fr) 1993-02-02
CA1255694A (fr) 1989-06-13
IE851931L (en) 1986-02-06
KR940000817B1 (ko) 1994-02-02
FI852986A0 (fi) 1985-08-02
FI79712C (fi) 1990-02-12
DOP1990004769A (es) 1999-08-19
ES545899A0 (es) 1986-11-16
ATE47396T1 (de) 1989-11-15
DK167282B1 (da) 1993-10-04
NO165401B (no) 1990-10-29
EP0177443B1 (fr) 1989-10-18
ES555602A0 (es) 1987-07-01
AR244696A1 (es) 1993-11-30
AR240832A2 (es) 1991-02-28
US4639338A (en) 1987-01-27
DK355485A (da) 1986-02-07
KR860001821A (ko) 1986-03-22
IE58077B1 (en) 1993-06-30
HK42591A (en) 1991-06-07
AU591066B2 (en) 1989-11-30
SG91390G (en) 1991-01-18
PT80916A (en) 1985-09-01
ZA855892B (en) 1986-03-26
CY1570A (en) 1991-12-20
DK355485D0 (da) 1985-08-05
ES8701188A1 (es) 1986-11-16
PH24854A (en) 1990-12-26
DE3573783D1 (en) 1989-11-23
EP0177443A1 (fr) 1986-04-09
GR851910B (fr) 1985-12-03
PT80916B (pt) 1987-12-30
HUT38361A (en) 1986-05-28
NO853087L (no) 1986-02-07
AR244698A1 (es) 1993-11-30
IL75990A (en) 1989-07-31
FI852986L (fi) 1986-02-07
JPS6143196A (ja) 1986-03-01
AU4577785A (en) 1986-02-13
FI79712B (fi) 1989-10-31
MX9203373A (es) 1992-09-01
AR244697A1 (es) 1993-11-30
US4711880A (en) 1987-12-08
NO165401C (no) 1991-02-06
ES8706707A1 (es) 1987-07-01
DD239597A5 (de) 1986-10-01

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