AT124719B - Process for the iodination of pyridine derivatives. - Google Patents

Process for the iodination of pyridine derivatives.

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Publication number
AT124719B
AT124719B AT124719DA AT124719B AT 124719 B AT124719 B AT 124719B AT 124719D A AT124719D A AT 124719DA AT 124719 B AT124719 B AT 124719B
Authority
AT
Austria
Prior art keywords
iodination
pyridine derivatives
iodine
reaction products
yield
Prior art date
Application number
Other languages
German (de)
Inventor
Gerd Dr Kochendoerfer
Original Assignee
Gerd Dr Kochendoerfer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gerd Dr Kochendoerfer filed Critical Gerd Dr Kochendoerfer
Application granted granted Critical
Publication of AT124719B publication Critical patent/AT124719B/en

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  • Pyridine Compounds (AREA)

Description

  

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  Verfahren zur Jodierung von Pyridinderivaten. 
 EMI1.1 
 
 EMI1.2 
 
 EMI1.3 
 
 EMI1.4 
 
 EMI1.5 
 Pyridins in sauren oder im Verlaufe der Reaktion sauer werdenden Lösungen jodiert und aus den entstandenen Reaktionsprodukten durch Kochen mit Alkalilauge die Jodderivate abgeschieden. Die hiebei erzielten Ergebnisse sind aber sowohl bezüglich der Ausbeute als auch der Beschaffenheit der erzielten Produkte nicht befriedigend. So soll die Ausbeute an Jodaminopyridin nur etwa   50%   des theoretischen Wertes betragen. Die weiteren Nachteile dieses Verfahrens bestehen darin, dass durch dasselbe 
 EMI1.6 
 

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 EMI2.1 
 organischen Lösungsmitteln, dagegen ziemlich   löslich   in heissem 50%igem Alkohol und   hochsiedenden   Lösungsmitteln, wie z. B.

   Tetralin, in der Wärme, leicht löslich in sehr verdünntem Alkali. Mit Wasserdampf ist es nicht   flüchtig.   
 EMI2.2 
 sieren aus Eisessig einen Schmelzpunkt von   2750   ; Ausbeute : 16 g.



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  Process for the iodination of pyridine derivatives.
 EMI1.1
 
 EMI1.2
 
 EMI1.3
 
 EMI1.4
 
 EMI1.5
 Pyridines is iodized in acidic solutions or solutions that become acidic in the course of the reaction and the iodine derivatives are separated from the resulting reaction products by boiling with alkali. However, the results obtained here are unsatisfactory in terms of both the yield and the nature of the products obtained. The yield of iodaminopyridine is said to be only about 50% of the theoretical value. The other disadvantages of this method are that by doing the same thing
 EMI1.6
 

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 EMI2.1
 organic solvents, but quite soluble in hot 50% alcohol and high-boiling solvents, such as. B.

   Tetralin, when hot, easily soluble in very dilute alkali. It is not volatile with water vapor.
 EMI2.2
 size from glacial acetic acid a melting point of 2750; Yield: 16 g.

Claims (1)

PATENT-ANSPRUCH : Verfahren zur Jodierting von Pyridinderivaten, welche in a-Stellung eine Amino-bzw. Hydroxylgruppe enthalten, mit Hilfe von Jod oder Jod liefernden Mitteln unter Erwärmen und Zersetzung der hiebei gebildeten Reaktionsprodukte mittels verdünnter Alkalilaugen, dadurch gekennzeichnet, dass die Jodierung in Gegenwart solcher Mengen von Stoffen, die imstande sind, die freiwerdende Jodwasser- EMI2.3 PATENT CLAIM: Process for the iodination of pyridine derivatives, which in the α-position have an amino or. Containing hydroxyl group, with the help of iodine or iodine-supplying agents with heating and decomposition of the reaction products formed thereby by means of dilute alkali solutions, characterized in that the iodination in the presence of such amounts of substances which are capable of the liberated iodine water EMI2.3
AT124719D 1925-12-28 1925-12-28 Process for the iodination of pyridine derivatives. AT124719B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT124719T 1925-12-28

Publications (1)

Publication Number Publication Date
AT124719B true AT124719B (en) 1931-10-10

Family

ID=3633978

Family Applications (1)

Application Number Title Priority Date Filing Date
AT124719D AT124719B (en) 1925-12-28 1925-12-28 Process for the iodination of pyridine derivatives.

Country Status (1)

Country Link
AT (1) AT124719B (en)

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