AT130806B - Process for the production of a lozenge that is difficult to disintegrate. - Google Patents
Process for the production of a lozenge that is difficult to disintegrate.Info
- Publication number
- AT130806B AT130806B AT130806DA AT130806B AT 130806 B AT130806 B AT 130806B AT 130806D A AT130806D A AT 130806DA AT 130806 B AT130806 B AT 130806B
- Authority
- AT
- Austria
- Prior art keywords
- lozenge
- disintegrate
- difficult
- production
- cellulose
- Prior art date
Links
- 239000007937 lozenge Substances 0.000 title claims description 10
- 238000000034 method Methods 0.000 title claims description 4
- 238000004519 manufacturing process Methods 0.000 title claims description 3
- 239000001913 cellulose Substances 0.000 claims description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 239000000835 fiber Substances 0.000 claims description 5
- 235000010980 cellulose Nutrition 0.000 claims description 4
- 229920002678 cellulose Polymers 0.000 claims description 4
- 235000010603 pastilles Nutrition 0.000 claims description 4
- 235000019814 powdered cellulose Nutrition 0.000 claims description 3
- 229920003124 powdered cellulose Polymers 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 150000001768 cations Chemical class 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 206010052428 Wound Diseases 0.000 claims 2
- 208000027418 Wounds and injury Diseases 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 description 3
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 102000015728 Mucins Human genes 0.000 description 1
- 108010063954 Mucins Proteins 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 230000027455 binding Effects 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- GRWVQDDAKZFPFI-UHFFFAOYSA-H chromium(III) sulfate Chemical compound [Cr+3].[Cr+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRWVQDDAKZFPFI-UHFFFAOYSA-H 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910000358 iron sulfate Inorganic materials 0.000 description 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000024033 toxin binding Effects 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
<Desc/Clms Page number 1>
Verfahren zur Herstellung einer schwerzerfallbaren Pastille.
Durch das im folgenden beschriebene Verfahren lässt sich eine trockene Pastille herstellen, welche schwer zerfallbar ist und daher geeignet ist, an sich bekannte Wundheilstoffe in wunde Körperhöhlungen einzuführen und dort lange einwirken zu lassen.
Man hat bereits Tabletten aus Zellulose hergestellt. Man verwendete lange Fasern und bedurfte eines hohen Druckes, um die Arzneimittel der Pastille einzuverleiben. Sie wurden rasch abgegeben (D. R. P. Nr. 141. 009). Man hat auch Zellulose zur Herstellung von Pastillen verwendet, die so fein gemahlen war, dass sie ihre Faserstruktur verloren hat. Auch eine derartige Pastille ist leicht zerfallend (R. D. P. Nr. 311.148).
Im Gegensatz hiezu wird gemäss der Erfindung als Grundstoff für die Pastille Zellulose verwendet, diese auch pulverförmig ist, aber noch ihre Faserstruktur erhalten hat. Die untere Grenze derartiger Zellulosepulverteilchen liegt bei etwa 0'1 mum. Mit derartigem Zellulosepulver tritt die Wirkung der schweren Zerfallbarkeit der Pastille ein, wenn die gepulverte Zellulose mit mindestens einem Salz der dreiwertigen Kationen zu einer dickflüssigen Masse verarbeitet wird, aus welcher nach dem Trocknen Pastillen ausgestochen werden. Wird die gleiche Menge desselben Salzes einem Zellulosepulver beigemengt, dessen Struktur völlig zerstört ist, die also totgemahlen ist, so ergibt sich eine leichtzerfallende Pastille.
Beispiel : Die gepulverte Zellulose, deren Faserstruktur erhalten ist, wird mit einer gleichen Gewichtsmenge von Aluminiumsulfat vermischt. An Stelle des Aluminiumsulfates kann auch Eisensulfat oder ein Chromsulfat treten. In manchen Fällen kann es zweckmässig sein, dass die Pastille schwach alkalisch wirkt. In solchen Fällen kann den oben angegebenen Bestandteilen noch etwas Natriumacetat oder Natriumborat beigemengt werden.
Die erfindungsgemässe Pastille weist insbesondere die Eigenschaft auf, dass sie in den von der menschlichen Schleimhaut abgesonderten Flüssigkeiten sehr schwer zerfällt, das Sieben-bis Achtfache ihres Eigengewichtes an Flüssigkeit aufzunehmen vermag und eine toxinbindende und mucinbindende Wirkung ausübt.
**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.
<Desc / Clms Page number 1>
Process for the production of a lozenge that is difficult to disintegrate.
With the method described below, a dry lozenge can be produced which is difficult to disintegrate and is therefore suitable for introducing known wound healing substances into sore body cavities and allowing them to act for a long time.
Cellulose tablets have already been made. Long fibers were used and high pressure was required to incorporate the drugs into the lozenge. They were delivered quickly (D. R. P. No. 141, 009). Cellulose was also used to make pastilles that were ground so finely that they lost their fiber structure. Such a lozenge also disintegrates easily (R. D. P. No. 311.148).
In contrast to this, according to the invention, cellulose is used as the base material for the pastille, which is also in powder form, but has still retained its fiber structure. The lower limit of such cellulose powder particles is about 0.1 μm. With such a cellulose powder, the effect of the lozenge being difficult to disintegrate occurs when the powdered cellulose is processed with at least one salt of the trivalent cations to form a viscous mass, from which lozenges are cut after drying. If the same amount of the same salt is added to a cellulose powder, the structure of which has been completely destroyed, that is, which is ground to death, the result is an easily disintegrating lozenge.
Example: The powdered cellulose, the fiber structure of which has been preserved, is mixed with an equal amount by weight of aluminum sulfate. Iron sulfate or a chromium sulfate can also be used in place of aluminum sulfate. In some cases it can be useful that the lozenge has a weakly alkaline effect. In such cases, a little sodium acetate or sodium borate can be added to the ingredients listed above.
The pastille according to the invention has in particular the property that it is very difficult to disintegrate in the fluids secreted by the human mucous membrane, is able to absorb seven to eight times its own weight in fluid and has a toxin-binding and mucin-binding effect.
** WARNING ** End of DESC field may overlap beginning of CLMS **.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT130806T | 1931-03-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT130806B true AT130806B (en) | 1932-12-10 |
Family
ID=3636681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT130806D AT130806B (en) | 1931-03-12 | 1931-03-12 | Process for the production of a lozenge that is difficult to disintegrate. |
Country Status (1)
| Country | Link |
|---|---|
| AT (1) | AT130806B (en) |
-
1931
- 1931-03-12 AT AT130806D patent/AT130806B/en active
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